PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35334282-4 2022 The present study seeks to further confirm the internal relationship between vitamin D deficiency and I/R-induced AKI in patients, and to explore the underlying mechanisms of ROS, NF-kappaB signaling pathways and pyroptosis in the renal ischemia-reperfusion injury, as well as investigating the protective role of cholecalciferol. Vitamin D 77-86 nuclear factor kappa B subunit 1 Homo sapiens 180-189 34183042-14 2021 Vitamin D reduced the phospho-NF-kappaB/p65 expression in the TNF-alpha-treated NP cells. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 30-40 34183042-15 2021 CONCLUSION: Vitamin D can attenuate TNF-alpha-induced NP cells apoptosis through interfering with the NF-kappaB pathway. Vitamin D 12-21 nuclear factor kappa B subunit 1 Homo sapiens 102-111 35364123-0 2022 The link between vitamin D status and NF-kappaB-associated renal dysfunction in experimental diabetes mellitus. Vitamin D 17-26 nuclear factor kappa B subunit 1 Homo sapiens 38-47 35364123-11 2022 Restoration of vitamin D status normalized vitamin D-endocrine system, decreased NF-kappaB activation and caspase-3 protein level in the kidneys of diabetic animals. Vitamin D 15-24 nuclear factor kappa B subunit 1 Homo sapiens 81-90 31905893-6 2019 Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-kappaB pathway to decrease CAD progression. Vitamin D 45-54 nuclear factor kappa B subunit 1 Homo sapiens 95-104 33578174-0 2021 Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-kappaB pathway in monocytes from pregnant women with preeclampsia. Vitamin D 17-26 nuclear factor kappa B subunit 1 Homo sapiens 103-112 33362771-9 2020 Finally, in-depth analysis and literature mining revealed that Vitamin D binds with its receptor and could work through two different pathways: (i) it inhibits the expression of pro-inflammatory cytokines through blocking the TNF induced NFkB1 signaling pathway; and (ii) it initiates the expression of interferon-stimulating genes (ISGs) for antiviral defense program through activating the IFN-alpha induced Jak-STAT signaling pathway. Vitamin D 63-72 nuclear factor kappa B subunit 1 Homo sapiens 238-243 35091041-4 2022 Vitamin D is a known inhibitor of NF-kappaB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 34-43 35091041-4 2022 Vitamin D is a known inhibitor of NF-kappaB signaling; further, vitamin D deficiency is prevalent in RTT patients and male Mecp2-null mice. Vitamin D 64-73 nuclear factor kappa B subunit 1 Homo sapiens 34-43 33912936-3 2021 Although vitamin D inhibits inflammation and ameliorates SHPT, the contribution of vitamin D deficiency to SHPT via local NF-kappaB activation remains to be clarified. Vitamin D 83-92 nuclear factor kappa B subunit 1 Homo sapiens 122-131 33912936-12 2021 Vitamin D deficiency may be involved in SHPT via the activation of NF-kappaB pathway. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 67-76 33883570-6 2021 Protein-protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-kappaB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. Vitamin D 64-73 nuclear factor kappa B subunit 1 Homo sapiens 126-135 32755551-0 2020 Vitamin D inhibits Tissue Factor and CAMs expression in oxidized low-density lipoproteins-treated human endothelial cells by modulating NF-kappaB pathway. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 136-145 32413483-9 2020 The inhibitory or stimulatory effects of vitamin D on AGE receptors are mediated by various signaling pathways, MAPK/NF-kappaB, ADAM10/MMP9 and AT1R. Vitamin D 41-50 nuclear factor kappa B subunit 1 Homo sapiens 117-126 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 nuclear factor kappa B subunit 1 Homo sapiens 268-290 31681485-14 2019 In addition, vitamin D downregulated TNF-alpha-induced nuclear factor kappa B (NF-kappaB) signaling in the HGKs. Vitamin D 13-22 nuclear factor kappa B subunit 1 Homo sapiens 55-77 31681485-14 2019 In addition, vitamin D downregulated TNF-alpha-induced nuclear factor kappa B (NF-kappaB) signaling in the HGKs. Vitamin D 13-22 nuclear factor kappa B subunit 1 Homo sapiens 79-88 31681485-17 2019 Vitamin D may reinforce ECJs by downregulating NF-kappaB signaling, which is upregulated by TNF-alpha. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 47-56 31819048-0 2019 Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 106-115 31288897-0 2019 Vitamin D attenuates lipopolysaccharide-induced inflammatory response in endothelial cells through inhibition of PI3K/Akt/NF-kappaB signaling pathway. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 122-131 30639520-12 2019 These data suggest a key role of vitamin D in the control of inflammatory cytokine responses during DENV infection of human macrophages via the TLR4/NF-kappaB/miR-155-5p/SOCS-1 axis. Vitamin D 33-42 nuclear factor kappa B subunit 1 Homo sapiens 149-158 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 nuclear factor kappa B subunit 1 Homo sapiens 292-301 27923595-10 2017 The vitamin D compounds also down-regulated the Notch signaling molecules, Notch1, Notch2, Notch3, JAG1, JAG2, HES1 and NFkappaB, which are involved in breast cancer stem cell maintenance. Vitamin D 4-13 nuclear factor kappa B subunit 1 Homo sapiens 120-128 29123173-0 2017 Effect of vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: a randomized placebo-controlled trial. Vitamin D 10-19 nuclear factor kappa B subunit 1 Homo sapiens 56-78 29123173-1 2017 In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFkappaB) activity. Vitamin D 30-39 nuclear factor kappa B subunit 1 Homo sapiens 75-97 29123173-1 2017 In-vitro studies suggest that vitamin D reduces inflammation by inhibiting nuclear factor kappa-B (NFkappaB) activity. Vitamin D 30-39 nuclear factor kappa B subunit 1 Homo sapiens 99-107 29123173-2 2017 Yet, no trials have examined the effects of vitamin D supplementation on NFkappaB activity in-vivo in humans. Vitamin D 44-53 nuclear factor kappa B subunit 1 Homo sapiens 73-81 29123173-3 2017 We conducted a double-blind randomized trial (RCT) examining effects of vitamin D supplementation on inflammatory markers and NFkappaB activity in peripheral blood mononuclear cells (PBMCs). Vitamin D 72-81 nuclear factor kappa B subunit 1 Homo sapiens 126-134 30453584-5 2018 Moreover, NF-kappaB up-regulation and nuclear translocation were detected, concomitantly with TG2 as well as TNF-alpha increased expression, in PBMC of vitamin D-deficient subjects. Vitamin D 152-161 nuclear factor kappa B subunit 1 Homo sapiens 10-19 30216977-4 2018 Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-kappaB) pathway, and immune cells. Vitamin D 36-45 nuclear factor kappa B subunit 1 Homo sapiens 186-208 30216977-4 2018 Mechanistic studies have shown that vitamin D influences inflammatory processes involved in cancer progression, including cytokines, prostaglandins, MAP kinase phosphatase 5 (MKP5), the nuclear factor kappa B (NF-kappaB) pathway, and immune cells. Vitamin D 36-45 nuclear factor kappa B subunit 1 Homo sapiens 210-219 28732679-1 2018 Vitamin D has been reported to have anti-inflammatory properties in in vitro and animal studies, which are thought to occur via inhibition of the nuclear factor kappa-B (NFkappaB) pathway. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 146-168 28732679-1 2018 Vitamin D has been reported to have anti-inflammatory properties in in vitro and animal studies, which are thought to occur via inhibition of the nuclear factor kappa-B (NFkappaB) pathway. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 170-178 28732679-2 2018 However, the association between vitamin D and in vivo NFkappaB activity in humans has not previously been reported. Vitamin D 33-42 nuclear factor kappa B subunit 1 Homo sapiens 55-63 28732679-11 2018 Although in-vitro studies suggest that vitamin D inhibits NFkappaB activity, our novel cross-sectional data from a cohort of healthy individuals suggest that vitamin D may regulate rather than inhibit the NFkappaB pathway. Vitamin D 39-48 nuclear factor kappa B subunit 1 Homo sapiens 58-66 28732679-11 2018 Although in-vitro studies suggest that vitamin D inhibits NFkappaB activity, our novel cross-sectional data from a cohort of healthy individuals suggest that vitamin D may regulate rather than inhibit the NFkappaB pathway. Vitamin D 158-167 nuclear factor kappa B subunit 1 Homo sapiens 205-213 28732679-12 2018 Large-scale intervention and mechanistic studies are needed to further investigate the effects of vitamin D on NFkappaB activity in vivo in humans. Vitamin D 98-107 nuclear factor kappa B subunit 1 Homo sapiens 111-119 17049230-0 2007 The Vitamin D analogue TX 527 blocks NF-kappaB activation in peripheral blood mononuclear cells of patients with Crohn"s disease. Vitamin D 4-13 nuclear factor kappa B subunit 1 Homo sapiens 37-46 24747771-8 2014 This manuscript reports novel findings regarding the effects of 1alpha,25-dihydroxyvitamin D3 on NFkappaB signaling in tamoxifen-resistant breast cancer cells and suggests that vitamin D might be interesting for further evaluation as a new strategy to treat antiestrogen-resistant breast cancers. Vitamin D 83-92 nuclear factor kappa B subunit 1 Homo sapiens 97-105 24105653-6 2014 Vitamin D restrained the expression of both NFkappaB- and STAT1-induced antiviral genes. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 44-53 22095230-6 2011 Active forms of vitamin D were found to inhibit NF-kappaB activity in nonpigmented cells, while having no effect on pigmented cells. Vitamin D 16-25 nuclear factor kappa B subunit 1 Homo sapiens 48-57 20206692-5 2010 Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response. Vitamin D 249-258 nuclear factor kappa B subunit 1 Homo sapiens 15-36 20206692-5 2010 Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response. Vitamin D 249-258 nuclear factor kappa B subunit 1 Homo sapiens 38-47 20206692-5 2010 Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response. Vitamin D 249-258 nuclear factor kappa B subunit 1 Homo sapiens 162-171 20206692-6 2010 Together, we conclude that NF-kappaB signaling is critical for vitamin D sensitivity, and dysregulation of this pathway would result in vitamin D resistance and disease progression. Vitamin D 63-72 nuclear factor kappa B subunit 1 Homo sapiens 27-36 20371119-1 2010 1alpha,25-Dihydroxyvitamin D(3) (VD(3)), the biologically active form of vitamin D, may have either pro- or anti-inflammatory activities because of its diverse actions on nuclear factor kappa B (NF-kappaB). Vitamin D 19-28 nuclear factor kappa B subunit 1 Homo sapiens 171-193 20371119-1 2010 1alpha,25-Dihydroxyvitamin D(3) (VD(3)), the biologically active form of vitamin D, may have either pro- or anti-inflammatory activities because of its diverse actions on nuclear factor kappa B (NF-kappaB). Vitamin D 19-28 nuclear factor kappa B subunit 1 Homo sapiens 195-204 26369816-8 2016 Here, we review the relationship between vitamin D analogs and inflammation based on observations of immune cells, prostaglandin and NFkappaB pathways, as well as common inflammatory diseases. Vitamin D 41-50 nuclear factor kappa B subunit 1 Homo sapiens 133-141 24262718-9 2014 CONCLUSION: Our results suggest that vitamin D treatment decreases inflammation-induced cytokines and contractile-associated factors in the uterine myometrial smooth muscle cells through the NFkappaB pathway. Vitamin D 37-46 nuclear factor kappa B subunit 1 Homo sapiens 191-199 22841897-3 2012 We have previously reported that the active form of vitamin D, 1alpha,25-dihydroxyvitamin D(3) (1alpha,25-(OH)(2)D(3)), inhibits tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation. Vitamin D 52-61 nuclear factor kappa B subunit 1 Homo sapiens 177-186 22683670-0 2012 NFkappaB pathway is down-regulated by 1alpha,25(OH)(2)-vitamin D(3) in endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein coupled receptor. Vitamin D 55-64 nuclear factor kappa B subunit 1 Homo sapiens 0-8 21350098-7 2011 There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFkappaB activity, and TLR4 expression (P < .05). Vitamin D 53-62 nuclear factor kappa B subunit 1 Homo sapiens 111-119 20385167-2 2010 One of the signaling pathways reported to be targeted by vitamin D is the NF-kappaB pathway, which is highly active in most immune cell types, including T cells. Vitamin D 57-66 nuclear factor kappa B subunit 1 Homo sapiens 74-83 20385167-3 2010 However, the effects of vitamin D on the NF-kappaB pathway in T cells are not fully understood. Vitamin D 24-33 nuclear factor kappa B subunit 1 Homo sapiens 41-50 20008294-0 2010 Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 61-70 20008294-5 2010 We found that vitamin D induces IkappaBalpha, an NF-kappaB inhibitor, in airway epithelium and decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and CXCL10. Vitamin D 14-23 nuclear factor kappa B subunit 1 Homo sapiens 49-58 20008294-5 2010 We found that vitamin D induces IkappaBalpha, an NF-kappaB inhibitor, in airway epithelium and decreases RSV induction of NF-kappaB-driven genes such as IFN-beta and CXCL10. Vitamin D 14-23 nuclear factor kappa B subunit 1 Homo sapiens 122-131 20008294-8 2010 Inhibiting NF-kappaB with an adenovirus vector that expressed a nondegradable form of IkappaBalpha mimicked the effects of vitamin D. Vitamin D 123-132 nuclear factor kappa B subunit 1 Homo sapiens 11-20 17397830-4 2007 The reactivation of NF-kappaB was concomitant with increased IKK activities, IKK-mediated IkappaBalpha phosphorylation, p65 phosphorylation at residues S276 and S536, p65 nuclear translocation and p65 recruitment to the NF-kappaB/vitamin D responsive element promoters. Vitamin D 230-239 nuclear factor kappa B subunit 1 Homo sapiens 20-29 11281654-0 2001 BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway. Vitamin D 37-46 nuclear factor kappa B subunit 1 Homo sapiens 6-9 16455676-0 2006 Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels. Vitamin D 0-9 nuclear factor kappa B subunit 1 Homo sapiens 20-28 16455676-2 2006 The aim of the present study is to examine whether this vitamin D inhibition of TNFalpha is mediated by its major transcription factor, nuclear factor-kappaB (NFkappaB). Vitamin D 56-65 nuclear factor kappa B subunit 1 Homo sapiens 159-167 16455676-7 2006 By using a reporter gene and EMSA we found that vitamin D markedly reduced NFkappaB activity. Vitamin D 48-57 nuclear factor kappa B subunit 1 Homo sapiens 75-83 11281654-4 2001 Therefore, we investigated the effect of the recently isolated BAG-1 p50 on the vitamin D pathway. Vitamin D 80-89 nuclear factor kappa B subunit 1 Homo sapiens 69-72 11281654-7 2001 These results suggest that BAG-1 p50 is a novel regulator of the vitamin D signaling pathway, and its overexpression may lead to cellular resistance to 1,25(OH)2D3 therapy. Vitamin D 65-74 nuclear factor kappa B subunit 1 Homo sapiens 33-36 9801142-1 1998 1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65. Vitamin D 19-28 nuclear factor kappa B subunit 1 Homo sapiens 95-104 9801142-1 1998 1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65. Vitamin D 19-28 nuclear factor kappa B subunit 1 Homo sapiens 167-176 9801142-1 1998 1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2-D3), the active metabolite of vitamin D, can inhibit NF-kappaB activity in human MRC-5 fibroblasts, targeting DNA binding of NF-kappaB but not translocation of its subunits p50 and p65. Vitamin D 19-28 nuclear factor kappa B subunit 1 Homo sapiens 215-218