PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23662440-9 2012 Proper supplementation with vitamin D increase the concentration of substrate for local 1,25(OH)2D synthesis 25(OH)D, which directly suppress PTH, increase Klotho, and decrease FGF-23 by proanabolic action on bone. Vitamin D 28-37 fibroblast growth factor 23 Homo sapiens 177-183 34346986-5 2021 In participants with the estimated glomerular filtration rate >45mL/minute/1.73m2, mean fibroblast growth factor 23 level was higher in those with 25(OH) vitamin D <20ng/mL than in those with 25(OH) vitamin D >=20ng/mL (75.6RU/mL+-42.8 versus 68.5RU/mL+-41.7; p<0.001). Vitamin D 154-163 fibroblast growth factor 23 Homo sapiens 88-115 34534708-4 2022 To reach the correct diagnosis, clinicians must recognize the typical clinical manifestations of intravenous iron-induced hypophosphatemia and identify a specific pattern of biochemical changes (hyperphosphaturic hypophosphatemia triggered by high FGF23 that causes low 1,25 (OH)2 vitamin D, hypocalcemia and secondary hyperparathyroidism). Vitamin D 281-290 fibroblast growth factor 23 Homo sapiens 248-253 34710560-0 2022 The effect of vitamin D supplementation on serum levels of fibroblast growth factor- 23: A systematic review and meta-analysis of randomized controlled trials. Vitamin D 14-23 fibroblast growth factor 23 Homo sapiens 59-87 34710560-2 2022 This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to investigate the effect of vitamin D supplementation on serum levels of FGF-23. Vitamin D 116-125 fibroblast growth factor 23 Homo sapiens 161-167 34930854-1 2021 INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 14-41 34930854-1 2021 INTRODUCTION: Fibroblast growth factor-23 (FGF23) is responsible for regulating the metabolism of phosphorus and vitamin D by affecting the kidneys and parathyroid gland. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 43-48 34147708-3 2021 Elevated FGF23 results in renal phosphate wasting and compromised vitamin D activation, ultimately resulting in osteomalacia. Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 9-14 34950827-8 2021 The purpose of this review is to highlight our current understanding of the molecular mechanisms underlying the regulation of vitamin D metabolism by FGF23, and to discuss the role of these mechanisms in physiology and pathophysiology. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 150-155 34642495-0 2022 Correction: The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 39-66 34710560-3 2022 PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched, from database inception to November 2020, for RCTs that evaluated the effects of native or active vitamin D supplementation on serum levels of FGF-23 in adults. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 219-225 34255195-7 2021 Furthermore, the diagnostic sensitivity of FGF23-related hypophosphatemia with vitamin D deficiency remained at 100%. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 43-48 34950827-1 2021 Apart from its phosphaturic action, the bone-derived hormone fibroblast growth factor-23 (FGF23) is also an essential regulator of vitamin D metabolism. Vitamin D 131-140 fibroblast growth factor 23 Homo sapiens 61-88 34950827-1 2021 Apart from its phosphaturic action, the bone-derived hormone fibroblast growth factor-23 (FGF23) is also an essential regulator of vitamin D metabolism. Vitamin D 131-140 fibroblast growth factor 23 Homo sapiens 90-95 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 104-113 fibroblast growth factor 23 Homo sapiens 25-30 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 104-113 fibroblast growth factor 23 Homo sapiens 52-57 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 229-238 fibroblast growth factor 23 Homo sapiens 25-30 34950827-2 2021 The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme in vitamin D hormone (1,25(OH)2D) activation, 1alpha-hydroxylase, and activates transcription of the key enzyme responsible for vitamin D degradation, 24-hydroxylase, in proximal renal tubules. Vitamin D 229-238 fibroblast growth factor 23 Homo sapiens 52-57 34950827-5 2021 During recent years, big strides have been made toward a more complete understanding of the mechanisms underlying the FGF23-mediated regulation of vitamin D metabolism, especially at the genomic level. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 118-123 34346986-5 2021 In participants with the estimated glomerular filtration rate >45mL/minute/1.73m2, mean fibroblast growth factor 23 level was higher in those with 25(OH) vitamin D <20ng/mL than in those with 25(OH) vitamin D >=20ng/mL (75.6RU/mL+-42.8 versus 68.5RU/mL+-41.7; p<0.001). Vitamin D 199-208 fibroblast growth factor 23 Homo sapiens 88-115 34203792-8 2021 Burosumab binds circulating intact FGF23 and blocks its biological effects in target tissues, resulting in increased serum inorganic phosphate (Pi) concentrations and increased conversion of inactive vitamin D to active 1,25-vitD. Vitamin D 200-209 fibroblast growth factor 23 Homo sapiens 35-40 34296353-1 2022 Fibroblast growth factor 23 (FGF-23), a hormone mainly secreted by osteocytes and osteoblasts, regulates phosphate and vitamin D levels. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 0-27 34296353-1 2022 Fibroblast growth factor 23 (FGF-23), a hormone mainly secreted by osteocytes and osteoblasts, regulates phosphate and vitamin D levels. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 29-35 35084563-1 2022 Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 0-27 34268038-20 2021 Interestingly, FGF-23 is shown to have a potential cardiovascular (CV) morbidity and mortality through various mechanisms like activation of myocardial FGF-23 receptors, endothelial dysfunction, inflammation, and altered phosphorus and vitamin D metabolisms. Vitamin D 236-245 fibroblast growth factor 23 Homo sapiens 15-21 34286168-1 2021 Purpose: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23). Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 179-206 34286168-1 2021 Purpose: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23). Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 208-213 35084563-1 2022 Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 29-34 34055103-3 2021 It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its excess or deficiency leads to various hereditary diseases. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 92-97 35090436-1 2022 BACKGROUND: Tumor-induced osteomalacia (TIO) is a rare, acquired disease of renal phosphate wasting and disturbed vitamin D homeostasis as a result of the action of a phosphaturic protein - FGF-23, produced by a neoplasm. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 190-196 35145798-17 2022 In this case report, we want to highlight the paramount importance of adequate tumor screening in adult patients with acquired hypophosphatemia, and the crucial lead that phosphate and vitamin D regulating hormones (FGF23) have for suspecting TIO. Vitamin D 185-194 fibroblast growth factor 23 Homo sapiens 216-221 35053218-10 2022 Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 77-82 33928687-0 2021 The effect of vitamin D supplementation on fibroblast growth factor-23 in patients with chronic kidney disease: A systematic review and meta-analysis. Vitamin D 14-23 fibroblast growth factor 23 Homo sapiens 43-70 33928687-1 2021 This is a meta-analysis of randomized controlled trials (RCTs) investigating the effects of oral vitamin D supplementation on serum fibroblast growth factor-23 (FGF23) concentrations in patients with chronic kidney disease (CKD). Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 132-159 33928687-1 2021 This is a meta-analysis of randomized controlled trials (RCTs) investigating the effects of oral vitamin D supplementation on serum fibroblast growth factor-23 (FGF23) concentrations in patients with chronic kidney disease (CKD). Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 161-166 33928687-8 2021 However, further high-quality trials are required to identify the influence of oral vitamin D supplementation on FGF23 levels in patients with CKD. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 113-118 33837680-1 2021 OBJECTIVES: X-linked hypophosphatemic rickets (XLH) is a congenital fibroblast growth factor (FGF)23-related metabolic bone disease that is treated with active vitamin D and phosphate as conventional therapies. Vitamin D 160-169 fibroblast growth factor 23 Homo sapiens 94-100 33895867-6 2021 An increase in Fibroblast Growth Factor 23 (FGF23) with analogue administration was found in all 3 studies reporting FGF23, but was unaltered in 4 studies with vitamin D or calcifediol. Vitamin D 160-169 fibroblast growth factor 23 Homo sapiens 44-49 33792238-2 2021 Additionally, FGF23 interacts with vitamin D and parathyroid hormone in a complex metabolic pathway whose detailed mechanisms are still not clear in human physiology and disease. Vitamin D 35-44 fibroblast growth factor 23 Homo sapiens 14-19 33000285-1 2021 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 0-27 33593830-4 2021 There is a plausible biological explanation since high-dose bolus replacement induces long-term expression of the catabolic enzyme 24-hydroxylase and fibroblast growth factor 23, both of which have vitamin D inactivating effects. Vitamin D 198-207 fibroblast growth factor 23 Homo sapiens 150-177 33000285-1 2021 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 29-34 33374582-5 2020 Plasma calcitriol concentrations are inversely proportional to caloric intake due to modulation by FGF23 of the enzymes implicated in vitamin D metabolism. Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 99-104 33295878-4 2021 Circulatory FGF23 is high in patients with these hypophosphatemic diseases while FGF23 is rather low in those with chronic hypophosphatemia from other causes such as vitamin D deficiency. Vitamin D 166-175 fibroblast growth factor 23 Homo sapiens 81-86 33295878-9 2021 Phosphate and active vitamin D have been used for patients with hypophosphatemic diseases caused by excessive actions of FGF23 including TIO patients with unresectable tumors. Vitamin D 21-30 fibroblast growth factor 23 Homo sapiens 121-126 33035687-2 2021 Fibroblast growth factor 23 (FGF23), a hormone involved in phosphate, vitamin D and iron homeostasis, is linked to LVH and HF. Vitamin D 70-79 fibroblast growth factor 23 Homo sapiens 0-27 33035687-2 2021 Fibroblast growth factor 23 (FGF23), a hormone involved in phosphate, vitamin D and iron homeostasis, is linked to LVH and HF. Vitamin D 70-79 fibroblast growth factor 23 Homo sapiens 29-34 33241290-10 2021 This discrepancy may be due to further enhancement of circulating FGF23 and faster progression of CKD associated with reduced sKlotho and higher serum phosphate in vitamin D-treated patients. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 66-71 32743932-8 2021 RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use. Vitamin D 162-171 fibroblast growth factor 23 Homo sapiens 40-45 32743932-8 2021 RESULTS: Patients with higher levels of FGF23 were younger and had higher levels of serum albumin, creatinine, albumin-corrected calcium, phosphorus, PTH, 25(OH)-vitamin D, and had higher percentages of intravenous (IV) iron, IV vitamin D and cinacalcet use. Vitamin D 229-238 fibroblast growth factor 23 Homo sapiens 40-45 33424930-1 2020 Fibroblast growth factor 23 (FGF23), which is involved in the regulation of vitamin D, is an emerging independent risk factor for cardiovascular diseases. Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 0-27 33424930-1 2020 Fibroblast growth factor 23 (FGF23), which is involved in the regulation of vitamin D, is an emerging independent risk factor for cardiovascular diseases. Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 29-34 33257569-2 2020 FGF23 stimulates the assembly of a signaling complex composed of alpha-Klotho (KLA) and FGF receptor (FGFR) resulting in kinase activation, regulation of phosphate homeostasis, and vitamin D levels. Vitamin D 181-190 fibroblast growth factor 23 Homo sapiens 0-5 32855522-0 2021 The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Vitamin D 14-23 fibroblast growth factor 23 Homo sapiens 27-54 33306729-1 2020 BACKGROUND: Concentrations of fibroblast growth factor 23 (FGF-23), a hormone that regulates phosphorus and vitamin D metabolism, increase as kidney function declines. Vitamin D 108-117 fibroblast growth factor 23 Homo sapiens 30-57 33306729-1 2020 BACKGROUND: Concentrations of fibroblast growth factor 23 (FGF-23), a hormone that regulates phosphorus and vitamin D metabolism, increase as kidney function declines. Vitamin D 108-117 fibroblast growth factor 23 Homo sapiens 59-65 32430147-1 2020 BACKGROUND: Fibroblast growth factor 23 (FGF23), an important regulator of phosphate and vitamin D metabolism, has also been suggested to perform metabolic functions. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 12-39 32430147-1 2020 BACKGROUND: Fibroblast growth factor 23 (FGF23), an important regulator of phosphate and vitamin D metabolism, has also been suggested to perform metabolic functions. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 41-46 33112809-2 2020 High FGF23 causes hypophosphataemia, reduced active vitamin D concentration and clinically manifests as rickets in children and osteomalacia in children and adults. Vitamin D 52-61 fibroblast growth factor 23 Homo sapiens 5-10 32701599-2 2020 Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD). Vitamin D 158-167 fibroblast growth factor 23 Homo sapiens 83-110 32701599-2 2020 Study of inherited and acquired hypophosphatemic syndromes led to the discovery of fibroblast growth factor 23 (FGF23) as a potent regulator of phosphate and vitamin D metabolism, and advanced our understanding of the pathophysiology of mineral and bone disorder in chronic kidney disease (CKD-MBD). Vitamin D 158-167 fibroblast growth factor 23 Homo sapiens 112-117 32729975-2 2020 Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 52-79 32729975-2 2020 Here, we demonstrate systemic and direct effects of Fibroblast growth factor 23 (FGF23) and Klotho, which normally regulate vitamin D and mineral homeostasis, on testicular function. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 81-86 32729975-10 2020 In conclusion, this translational study suggests that FGF23 and Klotho influence gonadal function and testicular mineral ion homeostasis both directly and indirectly through systemic changes in vitamin D and mineral homeostasis. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 54-59 32919110-1 2020 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 27-54 32919110-1 2020 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 56-61 32964520-1 2020 Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 0-27 32964520-1 2020 Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 29-34 32982979-6 2020 FGF23 acts on the kidneys through partner fibroblast growth factor receptors (FGFRs) and the co-receptor Klotho to promote phosphaturia via a downregulation of phosphate transporters, as well as the control of vitamin D metabolizing enzymes to reduce blood 1,25D. Vitamin D 210-219 fibroblast growth factor 23 Homo sapiens 0-5 32982966-2 2020 The alpha-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 45-72 32982966-2 2020 The alpha-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and vitamin D metabolism. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 74-79 32855522-2 2021 We therefore aimed to synthesize the evidence for the effect of vitamin D administration on circulating FGF23 concentrations. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 104-109 32855522-6 2021 The weighted mean difference in FGF23 in the vitamin D versus placebo group was +21 pg/ml (95% CI: 13-28 pg/ml; P < 0.001) with considerable heterogeneity among studies (I2 = 99%). Vitamin D 45-54 fibroblast growth factor 23 Homo sapiens 32-37 32855522-8 2021 Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001). Vitamin D 48-57 fibroblast growth factor 23 Homo sapiens 14-19 32855522-8 2021 Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001). Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 14-19 32855522-8 2021 Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001). Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 14-19 32855522-8 2021 Moreover, the FGF23 increment was influenced by vitamin D dose/type (vitamin D dose equivalent <= 2000 IU/day: +2 pg/ml [95% CI: 0-3 pg/ml]; vitamin D dose equivalent > 2000 IU/day: +18 pg/ml [95% CI: 6-30 pg/ml]; administration of activated vitamin D: +67 pg/ml [95% CI: 16-117 pg/ml]; Pinteraction = 0.001). Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 14-19 32855522-10 2021 In conclusion, this meta-analysis of RCTs demonstrates that vitamin D administration of >2000 IU/d vitamin D or activated vitamin D significantly increased concentrations of the cardiovascular risk marker FGF23, especially in patients with end-stage kidney/heart failure. Vitamin D 60-69 fibroblast growth factor 23 Homo sapiens 205-210 32855522-10 2021 In conclusion, this meta-analysis of RCTs demonstrates that vitamin D administration of >2000 IU/d vitamin D or activated vitamin D significantly increased concentrations of the cardiovascular risk marker FGF23, especially in patients with end-stage kidney/heart failure. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 205-210 32855522-10 2021 In conclusion, this meta-analysis of RCTs demonstrates that vitamin D administration of >2000 IU/d vitamin D or activated vitamin D significantly increased concentrations of the cardiovascular risk marker FGF23, especially in patients with end-stage kidney/heart failure. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 205-210 32513031-2 2020 FGF19 and FGF21 regulate bile acid and energy homeostasis, respectively, whereas FGF23 regulates vitamin D and phosphate homeostasis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 81-86 32576601-2 2020 Fibroblast growth factor 23 (FGF23) is often elevated in CKD, and may impair immune function directly or indirectly through proinflammatory and vitamin D-suppressing pathways. Vitamin D 144-153 fibroblast growth factor 23 Homo sapiens 0-27 32576601-2 2020 Fibroblast growth factor 23 (FGF23) is often elevated in CKD, and may impair immune function directly or indirectly through proinflammatory and vitamin D-suppressing pathways. Vitamin D 144-153 fibroblast growth factor 23 Homo sapiens 29-34 31792685-9 2020 These results indicate that FGF23 is a physiological regulator of phosphate and vitamin D metabolism and indispensable for the maintenance of serum phosphate levels. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 28-33 32418499-1 2020 FGF-23 (fibroblast growth factor 23) regulates phosphorus and vitamin D. Vitamin D 62-71 fibroblast growth factor 23 Homo sapiens 0-6 32418499-1 2020 FGF-23 (fibroblast growth factor 23) regulates phosphorus and vitamin D. Vitamin D 62-71 fibroblast growth factor 23 Homo sapiens 8-35 32605590-2 2020 Excess FGF23 activity leads to increased phosphate excretion in the kidneys - mediated by downregulation of renal tubular phosphate transporters - and reduced phosphate absorption in the intestines - due to impaired vitamin D activation. Vitamin D 216-225 fibroblast growth factor 23 Homo sapiens 7-12 32655262-5 2020 Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 0-27 32655262-5 2020 Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 29-35 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 309-336 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 338-344 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 309-336 32647755-6 2020 There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 338-344 31792685-6 2020 FGF23 also decreases 1,25-dihydroxyvitamin D levels by regulating the expression of vitamin D-metabolizing enzymes, which results in reduced intestinal phosphate absorption. Vitamin D 35-44 fibroblast growth factor 23 Homo sapiens 0-5 32004706-0 2020 Fibroblast growth factor 23 counters vitamin D metabolism and action in human mesenchymal stem cells. Vitamin D 37-46 fibroblast growth factor 23 Homo sapiens 0-27 32004706-3 2020 In this study, we tested the hypothesis that FGF23 inhibits vitamin D metabolism and action in hMSCs. Vitamin D 60-69 fibroblast growth factor 23 Homo sapiens 45-50 32004706-9 2020 These data demonstrate that dysregulated vitamin D metabolism in hMSCs may contribute to impaired osteoblastogenesis and altered bone and mineral metabolism in CKD subjects due to elevated FGF23. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 189-194 32405607-1 2020 Context: alphaKlotho is a hormone and co-receptor for fibroblast growth factor 23 (FGF23), a hormone that downregulates active vitamin D synthesis and promotes phosphate excretion. Vitamin D 127-136 fibroblast growth factor 23 Homo sapiens 54-81 32405607-1 2020 Context: alphaKlotho is a hormone and co-receptor for fibroblast growth factor 23 (FGF23), a hormone that downregulates active vitamin D synthesis and promotes phosphate excretion. Vitamin D 127-136 fibroblast growth factor 23 Homo sapiens 83-88 32045827-13 2020 Therefore, an appropriate vitamin D analog should be chosen for each patient with mineral and bone disorder, considering its effect on FGF23 production. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 135-140 32355520-1 2020 To clarify the regulation of astragalus on the aging BMSCs model and the effect of astragalus on Vitamin D (VD)-FGF23-Klotho axis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 112-117 32204545-7 2020 Megalin-Cubilin-Amnionless and the FGF23-Klotho axis represent two Vitamin D-linked mechanisms that could modulate and ameliorate the damage response at the renal tubular level, balancing Vitamin D therapy with an effect potent enough to contrast the inflammatory cascades, but which avoids potential severe side effects. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 35-40 31949415-12 2019 The increase of serum hepcidin levels may be inhibited by effective treatment of anemia with iron supplementation and erythropoietin, and the treatment of secondary hyperparathyroidism with phosphate binders and the active form of vitamin D, which decrease serum parathyroid hormone and fibroblast growth factor-23 levels, and control inflammation to some extent. Vitamin D 231-240 fibroblast growth factor 23 Homo sapiens 287-314 31465293-0 2019 The role of vitamin D replacement therapy in serum FGF23 concentration in children with myelomeningocele compared with healthy children - a preliminary study. Vitamin D 12-21 fibroblast growth factor 23 Homo sapiens 51-56 31905439-6 2019 Excessive action of fibroblast growth factor 23 (FGF23), a key regulator of Pi metabolism, leads to renal Pi wasting and impairs vitamin D activation. Vitamin D 129-138 fibroblast growth factor 23 Homo sapiens 20-47 31905439-6 2019 Excessive action of fibroblast growth factor 23 (FGF23), a key regulator of Pi metabolism, leads to renal Pi wasting and impairs vitamin D activation. Vitamin D 129-138 fibroblast growth factor 23 Homo sapiens 49-54 31465293-1 2019 Background Fibroblast growth factor 23 (FGF23) is a recently discovered bone-derived regulator of vitamin D metabolism and phosphate homeostasis. Vitamin D 98-107 fibroblast growth factor 23 Homo sapiens 11-38 31465293-1 2019 Background Fibroblast growth factor 23 (FGF23) is a recently discovered bone-derived regulator of vitamin D metabolism and phosphate homeostasis. Vitamin D 98-107 fibroblast growth factor 23 Homo sapiens 40-45 31465293-4 2019 We aimed to investigate the influence of vitamin D replacement therapy on serum FGF23 concentration in children with MMC and compare the results with healthy participants. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 80-85 31465293-10 2019 In MMC children we found a significant decrease in median serum FGF23 after vitamin D replacement therapy (from 42.1 to 0 RU/mL, p < 0.001). Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 64-69 31465293-15 2019 Vitamin D replacement therapy decreases FGF23 concentrations in MMC children, although further studies are still warranted to gain detailed insight on the FGF23 in the MMC population. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 40-45 31495905-7 2019 FGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calcium, vitamin D, and parathyroid hormone that are important for bone health and systemic mineral balance. Vitamin D 105-114 fibroblast growth factor 23 Homo sapiens 0-5 31372708-0 2019 Oral vitamin D3 supplementation increases serum fibroblast growth factor 23 concentration in vitamin D-deficient patients: a systematic review and meta-analysis. Vitamin D 5-14 fibroblast growth factor 23 Homo sapiens 48-75 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 28-37 fibroblast growth factor 23 Homo sapiens 73-100 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 28-37 fibroblast growth factor 23 Homo sapiens 102-107 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 115-124 fibroblast growth factor 23 Homo sapiens 73-100 31372708-1 2019 Studies have suggested that vitamin D supplementation may increase serum fibroblast growth factor 23 (FGF23) among vitamin D-deficient patients although the results were inconsistent across the studies. Vitamin D 115-124 fibroblast growth factor 23 Homo sapiens 102-107 31372708-8 2019 The meta-analyses found that serum intact FGF23 increased significantly after oral vitamin D3 supplementation in vitamin D-deficient participants with the pooled SMD of 0.36 (95%CI, 0.14, 0.57; p = 0.001; I2 of 36%). Vitamin D 83-92 fibroblast growth factor 23 Homo sapiens 42-47 31372708-9 2019 Serum C-terminal FGF23 also increased after vitamin D3 supplementation in vitamin D-deficient participants with the pooled SMD of 0.28 although without reaching statistical significance (95%CI, - 0.08, 0.65; p = 0.13; I2 of 0%). Vitamin D 44-53 fibroblast growth factor 23 Homo sapiens 17-22 31372708-11 2019 Vitamin D supplementation leads to a significant increase in serum intact FGF23 among vitamin D-deficient patients. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 74-79 31372708-11 2019 Vitamin D supplementation leads to a significant increase in serum intact FGF23 among vitamin D-deficient patients. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 74-79 31372708-13 2019 The present systematic review and meta-analysis revealed that serum intact FGF23 concentration increased significantly after oral vitamin D3 supplementation in vitamin D-deficient participants. Vitamin D 130-139 fibroblast growth factor 23 Homo sapiens 75-80 31377240-0 2019 Vitamin D sterols increase FGF23 expression by stimulating osteoblast and osteocyte maturation in CKD bone. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 27-32 31485552-4 2019 FGF23-mediated forms of hypophosphatemia are characterized by phosphaturia and low or low-normal calcitriol concentrations, and unlike nutritional rickets, these cannot be cured with nutritional vitamin D supplementation. Vitamin D 195-204 fibroblast growth factor 23 Homo sapiens 0-5 31261249-2 2019 The overproduction of fibroblast growth factor 23 causes a paraneoplastic syndrome characterized by hyperphosphaturia, hypophosphatemia, hypovitaminosis D, and vitamin D refractory rickets/osteomalacia, effects that disappear with tumor removal. Vitamin D 160-169 fibroblast growth factor 23 Homo sapiens 22-49 31599133-9 2019 Conventional therapy for XLH and other disorders of FGF23-mediated hypophosphatemia involves multiple daily doses of oral phosphate salts and active vitamin D analogs, such as calcitriol or alfacalcidol. Vitamin D 149-158 fibroblast growth factor 23 Homo sapiens 52-57 30613854-1 2019 INTRODUCTION: X-linked hypophosphatemic rickets (XLH) can occasionally cause premature fusion of cranial sutures through an increased level of fibroblast growth factor 23 (FGF-23), which leads to the dysregulation of phosphate and vitamin D metabolism. Vitamin D 231-240 fibroblast growth factor 23 Homo sapiens 143-170 30613854-1 2019 INTRODUCTION: X-linked hypophosphatemic rickets (XLH) can occasionally cause premature fusion of cranial sutures through an increased level of fibroblast growth factor 23 (FGF-23), which leads to the dysregulation of phosphate and vitamin D metabolism. Vitamin D 231-240 fibroblast growth factor 23 Homo sapiens 172-178 31461904-3 2019 FGF23 is a bone-derived hormone that is essential for regulating vitamin D and phosphate homeostasis. Vitamin D 65-74 fibroblast growth factor 23 Homo sapiens 0-5 31044263-3 2019 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is an endocrine hormone-regulating phosphate and vitamin D metabolism. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 14-41 31044263-3 2019 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is an endocrine hormone-regulating phosphate and vitamin D metabolism. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 43-48 31044263-10 2019 CONCLUSIONS: Taken together, high FGF23 levels are associated with impaired trabecular bone microarchitecture in osteoporosis patients, and this association seems to occur after adjustment of confounding variables including phosphate and vitamin D. Vitamin D 238-247 fibroblast growth factor 23 Homo sapiens 34-39 31037817-1 2019 FGF-23 is a 32 kDa protein that is a key regulator of phosphorus and vitamin D metabolism. Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 0-6 31485552-7 2019 Historically phosphate supplementation and therapy using analogs of highly active vitamin D (eg, calcitriol, alfacalcidol, paricalcitol, eldecalcitol) have been used to manage conditions involving hypophosphatemia; however, recently a neutralizing antibody for FGF23 (burosumab) has emerged as a promising treatment agent for FGF23-mediated disorders. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 261-266 31485552-7 2019 Historically phosphate supplementation and therapy using analogs of highly active vitamin D (eg, calcitriol, alfacalcidol, paricalcitol, eldecalcitol) have been used to manage conditions involving hypophosphatemia; however, recently a neutralizing antibody for FGF23 (burosumab) has emerged as a promising treatment agent for FGF23-mediated disorders. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 326-331 31035488-4 2019 The patients with any vitamin D formulation had higher serum concentrations of 25-hydroxy vitamin D and fibroblast growth factor-23 and tended to have higher mortality rates (42% vs. 25%, p = 0.07). Vitamin D 22-31 fibroblast growth factor 23 Homo sapiens 104-131 30813741-1 2019 BACKGROUND: Fibroblast growth factor 23 (FGF23), a potent regulator of phosphate and vitamin D metabolism, is a new biomarker of kidney, bone and cardiovascular disorders. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 12-39 30813741-1 2019 BACKGROUND: Fibroblast growth factor 23 (FGF23), a potent regulator of phosphate and vitamin D metabolism, is a new biomarker of kidney, bone and cardiovascular disorders. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 41-46 29481636-7 2018 Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 44-49 31058117-1 2019 Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 0-27 31058117-1 2019 Fibroblast growth factor 23 (FGF 23), an endocrine hormone regulating the homeostasis of phosphate and vitamin D, has been shown to play a role in cardiovascular disease. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 29-35 30909513-2 2019 Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases. Vitamin D 73-82 fibroblast growth factor 23 Homo sapiens 31-36 29602956-0 2019 Effects of vitamin D supplementation on FGF23: a randomized-controlled trial. Vitamin D 11-20 fibroblast growth factor 23 Homo sapiens 40-45 30778159-9 2019 Although 1,25(OH)2D and 24,25(OH)2D are decreased in CKD patient serum, our findings suggest that PTH and FGF23 retain their effects to regulate vitamin D metabolism even in the kidneys of these patients, while production of 1,25(OH)2D and 24,25(OH)2D from 25(OH)D is restricted due to either impairment of megalin-mediated reabsorption of the 25(OH)D-DBP complex or reduced renal mass. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 106-111 30456544-10 2019 CONCLUSION: Vitamin D deficiency was common in kidney transplant recipients in North India, associated with low FGF23 and high E-selectin. Vitamin D 12-21 fibroblast growth factor 23 Homo sapiens 112-117 29481636-11 2018 Conclusions: Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD. Vitamin D 13-22 fibroblast growth factor 23 Homo sapiens 132-137 30217807-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 12-39 30217676-1 2018 Fibroblast growth factor (FGF) 23 is a bone-derived phosphotropic hormone that regulates phosphate and vitamin D metabolism. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 0-33 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 12-39 29660161-1 2018 BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 41-47 30217807-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 41-46 30217807-12 2018 CONCLUSIONS: Common genetic variants located near genes involved in vitamin D metabolism and renal phosphate transport are associated with differences in circulating FGF23 concentrations. Vitamin D 68-77 fibroblast growth factor 23 Homo sapiens 166-171 29996975-13 2018 CONCLUSIONS: An oral glucose load in vitamin D deficient patients with impaired glucose metabolism decreased FGF23 concentrations, which cannot be attributed to changes in insulin concentration. Vitamin D 37-46 fibroblast growth factor 23 Homo sapiens 109-114 29633705-2 2018 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 0-27 29633705-2 2018 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone with a pivotal role in phosphorus and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 29-34 29574933-0 2018 The association of serum FGF23 and non-alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients. Vitamin D 87-96 fibroblast growth factor 23 Homo sapiens 25-30 29574933-11 2018 In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver. Vitamin D 39-48 fibroblast growth factor 23 Homo sapiens 144-149 29574933-11 2018 In conclusion, both high FGF23 and low vitamin D levels showed an independent relationship with NAFLD in Chinese T2DM patients, indicating that FGF23 and vitamin D function via different regulatory pathways in the liver. Vitamin D 154-163 fibroblast growth factor 23 Homo sapiens 25-30 29946298-1 2018 Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/alpha-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism. Vitamin D 180-189 fibroblast growth factor 23 Homo sapiens 0-27 29946298-1 2018 Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone that activates FGFR/alpha-Klotho binary complexes in the kidney renal tubules to regulate phosphate reabsorption and vitamin D metabolism. Vitamin D 180-189 fibroblast growth factor 23 Homo sapiens 29-35 29679282-3 2018 Inhibition of FGF23 by burosumab results in increased renal phosphate reabsorption and increased serum levels of phosphorus and active vitamin D. Vitamin D 135-144 fibroblast growth factor 23 Homo sapiens 14-19 29760049-1 2018 Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy. Vitamin D 96-105 fibroblast growth factor 23 Homo sapiens 0-27 29760049-1 2018 Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy. Vitamin D 96-105 fibroblast growth factor 23 Homo sapiens 29-34 29519954-2 2018 We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 110-137 29519954-2 2018 We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 139-144 30134801-0 2018 Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study. Vitamin D 32-41 fibroblast growth factor 23 Homo sapiens 26-31 30134801-3 2018 We therefore sought evidence for dysregulation of the PTH-FGF23-vitamin D axis in RRMS. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 58-63 30134801-12 2018 CONCLUSIONS: This study revealed a dysequilibrium of the PTH-FGF23-vitamin D axis in RRMS, with lower plasma PTH, higher plasma iFGF23 and a lower serum 1,25(OH)2D to 25OHD ratio in RRMS compared with HC subjects. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 61-66 29886473-4 2018 The increased FGF23 levels gradually lead to myocardial hypertrophy, inflammatory, vascular calcification, and low level of vitamin D, which contribute to the progress of CKD, cardiovascular complications and even death. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 14-19 28795342-0 2018 Effect of Cholecalciferol therapy on serum FGF23 in vitamin D deficient patients: a randomized clinical trial. Vitamin D 52-61 fibroblast growth factor 23 Homo sapiens 43-48 28087977-9 2018 The reduced levels of Vitamin D, and urinary losses may contribute to lower levels of FGF23 in NS. Vitamin D 22-31 fibroblast growth factor 23 Homo sapiens 86-91 28795342-2 2018 However, the effect of Cholecalciferol therapy on FGF23 serum level in patients with vitamin D deficiency has not been studied, yet. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 50-55 28795342-6 2018 However, delta values of serum 25(OH)D3, 1,25(OH)2D3 and FGF23 in vitamin D treated group were more than the placebo-treated ones (P < 0.001, P = 0.002, and P = 0.04, respectively). Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 57-62 29342138-2 2018 This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and vitamin D homeostasis. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 32-37 30380963-11 2018 A positive correlation was found between FGF23 and phosphate, parathyroid hormone (PTH) and vitamin D, 25(OH)D and 1,25(OH)2D-total assays, respectively. Vitamin D 92-101 fibroblast growth factor 23 Homo sapiens 41-46 30269115-4 2018 The main physiological function of FGF23 is to suppress phosphate reabsorption and active vitamin D production in the proximal tubule of the kidney, thereby lowering serum concentration of inorganic phosphate. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 35-40 30041203-1 2018 Fibroblast growth factor 23 (FGF23) is a regulator of phosphate and vitamin D homeostasis that carries out primary bone- and mineral-related physiological functions to increase renal phosphate excretion and reduce 1alpha-hydroxylation of 25-hydroxyvitamin D. Vitamin D 68-77 fibroblast growth factor 23 Homo sapiens 0-27 30041203-1 2018 Fibroblast growth factor 23 (FGF23) is a regulator of phosphate and vitamin D homeostasis that carries out primary bone- and mineral-related physiological functions to increase renal phosphate excretion and reduce 1alpha-hydroxylation of 25-hydroxyvitamin D. Vitamin D 68-77 fibroblast growth factor 23 Homo sapiens 29-34 29621752-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 12-39 29621752-1 2018 BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 41-47 28063327-10 2017 CONCLUSION: Newly diagnosed LN patients demonstrated elevated FGF23 levels that were positively correlated to urinary MCP1, independently of vitamin D levels and kidney function. Vitamin D 141-150 fibroblast growth factor 23 Homo sapiens 62-67 28860784-13 2017 This suggests that serum FGF23 levels should be monitored regularly, especially in those who use combination of vitamin D and calcium carbonate from the early stages of CKD. Vitamin D 112-121 fibroblast growth factor 23 Homo sapiens 25-30 27622885-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. Vitamin D 193-202 fibroblast growth factor 23 Homo sapiens 0-27 27622885-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. Vitamin D 193-202 fibroblast growth factor 23 Homo sapiens 29-34 28615947-5 2017 Serum phosphate levels influence fibroblast growth factor 23 (FGF-23) production, a phosphatonin that modulates serum phosphate reabsorption, PTH synthesis, and vitamin D production. Vitamin D 161-170 fibroblast growth factor 23 Homo sapiens 33-60 28615947-5 2017 Serum phosphate levels influence fibroblast growth factor 23 (FGF-23) production, a phosphatonin that modulates serum phosphate reabsorption, PTH synthesis, and vitamin D production. Vitamin D 161-170 fibroblast growth factor 23 Homo sapiens 62-68 29096595-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 0-27 29096595-1 2017 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone, mainly produced by osteoblasts and osteocytes in response to increased extracellular phosphate and circulating vitamin D hormone. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 29-34 28110703-1 2017 Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers. Vitamin D 75-84 fibroblast growth factor 23 Homo sapiens 0-27 28131132-1 2017 Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 0-27 28131132-1 2017 Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 29-34 27017221-1 2017 The fibroblast growth factor (FGF) 23/Klotho axis is a principal regulator of phosphate hemostasis and vitamin D metabolism, but limited data is available on its role in the central nervous system. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 4-37 28110703-1 2017 Fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism produced primarily in bone by osteocytes and mature osteoblasts, is now known to have growth factor activity for many prostate cancers. Vitamin D 75-84 fibroblast growth factor 23 Homo sapiens 29-34 27941640-8 2016 Among the factors increasing plasma FGF23 concentration, active vitamin D analogues play a significant role. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 36-41 29179169-5 2017 In this review, I will discuss about the roles of Enpp1 in regulating the FGF23-Klotho-vitamin D axis and bones. Vitamin D 87-96 fibroblast growth factor 23 Homo sapiens 74-79 27652999-2 2016 RECENT FINDINGS: FGF-23 is a hormone produced by osteocytes and osteoblasts that aids with phosphate excretion by the kidney and acts as a negative feedback regulator for activated vitamin D synthesis. Vitamin D 181-190 fibroblast growth factor 23 Homo sapiens 17-23 26620085-1 2016 FGF23 is essential for the homeostasis of phosphate, and vitamin D. Vitamin D 57-66 fibroblast growth factor 23 Homo sapiens 0-5 27215557-3 2016 Klotho and FGF23 are crucial components for the regulation of vitamin D metabolism and subsequently blood phosphate levels. Vitamin D 62-71 fibroblast growth factor 23 Homo sapiens 11-16 27812184-2 2016 Fibroblast growth factor 23 (FGF23) is a hormone that inhibits vitamin D activation yet few studies examined whether FGF23 is associated with cognitive impairment. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 0-27 27812184-2 2016 Fibroblast growth factor 23 (FGF23) is a hormone that inhibits vitamin D activation yet few studies examined whether FGF23 is associated with cognitive impairment. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 29-34 26943611-2 2016 FGF23 was originally shown to play a central role in phosphate (Pi) and vitamin D metabolism, and a number of diseases associated with dysregulated Pi metabolism have been attributed to abnormal FGF23 signaling activities. Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 0-5 26943611-3 2016 The discovery of Klotho as a co-receptor for FGF23 signaling has also accelerated understanding on the molecular mechanisms underlying Pi and vitamin D metabolism. Vitamin D 142-151 fibroblast growth factor 23 Homo sapiens 45-50 27178987-1 2016 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 0-27 27178987-1 2016 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 29-34 26307135-8 2016 Lower levels of intact FGF23 with recent use of tenofovir, efavirenz or lopinavir may reflect their adverse effects on bone and vitamin D metabolism relative to other drugs in their respective drug classes. Vitamin D 128-137 fibroblast growth factor 23 Homo sapiens 23-28 28497083-1 2017 Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 27-54 28497083-1 2017 Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 56-61 27495287-8 2016 RESULTS: After 6 weeks of oral sodium bicarbonate, the median FGF23 increased significantly from 150.9 RU/mL (IQR 107.7-267.43) to 191.4 RU/mL (IQR 132.6-316.9) (p = 0.048) and this persisted after excluding participants who received activated vitamin D. Vitamin D 244-253 fibroblast growth factor 23 Homo sapiens 62-67 26939683-0 2016 Fibroblast growth factor-23 and renin-angiotensin system levels in vitamin-D-dependent rickets type I. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 0-37 26864938-2 2016 Initially discovered as a regulator of phosphate and vitamin D homeostasis, FGF23 has now been implicated in several pathophysiological mechanisms that may negatively impact the cardiovascular and renal systems. Vitamin D 53-62 fibroblast growth factor 23 Homo sapiens 76-81 27403909-2 2016 FGF23 together with its cofactor, alpha-Klotho protein, plays a pivotal role in calcium-phosphorus metabolism in patients with CKD by decreasing secretion of active metabolite of vitamin D and antagonizing phosphate resorption in renal tubules. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 0-5 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 29-56 27721584-1 2016 BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 58-64 27215149-1 2016 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 14-41 27215149-1 2016 INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 43-48 27191351-1 2016 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes and osteoblasts that regulates phosphorus and vitamin D homeostasis. Vitamin D 137-146 fibroblast growth factor 23 Homo sapiens 19-46 27191351-1 2016 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes and osteoblasts that regulates phosphorus and vitamin D homeostasis. Vitamin D 137-146 fibroblast growth factor 23 Homo sapiens 48-53 27219044-4 2016 FGF-23 acts to counter-regulate the effects of vitamin D on innate immunity and cardiovascular responses. Vitamin D 47-56 fibroblast growth factor 23 Homo sapiens 0-6 27219044-5 2016 FGF-23 is ectopically expressed along with alpha-Kl in activated macrophages, creating a proinflammatory paracrine signaling pathway that counters the antiinflammatory actions of vitamin D. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 0-6 27219044-9 2016 SUMMARY: FGF-23 participates in a bone-kidney axis regulating mineral homeostasis, proinflammatory paracrine macrophage signaling pathways, and in a bone-cardio-renal axis regulating hemodynamics that counteract the effects of vitamin D. Vitamin D 227-236 fibroblast growth factor 23 Homo sapiens 9-15 26928188-1 2016 UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 69-96 26928188-1 2016 UNLABELLED: There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 98-103 26476373-4 2016 A relevant number of studies support the notion that FGF23, a bone-derived hormone, not only regulates the most important mineral metabolism (MM) related factors (phosphate, parathyroid hormone, vitamin D, etc. Vitamin D 195-204 fibroblast growth factor 23 Homo sapiens 53-58 27134818-2 2016 Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with "traditional" feedback loops for mineral metabolism. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 57-84 27134818-2 2016 Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with "traditional" feedback loops for mineral metabolism. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 86-91 26813507-1 2016 FGF23-related hypophosphatemic rickets is basically treated with active vitamin D and phosphorus. Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 0-5 26784540-1 2016 Overexpression of FGF23 results in hypophosphatemic rickets, which is characterized by renal phosphate wasting, inappropriately low circulating levels of the active form of vitamin D, and skeletal abnormalities. Vitamin D 173-182 fibroblast growth factor 23 Homo sapiens 18-23 26287968-1 2016 Although fibroblast growth factor (FGF) 23 was recently identified as a phosphatonin that influences vitamin D metabolism, the underlying signaling mechanisms remain unclear. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 35-38 27355663-1 2016 BACKGROUND: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates the homeostasis of phosphate and vitamin D. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 12-39 26943634-2 2016 We aimed to explore the effects of vitamin D supplementation on serum FGF23 and to elucidate longitudinal changes in FGF23, in addition to studying its association with mineral metabolism in early infancy. Vitamin D 35-44 fibroblast growth factor 23 Homo sapiens 70-75 27012053-4 2016 Therefore, the elevated expression of FGF-23 may play a crucial role in defining the immune response to vitamin D and this, in turn, may be a key determinant of infection in patients. Vitamin D 104-113 fibroblast growth factor 23 Homo sapiens 38-44 27355663-1 2016 BACKGROUND: Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates the homeostasis of phosphate and vitamin D. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 41-46 26273098-2 2015 Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 0-27 26069294-2 2016 However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways. Vitamin D 9-18 fibroblast growth factor 23 Homo sapiens 130-159 26069294-2 2016 However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and vitamin D-fibroblast growth factor-23 (FGF-23)-Klotho pathways. Vitamin D 9-18 fibroblast growth factor 23 Homo sapiens 161-167 26567701-1 2016 The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 65-70 27081473-4 2015 There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). Vitamin D 59-68 fibroblast growth factor 23 Homo sapiens 40-45 27125741-3 2016 The discovery of KL as a partner for FGF23 led to significant advances in understanding of the molecular mechanisms underlying phosphate and vitamin D metabolism, and simultaneously clarified the pathogenic roles of the FGF23 signaling pathway in human diseases. Vitamin D 141-150 fibroblast growth factor 23 Homo sapiens 37-42 27125741-4 2016 These novel insights led to the development of new strategies to combat disorders associated with the dysregulated metabolism of phosphate and vitamin D, and clinical trials on the blockade of FGF23 signaling in X-linked hypophosphatemic rickets are ongoing. Vitamin D 143-152 fibroblast growth factor 23 Homo sapiens 193-198 26503876-1 2015 FGF23 produced mainly by osteocytes plays a central role in phosphate homeostasis by increasing the renal phosphate excretion and suppressing the vitamin D activation. Vitamin D 146-155 fibroblast growth factor 23 Homo sapiens 0-5 26273098-2 2015 Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 29-35 26424141-10 2015 While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (FGF-23) levels, which may be detrimental in dialysis patients. Vitamin D 16-25 fibroblast growth factor 23 Homo sapiens 96-123 26424141-10 2015 While activated vitamin D therapy is associated with improved outcomes, it also leads to higher fibroblast growth factor 23 (FGF-23) levels, which may be detrimental in dialysis patients. Vitamin D 16-25 fibroblast growth factor 23 Homo sapiens 125-131 26193703-1 2015 BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 22-49 25168424-5 2015 Active vitamin D sterols increase FGF23 levels, whereas therapy with calcimimetics decreases FGF23 levels. Vitamin D 7-16 fibroblast growth factor 23 Homo sapiens 34-39 26019137-2 2015 Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D. Vitamin D 189-198 fibroblast growth factor 23 Homo sapiens 0-27 26019137-2 2015 Fibroblast growth factor 23 (FGF23) is an endocrine FGF, normally expressed by osteocytes, which plays a critical role in phosphate homeostasis via a feedback loop involving the kidney and vitamin D. Vitamin D 189-198 fibroblast growth factor 23 Homo sapiens 29-34 26193703-1 2015 BACKGROUND: Increased fibroblast growth factor 23 (FGF23), a bone-derived hormone involved in the regulation of phosphate and vitamin D metabolism, has been related to the development of cardiovascular disease (CVD) in chronic kidney disease patients and in the general population. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 51-56 26347327-6 2015 Fibroblast growth factor23 (FGF23) is a bone-derived hormone that plays an important role in the regulation of phosphate and vitamin D metabolism. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 0-26 25934099-9 2015 KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 7-34 25934099-9 2015 KLOTHO/fibroblast growth factor 23 (FGF23) contribute to control Ca(2+), phosphate, and vitamin D metabolism, and their dysregulation may participate in age-related disease. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 36-41 26347327-6 2015 Fibroblast growth factor23 (FGF23) is a bone-derived hormone that plays an important role in the regulation of phosphate and vitamin D metabolism. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 28-33 26296372-1 2015 Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 0-27 26131357-5 2015 FGF23 can also fine-tune vitamin D homeostasis by suppressing renal expression of 1-alpha hydroxylase (1alpha(OH)ase). Vitamin D 25-34 fibroblast growth factor 23 Homo sapiens 0-5 25873267-0 2015 Effect of Cinacalcet and Vitamin D Analogs on Fibroblast Growth Factor-23 during the Treatment of Secondary Hyperparathyroidism. Vitamin D 25-34 fibroblast growth factor 23 Homo sapiens 46-73 25873267-10 2015 Changes in FGF-23 in the vitamin D analog but not the cinacalcet arm were correlated with changes in Ca (cinacalcet: r=0.11, P=0.30; vitamin D analog: r=0.32, P<0.01) and P (cinacalcet: r=0.19, P=0.07; vitamin D analog: r=0.49, P<0.001). Vitamin D 25-34 fibroblast growth factor 23 Homo sapiens 11-17 25873267-10 2015 Changes in FGF-23 in the vitamin D analog but not the cinacalcet arm were correlated with changes in Ca (cinacalcet: r=0.11, P=0.30; vitamin D analog: r=0.32, P<0.01) and P (cinacalcet: r=0.19, P=0.07; vitamin D analog: r=0.49, P<0.001). Vitamin D 133-142 fibroblast growth factor 23 Homo sapiens 11-17 25873267-10 2015 Changes in FGF-23 in the vitamin D analog but not the cinacalcet arm were correlated with changes in Ca (cinacalcet: r=0.11, P=0.30; vitamin D analog: r=0.32, P<0.01) and P (cinacalcet: r=0.19, P=0.07; vitamin D analog: r=0.49, P<0.001). Vitamin D 133-142 fibroblast growth factor 23 Homo sapiens 11-17 25873267-11 2015 Changes in FGF-23 were correlated with changes in CaxP in both arms (cinacalcet: r=0.26, P=0.01; vitamin D analog: r=0.57, P<0.001). Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 11-17 25873267-15 2015 It is possible that effects of cinacalcet and vitamin D analogs on FGF-23 may be mediated indirectly by other effects on bone and mineral metabolism. Vitamin D 46-55 fibroblast growth factor 23 Homo sapiens 67-73 26296372-1 2015 Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of phosphate and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 29-34 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 55-64 fibroblast growth factor 23 Homo sapiens 100-105 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 106-115 fibroblast growth factor 23 Homo sapiens 34-39 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 106-115 fibroblast growth factor 23 Homo sapiens 100-105 25451947-0 2015 Serum free 1,25-dihydroxy-vitamin D is more closely associated with fibroblast growth factor 23 than other vitamin D forms in chronic dialysis patients. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 68-95 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 66-93 26338395-3 2015 New factors and hormones have been identified, such as Klotho and fibroblast growth factor-23 (FGF-23) that interact with vitamin D and the parathyroid hormone in the renal management of calcium and phosphorus. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 95-101 25716806-1 2015 Cross talks among vitamin D endocrine system, PTH and FGF23]. Vitamin D 18-27 fibroblast growth factor 23 Homo sapiens 54-59 24620922-11 2015 CONCLUSIONS: In community-dwelling elderly individuals with highly prevalent vitamin D deficiency, FGF-23 levels were associated with LV hypertrophy and predicted mortality independently of two robust cardiac biomarkers. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 99-105 25366373-0 2015 Associations between the levels of sclerostin, phosphate, and fibroblast growth factor-23 and treatment with vitamin D in hemodialysis patients with low intact PTH level. Vitamin D 109-118 fibroblast growth factor 23 Homo sapiens 62-89 25270396-2 2015 Elevated fibroblast growth factor (FGF)-23 in cyclosporine A (CsA) users with SLE are associated with decreased active vitamin D and osteocalcin. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 9-42 26066475-1 2015 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 19-46 26066475-1 2015 PURPOSE OF REVIEW: Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D homeostasis and rises as kidney function declines. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 48-53 25597001-5 2015 End-stage renal disease (ESRD) is also associated with a decrease in vitamin D activity by mechanisms including the increase of plasma phosphate concentration, secretion of FGF-23 and decrease in 1alpha-hydroxylase activity. Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 173-179 25451947-2 2015 However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population. Vitamin D 49-58 fibroblast growth factor 23 Homo sapiens 63-90 25451947-2 2015 However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population. Vitamin D 49-58 fibroblast growth factor 23 Homo sapiens 92-98 25451947-10 2015 CONCLUSION: The relationship between FGF-23 and vitamin D is stronger using free forms of 25-OH-D and 1,25-(OH)2-D. Vitamin D 48-57 fibroblast growth factor 23 Homo sapiens 37-43 25637898-3 2015 It is caused by a tumor that produces fibroblast growth factor 23, a hormone that decreases the tubular phosphate reabsorption and impairs renal hydroxylation of vitamin D. Vitamin D 162-171 fibroblast growth factor 23 Homo sapiens 38-65 25563643-1 2015 BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 24-51 25563643-1 2015 BACKGROUND AND PURPOSE: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 53-58 26693712-1 2015 BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 12-39 26693712-1 2015 BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 41-46 25530521-2 2015 Fibroblast growth factor 23 (FGF23) is a hormone mainly produced by osteocytes and regulates phosphate and vitamin D metabolism by binding to Klotho-FGF receptor complex. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 0-27 25530521-2 2015 Fibroblast growth factor 23 (FGF23) is a hormone mainly produced by osteocytes and regulates phosphate and vitamin D metabolism by binding to Klotho-FGF receptor complex. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 29-34 25530521-3 2015 Most diseases previously called vitamin D-resistant rickets/osteomalacia or familial hypophosphatemic rickets/osteomalacia have been shown to be caused by excess actions of FGF23. Vitamin D 32-41 fibroblast growth factor 23 Homo sapiens 173-178 26023015-5 2015 FGF23, in cooperation with Klotho, inhibits phosphate reabsorption and vitamin D production at the kidney. Vitamin D 71-80 fibroblast growth factor 23 Homo sapiens 0-5 26068724-3 2015 The aim of this study was to elucidate which factor, FGF-23 or PTH, plays a more important role in the regulation of vitamin D metabolites in subjects with estimated glomerular filtration (eGFR) >=60 ml/min/1.73 m(2). Vitamin D 117-126 fibroblast growth factor 23 Homo sapiens 53-59 26068724-7 2015 CONCLUSIONS: This study demonstrated that, even in subjects with eGFR >=60 ml/min/1.73 m(2), FGF-23 might play an important role in the regulation of vitamin D metabolism. Vitamin D 153-162 fibroblast growth factor 23 Homo sapiens 96-102 26068724-8 2015 In addition to the established role of PTH, the association between FGF-23 and indices of vitamin D metabolism suggested the potential role of FGF-23 on phosphate metabolism in such patients. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 68-74 24973411-2 2014 The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis. Vitamin D 118-127 fibroblast growth factor 23 Homo sapiens 17-44 25470522-8 2015 Moreover, osteocalcin also influences phosphate metabolism via osteocyte-derived FGF23 (which targets the kidneys and parathyroid glands to control phosphate reabsorption and metabolism of vitamin D). Vitamin D 189-198 fibroblast growth factor 23 Homo sapiens 81-86 25339487-6 2014 Fibroblast Growth Factor 23, a bone-derived hormone that regulates vitamin D synthesis in renal proximal tubules and renal phosphate reabsorption, has been suggested to be the missing link between CKD and CVD. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 0-27 24960544-0 2014 Activation of FGF-23 mediated vitamin D degradative pathways by cholecalciferol. Vitamin D 30-39 fibroblast growth factor 23 Homo sapiens 14-20 24960544-11 2014 In addition, catabolism of 25(OH)D may also contribute to the low circulating vitamin D levels in CKD, since elevations of FGF-23 in CKD are associated with increased 24,25(OH)2D after cholecalciferol administration. Vitamin D 78-87 fibroblast growth factor 23 Homo sapiens 123-129 25200615-1 2014 BACKGROUND: Fibroblast growth factor 23 (FGF23) is an important regulatory hormone in phosphate and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 12-39 25200615-1 2014 BACKGROUND: Fibroblast growth factor 23 (FGF23) is an important regulatory hormone in phosphate and vitamin D metabolism. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 41-46 24973411-2 2014 The discovery of fibroblast growth factor 23 (FGF23) as a key regulator of renal phosphate handling and activation of vitamin D has revolutionized our comprehension of phosphate homeostasis. Vitamin D 118-127 fibroblast growth factor 23 Homo sapiens 46-51 24973411-3 2014 Through as yet undetermined mechanisms, circulating and dietary phosphate appear to have a direct effect on FGF23 release by bone cells that, in turn, causes renal phosphate excretion and decreases intestinal phosphate absorption through a decrease in vitamin D production. Vitamin D 252-261 fibroblast growth factor 23 Homo sapiens 108-113 24973411-4 2014 Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. Vitamin D 83-92 fibroblast growth factor 23 Homo sapiens 51-56 24973411-4 2014 Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. Vitamin D 113-122 fibroblast growth factor 23 Homo sapiens 51-56 24429404-0 2014 The impact of vitamin D status on the relative increase in fibroblast growth factor 23 and parathyroid hormone in chronic kidney disease. Vitamin D 14-23 fibroblast growth factor 23 Homo sapiens 59-86 25198236-0 2014 Changes of fibroblast growth factor 23 (FGF23) levels following calcitriol treatment in a vitamin D deficient patient. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 11-38 25198236-0 2014 Changes of fibroblast growth factor 23 (FGF23) levels following calcitriol treatment in a vitamin D deficient patient. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 40-45 24947687-8 2014 CONCLUSIONS: The determinants of the serum FGF-23 level in MHD patients without residual renal function were age, serum phosphate, Ca, iPTH levels, the active vitamin D dose and the GNRI. Vitamin D 159-168 fibroblast growth factor 23 Homo sapiens 43-49 24429404-3 2014 As vitamin D insufficiency is associated with elevated PTH, we determined the effect of vitamin D status on FGF23 and PTH levels in relation to glomerular filtration rate (GFR) in people with CKD stage 3. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 108-113 24429404-7 2014 However, when 752 people with vitamin D insufficiency or deficiency were excluded, FGF23 was elevated in a greater proportion than PTH at all levels of eGFR. Vitamin D 30-39 fibroblast growth factor 23 Homo sapiens 83-88 24429404-10 2014 Future studies of FGF23 in people with CKD should routinely determine their vitamin D status. Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 18-23 24750549-3 2014 FGF23 has emerged as a major alpha-klotho-dependent endocrine regulator of mineral metabolism, functioning to activate vitamin D and as a phosphatonin. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 0-5 23664548-3 2013 In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency. Vitamin D 311-320 fibroblast growth factor 23 Homo sapiens 218-245 24922628-1 2014 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 12-39 24922628-1 2014 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone involved in phosphorous regulation and vitamin D metabolism that may be associated with cardiovascular risk, and it is a potential target for intervention. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 41-47 25031885-1 2014 Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Vitamin D 108-117 fibroblast growth factor 23 Homo sapiens 0-27 25031885-1 2014 Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Vitamin D 108-117 fibroblast growth factor 23 Homo sapiens 29-34 24577200-0 2014 Serum fibroblast growth factor 23 is a useful marker to distinguish vitamin D-deficient rickets from hypophosphatemic rickets. Vitamin D 68-77 fibroblast growth factor 23 Homo sapiens 6-33 24577200-2 2014 Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 72-99 24577200-2 2014 Vitamin D deficiency can influence biochemical results of patients with fibroblast growth factor 23 (FGF23)-related hereditary hypophosphatemic rickets (HR), making differential diagnosis difficult. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 101-106 23296792-1 2014 Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 0-27 23296792-1 2014 Fibroblast growth factor-23 (FGF-23) has emerged as an important hormone involved in phosphorus and vitamin D homeostasis. Vitamin D 100-109 fibroblast growth factor 23 Homo sapiens 29-35 23623649-1 2014 Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 0-27 23623649-1 2014 Fibroblast growth factor 23 (FGF-23) is a bone-derived circulating phosphaturic factor that decreases serum concentration of phosphate and vitamin D, suggested to actively participate in a complex renal-gastrointestinal-skeletal axis. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 29-35 24920722-1 2014 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone that promotes urinary phosphate excretion and regulates vitamin D metabolism. Vitamin D 118-127 fibroblast growth factor 23 Homo sapiens 12-39 24920722-1 2014 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a hormone that promotes urinary phosphate excretion and regulates vitamin D metabolism. Vitamin D 118-127 fibroblast growth factor 23 Homo sapiens 41-47 24605214-10 2014 Especially, excess actions of FGF23 cause several hypophosphatemic rickets/osteomalacia with relatively low level of 1,25(OH)2D that had been classified as vitamin D-resistant rickets/osteomalacia. Vitamin D 156-165 fibroblast growth factor 23 Homo sapiens 30-35 24535626-10 2014 CONCLUSIONS: These results suggest that TDF-containing cART may alter the FGF23 response to vitamin D supplementation in HIV-infected youths. Vitamin D 92-101 fibroblast growth factor 23 Homo sapiens 74-79 23877588-7 2013 Other factors such as dietary vitamin D compounds, calcium, and metabolic acidosis all increase FGF-23 levels. Vitamin D 30-39 fibroblast growth factor 23 Homo sapiens 96-102 23340856-5 2013 FGF23 is an endocrine fibroblast growth factor acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D with key effects on the bone/kidney/parathyroid axis, and has been shown to increase in patients with ADPKD, even with normal renal function. Vitamin D 121-130 fibroblast growth factor 23 Homo sapiens 0-5 23852336-1 2013 BACKGROUND: The relationship between fibroblast growth factor 23 (FGF23) and vitamin D production and catabolism post-renal transplantation has not been characterized. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 37-64 23852336-1 2013 BACKGROUND: The relationship between fibroblast growth factor 23 (FGF23) and vitamin D production and catabolism post-renal transplantation has not been characterized. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 66-71 23664548-3 2013 In particular, there is accumulating evidence indicating a key role for the complex and yet incompletely understood system of divalent cation regulation, which includes phosphate metabolism and the recently discovered fibroblast growth factor 23 (FGF-23)/klotho system, which seems inextricably associated with vitamin D deficiency. Vitamin D 311-320 fibroblast growth factor 23 Homo sapiens 247-253 24015259-1 2013 OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 11-38 23625971-4 2013 FGF23 is a hormone produced by osteoblasts/osteocytes in bone that acts on the kidney to regulate phosphate and vitamin D metabolism through activation of FGF receptor/alpha-Klotho co-receptor complexes. Vitamin D 112-121 fibroblast growth factor 23 Homo sapiens 0-5 24015259-1 2013 OBJECTIVE: Fibroblast growth factor 23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and is associated with coronary artery calcification, and has been implicated in the pathogenesis of cardiovascular disease. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 40-45 23117582-1 2013 Fibroblast growth factor 23 (FGF23) is an "endocrine" FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1alpha hydroxylase and a stimulation of the 24 hydroxylase. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 0-27 23505057-1 2013 Fibroblast growth factor 23 (FGF23) is an osteocyte-derived hormone that regulates phosphate and vitamin D homeostasis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 0-27 23505057-1 2013 Fibroblast growth factor 23 (FGF23) is an osteocyte-derived hormone that regulates phosphate and vitamin D homeostasis. Vitamin D 97-106 fibroblast growth factor 23 Homo sapiens 29-34 23748358-0 2013 FGF23 modifies the relationship between vitamin D and cardiac remodeling. Vitamin D 40-49 fibroblast growth factor 23 Homo sapiens 0-5 23748358-1 2013 BACKGROUND: There is growing evidence to support an important role for vitamin D and related hormones, parathyroid hormone and fibroblast growth factor 23 (FGF23), on cardiac remodeling in chronic kidney disease. Vitamin D 71-80 fibroblast growth factor 23 Homo sapiens 156-161 23532406-3 2013 FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells. Vitamin D 44-53 fibroblast growth factor 23 Homo sapiens 0-5 23443925-1 2013 Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism. Vitamin D 111-120 fibroblast growth factor 23 Homo sapiens 0-27 23443925-1 2013 Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates phosphate and vitamin D metabolism. Vitamin D 111-120 fibroblast growth factor 23 Homo sapiens 29-34 23117582-1 2013 Fibroblast growth factor 23 (FGF23) is an "endocrine" FGF acting in the kidney as a phosphaturic hormone and a suppressor of active vitamin D, through an inhibition of the 1alpha hydroxylase and a stimulation of the 24 hydroxylase. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 29-34 23284004-2 2013 Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23). Vitamin D 32-41 fibroblast growth factor 23 Homo sapiens 141-168 23471660-1 2013 Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 10-37 23471660-1 2013 Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. Vitamin D 136-145 fibroblast growth factor 23 Homo sapiens 39-44 23471660-2 2013 In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 68-73 23465500-2 2013 FGF23 is important in the regulation of phosphate and vitamin D metabolism, whereas Ocn participates in endocrine networks, coordinating bone and fat mass, energy metabolism, and sex hormone production. Vitamin D 54-63 fibroblast growth factor 23 Homo sapiens 0-5 23465502-2 2013 Renal vitamin D metabolism requires filtration and tubular reabsorption of 25-hydroxyvitamin D and is regulated by parathyroid hormone, fibroblast growth factor-23, and 1,25-dihydroxyvitamin D. Vitamin D 6-15 fibroblast growth factor 23 Homo sapiens 136-163 22959760-1 2013 Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23). Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 187-214 22959760-1 2013 Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23). Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 216-222 22959760-1 2013 Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23). Vitamin D 133-142 fibroblast growth factor 23 Homo sapiens 187-214 22959760-1 2013 Vitamin D-resistant rickets is the common clinical outcome of multiple genetic mutations that alter the regulation of phosphorus and vitamin D metabolism, mainly through their effects on fibroblast growth factor 23 (FGF-23). Vitamin D 133-142 fibroblast growth factor 23 Homo sapiens 216-222 23284004-2 2013 Treatment with loading doses of vitamin D may increase 1,25(OH)(2) vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23). Vitamin D 32-41 fibroblast growth factor 23 Homo sapiens 170-176 23284004-3 2013 OBJECTIVE: The aim was to determine the effects of high-dose vitamin D on circulating concentrations of 1,25(OH)(2) vitamin D and FGF-23 in patients with osteoporosis and vitamin D insufficiency. Vitamin D 61-70 fibroblast growth factor 23 Homo sapiens 130-136 23284004-9 2013 There was a positive correlation between FGF-23 and serum phosphate (r = 0.36, P = .024) and calcium (r = 0.532, P < .001) and a negative correlation between total 1,25(OH)(2)-vitamin D and FGF-23 (r = -0.32, P = .036) at 3 months. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 41-47 23284004-10 2013 CONCLUSIONS: High-dose vitamin D increases 1,25(OH)(2)-vitamin D and FGF-23 concentration. Vitamin D 23-32 fibroblast growth factor 23 Homo sapiens 69-75 23284004-11 2013 Further studies are required to determine whether adjusting vitamin D dose and frequency to minimize increases in FGF-23 may prevent the adverse outcomes associated with high-dose intermittent vitamin D supplementation. Vitamin D 193-202 fibroblast growth factor 23 Homo sapiens 114-120 23635517-8 2013 CONCLUSIONS: Baseline vitamin D status and serum phosphorous are independent determinants of the longitudinal variation in PTH and FGF23, respectively. Vitamin D 22-31 fibroblast growth factor 23 Homo sapiens 131-136 23206185-2 2013 Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 29-34 23206185-2 2013 Fibroblast growth factor 23 (FGF23) and its obligatory co-receptor Klotho (KL) play a key role in this process by influencing both renal phosphate reabsorption and vitamin D metabolism. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 0-27 22986488-3 2013 While the human studies, which modulated the dietary or serum phosphate showed in rather controversial results, manipulation of the active vitamin D definitely affected FGF-23 in animals. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 169-175 22986488-4 2013 This study was conducted to elucidate the relationship between active vitamin D directly stimulated by ultraviolet B (UVB) exposure and FGF-23 level in human. Vitamin D 70-79 fibroblast growth factor 23 Homo sapiens 136-142 23652546-8 2013 Studies have also documented negative effect of FGF23/klotho system on vitamin D metabolism and Na/Pi cotransporter activities. Vitamin D 71-80 fibroblast growth factor 23 Homo sapiens 48-53 22739976-1 2012 Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites. Vitamin D 117-126 fibroblast growth factor 23 Homo sapiens 26-55 22886720-9 2013 Elevated expression of FGF23 may therefore play a crucial role in defining immune responses to vitamin D and this, in turn, may be a key determinant of infection in patients with chronic kidney disease (CKD). Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 23-28 23942553-4 2013 Recently, this view has been challenged by the observation that fibroblast growth factor-23 (FGF23), a newly discovered hormone produced in the bone that regulates phosphate and vitamin D metabolism by the kidney, is a strong predictor of adverse cardiovascular outcomes in patients with CKD and ESRD. Vitamin D 178-187 fibroblast growth factor 23 Homo sapiens 64-91 23942553-4 2013 Recently, this view has been challenged by the observation that fibroblast growth factor-23 (FGF23), a newly discovered hormone produced in the bone that regulates phosphate and vitamin D metabolism by the kidney, is a strong predictor of adverse cardiovascular outcomes in patients with CKD and ESRD. Vitamin D 178-187 fibroblast growth factor 23 Homo sapiens 93-98 23085014-9 2013 Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health. Vitamin D 167-176 fibroblast growth factor 23 Homo sapiens 239-266 23085014-9 2013 Serum 25-OHD(3) concentration is only poorly responsive to increases in vitamin D intake, and the prolonged routine consumption of thousands of international units of vitamin D may interfere with the regulation of phosphate homeostasis by fibroblast growth factor-23 (FGF23) and the Klotho gene product, with consequences that are detrimental to human health. Vitamin D 167-176 fibroblast growth factor 23 Homo sapiens 268-273 22921424-10 2012 Speculations about the vitamin D usage in prevention or therapy of cardiovascular disease need to take potential drawbacks of vitamin D overdosing into account: Vitamin D overdosing might induce hypercalcemia, hyperphosphatemia, and increases in fibroblast growth-factor 23. Vitamin D 23-32 fibroblast growth factor 23 Homo sapiens 246-273 22921424-10 2012 Speculations about the vitamin D usage in prevention or therapy of cardiovascular disease need to take potential drawbacks of vitamin D overdosing into account: Vitamin D overdosing might induce hypercalcemia, hyperphosphatemia, and increases in fibroblast growth-factor 23. Vitamin D 161-170 fibroblast growth factor 23 Homo sapiens 246-273 23108197-5 2012 Iron deficiency may affect autosomal dominant hypophosphatemic rickets phenotype by regulating FGF23 production.Current treatment with activated vitamin D metabolites and oral inorganic phosphate salts may partially correct skeletal lesions and linear growth in patients with hypophosphatemic rickets. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 95-100 22848110-4 2012 Recently, a phosphaturic hormone, the fibroblast growth factor-23 (FGF-23), has been reported as a key regulator of P and vitamin D metabolism. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 38-65 22848110-4 2012 Recently, a phosphaturic hormone, the fibroblast growth factor-23 (FGF-23), has been reported as a key regulator of P and vitamin D metabolism. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 67-73 22848110-6 2012 The elevated FGF-23 levels result in a negative P balance to maintain P homeostasis, inducing phosphaturia, independently of PTH, and suppressing vitamin D synthesis. Vitamin D 146-155 fibroblast growth factor 23 Homo sapiens 13-19 23217254-2 2012 With emphasis on human metabolism, we critically review current data, and propose that--although a number of questions remain--circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation. Vitamin D 188-197 fibroblast growth factor 23 Homo sapiens 139-144 22921867-1 2012 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D. Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 0-27 22921867-1 2012 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates and is regulated by blood levels of phosphate and active vitamin D. Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 29-34 22739976-1 2012 Progressive elevations of fibroblastic growth factor 23 (FGF23) in chronic kidney disease may reduce serum 25-hydroxyvitamin D (25(OH)) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels, via stimulation of 24-hydroxylase (Cyp24a1)-mediated catabolism of these vitamin D metabolites. Vitamin D 117-126 fibroblast growth factor 23 Homo sapiens 57-62 23128114-3 2012 Their characterization of the underlying mechanisms provides new understanding of how kidney disease impairs the health benefits of vitamin D-FGF23/klotho interactions. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 142-147 22103239-1 2012 UNLABELLED: Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 12-39 22103239-1 2012 UNLABELLED: Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 41-46 23023636-2 2012 FGF23 exerts its effects in kidney by decreasing both renal phosphate (Pi) reabsorption and vitamin D activation. Vitamin D 92-101 fibroblast growth factor 23 Homo sapiens 0-5 23023636-4 2012 Circulating level of FGF23 appears to be regulated by systemic factors as well, including vitamin D and PTH. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 21-26 22700885-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 plays an important role in regulating phosphate and vitamin D homeostasis. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 27-54 22807503-6 2012 The pathogenesis of CKD-MBD is incompletely understood but has recently been redefined with the emergence of fibroblast growth factor 23 (FGF-23) as a major influence on control of vitamin D and parathyroid hormone. Vitamin D 181-190 fibroblast growth factor 23 Homo sapiens 109-136 22807503-6 2012 The pathogenesis of CKD-MBD is incompletely understood but has recently been redefined with the emergence of fibroblast growth factor 23 (FGF-23) as a major influence on control of vitamin D and parathyroid hormone. Vitamin D 181-190 fibroblast growth factor 23 Homo sapiens 138-144 22733815-1 2012 FGFs 19, 21, and 23 are hormones that regulate in a Klotho co-receptor-dependent fashion major metabolic processes such as glucose and lipid metabolism (FGF21) and phosphate and vitamin D homeostasis (FGF23). Vitamin D 178-187 fibroblast growth factor 23 Homo sapiens 201-206 22703926-13 2012 CONCLUSIONS: FGF-23, a hormone involved in phosphorous and vitamin D homeostasis, is independently associated with all-cause death and incident HF in community-living older persons. Vitamin D 59-68 fibroblast growth factor 23 Homo sapiens 13-19 23951494-1 2012 FGF23 is a hormone that regulates phosphate and vitamin D metabolism by binding to Klotho-fibroblast growth factor (FGF) receptor complex. Vitamin D 48-57 fibroblast growth factor 23 Homo sapiens 0-5 22754549-1 2012 CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). Vitamin D 94-103 fibroblast growth factor 23 Homo sapiens 131-164 22742720-0 2012 Fibroblast growth factor 23 and parathyroid hormone after treatment with active vitamin D and sevelamer carbonate in patients with chronic kidney disease stage 3b, a randomized crossover trial. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 0-27 22742720-3 2012 The use of active vitamin D and phosphate binders as recommended in international guidelines, may affect the level of FGF23 and thereby clinical outcome. Vitamin D 18-27 fibroblast growth factor 23 Homo sapiens 118-123 22742720-4 2012 We investigated the effects of a phosphate binder and active vitamin D on the serum levels of intact FGF23 (iFGF23) and intact parathyroid hormone (iPTH) in patients with CKD stage 3b (glomerular filtration rate (GFR) 30-44 ml/min/1.73 m(2)). Vitamin D 61-70 fibroblast growth factor 23 Homo sapiens 101-106 22140123-8 2012 Independent predictors of rise in FGF23 were baseline levels of FGF23 (P < 0.01), changes in ionized calcium (P < 0.01) and phosphate (P < 0.01) and cumulative dose of vitamin D analogues (P = 0.024). Vitamin D 177-186 fibroblast growth factor 23 Homo sapiens 34-39 22523113-1 2012 The discovery of fibroblast growth factor-23 (FGF-23) as a key regulator of phosphate and vitamin D metabolism has forced a rethink about the mineral and bone disorder of chronic kidney disease (CKD). Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 17-44 22523113-1 2012 The discovery of fibroblast growth factor-23 (FGF-23) as a key regulator of phosphate and vitamin D metabolism has forced a rethink about the mineral and bone disorder of chronic kidney disease (CKD). Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 46-52 22523113-3 2012 Nevertheless, despite the known action of active vitamin D therapies to increase FGF-23, this should probably still form an important part of the management of patients with hyperparathyroidism and perhaps at low doses of essentially all patients with advanced renal disease. Vitamin D 49-58 fibroblast growth factor 23 Homo sapiens 81-87 22421513-0 2012 Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease. Vitamin D 17-26 fibroblast growth factor 23 Homo sapiens 8-13 22421513-1 2012 FGF23 is a bone-derived hormone that regulates systemic phosphate homeostasis, vitamin D metabolism and alpha-Klotho expression through a novel bone-kidney axis. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 0-5 23214203-4 2012 FGF-23 with a coreceptor (Klotho protein) inhibits renal phosphate reabsorption and synthesis of calcitriol by reducing 1alpha-hydroxylase (CYP27B1) activity, reducing vitamin D-dependent phosphate intestinal absorption. Vitamin D 168-177 fibroblast growth factor 23 Homo sapiens 0-6 22703926-2 2012 BACKGROUND: FGF-23 increases renal phosphorus excretion and inhibits vitamin D activation. Vitamin D 69-78 fibroblast growth factor 23 Homo sapiens 12-18 22247037-1 2012 Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms. Vitamin D 56-65 fibroblast growth factor 23 Homo sapiens 0-27 22247037-1 2012 Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms. Vitamin D 56-65 fibroblast growth factor 23 Homo sapiens 29-34 22493603-3 2012 The etiology of the hypercalcemia is presumed to be a neoplastic expression of fibroblast growth factor-23, which was found to be inappropriately high-to-normal when other factors such as parathyroid hormone, calcitonin and vitamin D were appropriately low or low-to-normal. Vitamin D 224-233 fibroblast growth factor 23 Homo sapiens 79-106 21390563-1 2012 Fibroblast growth factor 23 (FGF23) is a novel hormone produced by bone with known functions to regulate urinary phosphate excretion, as well as vitamin D and PTH production. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 0-27 21390563-1 2012 Fibroblast growth factor 23 (FGF23) is a novel hormone produced by bone with known functions to regulate urinary phosphate excretion, as well as vitamin D and PTH production. Vitamin D 145-154 fibroblast growth factor 23 Homo sapiens 29-34 22393163-7 2012 Chromatin immunoprecipitation (ChIP) assay revealed, for the first time, the presence of two vitamin D response elements (VDREs) in the FGF23 promoter. Vitamin D 93-102 fibroblast growth factor 23 Homo sapiens 136-141 22025115-8 2012 RRF, serum phosphorus and calcium levels and active vitamin D therapy explain 69% of the variation in FGF-23. Vitamin D 52-61 fibroblast growth factor 23 Homo sapiens 102-108 21898178-1 2012 Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate and vitamin D metabolism. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 0-27 21898178-1 2012 Fibroblast growth factor 23 (FGF23) is a hormone regulating phosphate and vitamin D metabolism. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 29-34 22293059-15 2012 Furthermore, we found baseline FGF23 to predict PTH levels after 16 weeks of vitamin D analog treatment. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 31-36 21730210-1 2012 BACKGROUND: Elevated fibroblast growth factor 23 (FGF23) is associated with adverse clinical outcomes and development of secondary hyperparathyroidism (SHPT) refractory to active vitamin D. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 21-48 21730210-1 2012 BACKGROUND: Elevated fibroblast growth factor 23 (FGF23) is associated with adverse clinical outcomes and development of secondary hyperparathyroidism (SHPT) refractory to active vitamin D. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 50-55 22121948-8 2012 The relationship between FGF23 and serum vitamin D needs further evaluation. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 25-30 22246283-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 27-54 22396166-3 2012 Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 61-70 fibroblast growth factor 23 Homo sapiens 0-27 22396166-3 2012 Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 61-70 fibroblast growth factor 23 Homo sapiens 29-34 22396168-2 2012 Particularly, appropriate actions of FGF23 are essential for maintaining physiological phosphate and vitamin D metabolism. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 37-42 21932165-0 2012 The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Vitamin D 12-21 fibroblast growth factor 23 Homo sapiens 29-34 22249518-0 2012 Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism. Vitamin D 53-62 fibroblast growth factor 23 Homo sapiens 22-28 22249518-1 2012 The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of hereditary hypophosphatemic and hyperphosphatemic disorders, as well as acquired disorders of phosphate metabolism, such as chronic kidney disease. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 17-44 22249518-1 2012 The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of hereditary hypophosphatemic and hyperphosphatemic disorders, as well as acquired disorders of phosphate metabolism, such as chronic kidney disease. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 46-52 22249518-5 2012 These FGF-23 regulatory pathways may enable systemic phosphate and vitamin D homeostasis to be coordinated with bone mineralization. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 6-12 22396160-4 2012 FGF23 is secreted from bone and acts on kidney to inhibit phosphate reabsorption and vitamin D synthesis. Vitamin D 85-94 fibroblast growth factor 23 Homo sapiens 0-5 22396161-1 2012 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and circulating phosphate and possibly PTH. Vitamin D 146-155 fibroblast growth factor 23 Homo sapiens 0-27 22396161-1 2012 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and circulating phosphate and possibly PTH. Vitamin D 146-155 fibroblast growth factor 23 Homo sapiens 29-34 22396162-0 2012 Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis. Vitamin D 111-120 fibroblast growth factor 23 Homo sapiens 13-18 22396162-3 2012 In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. Vitamin D 201-210 fibroblast growth factor 23 Homo sapiens 13-18 22396162-3 2012 In addition, FGF23 production is regulated by 1,25(OH)2D in a feedback loop where FGF23 stimulate Cyp24 mediated degradation of 1,25(OH)2D that serves to protect the organism from the toxic effects of vitamin D excess. Vitamin D 201-210 fibroblast growth factor 23 Homo sapiens 82-87 22246283-1 2012 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 56-61 22606047-0 2012 Fibroblast growth factor-23 helps explain the biphasic cardiovascular effects of vitamin D in chronic kidney disease. Vitamin D 81-90 fibroblast growth factor 23 Homo sapiens 0-27 21914460-0 2011 Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 65-92 22606047-5 2012 Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 0-27 22606047-5 2012 Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 29-35 22606047-5 2012 Fibroblast growth factor-23 (FGF-23) is a recently identified member of the FGF family, and thought to be actively involved in renal phosphate and vitamin D homeostasis. Vitamin D 147-156 fibroblast growth factor 23 Homo sapiens 29-32 22606047-6 2012 More specifically, Vitamin D stimulates FGF-23 secretion and is inhibited by increased FGF-23. Vitamin D 19-28 fibroblast growth factor 23 Homo sapiens 40-46 22606047-6 2012 More specifically, Vitamin D stimulates FGF-23 secretion and is inhibited by increased FGF-23. Vitamin D 19-28 fibroblast growth factor 23 Homo sapiens 87-93 22606047-7 2012 Given this background, we hypothesize that FGF-23 may provide a unique tool to explain the biphasic cardiovascular effects of vitamin D in CKD. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 43-49 22298654-4 2012 FGF23 is a recently discovered hormone, predominately produced by osteoblasts/osteocytes, whose major functions are to inhibit renal tubular phosphate reabsorption and suppress circulating 1,25(OH)(2)D levels by decreasing Cyp27b1-mediated formation and stimulating Cyp24-mediated catabolism of 1,25(OH)(2)D. FGF23 participates in a new bone/kidney axis that protects the organism from excess vitamin D and coordinates renal PO(4)(3-) handling with bone mineralization/turnover. Vitamin D 393-402 fibroblast growth factor 23 Homo sapiens 0-5 21914460-5 2011 Dietary Pi intake and serum Pi concentration also are important determinants of the circulating concentration of FGF-23, itself a potent regulator of Pi and vitamin D metabolism. Vitamin D 157-166 fibroblast growth factor 23 Homo sapiens 113-119 22034506-1 2011 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 27-54 22034506-1 2011 BACKGROUND AND OBJECTIVES: Fibroblast growth factor 23 (FGF23) regulates phosphorus and vitamin D metabolism. Vitamin D 88-97 fibroblast growth factor 23 Homo sapiens 56-61 21903990-6 2011 In adjusted analyses, absence of residual renal function and greater dialysis vintage associated with higher FGF23, independent of demographics, laboratory values, peritoneal dialysis modality and adequacy, and treatment with vitamin D analogs and phosphate binders. Vitamin D 226-235 fibroblast growth factor 23 Homo sapiens 109-114 21496980-3 2011 FGF-23 is a bone-derived hormone that suppresses phosphate reabsorption and 1,25 dihydroxyvitamin D(3) (vitamin D) synthesis in the kidney. Vitamin D 90-99 fibroblast growth factor 23 Homo sapiens 0-6 21924212-3 2011 In this sense, fibroblast growth factor 23 (FGF-23) has been identified as a new hormone involved in phosphate regulation through feedback mechanisms involving parathyroid hormone and vitamin D. Vitamin D 184-193 fibroblast growth factor 23 Homo sapiens 15-42 21924212-3 2011 In this sense, fibroblast growth factor 23 (FGF-23) has been identified as a new hormone involved in phosphate regulation through feedback mechanisms involving parathyroid hormone and vitamin D. Vitamin D 184-193 fibroblast growth factor 23 Homo sapiens 44-50 21786227-6 2011 The association between altered levels of FGF23 and bone disease could be mainly due to the dysregulation of phosphate-handling and vitamin D metabolism, more than to a direct antiosteoblastic activity of FGF23. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 42-47 21786227-10 2011 This paradox highlights the need for future prospective randomized trials to evaluate the correlation between vitamin D therapy and FGF23 levels in dialysis patients. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 132-137 21496980-4 2011 Klotho also is expressed in the parathyroid gland, where FGF-23 decreases parathyroid hormone expression and secretion, further suppressing vitamin D synthesis in kidney. Vitamin D 140-149 fibroblast growth factor 23 Homo sapiens 57-63 21496980-5 2011 Thus, FGF-23 functions as a phosphaturic hormone and a counter-regulatory hormone for vitamin D, thereby inducing negative phosphate balance. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 6-12 21610497-7 2011 New data from the uremic rat and humans suggest that dysfunctional vitamin D metabolism is due to changes in CYP24A1 expression caused by phosphate and FGF-23 elevations. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 152-158 21504790-2 2011 However, research during the past decade provided substantial evidence that a so called "hormone-like" subgroup of FGFs, comprised of FGF19, FGF21 and FGF23, is involved in the regulation of diverse metabolic pathways to control glucose, lipid, bile acid, phosphate and vitamin D metabolism. Vitamin D 270-279 fibroblast growth factor 23 Homo sapiens 151-156 21610497-8 2011 SUMMARY: Changes in serum phosphate and FGF-23 levels in the CKD patient increase CYP24A1 expression resulting in decreased vitamin D status. Vitamin D 124-133 fibroblast growth factor 23 Homo sapiens 40-46 21490240-2 2011 The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23). Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 102-129 21490240-2 2011 The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23). Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 131-136 21497493-1 2011 Since its first description as a phosphaturic agent in the early 2000s, fibroblast growth factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism after PTH and vitamin D. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 72-99 21497493-1 2011 Since its first description as a phosphaturic agent in the early 2000s, fibroblast growth factor 23 (FGF23) has rapidly become the third key player of phosphate/calcium metabolism after PTH and vitamin D. Vitamin D 194-203 fibroblast growth factor 23 Homo sapiens 101-106 21234310-4 2010 Both Klotho and FGF-23, linked by a receptor mechanism, affect vitamin D synthesis and parathyroid hormone (PTH) secretion. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 16-22 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 149-158 fibroblast growth factor 23 Homo sapiens 12-39 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 149-158 fibroblast growth factor 23 Homo sapiens 41-47 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 184-193 fibroblast growth factor 23 Homo sapiens 12-39 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 184-193 fibroblast growth factor 23 Homo sapiens 41-47 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 314-323 fibroblast growth factor 23 Homo sapiens 12-39 21383962-1 2011 BACKGROUND: Fibroblast growth factor-23 (FGF-23) is a phosphaturic peptide and a key component of an endocrine feedback loop along with the hormonal vitamin D metabolite 1,25(OH)(2)D. Vitamin D has been shown to be inversely related to colorectal neoplasia; therefore, we hypothesized that the effect of FGF-23 on vitamin D metabolite concentrations could have implications for the risk of colorectal neoplasia. Vitamin D 314-323 fibroblast growth factor 23 Homo sapiens 41-47 21292848-11 2011 Vitamin D sterols can improve vitamin D deficiency and PTH levels but may worsen phosphate retention and increase FGF-23 levels, and thus, may also require concomitant phosphate binder therapy. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 114-120 21404002-1 2011 Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 0-27 21404002-1 2011 Fibroblast growth factor 23 (FGF23), a hormone primarily produced in bone cells, targets the kidney to accelerate phosphate excretion into the urine and suppresses vitamin D synthesis, thereby inducing a negative phosphate balance. Vitamin D 164-173 fibroblast growth factor 23 Homo sapiens 29-34 21611969-1 2011 Tumor-induced osteomalacia (TIO) is characterized by renal phosphate wasting, hypophosphatemia, and aberrant vitamin D(3) metabolism and is caused by fibroblast growth factor 23 (FGF-23)-producing mesenchymal tumors, which are often difficult to locate. Vitamin D 109-118 fibroblast growth factor 23 Homo sapiens 179-185 20966399-2 2011 Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 0-27 20966399-2 2011 Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease. Vitamin D 80-89 fibroblast growth factor 23 Homo sapiens 29-34 21865755-3 2011 When phosphate is in excess, FGF-23 is secreted from bone and acts on the kidney to promote phosphate excretion into urine and to suppress vitamin D synthesis, thereby inducing negative phosphate balance. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 29-35 21897759-2 2011 The discovery of Fibroblast Growth Factor 23 (FGF23) has revolutionized our understanding about the links between mineral metabolism, vitamin D and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 17-44 21897759-2 2011 The discovery of Fibroblast Growth Factor 23 (FGF23) has revolutionized our understanding about the links between mineral metabolism, vitamin D and parathyroid hormone (PTH). Vitamin D 134-143 fibroblast growth factor 23 Homo sapiens 46-51 20707671-1 2010 UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 33-60 20707671-1 2010 UNLABELLED: Abstract Background: Fibroblast growth factor 23 (FGF-23), a phosphaturic peptide hormone secreted by the osteoblasts, is an important regulator of phosphorus and vitamin D metabolism. Vitamin D 175-184 fibroblast growth factor 23 Homo sapiens 62-68 20732956-0 2010 Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term. Vitamin D 11-20 fibroblast growth factor 23 Homo sapiens 50-55 20732956-0 2010 Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 50-55 20732956-7 2010 RESULTS: Serum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group. Vitamin D 64-73 fibroblast growth factor 23 Homo sapiens 15-20 20732956-7 2010 RESULTS: Serum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 15-20 20732956-8 2010 Serum FGF23 and phosphate concentrations further decreased significantly during replacement of vitamin D (P<0.05). Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 6-11 20732956-9 2010 A significant negative correlation was evident between FGF23 and PTH before vitamin D replacement in the patients (r=-0.469, P<0.05). Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 55-60 20732956-10 2010 CONCLUSION: Decreased FGF23 concentrations, which further decline during vitamin D replacement therapy, may have favorable action on bone mineralization by counterregulatory effect on phosphate homeostasis. Vitamin D 73-82 fibroblast growth factor 23 Homo sapiens 22-27 20732956-11 2010 Lower 1,25(OH)2D concentrations at baseline and hypophosphatemia during treatment may have dominating effects on FGF23 concentrations in vitamin D deficiency, leading to decreased FGF23 concentrations at baseline and during replacement therapy. Vitamin D 137-146 fibroblast growth factor 23 Homo sapiens 113-118 20394945-9 2010 Abnormal vitamin D metabolism is suggested as the mechanism, possibly involving defective up-regulation of the 24-hydroxylase by 1,25-(OH)2D3, and the klotho-FGF23 axis. Vitamin D 9-18 fibroblast growth factor 23 Homo sapiens 158-163 20658451-5 2010 In patients undergoing dialysis, FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D therapy, but fail to suppress the secretion of parathyroid hormone, presumably due to decreased expression of the Klotho-FGFR1 complex. Vitamin D 112-121 fibroblast growth factor 23 Homo sapiens 33-38 21030971-1 2010 Fibroblast growth factor 23 (FGF23) modulates the metabolism of minerals and vitamin D. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 0-27 21030971-1 2010 Fibroblast growth factor 23 (FGF23) modulates the metabolism of minerals and vitamin D. Vitamin D 77-86 fibroblast growth factor 23 Homo sapiens 29-34 20730630-15 2010 Fgf23 regulates serum phosphate and active vitamin D levels. Vitamin D 43-52 fibroblast growth factor 23 Homo sapiens 0-5 20798257-8 2010 FGF23 plays a central role in vitamin D metabolism: It inhibits calcitriol synthesis in the kidney and stimulates the catabolism of active vitamin D sterols. Vitamin D 30-39 fibroblast growth factor 23 Homo sapiens 0-5 20798257-8 2010 FGF23 plays a central role in vitamin D metabolism: It inhibits calcitriol synthesis in the kidney and stimulates the catabolism of active vitamin D sterols. Vitamin D 139-148 fibroblast growth factor 23 Homo sapiens 0-5 20394945-3 2010 Vitamin D receptor expression (VDR), 24-hydroxylase activity, and functional gene polymorphisms of vitamin D metabolism regulators VDR(rs4516035), 1-hydroxylase(rs10877012), 24-hydroxylase(rs2248359), FGF23(rs7955866), Klotho(rs9536314, rs564481, rs648202), were evaluated. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 201-206 20583336-4 2010 Finally, new data demonstrate the ability to alter FGF23 levels using common CKD therapies such as phosphate binders, active vitamin D, and cinacalcet. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 51-56 20407479-8 2010 Thus we found that FGF23 likely has an important role in pediatric calcium and phosphate homeostasis, and in vitamin D metabolism, even at an early stage of CKD. Vitamin D 109-118 fibroblast growth factor 23 Homo sapiens 19-24 20507957-1 2010 The discovery of fibroblast growth factor 23 (FGF23) has clarified much of our understanding of abnormalities in phosphorus and vitamin D metabolism in chronic kidney disease (CKD). Vitamin D 128-137 fibroblast growth factor 23 Homo sapiens 17-44 20507957-1 2010 The discovery of fibroblast growth factor 23 (FGF23) has clarified much of our understanding of abnormalities in phosphorus and vitamin D metabolism in chronic kidney disease (CKD). Vitamin D 128-137 fibroblast growth factor 23 Homo sapiens 46-51 20507957-7 2010 In addition, given that treatment with activated vitamin D compounds stimulates FGF23, these data have raised important new questions about the optimal use of activated vitamin D compounds in the management of bone and mineral disorders in CKD. Vitamin D 49-58 fibroblast growth factor 23 Homo sapiens 80-85 20585181-5 2010 In patients undergoing dialysis, FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D therapy, which in turn cause hypophosphatemia and reduced 1,25-dihydroxyvitamin D after kidney transplantation. Vitamin D 112-121 fibroblast growth factor 23 Homo sapiens 33-38 20059333-2 2010 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels. Vitamin D 151-160 fibroblast growth factor 23 Homo sapiens 0-27 19626341-2 2010 When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance. Vitamin D 165-174 fibroblast growth factor 23 Homo sapiens 29-56 19626341-2 2010 When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on the kidney to promote phosphate excretion into urine and suppress vitamin D synthesis, thereby inducing negative phosphate balance. Vitamin D 165-174 fibroblast growth factor 23 Homo sapiens 58-63 19965919-1 2010 CONTEXT: Fibroblast growth factor 23 (FGF23) regulates phosphorus homeostasis and vitamin D metabolism. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 9-36 19965919-1 2010 CONTEXT: Fibroblast growth factor 23 (FGF23) regulates phosphorus homeostasis and vitamin D metabolism. Vitamin D 82-91 fibroblast growth factor 23 Homo sapiens 38-43 20177401-4 2010 Recent findings also indicate that fibroblast growth factor 23 has feedback mechanisms involving parathyroid hormone and vitamin D that control phosphate homeostasis. Vitamin D 121-130 fibroblast growth factor 23 Homo sapiens 35-62 20012997-1 2010 Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). Vitamin D 120-129 fibroblast growth factor 23 Homo sapiens 48-75 20012997-1 2010 Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD). Vitamin D 120-129 fibroblast growth factor 23 Homo sapiens 77-83 20408440-11 2010 These results indicate that FGF23 is a hormone regulating phosphate and vitamin D metabolism. Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 28-33 20059333-2 2010 Fibroblast growth factor 23 (FGF23) is part of a previously unrecognized hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25(OH)(2)-vitamin D (1,25(OH)(2)D), dietary and serum phosphorus levels. Vitamin D 151-160 fibroblast growth factor 23 Homo sapiens 29-34 19965548-0 2010 Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD. Vitamin D 46-55 fibroblast growth factor 23 Homo sapiens 59-64 20731116-3 2010 FGF-23 is shown to be an important phosphaturic hormone that inhibits hypercalcemic and hyperphosphatemic effects of elevated serum vitamin D concentrations. Vitamin D 132-141 fibroblast growth factor 23 Homo sapiens 0-6 19756714-2 2010 Klotho is a coactivator of FGF23, a regulator of phosphate and vitamin D metabolism. Vitamin D 63-72 fibroblast growth factor 23 Homo sapiens 27-32 19770756-2 2009 RECENT FINDINGS: FGF23 regulates phosphorus and vitamin D metabolism. Vitamin D 48-57 fibroblast growth factor 23 Homo sapiens 17-22 19683963-6 2009 In particular, "hormone-like" FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined. Vitamin D 126-135 fibroblast growth factor 23 Homo sapiens 48-53 19524924-1 2009 Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 0-27 19524924-1 2009 Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Vitamin D 89-98 fibroblast growth factor 23 Homo sapiens 29-34 19121771-1 2009 The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs. Vitamin D 154-163 fibroblast growth factor 23 Homo sapiens 65-92 19555782-1 2009 Fibroblast growth factor 23 (FGF23) is a humoral factor that is produced by osteocytes and regulates phosphate and vitamin D metabolism. Vitamin D 115-124 fibroblast growth factor 23 Homo sapiens 0-27 19555782-1 2009 Fibroblast growth factor 23 (FGF23) is a humoral factor that is produced by osteocytes and regulates phosphate and vitamin D metabolism. Vitamin D 115-124 fibroblast growth factor 23 Homo sapiens 29-34 19371802-7 2009 New pathways of vitamin D regulation also have been discovered, involving fibroblast growth factor-23 and klotho. Vitamin D 16-25 fibroblast growth factor 23 Homo sapiens 74-112 19844248-2 2009 The endocrine actions of FGF23, in association with parathyroid hormone and vitamin D, mobilize sodium-phosphate cotransporters that control renal phosphate transport in proximal tubular epithelial cells. Vitamin D 76-85 fibroblast growth factor 23 Homo sapiens 25-30 19844248-5 2009 Several factors, including phosphate and vitamin D, can regulate the production of both FGF23 and Klotho and influence their functions. Vitamin D 41-50 fibroblast growth factor 23 Homo sapiens 88-93 18974917-3 2009 INTRODUCTION: FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D. Vitamin D 107-116 fibroblast growth factor 23 Homo sapiens 14-19 18854401-1 2009 CONTEXT: Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate. Vitamin D 93-102 fibroblast growth factor 23 Homo sapiens 108-135 18854401-1 2009 CONTEXT: Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate. Vitamin D 93-102 fibroblast growth factor 23 Homo sapiens 137-142 18854401-8 2009 EVIDENCE SYNTHESIS: Serum FGF23 concentrations in the patient with Jansen"s syndrome were found to be markedly and persistently elevated, compared with values in healthy, age-matched controls, despite hypophosphatemia and normal 1,25(OH)(2) vitamin D levels. Vitamin D 241-250 fibroblast growth factor 23 Homo sapiens 26-31 19121771-2 2009 FGF23 is a 251-amino acid secreted protein produced by osteoblasts and osteocytes in bone following the stimulation by phosphate and vitamin D or the inhibition by dentin matrix protein 1. Vitamin D 133-142 fibroblast growth factor 23 Homo sapiens 0-5 20107581-1 2009 Phosphatonin fibroblast growth factor-23 (FGF-23) is involved in phosphate (P) excretion and vitamin D metabolism. Vitamin D 93-102 fibroblast growth factor 23 Homo sapiens 42-48 18957950-2 2009 These include the discovery that the calcium-sensing receptor has an important role in the regulation of parathyroid gland function, the development of calcimimetics to target this receptor, the recognition that vitamin D receptor activation has important functions beyond the regulation of mineral metabolism, the identification of the phosphaturic factor fibroblast growth factor 23 and the contribution of this hormone to disordered phosphate and vitamin D metabolism in CKD. Vitamin D 212-221 fibroblast growth factor 23 Homo sapiens 357-384 19820750-1 2009 FGF23 is a recently identified hormone regulating mineral and vitamin D metabolism. Vitamin D 62-71 fibroblast growth factor 23 Homo sapiens 0-5 19820750-4 2009 FGF23 can also be used as a predictor of mortality as well as future development of refractory hyperparathyroidism in patients undergoing dialysis therapy, where FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D treatment. Vitamin D 241-250 fibroblast growth factor 23 Homo sapiens 0-5 19820750-4 2009 FGF23 can also be used as a predictor of mortality as well as future development of refractory hyperparathyroidism in patients undergoing dialysis therapy, where FGF23 levels are markedly elevated in response to hyperphosphatemia and active vitamin D treatment. Vitamin D 241-250 fibroblast growth factor 23 Homo sapiens 162-167 24459525-14 2008 FGF23:klotho complex bound to FGF receptor inhibits 1alpha-hydroxylase of vitamin D, and contributes to calcium reabsorption and phosphate excretion in the kidney. Vitamin D 74-83 fibroblast growth factor 23 Homo sapiens 0-5 18829467-1 2008 FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion. Vitamin D 170-179 fibroblast growth factor 23 Homo sapiens 44-49 19121771-1 2009 The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs. Vitamin D 154-163 fibroblast growth factor 23 Homo sapiens 94-99 19121771-1 2009 The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs. Vitamin D 309-318 fibroblast growth factor 23 Homo sapiens 65-92 19121771-1 2009 The discovery that two recently identified molecules, klotho and fibroblast growth factor 23 (FGF23), played an important role in calcium, phosphate, and vitamin D metabolism has transformed our traditional physiological view in which bone and mineral homeostasis was mainly regulated by parathyroid hormone, vitamin D, and calcitonin, according to mineral body needs. Vitamin D 309-318 fibroblast growth factor 23 Homo sapiens 94-99 17982392-5 2007 Recently, fibroblast growth factor 23 (FGF23) has emerged as an important humoral factor regulating phosphate and vitamin D homeostasis. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 10-37 18166826-1 2008 OBJECTIVE: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 11-38 18166826-1 2008 OBJECTIVE: Fibroblast growth factor-23 (FGF23) is a circulating factor involved in phosphate (Pi) and vitamin D metabolism. Vitamin D 102-111 fibroblast growth factor 23 Homo sapiens 40-45 17976083-1 2007 Fibroblast growth factor-23 (FGF-23) is a circulating factor regulating phosphate and vitamin D homeostasis. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 0-27 17976083-1 2007 Fibroblast growth factor-23 (FGF-23) is a circulating factor regulating phosphate and vitamin D homeostasis. Vitamin D 86-95 fibroblast growth factor 23 Homo sapiens 29-35 17976083-2 2007 Phosphate intake and an administration of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) increase circulating FGF-23 levels, and elevated FGF-23 prevents hyperphosphatemia and vitamin D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)(2)D level, comprising a feedback loop to maintain phosphate and vitamin D homeostasis. Vitamin D 56-65 fibroblast growth factor 23 Homo sapiens 108-114 17976083-2 2007 Phosphate intake and an administration of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) increase circulating FGF-23 levels, and elevated FGF-23 prevents hyperphosphatemia and vitamin D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)(2)D level, comprising a feedback loop to maintain phosphate and vitamin D homeostasis. Vitamin D 56-65 fibroblast growth factor 23 Homo sapiens 136-142 17976083-2 2007 Phosphate intake and an administration of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) increase circulating FGF-23 levels, and elevated FGF-23 prevents hyperphosphatemia and vitamin D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)(2)D level, comprising a feedback loop to maintain phosphate and vitamin D homeostasis. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 136-142 17976083-7 2007 FGF-23 may have a physiological role in preventing tissue damage such as ectopic calcifications, partly via suppressing the serum calcium x phosphate product by accelerating urinary phosphate excretion and suppressing vitamin D activation. Vitamin D 218-227 fibroblast growth factor 23 Homo sapiens 0-6 17710231-6 2007 Taken together, our findings provide what we believe to be the first evidence that loss-of-function mutations in human KL impair FGF23 bioactivity, underscoring the essential role of KL in FGF23-mediated phosphate and vitamin D homeostasis in humans. Vitamin D 218-227 fibroblast growth factor 23 Homo sapiens 129-134 17681143-1 2007 klotho was first described as an aging gene and was later shown to be a regulator of phosphate and vitamin D metabolism, acting as a coreceptor for FGF23. Vitamin D 99-108 fibroblast growth factor 23 Homo sapiens 148-153 18591745-5 2008 Recent studies suggest that FGF23 plays a certain role in premature aging process through altered P and vitamin D metabolism. Vitamin D 104-113 fibroblast growth factor 23 Homo sapiens 28-33 18256372-2 2008 Furthermore, vitamin D and phosphate stimulate FGF23 production, the pathogenic factor causing XLH. Vitamin D 13-22 fibroblast growth factor 23 Homo sapiens 47-52 17878606-4 2008 In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Vitamin D 79-88 fibroblast growth factor 23 Homo sapiens 13-18 18368510-4 2008 We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 36-63 18368510-4 2008 We have reviewed novel data linking fibroblast growth factor 23 (FGF-23) to phosphorus and vitamin D homeostasis. Vitamin D 91-100 fibroblast growth factor 23 Homo sapiens 65-71 17906399-4 2007 Recently, much attention is paid to the roles of FGF23 and Klotho, both of which are molecules critical in phosphate homeostasis, in vitamin D metabolism. Vitamin D 133-142 fibroblast growth factor 23 Homo sapiens 49-54 17982392-5 2007 Recently, fibroblast growth factor 23 (FGF23) has emerged as an important humoral factor regulating phosphate and vitamin D homeostasis. Vitamin D 114-123 fibroblast growth factor 23 Homo sapiens 39-44 17470992-4 2007 FGF23 is associated with vitamin D metabolism as well as tubular phosphate excretion. Vitamin D 25-34 fibroblast growth factor 23 Homo sapiens 0-5 17565275-3 2007 Physiologically, FGF23 is a counter-regulatory phosphaturic hormone for vitamin D and coordinates systemic phosphate homeostasis with skeletal mineralization. Vitamin D 72-81 fibroblast growth factor 23 Homo sapiens 17-22 17565275-9 2007 SUMMARY: FGF23 discovery has uncovered primary regulatory pathways and new systems biology governing bone mineralization, vitamin D metabolism, parathyroid gland function, and renal phosphate handling. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 9-14 17352646-5 2007 It is caused by mesenchymal tumors that produce the phosphate and vitamin D-regulating hormone, fibroblast growth factor (FGF)-23. Vitamin D 66-75 fibroblast growth factor 23 Homo sapiens 96-129 17635819-1 2007 The discovery of fibroblast growth factor 23 (FGF23), a novel bone-derived hormone that inhibits phosphate reabsorption and calcitriol production by the kidney, has uncovered primary regulatory pathways and new systems biology governing bone mineralization, vitamin D metabolism, parathyroid gland function and renal phosphate handling. Vitamin D 258-267 fibroblast growth factor 23 Homo sapiens 17-44 17635819-1 2007 The discovery of fibroblast growth factor 23 (FGF23), a novel bone-derived hormone that inhibits phosphate reabsorption and calcitriol production by the kidney, has uncovered primary regulatory pathways and new systems biology governing bone mineralization, vitamin D metabolism, parathyroid gland function and renal phosphate handling. Vitamin D 258-267 fibroblast growth factor 23 Homo sapiens 46-51 17374707-1 2007 CONTEXT: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disease caused by mesenchymal tumors that secrete fibroblast growth factor-23 (FGF-23), a newly-described vitamin D and phosphate-regulating hormone. Vitamin D 173-182 fibroblast growth factor 23 Homo sapiens 146-152 17470992-5 2007 Moreover, recent study using animal models revealed the task of klotho protein, which gene functions as an aging-suppressor gene, for the regulation of FGF23 signaling, Ca(2+) absorption and vitamin D modulation in the kidney. Vitamin D 191-200 fibroblast growth factor 23 Homo sapiens 152-157 17009074-3 2006 In the development of secondary hyperparathyroidism, it has recently been suggested that fibroblast growth factor 23 (FGF23) plays a crucial role, both as a phosphaturic factor and as a suppressor of active vitamin D (1,25D) production in the kidney. Vitamin D 207-216 fibroblast growth factor 23 Homo sapiens 89-116 17506310-0 2007 [Regulation of phosphorus-vitamin D metabolism by FGF23]. Vitamin D 26-35 fibroblast growth factor 23 Homo sapiens 50-55 16932898-6 2006 In chronic dialysis patients without residual renal function, FGF23 levels become extremely high due to stimulation by vitamin D therapy as well as by high levels of serum phosphate and PTH. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 62-67 16932898-7 2006 Recent investigations have demonstrated that serum FGF23 level can be a useful marker for the prediction of the future development of refractory hyperparathyroidism and the response to vitamin D therapy in dialysis patients. Vitamin D 185-194 fibroblast growth factor 23 Homo sapiens 51-56 17009074-3 2006 In the development of secondary hyperparathyroidism, it has recently been suggested that fibroblast growth factor 23 (FGF23) plays a crucial role, both as a phosphaturic factor and as a suppressor of active vitamin D (1,25D) production in the kidney. Vitamin D 207-216 fibroblast growth factor 23 Homo sapiens 118-123 17009074-5 2006 Furthermore, recent data suggest that FGF23 could be another useful marker for the prognosis of hyperparathyroidism, because a high serum level may reflect the cumulative dose of vitamin D analogues previously administered. Vitamin D 179-188 fibroblast growth factor 23 Homo sapiens 38-43 16234967-4 2005 INTRODUCTION: Fibroblast growth factor (FGF)-23 is a recently described hormone that has been shown to be involved in the regulation of phosphate and vitamin D metabolism. Vitamin D 150-159 fibroblast growth factor 23 Homo sapiens 14-47 16735491-1 2006 CONTEXT: Fibroblast growth factor 23 (FGF-23) is important in the regulation of phosphorus and vitamin D metabolism. Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 9-36 16735491-1 2006 CONTEXT: Fibroblast growth factor 23 (FGF-23) is important in the regulation of phosphorus and vitamin D metabolism. Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 38-44 16292192-0 2005 [FGF23, a "new" hormone regulating phosphate homeostasis and vitamin D metabolism]. Vitamin D 61-70 fibroblast growth factor 23 Homo sapiens 1-6 16292192-6 2005 It is now established that FGF23 regulates not only phosphate homeostasis, but also vitamin D metabolism. Vitamin D 84-93 fibroblast growth factor 23 Homo sapiens 27-32 16884396-5 2006 The interactions of FGF-23 with phosphate, parathyroid hormone and vitamin D are discussed in detail. Vitamin D 67-76 fibroblast growth factor 23 Homo sapiens 20-26 16369891-9 2006 The abnormal vitamin D mechanism in response to hypophosphatemia in MAS patients also proved recently to be caused by the increased circulating FGF-23 levels. Vitamin D 13-22 fibroblast growth factor 23 Homo sapiens 144-150 15698453-9 2005 The pretreatment FGF-23 levels were related to the iPTH levels, calcium x phosphate product levels, and history of active vitamin D therapy. Vitamin D 122-131 fibroblast growth factor 23 Homo sapiens 17-23 16076372-1 2005 Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 0-27 16076372-1 2005 Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 29-34 16076372-1 2005 Fibroblast growth factor 23 (FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism, as evidenced by the fact that FGF23 missense mutations cause autosomal dominant hypophosphatemic rickets (ADHR). Vitamin D 103-112 fibroblast growth factor 23 Homo sapiens 155-160 15671080-0 2005 Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells. Vitamin D 0-9 fibroblast growth factor 23 Homo sapiens 33-60 15671080-1 2005 Fibroblast growth factor-23 (FGF-23) has been recently identified as playing an important pathophysiological role in phosphate homeostasis and vitamin D metabolism. Vitamin D 143-152 fibroblast growth factor 23 Homo sapiens 0-27 15671080-1 2005 Fibroblast growth factor-23 (FGF-23) has been recently identified as playing an important pathophysiological role in phosphate homeostasis and vitamin D metabolism. Vitamin D 143-152 fibroblast growth factor 23 Homo sapiens 29-35 15749088-3 2005 However, it is now established that FGF23 can be a humoral messenger and an important regulator of phosphate homeostasis and vitamin D metabolism. Vitamin D 125-134 fibroblast growth factor 23 Homo sapiens 36-41 16279693-0 2005 [Regulatory effect of FGF23 on phosphate and vitamin D metabolism]. Vitamin D 45-54 fibroblast growth factor 23 Homo sapiens 22-27 15961556-9 2005 The destabilizing nature of these mutations provides new insight into the pathophysiology of TC and exemplifies the physiological importance of FGF23 in phosphate and vitamin D metabolism. Vitamin D 167-176 fibroblast growth factor 23 Homo sapiens 144-149 15930999-4 2005 Several animal experiments including overexpression or ablation of the FGF23 gene have recently revealed the significant effects of this factor on phosphate excretion and on vitamin D synthesis in the kidney. Vitamin D 174-183 fibroblast growth factor 23 Homo sapiens 71-76 15917335-3 2005 Several hypotheses were tested: that FGF-23 increases as renal function declines; is linearly associated with serum phosphate levels; is associated with increased phosphaturia independent of parathyroid hormone (PTH); and is associated with decreased calcitriol levels independent of renal function, hyperphosphatemia, and vitamin D stores. Vitamin D 323-332 fibroblast growth factor 23 Homo sapiens 37-43 15863037-4 2005 FGF23 circulates in the bloodstream, and animal models demonstrate that FGF23 controls phosphate and Vitamin D homeostasis through the regulation of specific renal proteins. Vitamin D 101-110 fibroblast growth factor 23 Homo sapiens 72-77 15956805-3 2005 Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy. Vitamin D 37-46 fibroblast growth factor 23 Homo sapiens 6-12 15838626-2 2005 Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 10-37 15838626-2 2005 Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism. Vitamin D 110-119 fibroblast growth factor 23 Homo sapiens 39-45 15838626-12 2005 These data suggested that FGF-23 is a possible causal factor for hypophosphatemia and abnormal vitamin D metabolism in MAS. Vitamin D 95-104 fibroblast growth factor 23 Homo sapiens 26-32 15956805-11 2005 Extremely high levels of serum FGF-23 in these patients may be attributed, at least in part, to the cumulative dose of vitamin D. Vitamin D 119-128 fibroblast growth factor 23 Homo sapiens 31-37 15284207-7 2004 Our findings strongly support the novel concept that high circulating levels of FGF23 are associated with profound disturbances in the regulation of phosphate and vitamin D metabolism as well as calcium homeostasis and that elevated PTH levels likely also contribute to the renal phosphate wasting associated with these disorders. Vitamin D 163-172 fibroblast growth factor 23 Homo sapiens 80-85 15577039-1 2004 Recent studies indicate that FGF-23, which was originally identified as an endogenous causative factor for hypophosphatemic diseases, is a physiologic factor for the regulation of phosphate homeostasis and vitamin D metabolism. Vitamin D 206-215 fibroblast growth factor 23 Homo sapiens 29-35 33233840-1 2020 The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. Vitamin D 123-132 fibroblast growth factor 23 Homo sapiens 25-52 33772215-0 2021 The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials. Vitamin D 14-23 fibroblast growth factor 23 Homo sapiens 27-54 33815294-9 2021 In children with severe or refractory symptoms, FGF23 inhibition using burosumab may provide superior outcomes compared to conventional medical therapy with phosphate supplements and active vitamin D analogues. Vitamin D 190-199 fibroblast growth factor 23 Homo sapiens 48-53 33233840-1 2020 The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. Vitamin D 123-132 fibroblast growth factor 23 Homo sapiens 54-59 33232874-1 2021 Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs / alpha-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D. Vitamin D 258-267 fibroblast growth factor 23 Homo sapiens 109-136 33232874-1 2021 Hereditary hypophosphatemic disorders, TIO, and CKD conditions are believed to be influenced by an excess of Fibroblast Growth Factor-23 (FGF-23) which activates a binary renal FGFRs / alpha-Klotho complex to regulate homeostatic metabolism of phosphate and vitamin D. Vitamin D 258-267 fibroblast growth factor 23 Homo sapiens 138-144