PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25405862-1 2014 BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese. Vitamin D 77-86 7-dehydrocholesterol reductase Homo sapiens 291-296 25405862-1 2014 BACKGROUND: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese. Vitamin D 345-354 7-dehydrocholesterol reductase Homo sapiens 291-296 24688000-7 2014 Third, among 24 candidate genes across vitamin D pathway, associations with BP traits that meet gene-wide significance level were found for NCOA3 (rs2235734), RXRA (rs875444), DHCR7 (rs1790370), VDR (rs2544037), and NCOR2 (rs1243733, rs1147289) in the WGHS and NCOR1, TP53BP1, and TYRP1 in the ICBP. Vitamin D 39-48 7-dehydrocholesterol reductase Homo sapiens 176-181 24184224-1 2014 PURPOSE: To test whether single nucleotide polymorphisms (SNPs) of the 4 vitamin D family genes (DHCR7, CYP2R1, CYP27B1, and CYP24A1) previously associated with several autoimmune diseases are associated with ocular Behcet disease, Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) with ankylosing spondylitis, or pediatric uveitis in the Chinese Han population. Vitamin D 73-82 7-dehydrocholesterol reductase Homo sapiens 97-102 25070320-2 2014 OBJECTIVE: We investigated whether 41 candidate single nucleotide polymorphisms (SNPs) in vitamin D and calcium pathway genes (GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR, and CASR) are associated with [25(OH)D] or modify the increase in [25(OH)D] from vitamin D3 supplementation. Vitamin D 90-99 7-dehydrocholesterol reductase Homo sapiens 131-136 24378747-9 2014 Furthermore, there is increasing evidence that the activity of DHCR7 may affect chronic liver diseases by influencing vitamin D levels. Vitamin D 118-127 7-dehydrocholesterol reductase Homo sapiens 63-68 24073854-3 2013 Our study aimed to identify the relationship between three vitamin D-related genes (group specific component [GC], cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1), and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and rickets in Han Chinese children from northeastern China. Vitamin D 59-68 7-dehydrocholesterol reductase Homo sapiens 262-267 22801813-0 2012 The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children. Vitamin D 51-60 7-dehydrocholesterol reductase Homo sapiens 19-24 23636220-4 2013 Single-nucleotide polymorphisms (SNPs) in the DHCR7/NADSYN1 (nicotinamide adenine dinucleotide synthase 1) and CYP2R1 loci, previously associated with circulating vitamin D levels, were tested in UK RA cases (n=3870) and controls (n=8430). Vitamin D 163-172 7-dehydrocholesterol reductase Homo sapiens 46-51 23837623-0 2013 DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes. Vitamin D 33-42 7-dehydrocholesterol reductase Homo sapiens 0-5 23837623-10 2013 CONCLUSIONS: Our results suggest that genetic variation in DHCR7 is the major adaptation affecting vitamin D metabolism in recent evolutionary history which helped early humans to avoid severe vitamin D deficiency and enabled them to inhabit areas further from the equator. Vitamin D 99-108 7-dehydrocholesterol reductase Homo sapiens 59-64 23319826-6 2013 RESULTS: In a linear regression model adjusting for month of blood sampling, age, and sex, vitamin D concentrations were predicted by GC genotype (P < 0.001), CYP2R1 genotype (P = 0.068), and DHCR7 genotype (P < 0.001), with a coefficient of determination (r(2)) of 0.175. Vitamin D 91-100 7-dehydrocholesterol reductase Homo sapiens 195-200 23219444-10 2013 The genomic and epigenomic approach reinforce the crucial roles played by the DHCR7, CYP2R1, and CYP24A1 genes in vitamin D metabolism. Vitamin D 114-123 7-dehydrocholesterol reductase Homo sapiens 78-83 22576297-8 2012 Homozygous carriers of the rare DHCR7 allele or the common CYP2R1 allele presented with reduced 25(OH)-vitamin D levels (P < 0.05). Vitamin D 103-112 7-dehydrocholesterol reductase Homo sapiens 32-37 22801813-3 2012 Our objective was to identify the relationship among three vitamin D-related genes (GC, CYP2R1 and DHCR7/NADSYN1) and the levels of 25(OH)D in northeastern Han Chinese children. Vitamin D 59-68 7-dehydrocholesterol reductase Homo sapiens 99-104 22130326-5 2012 The second SNP, rs12785878, is located near DHCR7 (Chr11), a genetic determinant of vitamin D insufficiency, and showed a size effect in MS similar to that recently observed in Type 1 diabetes (T1D; OR = 1.10; P = 0.009). Vitamin D 84-93 7-dehydrocholesterol reductase Homo sapiens 44-49 21972121-0 2012 Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans. Vitamin D 65-74 7-dehydrocholesterol reductase Homo sapiens 47-52 21972121-7 2012 In conclusion, GC and NADSYN1/DHCR7 loci individually and collectively contribute to variation in plasma vitamin D levels in Chinese Hans. Vitamin D 105-114 7-dehydrocholesterol reductase Homo sapiens 30-35 21441443-6 2011 We replicated the associations of four vitamin D metabolism genes (GC, DHCR7, CYP2R1, and CYP24A1) with 25(OH)D in control subjects. Vitamin D 39-48 7-dehydrocholesterol reductase Homo sapiens 71-76 21654390-3 2011 RECENT FINDINGS: Findings from large-scale genome-wide association meta-analyses on 25(OH)D confirmed the associations for loci nearby genes encoding vitamin D binding protein (GC, group component), 7-dehydrochlesterol reductase (DHCR7), 25-hydroxylase (CYP2R1) and 24-hydroxylase (CYP24A1), all influencing key sites for vitamin D metabolism. Vitamin D 150-159 7-dehydrocholesterol reductase Homo sapiens 230-235 34315477-10 2021 However, genetically regulated 25(OH)D deficiency due to vitamin D synthesis gene (DHCR7) may influence the risk of T2D. Vitamin D 57-66 7-dehydrocholesterol reductase Homo sapiens 83-88 16365879-0 2006 UVB-induced production of 1,25-dihydroxyvitamin D3 and vitamin D activity in human keratinocytes pretreated with a sterol delta7-reductase inhibitor. Vitamin D 40-49 7-dehydrocholesterol reductase Homo sapiens 115-138 34852423-11 2021 eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Vitamin D 54-63 7-dehydrocholesterol reductase Homo sapiens 138-168 34852423-11 2021 eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Vitamin D 54-63 7-dehydrocholesterol reductase Homo sapiens 170-175 34093899-0 2021 Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis. Vitamin D 32-41 7-dehydrocholesterol reductase Homo sapiens 63-68 34093899-2 2021 DHCR7 and CYP2R1 are crucial components of vitamin D-metabolizing enzymes. Vitamin D 43-52 7-dehydrocholesterol reductase Homo sapiens 0-5 33330279-3 2020 Different variants in the loci of the genes responsible for the synthesis, hydroxylation, and transport of vitamin D (such as DHCR7, CYP2R1, CYP24A1, and GC), as well as VDR gene polymorphisms may also be associated with the risk of vitamin D deficiency. Vitamin D 107-116 7-dehydrocholesterol reductase Homo sapiens 126-131 33692822-12 2021 Interpretation: Our results suggested that DHCR7 rs12785878 T>C might be associated with an increased risk of EOAD in the Chinese population, while other polymorphisms related to vitamin D insufficiency might not be. Vitamin D 179-188 7-dehydrocholesterol reductase Homo sapiens 43-48 33741398-0 2021 An intronic DHCR7 genetic polymorphism associates with vitamin D serum level and incidence of acute coronary syndrome. Vitamin D 55-64 7-dehydrocholesterol reductase Homo sapiens 12-17 33741398-5 2021 AIM: This study aims to correlate two polymorphisms in the DHCR7/NADSYN1 genetic locus with levels of circulatory vitamin D and the presentation of ACS in an Egyptian population. Vitamin D 114-123 7-dehydrocholesterol reductase Homo sapiens 59-64 33741398-9 2021 Allele A of the DHCR7 polymorphism was found to correlate with serum vitamin D deficiency and incidence of ACS classes: NSTEMI, STEMI and unstable angina, when compared to allele G. On the other hand, the NADSYN1 polymorphism rs2276360 correlated with serum 25(OH)D3 deficiency. Vitamin D 69-78 7-dehydrocholesterol reductase Homo sapiens 16-21 33741398-11 2021 CONCLUSION: We conclude that rs11606033, which is an intronic SNP between exon 4 and exon 5 of the DHCR7 gene, influences vitamin D serum abundance and more importantly ACS incidence. Vitamin D 122-131 7-dehydrocholesterol reductase Homo sapiens 99-104 33882819-3 2021 Seventeen SNPs of vitamin D metabolic pathway genes, including CYP24A1, CYP27A1, CYP27B1, CYP2R1, GC, and DHCR7, were genotyped with improved multiple ligase detection reaction (iMLDR). Vitamin D 18-27 7-dehydrocholesterol reductase Homo sapiens 106-111 32938288-0 2020 Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson"s disease. Vitamin D 20-29 7-dehydrocholesterol reductase Homo sapiens 49-54 32938288-9 2020 CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients. Vitamin D 143-152 7-dehydrocholesterol reductase Homo sapiens 52-57 32938288-9 2020 CONCLUSIONS: In conclusion, genetic variants of the DHCR7/NADSYN1 locus and the CYP2R1 gene might be related to the inefficient utilization of vitamin D independent from vitamin D levels, and it might result in differences in the clinical features of PD patients. Vitamin D 170-179 7-dehydrocholesterol reductase Homo sapiens 52-57 32289634-2 2020 The aim of this study was to determine whether 28 single nucleotide polymorphisms (SNPs) in six key vitamin D pathway genes (GC, DHCR7, CYP2 R1, CYP24 A1, CYP27 B1, VDR) were associated with differences in response to supplementation. Vitamin D 100-109 7-dehydrocholesterol reductase Homo sapiens 129-134 32102946-4 2020 We selected 21 SNPs in vitamin D-related genes (VDR, GC, C10orf88, CYP2R1, CYP24A1, CYP27B1, DHCR7, NADSYN1) to test genotype and genotype-treatment interactions in relation to prostate cancer. Vitamin D 23-32 7-dehydrocholesterol reductase Homo sapiens 93-98 31959263-3 2020 In 699 healthy 8-11-year-old children, we genotyped SNPs in vitamin D-related genes (DHCR7 (rs12785878, rs3829251); GC (rs4588, rs7041, rs12512631); CYP2R1 (rs10741657, rs10500804, rs156292); CYP27B1 (rs10877012); CYP24A1 (rs2296241); VDR (rs757343, rs2228570, rs11568820)). Vitamin D 60-69 7-dehydrocholesterol reductase Homo sapiens 85-90 32764491-8 2020 These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway. Vitamin D 173-182 7-dehydrocholesterol reductase Homo sapiens 57-62 31583252-5 2019 Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients. Vitamin D 172-181 7-dehydrocholesterol reductase Homo sapiens 103-108 29038561-8 2017 DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. Vitamin D 92-101 7-dehydrocholesterol reductase Homo sapiens 0-5 30316967-5 2019 Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D. Vitamin D 163-172 7-dehydrocholesterol reductase Homo sapiens 103-108 30796319-1 2019 Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D. Vitamin D 118-127 7-dehydrocholesterol reductase Homo sapiens 38-68 30796319-1 2019 Emerging evidence suggests a role for 7-dehydrocholesterol reductase (DHCR7) in the crosstalk between cholesterol and vitamin D. Vitamin D 118-127 7-dehydrocholesterol reductase Homo sapiens 70-75 30796319-2 2019 Our aim was to evaluate the impact of vitamin D-related polymorphisms and DHCR7 levels in the association between vitamin D deficiency and altered lipid profile in rheumatoid arthritis (RA). Vitamin D 114-123 7-dehydrocholesterol reductase Homo sapiens 74-79 29153269-14 2018 CONCLUSIONS: Genetic mutants in vitamin D pathway (GC, CYP3A4, CYP24A1, and NADSYN1/DHCR7) had significant associations with 25(OH)D levels among pregnant women in southeast China. Vitamin D 32-41 7-dehydrocholesterol reductase Homo sapiens 84-89 30405883-3 2018 In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. Vitamin D 54-63 7-dehydrocholesterol reductase Homo sapiens 76-81 30405883-3 2018 In the general population, genetic variants affecting vitamin D metabolism (DHCR7 rs12785878, CYP2R1 rs10741657, GC rs4588) have been associated with serum vitamin D. Vitamin D 156-165 7-dehydrocholesterol reductase Homo sapiens 76-81 30405883-10 2018 In conclusion, DHCR7 rs12785878 and GC rs4588, but not CYP2R1 rs10741657, are significantly associated with vitamin D levels. Vitamin D 108-117 7-dehydrocholesterol reductase Homo sapiens 15-20 29315215-2 2018 We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Vitamin D 78-87 7-dehydrocholesterol reductase Homo sapiens 210-215 29315215-2 2018 We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Vitamin D 186-195 7-dehydrocholesterol reductase Homo sapiens 210-215 31357732-3 2019 Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. Vitamin D 167-176 7-dehydrocholesterol reductase Homo sapiens 79-84 31357732-3 2019 Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. Vitamin D 219-228 7-dehydrocholesterol reductase Homo sapiens 79-84 31357732-8 2019 These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels. Vitamin D 152-161 7-dehydrocholesterol reductase Homo sapiens 28-33 30796319-7 2019 The associations among DHCR7, vitamin D and lipid profile followed a seasonal pattern, decreased DHCR7 (p = 0.008) and vitamin D (p < 0.001) and increased total-cholesterol (p = 0.025) being found in winter/spring. Vitamin D 119-128 7-dehydrocholesterol reductase Homo sapiens 23-28 30796319-8 2019 Increasing vitamin D upon TNFalpha-blockade paralleled RA clinical improvement (r = -0.610, p = 0.027) and DHCR7 elevation (r = 0.766, p = 0.002). Vitamin D 11-20 7-dehydrocholesterol reductase Homo sapiens 107-112 30796319-9 2019 In conclusion, vitamin D-related polymorphisms and DHCR7 are pivotal to understand the complex, seasonal associations between vitamin D and lipid profile in RA. Vitamin D 126-135 7-dehydrocholesterol reductase Homo sapiens 51-56 29153269-8 2018 Variants of NADSYN1/DHCR7 were significantly associated with 25(OH)D concentrations among pregnant women without vitamin D supplements. Vitamin D 113-122 7-dehydrocholesterol reductase Homo sapiens 20-25 28706201-5 2017 DHCR7 encodes an enzyme important in cutaneous synthesis of vitamin D and DHCR7 mutations are believed to be important for early humans to adapt to Northern Europe where residents have reduced ultraviolet-B exposure and tend to have light skin color. Vitamin D 60-69 7-dehydrocholesterol reductase Homo sapiens 0-5 28575224-12 2017 Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity. Vitamin D 102-111 7-dehydrocholesterol reductase Homo sapiens 34-39 26686945-6 2016 There was limited overlap between genetic determinants of vitamin D status and those associated with non-skeletal health outcomes: polymorphisms in DBP, CYP2R1 and DHCR7 were the most frequent to be reported to associate with circulating concentrations of 25(OH)D, while polymorphisms in VDR were most commonly reported to associate with non-skeletal health outcomes, among which infectious and autoimmune diseases were the most represented. Vitamin D 58-67 7-dehydrocholesterol reductase Homo sapiens 164-169 28415985-5 2017 Patients were genotyped for functional variants on vitamin D synthetic pathway including GC (rs4588, rs7041, rs22020, rs2282679), CYP2R1 (rs2060793, rs12794714), CYP27B1 (rs10877012), and DHCR7 (rs12785878). Vitamin D 51-60 7-dehydrocholesterol reductase Homo sapiens 188-193 28296915-6 2017 Thirteen SNPs derived from vitamin D cascade-related genes, including DHCR7 (rs12785878), CYP27B1 (rs10877012), CYP2R1 (rs2060793, rs12794714), GC (rs4588, rs7041, rs222020, rs2282679), and VDR (FokI, BsmI, Tru9I, ApaI, TaqI), were genotyped. Vitamin D 27-36 7-dehydrocholesterol reductase Homo sapiens 70-75 28382877-4 2017 In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (CYP2R1); 7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase-1(DHCR7/NADSYN1); group-specific complement (GC); and vitamin D receptor were genotyped. Vitamin D 27-36 7-dehydrocholesterol reductase Homo sapiens 124-176 27732326-6 2017 Results: Two single nucleotide polymorphisms (SNPs), rs3755967 (GC) and rs11603330 (DHCR7), were associated with higher risk of low vitamin D status [odds ratio (95% confidence interval) per minor allele, 1.27 (1.18 to 1.36) and 1.16 (1.08 to 1.25), respectively]. Vitamin D 132-141 7-dehydrocholesterol reductase Homo sapiens 84-89 27520299-6 2017 Here we provide evidence that phosphorylation plays a role in controlling DHCR7 activity, which may provide a means to divert flux from cholesterol synthesis to vitamin D production. Vitamin D 161-170 7-dehydrocholesterol reductase Homo sapiens 74-79 27520299-9 2017 Thus, we demonstrate that phosphorylation modulates DHCR7 activity in cells, and contributes to the overall synthesis of cholesterol, and probably vitamin D. Vitamin D 147-156 7-dehydrocholesterol reductase Homo sapiens 52-57 26686945-3 2016 We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (DHCR7, CYP2R1, CYP3A4, CYP27A1, DBP, LRP2, CUB, CYP27B1, CYP24A1, VDR and RXRA) and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D). Vitamin D 157-166 7-dehydrocholesterol reductase Homo sapiens 182-187 27401223-5 2016 We describe the functional environment around DHCR7, including pharmacological DHCR7 inhibitors and cholesterol and vitamin D synthesis. Vitamin D 116-125 7-dehydrocholesterol reductase Homo sapiens 46-51 25799011-3 2015 We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Vitamin D 15-24 7-dehydrocholesterol reductase Homo sapiens 44-49 27697512-0 2016 DHCR7: A vital enzyme switch between cholesterol and vitamin D production. Vitamin D 53-62 7-dehydrocholesterol reductase Homo sapiens 0-5 27697512-3 2016 Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin. Vitamin D 86-95 7-dehydrocholesterol reductase Homo sapiens 35-40 27697512-4 2016 Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production. Vitamin D 80-89 7-dehydrocholesterol reductase Homo sapiens 6-11 27697512-5 2016 Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis. Vitamin D 72-81 7-dehydrocholesterol reductase Homo sapiens 22-27 27697512-6 2016 This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis. Vitamin D 198-207 7-dehydrocholesterol reductase Homo sapiens 67-72 26149120-0 2015 Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes. Vitamin D 0-9 7-dehydrocholesterol reductase Homo sapiens 89-94 26149120-12 2015 : 361-31.357), while DHCR7/NADSYN1-rs12785878 was significantly associated with the presence of vitamin D deficiency in the Kazak ethnic population (P=0.011, OR=2.442, 95%C.I. Vitamin D 96-105 7-dehydrocholesterol reductase Homo sapiens 21-26 26149120-16 2015 Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations. Vitamin D 84-93 7-dehydrocholesterol reductase Homo sapiens 39-44 26887953-0 2016 Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. Vitamin D 108-117 7-dehydrocholesterol reductase Homo sapiens 36-66 26887953-9 2016 Thus, these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis. Vitamin D 95-104 7-dehydrocholesterol reductase Homo sapiens 31-36 26416604-6 2015 The T allele (vitamin-D-increasing allele) of DHCR7 rs12785878 was associated with greater decreases in insulin and HOMA-IR (p < 0.002) in response to high-protein diets, while there was no significant genotype effect on changes in these traits in the low-protein diet group. Vitamin D 14-23 7-dehydrocholesterol reductase Homo sapiens 46-51 25637936-6 2015 DHCR7 is important for both cholesterol and vitamin D synthesis, and we have identified a novel layer of regulation, whereby its activity is controlled by DHCR24. Vitamin D 44-53 7-dehydrocholesterol reductase Homo sapiens 0-5