PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11311530-12 2001 In combination with reports of a neuroprotective role for vitamin D in hippocampal cell survival, these data suggest that the endogenous vitamin D receptor may mitigate processes related to cellular homeostasis, perhaps through a calcium buffering mechanism. Vitamin D 58-67 vitamin D receptor Rattus norvegicus 137-155 11179723-3 2001 The organization of the vitamin D response element (VDRE), the multiple activities of the vitamin D receptor transactivation complex, and the necessity for protein-protein interactions between the VDR-RXR heterodimer activation complex and DNA binding proteins at other regulatory elements, including AP-1 sites and TATA boxes, provide for precise regulation of gene activity in concert with basal levels of transcription. Vitamin D 24-33 vitamin D receptor Rattus norvegicus 52-55 10677578-8 2000 Furthermore, as shown in gel mobility shift assays, both compounds clearly induced VDR binding to vitamin D response elements. Vitamin D 98-107 vitamin D receptor Rattus norvegicus 83-86 10702588-3 2000 The extra vitamin D resulted in greater serum 25(OH)D (51 +/- 3, vs. control of 21 +/- 2 nmol/L), and kidney mRNA for vitamin D receptor [VDR mRNA] (P = 0. Vitamin D 10-19 vitamin D receptor Rattus norvegicus 118-136 10702588-3 2000 The extra vitamin D resulted in greater serum 25(OH)D (51 +/- 3, vs. control of 21 +/- 2 nmol/L), and kidney mRNA for vitamin D receptor [VDR mRNA] (P = 0. Vitamin D 10-19 vitamin D receptor Rattus norvegicus 138-141 10724336-3 2000 In view of our previous studies showing up-regulation of vitamin D receptors (VDR) in the duodenal mucosa and in osteoblasts, the present study was designed to address a possible interaction between estrogen and the vitamin D endocrine system in the colonic mucosa. Vitamin D 57-66 vitamin D receptor Rattus norvegicus 78-81 10609555-6 2000 The expression of the three vitamin D-regulated genes calbindin-D28k, 1,25-dihydroxyvitamin D3-24-hydroxylase (24-OHase), and vitamin D receptor (VDR) were quantified in rat kidney homogenates by real-time reverse transcription-polymerase chain reaction. Vitamin D 28-37 vitamin D receptor Rattus norvegicus 126-144 10609555-6 2000 The expression of the three vitamin D-regulated genes calbindin-D28k, 1,25-dihydroxyvitamin D3-24-hydroxylase (24-OHase), and vitamin D receptor (VDR) were quantified in rat kidney homogenates by real-time reverse transcription-polymerase chain reaction. Vitamin D 28-37 vitamin D receptor Rattus norvegicus 146-149 10404392-1 1999 The ability of vitamin D receptor-retinoid X receptor (VDR-RXR) heterodimers to induce a DNA bend upon binding to various vitamin D response elements (VDRE) has been investigated by circular permutation and phasing analysis. Vitamin D 15-24 vitamin D receptor Rattus norvegicus 55-58 10571682-0 1999 Vitamin D receptor interactions with the rat parathyroid hormone gene: synergistic effects between two negative vitamin D response elements. Vitamin D 112-121 vitamin D receptor Rattus norvegicus 0-18 10571682-2 1999 Gel mobility shift assays using DNA restriction enzyme fragments and recombinant proteins for vitamin D and retinoic acid X receptors (VDR/RXR) revealed a sequence between -793 and -779 that bound a VDR/RXR heterodimer with high affinity (VDRE1). Vitamin D 94-103 vitamin D receptor Rattus norvegicus 199-202 10460470-1 1999 Vitamin D through its receptor (VDR) plays a major role in bone mineral metabolism. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 32-35 10342883-0 1999 Vitamin D represses retinoic acid-dependent transactivation of the retinoic acid receptor-beta2 promoter: the AF-2 domain of the vitamin D receptor is required for transrepression. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 129-147 10342883-3 1999 Incubation with vitamin D markedly reduced the response to RA caused by transcriptional interference of the vitamin D receptor (VDR) on the RARE. Vitamin D 16-25 vitamin D receptor Rattus norvegicus 108-126 10342883-3 1999 Incubation with vitamin D markedly reduced the response to RA caused by transcriptional interference of the vitamin D receptor (VDR) on the RARE. Vitamin D 16-25 vitamin D receptor Rattus norvegicus 128-131 10342883-5 1999 Overexpression of RXR in GH4C1 cells, as well as incubation with BMS649 (a RXR-specific ligand), increased the inhibitory effect of vitamin D, suggesting that the VDR/RXR heterodimer is the repressive species and that titration of RXR is not responsible for this inhibition. Vitamin D 132-141 vitamin D receptor Rattus norvegicus 163-166 10342883-7 1999 Furthermore, the ability to mediate transrepression by vitamin D was strongly decreased when a mutant VDR in which the last 12 C-terminal aminoacids have been deleted (VDR deltaAF-2) was used. Vitamin D 55-64 vitamin D receptor Rattus norvegicus 102-105 10342883-7 1999 Furthermore, the ability to mediate transrepression by vitamin D was strongly decreased when a mutant VDR in which the last 12 C-terminal aminoacids have been deleted (VDR deltaAF-2) was used. Vitamin D 55-64 vitamin D receptor Rattus norvegicus 168-171 10342883-8 1999 Because this region contains the domain responsible for ligand-dependent recruitment of coactivators, titration of common coactivators for VDR and RAR could be involved in the inhibitory effect of vitamin D. Vitamin D 197-206 vitamin D receptor Rattus norvegicus 139-142 9528970-1 1998 We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. Vitamin D 26-35 vitamin D receptor Rattus norvegicus 117-135 9886808-0 1999 AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Vitamin D 9-18 vitamin D receptor Rattus norvegicus 29-32 9886808-0 1999 AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Vitamin D 9-18 vitamin D receptor Rattus norvegicus 85-88 9749832-10 1998 These results indicate that a critical nucleotide sequence is necessary for the binding to the VDR and for mediating the vitamin D effect, and suggest the different regulation between the rat and human 24-hydroxylase gene. Vitamin D 121-130 vitamin D receptor Rattus norvegicus 95-98 9528970-1 1998 We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. Vitamin D 69-78 vitamin D receptor Rattus norvegicus 117-135 9528970-4 1998 Vitamin D deficiency decreased VDR mRNA in all three tissues. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 31-34 9528970-5 1998 Treatment with vitamin D or calcium-lactose reestablished the VDR mRNA content of the epidermis, but not that of the kidneys, and only the calcium-lactose diet increased duodenal VDR mRNA. Vitamin D 15-24 vitamin D receptor Rattus norvegicus 62-65 9528970-5 1998 Treatment with vitamin D or calcium-lactose reestablished the VDR mRNA content of the epidermis, but not that of the kidneys, and only the calcium-lactose diet increased duodenal VDR mRNA. Vitamin D 15-24 vitamin D receptor Rattus norvegicus 179-182 9528970-8 1998 The expression of VDR was decreased by vitamin D deficiency and returned to control values after vitamin D or calcium supplementation. Vitamin D 39-48 vitamin D receptor Rattus norvegicus 18-21 9528970-8 1998 The expression of VDR was decreased by vitamin D deficiency and returned to control values after vitamin D or calcium supplementation. Vitamin D 97-106 vitamin D receptor Rattus norvegicus 18-21 9528970-9 1998 Vitamin D treatment, but not calcium, induced VDR expression in the normally immature population. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 46-49 9528970-10 1998 Vitamin D and calcium, therefore, have distinct, tissue-specific effects on VDR. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 76-79 9143355-1 1997 The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes. Vitamin D 89-98 vitamin D receptor Rattus norvegicus 134-137 9541257-0 1998 Characteristics of vitamin D3 receptor (VDR) binding to the vitamin D response element (VDRE) in rat bone sialoprotein gene promoter. Vitamin D 19-28 vitamin D receptor Rattus norvegicus 40-43 9211344-1 1997 The biological action of calcitriol is mostly mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of target genes. Vitamin D 117-126 vitamin D receptor Rattus norvegicus 107-110 9180905-18 1997 Further, by eliminating the VDR-mediated component of the cellular response, we have provided further evidence for the existence of a membrane receptor(s) involved in mediating nongenomic effects of vitamin D metabolites. Vitamin D 199-208 vitamin D receptor Rattus norvegicus 28-31 9211349-1 1997 The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. Vitamin D 107-116 vitamin D receptor Rattus norvegicus 97-100 9058197-3 1997 Because the actions of 1,25-(OH)2D3 are mediated through the vitamin D receptor (VDR), that is a DNA binding transcription factor, vitamin D regulated genes should have VDR binding sites in their regulatory regions. Vitamin D 61-70 vitamin D receptor Rattus norvegicus 81-84 9058197-3 1997 Because the actions of 1,25-(OH)2D3 are mediated through the vitamin D receptor (VDR), that is a DNA binding transcription factor, vitamin D regulated genes should have VDR binding sites in their regulatory regions. Vitamin D 61-70 vitamin D receptor Rattus norvegicus 169-172 8914020-1 1996 The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. Vitamin D 107-116 vitamin D receptor Rattus norvegicus 97-100 9058197-4 1997 In this paper, we describe a novel vitamin D response element (VDRE)-containing sequence, clone 3, which was isolated through binding to VDR. Vitamin D 35-44 vitamin D receptor Rattus norvegicus 63-66 8940000-7 1996 These results demonstrate that VDRE-1 is a stronger mediator of vitamin D function than VDRE-2 due to the presence of the accessory element -169/-155 located adjacent to VDRE-1, although VDRE-2 exhibits a smaller dissociation constant for the vitamin D receptor-retinoid X receptor complex than VDRE-1. Vitamin D 64-73 vitamin D receptor Rattus norvegicus 243-261 8913867-4 1996 To determine whether the 1 beta-hydroxymethyl analogs induced a VDR-mediated transcription, we tested the induction of reporter gene expression through the osteocalcin vitamin D response element (VDRE) in ROS 17/2.8 cells and the induction of binding activity of VDR to VDRE in COS-1 cells. Vitamin D 168-177 vitamin D receptor Rattus norvegicus 64-67 8913867-4 1996 To determine whether the 1 beta-hydroxymethyl analogs induced a VDR-mediated transcription, we tested the induction of reporter gene expression through the osteocalcin vitamin D response element (VDRE) in ROS 17/2.8 cells and the induction of binding activity of VDR to VDRE in COS-1 cells. Vitamin D 168-177 vitamin D receptor Rattus norvegicus 196-199 8668154-9 1996 Thus, the present study indicates that this new VDR isoform negatively modulates the vitamin D signaling pathway, through a particular set of target genes. Vitamin D 85-94 vitamin D receptor Rattus norvegicus 48-51 8754789-1 1996 The aim of this study was to investigate the expression pattern of 1, 25-dihydroxyvitamin D3 receptor (VDR) and vitamin D-responsive gene expression during the steps of hard tissue formation in oro-facial development. Vitamin D 82-91 vitamin D receptor Rattus norvegicus 103-106 7577156-14 1995 The genomic action of vitamin D, in vitro, resulted in the synthesis of nuclear VDR and calbindins-D. Vitamin D 22-31 vitamin D receptor Rattus norvegicus 80-83 7646451-5 1995 1 alpha,24(S)-Dihydroxyvitamin D2 binds strongly to the vitamin D receptor and is biologically active in growth hormone and chloramphenicol acetyltransferase reporter gene expression systems in vitro, but binds poorly to rat vitamin D-binding globulin, DBP. Vitamin D 23-32 vitamin D receptor Rattus norvegicus 56-74 8619822-1 1996 The vitamin D receptor (VDR) binds to the vitamin D response element (VDRE) in the promoter region of target genes and acts as a ligand-dependent transcriptional regulator. Vitamin D 4-13 vitamin D receptor Rattus norvegicus 24-27 7597089-6 1995 In vitamin D-deficient rats with up-regulated renal 25-hydroxyvitamin D3 1 alpha-hydroxylase activity, expression of vitamin D receptor mRNA in renal proximal convoluted tubules was also down-regulated, indicating that the down-regulation of vitamin D receptor mRNA is not the result of the enhanced production of 1 alpha, 25-dihydroxyvitamin D3. Vitamin D 3-12 vitamin D receptor Rattus norvegicus 117-135 7615822-1 1995 The genomic action of calcitriol (1,25-dihydroxy-vitamin D3) is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 125-128 7597089-6 1995 In vitamin D-deficient rats with up-regulated renal 25-hydroxyvitamin D3 1 alpha-hydroxylase activity, expression of vitamin D receptor mRNA in renal proximal convoluted tubules was also down-regulated, indicating that the down-regulation of vitamin D receptor mRNA is not the result of the enhanced production of 1 alpha, 25-dihydroxyvitamin D3. Vitamin D 3-12 vitamin D receptor Rattus norvegicus 242-260 8144641-8 1994 These results indicate that a direct repeat motif, AGGTGAgt-gAGGGCG, located at -151 base pairs upstream in the antisense strand binds to a heterologous dimer consisting of the VDR occupied with 1,25-(OH)2D3 and the nuclear accessory factor and that it plays a critical role in mediating the vitamin D enhancement of the rat P450cc24 gene expression. Vitamin D 292-301 vitamin D receptor Rattus norvegicus 177-180 21153145-2 1995 Here we demonstrate that the vitamin D analogs, 25(OH)(2)-16-ene-23-yne-D(3) and 1alpha, 24S-(OH)(2)-22-en-26, 27-dehydro-vitamin D(3), which have been shown by others to bind to the intracellular vitamin D receptor (VDR), have similar effects to 1, 25(OH)(2)D(3) in increasing ALPA of IEC-6 cells. Vitamin D 29-38 vitamin D receptor Rattus norvegicus 197-215 21153145-2 1995 Here we demonstrate that the vitamin D analogs, 25(OH)(2)-16-ene-23-yne-D(3) and 1alpha, 24S-(OH)(2)-22-en-26, 27-dehydro-vitamin D(3), which have been shown by others to bind to the intracellular vitamin D receptor (VDR), have similar effects to 1, 25(OH)(2)D(3) in increasing ALPA of IEC-6 cells. Vitamin D 29-38 vitamin D receptor Rattus norvegicus 217-220 21153145-3 1995 A third vitamin D analog, 25-(OH)-16-ene-23-yne-D(3) (AT), which activates membrane 1,25(OH)(2)D(3) effects, but binds poorly to the intracellular VDR, did not stimulate ALPA of IEC-6 cells. Vitamin D 8-17 vitamin D receptor Rattus norvegicus 147-150 7819220-0 1995 Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene expression. Vitamin D 42-51 vitamin D receptor Rattus norvegicus 62-65 8179318-2 1994 The purified receptor is homogeneous, and is bound by 1,25-dihydroxyvitamin D3 with a Kd of 5 x 10(-10) M. The isolated receptor binds to the osteocalcin vitamin D response element in the presence of porcine intestinal nuclear extract stripped of endogenous vitamin D receptor as well. Vitamin D 68-77 vitamin D receptor Rattus norvegicus 258-276 7708726-3 1995 Most important, the two specific complexes formed by porcine nuclear extract with the vitamin D response elements from either the osteocalcin gene or the rat 24-hydroxylase gene are shifted to a larger complex by both an anti-vitamin D receptor antibody and an anti-RXR antibody, leaving no doubt that in vivo the nuclear accessory factor for the vitamin D receptor in the intestine is an RXR protein. Vitamin D 86-95 vitamin D receptor Rattus norvegicus 226-244 7708726-3 1995 Most important, the two specific complexes formed by porcine nuclear extract with the vitamin D response elements from either the osteocalcin gene or the rat 24-hydroxylase gene are shifted to a larger complex by both an anti-vitamin D receptor antibody and an anti-RXR antibody, leaving no doubt that in vivo the nuclear accessory factor for the vitamin D receptor in the intestine is an RXR protein. Vitamin D 86-95 vitamin D receptor Rattus norvegicus 347-365 8394128-6 1993 Transient transfection of osteosarcoma cells with a reporter vector containing a vitamin D responsive element derived from the rat osteocalcin gene yields equivalent transcriptional activation in the presence of either 1,25(OH)2D3 or OCT. Further experiments performed at various 1,25(OH)2D3 concentrations to assess the relationship between receptor phosphorylation and transcriptional activity in intact cells showed a positive correlation between these two parameters, indicating that the 1,25(OH)2D3 hormone stimulates VDR phosphorylation and transcriptional activation in parallel. Vitamin D 81-90 vitamin D receptor Rattus norvegicus 523-526 8415688-3 1993 An electrophoretic mobility-shift analysis demonstrated that VDR, derived from extracts of the small intestines of vitamin D-deficient rats, is capable of binding a vitamin D response element (DRE). Vitamin D 115-124 vitamin D receptor Rattus norvegicus 61-64 8415688-3 1993 An electrophoretic mobility-shift analysis demonstrated that VDR, derived from extracts of the small intestines of vitamin D-deficient rats, is capable of binding a vitamin D response element (DRE). Vitamin D 165-174 vitamin D receptor Rattus norvegicus 61-64 8229291-2 1993 Impaired development was observed in normocalcemic, vitamin D-deficient male and female rats, as revealed by low intestinal calcium transport, low renal vitamin D receptor levels and poor bone mineralization. Vitamin D 52-61 vitamin D receptor Rattus norvegicus 153-171 8385999-7 1993 Thus, dietary calcium is required for vitamin D to up-regulate the renal vitamin D receptor level. Vitamin D 38-47 vitamin D receptor Rattus norvegicus 73-91 1321435-3 1992 In addition, a vitamin D-responsive increase in OC gene transcription is accompanied by enhanced non-vitamin D receptor-mediated protein-DNA interactions in the "TATA" box region (nucleotides -44 to +23), which also contains a potential glucocorticoid responsive element. Vitamin D 15-24 vitamin D receptor Rattus norvegicus 101-119 33596463-6 2021 Such intricate unbalance in regard to vitamin D metabolizing enzymes was strongly associated with reduced bioavailability of calcitriol in the senile prostate, which in addition to decreased expression of the vitamin D receptor, further limits the protective actions mediated by vitamin D signaling. Vitamin D 38-47 vitamin D receptor Rattus norvegicus 209-227 2161536-0 1990 Serum calcium and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in rat kidney in vivo. Vitamin D 18-27 vitamin D receptor Rattus norvegicus 37-70 2161536-8 1990 This study demonstrates that serum calcium levels and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in vivo in kidney. Vitamin D 54-63 vitamin D receptor Rattus norvegicus 73-106 34338991-1 2021 Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3). Vitamin D 0-9 vitamin D receptor Rattus norvegicus 63-81 34338991-1 2021 Vitamin D is a secosteroid hormone mediating its functions via vitamin D receptor (VDR) and an endoplasmic reticulum chaperone, protein disulfide isomerase A3 (PDIA3). Vitamin D 0-9 vitamin D receptor Rattus norvegicus 83-86 35470763-7 2022 Our results demonstrated that maternal vitamin D deficiency increased anxiety and depression-related behaviors, increased levels of TNF-alpha and IL-1beta in serum, and decreased prefrontal protein expressions of BDNF and VDR in adult male offspring. Vitamin D 39-48 vitamin D receptor Rattus norvegicus 222-225 35470763-9 2022 CONCLUSION: It seems that developmental vitamin D deficiency disrupts brain development and has a long-lasting effect on VDR and BDNF signaling in the rat brain resulting in neuropsychiatric disorders in offspring. Vitamin D 40-49 vitamin D receptor Rattus norvegicus 121-124 1542030-3 1992 However, in the vitamin D-replete rat, administration of 1,25(OH)2D3 results in an induction of both calbindin and VDR mRNA in these tissues. Vitamin D 16-25 vitamin D receptor Rattus norvegicus 115-118 34769269-2 2021 Vitamin D derivatives with high VDR affinity and resistance to CYP24A1-mediated metabolism could be good therapeutic agents. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 32-35 34769269-6 2021 Vdr-gene-deficient rats can be used to assess the activities of vitamin D derivatives specialized for actions not mediated by VDR. Vitamin D 64-73 vitamin D receptor Rattus norvegicus 0-3 34769269-7 2021 One of our original vitamin D derivatives, which displays high affinity VDR binding and resistance to CYP24A1-dependent metabolism, has shown good therapeutic effects in Vdr (R270L) rats, although further analysis is needed. Vitamin D 20-29 vitamin D receptor Rattus norvegicus 72-75 34769269-7 2021 One of our original vitamin D derivatives, which displays high affinity VDR binding and resistance to CYP24A1-dependent metabolism, has shown good therapeutic effects in Vdr (R270L) rats, although further analysis is needed. Vitamin D 20-29 vitamin D receptor Rattus norvegicus 170-173 2551904-2 1989 We have used specific cDNAs to the rat vitamin D receptor (VDR) and to the mammalian vitamin D-dependent calcium-binding proteins (calbindin-D9k in intestine and calbindin-D28k in kidney) in order to obtain a better understanding of the regulation of the VDR gene and its relationship to calbindin gene expression. Vitamin D 39-48 vitamin D receptor Rattus norvegicus 59-62 2551904-5 1989 Vitamin D-deficient rats responded to dexamethasone treatment (100 micrograms/100 g of body weight/day for 4 days) with a 2.5-fold increase in intestinal VDR mRNA which was accompanied by a 4-fold decrease in intestinal calbindin-D9k mRNA. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 154-157 33325123-0 2021 Vitamin D rescues pancreatic beta cell dysfunction due to iron overload via elevation of the vitamin D receptor and maintenance of Ca2+ homeostasis. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 93-111 33878208-0 2021 Role of vitamin D-vitamin D receptor signaling on hyperoxia-induced bronchopulmonary dysplasia in neonatal rats. Vitamin D 8-17 vitamin D receptor Rattus norvegicus 18-36 33878208-11 2021 CONCLUSION: Vitamin D exerts protective effects on hyperoxia-induced BPD in neonatal rats by regulating vitamin D-VDR signaling pathways. Vitamin D 12-21 vitamin D receptor Rattus norvegicus 114-117 33878208-11 2021 CONCLUSION: Vitamin D exerts protective effects on hyperoxia-induced BPD in neonatal rats by regulating vitamin D-VDR signaling pathways. Vitamin D 104-113 vitamin D receptor Rattus norvegicus 114-117 33889003-9 2021 Calcitriol, the active form of vitamin D, could activate VDR and attenuate diabetic nephropathy including proteinuria and glomerular sclerosis. Vitamin D 31-40 vitamin D receptor Rattus norvegicus 57-60 32604067-8 2020 Using the method of immunofluorescent staining and western blot, vitamin D and 17beta-estradiol were demonstrated to upregulate each other"s receptors, including VDR, ERalpha, and ERbeta in the hippocampus of OVX rats. Vitamin D 65-74 vitamin D receptor Rattus norvegicus 162-165 32530517-9 2021 Mechanical loading showed a significant interaction with vitamin D deficiency with regard to mRNA expression of Vdr and Esr1. Vitamin D 57-66 vitamin D receptor Rattus norvegicus 112-115 32585450-1 2020 The biological activity of vitamin D, which mediated by the vitamin D receptor, is widespread throughout the body. Vitamin D 27-36 vitamin D receptor Rattus norvegicus 60-78 31810868-7 2020 RESULTS: It was also found that active VD increased the concentration of VD in serum and VDR in liver of NAFLD rats, and alleviated hepatic fibrosis. Vitamin D 39-41 vitamin D receptor Rattus norvegicus 89-92 32604067-9 2020 Additionally, the upregulation of VDR, calbindin-D28k, and calbindin-D9k suggested that the vitamin D signaling system was amplified by vitamin D and 17beta-estradiol. Vitamin D 92-101 vitamin D receptor Rattus norvegicus 34-37 32604067-9 2020 Additionally, the upregulation of VDR, calbindin-D28k, and calbindin-D9k suggested that the vitamin D signaling system was amplified by vitamin D and 17beta-estradiol. Vitamin D 136-145 vitamin D receptor Rattus norvegicus 34-37 32231239-1 2020 Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR. Vitamin D 35-44 vitamin D receptor Rattus norvegicus 64-82 32712621-10 2020 Vitamin D could decrease ROS level, apoptotic neuron cells and DUOX1 expression, and increase VDR expression. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 94-97 32452516-0 2020 Vitamin D-vitamin D receptor system downregulates expression of uncoupling proteins in brown adipocyte through interaction with hairless protein. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 10-28 32452516-12 2020 These data suggest that vitamin D suppresses expression of Ucps in brown adipocyte in a Vdr-dependent manner and the corepressor Hairless protein probably plays a role in the downregulation. Vitamin D 24-33 vitamin D receptor Rattus norvegicus 88-91 32231239-1 2020 Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR. Vitamin D 35-44 vitamin D receptor Rattus norvegicus 84-87 32231239-1 2020 Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR. Vitamin D 35-44 vitamin D receptor Rattus norvegicus 103-106 32231239-1 2020 Recent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 25-hydroxyvitamin D3 (25(OH)D3) and ligand-independent effects of the VDR. Vitamin D 35-44 vitamin D receptor Rattus norvegicus 103-106 30531693-8 2020 CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation. Vitamin D 55-64 vitamin D receptor Rattus norvegicus 132-135 32235811-1 2020 Vitamin D is associated with cardiovascular health through activating the vitamin D receptor that targets genes related to cardiovascular disease (CVD). Vitamin D 0-9 vitamin D receptor Rattus norvegicus 74-92 31430707-1 2019 BACKGROUND: Although modulation of the vitamin D receptor (VDR) and endothelin-A receptor (ETAR) has previously been reported to offer renoprotection against cisplatin-induced nephrotoxicity, the possible interaction between the ET-1 and vitamin D pathways remains obscure. Vitamin D 39-48 vitamin D receptor Rattus norvegicus 59-62 29138801-2 2018 Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor. Vitamin D 48-57 vitamin D receptor Rattus norvegicus 109-127 29308676-5 2018 CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN. Vitamin D 12-21 vitamin D receptor Rattus norvegicus 124-127 29308676-5 2018 CONCLUSION: Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN. Vitamin D 182-191 vitamin D receptor Rattus norvegicus 124-127 29552033-2 2018 We investigated the role of vitamin D in the regulation of 25OHD-1alpha-hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats. Vitamin D 28-37 vitamin D receptor Rattus norvegicus 98-101 29552033-8 2018 Vitamin D deficiency was accompanied by elevated synthesis of renal CYP27B1 and VDR. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 80-83 29552033-11 2018 Conclusions: T1D-induced vitamin D deficiency is associated with impairments of renal and extrarenal CYP27B1 and VDR expression. Vitamin D 25-34 vitamin D receptor Rattus norvegicus 113-116 30537097-1 2019 1alpha,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Rattus norvegicus 152-170 30537097-1 2019 1alpha,25-Dihydroxyvitamin D3 (also called 1,25(OH)2 D3 or calcitriol) is the biologically active form of vitamin D, which functions as a ligand to the vitamin D receptor (VDR). Vitamin D 19-28 vitamin D receptor Rattus norvegicus 172-175 28825325-0 2019 Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 56-59 29355791-10 2018 Vitamin D replacement after VDD could partially restore the muscle volume, muscle fiber size, and intramyonuclear VDR concentration levels (p<.05) of the paraspinal muscles. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 114-117 29355791-12 2018 Vitamin D replacement contributes to the recovery from atrophy and restoration of intramyonuclear VDR concentration in VDD status. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 98-101 29508414-0 2018 Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging-related prostate lesions. Vitamin D 8-17 vitamin D receptor Rattus norvegicus 28-31 29508414-7 2018 Interestingly, RXR expression in the aging prostate was similar to that found for its partner VDR, indicating that components of the VDR/RXR complex required for vitamin D signaling are affected in aging-related prostatic lesions. Vitamin D 162-171 vitamin D receptor Rattus norvegicus 133-136 28423519-3 2017 Both circulating vitamin D and muscle VDR expression increased after vitamin D administration, without exerting appreciable effects on body weight and muscle mass.The effects of vitamin D on muscle cells were studied in C2C12 myocytes. Vitamin D 69-78 vitamin D receptor Rattus norvegicus 38-41 28707894-3 2017 The present study primarily focused on the creation of a condition that prevents the genomic or nongenomic action of vitamin D by disrupting vitamin D receptors (VDR or PDIA3/1,25MARRS); the effects of these disruptions on the series of proteins involved in secretases that play a crucial role in amyloid pathology and on amyloid beta (Abeta) production in primary cortical neurons were observed. Vitamin D 117-126 vitamin D receptor Rattus norvegicus 162-165 28377587-5 2017 Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 90-108 28377587-5 2017 Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 110-113 28377587-5 2017 Furthermore, we discovered that the mediation of vitamin D on GSN might occur through the vitamin D receptor (VDR) by using gene interruption and overexpression to regulate the level of VDR in PC12 cells (a rat sympathetic nerve cell line). Vitamin D 49-58 vitamin D receptor Rattus norvegicus 186-189 27576086-4 2017 The affinities of the synthesized vitamin D analogs to the full-length recombinant rat VDR were examined, as well as their differentiating and transcriptional activities. Vitamin D 34-43 vitamin D receptor Rattus norvegicus 87-90 28423519-3 2017 Both circulating vitamin D and muscle VDR expression increased after vitamin D administration, without exerting appreciable effects on body weight and muscle mass.The effects of vitamin D on muscle cells were studied in C2C12 myocytes. Vitamin D 69-78 vitamin D receptor Rattus norvegicus 38-41 28423519-5 2017 Vitamin D treatment resulted in VDR overexpression and myogenin down-regulation. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 32-35 28423519-6 2017 Silencing VDR expression in C2C12 cultures abrogated the inhibition of differentiation exerted by vitamin D treatment.These data suggest that VDR overexpression in tumor-bearing animals contributes to muscle wasting by impairing muscle regenerative program. Vitamin D 98-107 vitamin D receptor Rattus norvegicus 10-13 28423519-6 2017 Silencing VDR expression in C2C12 cultures abrogated the inhibition of differentiation exerted by vitamin D treatment.These data suggest that VDR overexpression in tumor-bearing animals contributes to muscle wasting by impairing muscle regenerative program. Vitamin D 98-107 vitamin D receptor Rattus norvegicus 142-145 27504197-10 2016 In diabetic groups; serum vitamin D was found to be correlated negatively with serum glucose, insulin, HOMA, cholesterol, triglycerides, and LDL and positively correlated with HDL and tissue VDR. Vitamin D 26-35 vitamin D receptor Rattus norvegicus 191-194 28303937-0 2017 Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 45-48 23896933-0 2011 19F NMR study on the complex of fluorinated vitamin D derivatives with vitamin D receptor: elucidation of the conformation of vitamin D ligands accommodated in the receptor. Vitamin D 44-53 vitamin D receptor Rattus norvegicus 71-89 25336523-1 2014 Despite the presence of vitamin D receptor (VDR) in endothelial cells, the effect of vitamin D on endothelial function is unknown. Vitamin D 24-33 vitamin D receptor Rattus norvegicus 44-47 23250517-0 2013 Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 68-71 23250517-0 2013 Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement. Vitamin D 58-67 vitamin D receptor Rattus norvegicus 68-71 23250517-1 2013 Vitamin D receptor (VDR) and the enzymes involved in bioactivation of vitamin D, shown to be expressed in the central nervous system, particularly in areas affected by neurodegenerative disorders, especially in hippocampus. Vitamin D 70-79 vitamin D receptor Rattus norvegicus 0-18 23250517-1 2013 Vitamin D receptor (VDR) and the enzymes involved in bioactivation of vitamin D, shown to be expressed in the central nervous system, particularly in areas affected by neurodegenerative disorders, especially in hippocampus. Vitamin D 70-79 vitamin D receptor Rattus norvegicus 20-23 23250517-12 2013 Higher gene expression of 24OHase and VDR might indicate "higher requirement of vitamin D" in hippocampus and potential consequences of vitamin D deficiency in cognitive decline, neurodegeneration, and Alzheimer"s disease. Vitamin D 80-89 vitamin D receptor Rattus norvegicus 38-41 23250517-12 2013 Higher gene expression of 24OHase and VDR might indicate "higher requirement of vitamin D" in hippocampus and potential consequences of vitamin D deficiency in cognitive decline, neurodegeneration, and Alzheimer"s disease. Vitamin D 136-145 vitamin D receptor Rattus norvegicus 38-41 26778336-9 2016 CONCLUSION: We propose that in obese rat adipocytes, 1,25(OH)2 D down-regulates VDR, resulting in vitamin D resistance, characterized by higher Cyp27b1/1alpha-Hydroxylase and adipogenesis. Vitamin D 98-107 vitamin D receptor Rattus norvegicus 80-83 25031721-9 2014 The mRNA expression of VDR was elevated by vitamin D treatment in these diabetic nephropathy models. Vitamin D 43-52 vitamin D receptor Rattus norvegicus 23-26 24535566-2 2014 Almost all actions of Vitamin D are mediated by the transcription factor, vitamin D receptor (VDR), which has been widely identified in the central nervous system. Vitamin D 22-31 vitamin D receptor Rattus norvegicus 74-92 24535566-2 2014 Almost all actions of Vitamin D are mediated by the transcription factor, vitamin D receptor (VDR), which has been widely identified in the central nervous system. Vitamin D 22-31 vitamin D receptor Rattus norvegicus 94-97 23669253-13 2013 Therefore, we concluded that vitamin D may play a pivotal role in exercise-induced muscle damage and inflammation through the modulation of MAPK and NF-kappaB involved with VDR. Vitamin D 29-38 vitamin D receptor Rattus norvegicus 173-176 23352937-6 2013 The nuclear expression of VDR in TH-positive neurons during critical periods of brain development suggests that alterations in early life vitamin D status may influence the orderly development of dopaminergic neurons. Vitamin D 138-147 vitamin D receptor Rattus norvegicus 26-29 23752060-2 2013 The aim of this study was to determine the expression of the vitamin D receptor (VDR), 25-hydroxyvitamin D3 24-hydroxylase (an accelerator of vitamin D catabolism), and the L-type voltage-sensitive calcium channel A1C (LVSCC-A1C) in hippocampal neurons in response to beta amyloid and vitamin D treatments to test the protective effects of vitamin D and the probable effects of beta amyloid on vitamin D catabolism. Vitamin D 61-70 vitamin D receptor Rattus norvegicus 81-84 23752060-5 2013 CONCLUSION: Beta amyloid may disrupt the vitamin D-VDR pathway and cause defective utilization of vitamin D by suppressing the level of the VDR and elevating the level of 24OHase. Vitamin D 41-50 vitamin D receptor Rattus norvegicus 51-54 23752060-5 2013 CONCLUSION: Beta amyloid may disrupt the vitamin D-VDR pathway and cause defective utilization of vitamin D by suppressing the level of the VDR and elevating the level of 24OHase. Vitamin D 98-107 vitamin D receptor Rattus norvegicus 140-143 22221397-9 2012 We demonstrated that the restoring effect of vitamin D(3) is mediated through VDR modulation, thereby improving signal transduction and controlling free radicals in the liver of diabetic rats. Vitamin D 45-54 vitamin D receptor Rattus norvegicus 78-81 22112050-2 2011 When bound to a variety of vitamin D analogues, VDR manifests a wide diversity of physiological actions. Vitamin D 27-36 vitamin D receptor Rattus norvegicus 48-51 23896933-2 2011 The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD. Vitamin D 19-28 vitamin D receptor Rattus norvegicus 34-52 23896933-2 2011 The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD. Vitamin D 19-28 vitamin D receptor Rattus norvegicus 54-57 23896933-2 2011 The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD. Vitamin D 19-28 vitamin D receptor Rattus norvegicus 187-190 23896933-2 2011 The interaction of vitamin D with vitamin D receptor (VDR) was investigated by (19)F NMR spectroscopy of the complexes of three fluorinated vitamin D derivatives with the full-length rat VDR-LBD. Vitamin D 34-43 vitamin D receptor Rattus norvegicus 54-57 23896933-6 2011 The fluorinated vitamin D derivatives showed marked changes in the chemical shift (Delta4-19.7 ppm) upon VDR-complex formation, and the ab initio MO method suggested that van der Waals interactions play a major role in the complex formation. Vitamin D 16-25 vitamin D receptor Rattus norvegicus 105-108 18534255-1 2008 Vitamin D (VD), is a steroid hormone with multiple functions in the central nervous system (CNS), producing numerous physiological effects mediated by its receptor (VDR). Vitamin D 0-9 vitamin D receptor Rattus norvegicus 165-168 20655720-11 2011 In conclusion, vitamin D(3) shows a potential therapeutic effect in normalizing diabetes-induced alterations in cholinergic, insulin and vitamin D receptor and maintains a normal glucose transport and utilisation in the cortex. Vitamin D 15-24 vitamin D receptor Rattus norvegicus 137-155 18502116-6 2008 Vitamin D receptor (vdr) and retinoid X receptor alpha (rxralpha), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased. Vitamin D 135-144 vitamin D receptor Rattus norvegicus 0-18 18502116-6 2008 Vitamin D receptor (vdr) and retinoid X receptor alpha (rxralpha), encoding nuclear receptors involved in the biological activities of vitamin D, showed a lower expression in kidney, while their protein levels were paradoxically increased. Vitamin D 135-144 vitamin D receptor Rattus norvegicus 20-23 15659788-12 2004 VD/VD-R binds to the vitamin D-responsive element (VDRE) on the target genes. Vitamin D 21-30 vitamin D receptor Rattus norvegicus 3-7 17234669-9 2007 CONCLUSIONS: Direct injection of OCT into the PTG enables the administration of the highly concentrated drug for specific binding to nuclear vitamin D binding sites, including VDR of PTC, which markedly suppresses the parathyroid hormone, improves the response to calcium and vitamin D and induces apoptosis in PTC. Vitamin D 141-150 vitamin D receptor Rattus norvegicus 176-179 17234669-9 2007 CONCLUSIONS: Direct injection of OCT into the PTG enables the administration of the highly concentrated drug for specific binding to nuclear vitamin D binding sites, including VDR of PTC, which markedly suppresses the parathyroid hormone, improves the response to calcium and vitamin D and induces apoptosis in PTC. Vitamin D 276-285 vitamin D receptor Rattus norvegicus 176-179 17223343-7 2007 The prepared Vitamin D analog 6 exhibited limited binding ability to the rat intestinal Vitamin D receptor being ca. Vitamin D 13-22 vitamin D receptor Rattus norvegicus 88-106 15746989-14 2005 This study supports the hypothesis that prolongation of VDR half-life increases VDR tissue levels and mediates increased VDR-regulated genes that result in hypercalciuria through actions on vitamin D-regulated calcium transport in intestine, bone, and kidney. Vitamin D 190-199 vitamin D receptor Rattus norvegicus 56-59 17974622-1 2008 We have previously shown that the active form of vitamin D, 1,25 dihydroxyvitamin D3 [1,25(OH)(2)D(3)], has both genomic and rapid nongenomic effects in heart cells; however, the subcellular localization of the vitamin D receptor (VDR) in heart has not been studied. Vitamin D 49-58 vitamin D receptor Rattus norvegicus 211-229 17974622-1 2008 We have previously shown that the active form of vitamin D, 1,25 dihydroxyvitamin D3 [1,25(OH)(2)D(3)], has both genomic and rapid nongenomic effects in heart cells; however, the subcellular localization of the vitamin D receptor (VDR) in heart has not been studied. Vitamin D 49-58 vitamin D receptor Rattus norvegicus 231-234 16521124-1 2006 The vitamin D receptor (VDR) is believed to mediate different biologic actions of vitamin D3, an active metabolite of vitamin D, through regulation of gene expression after binding to specific DNA-response element (VDRE) on target genes. Vitamin D 4-13 vitamin D receptor Rattus norvegicus 24-27 15878768-1 2005 BACKGROUND: Vitamin D might have an influence on glucose concentrations, due to the presence of VDR receptors on the pancreas. Vitamin D 12-21 vitamin D receptor Rattus norvegicus 96-99 15211579-11 2004 These results show that TNF-alpha inhibition of vitamin D-action includes stable integration of p65 in the VDR transcription complex. Vitamin D 48-57 vitamin D receptor Rattus norvegicus 107-110 14978251-6 2004 Vitamin D stimulated endogenous SULT2A1 expression and induced transfected human, mouse, and rat SULT2A1 promoters in liver and intestinal cells upon cotransfection with VDR. Vitamin D 0-9 vitamin D receptor Rattus norvegicus 170-173 12198242-5 2002 The vitamin D response element is sufficient for the PKA enhancement of VDR-mediated transcription and is also sufficient to observe the inhibitory effect of ICER. Vitamin D 4-13 vitamin D receptor Rattus norvegicus 72-75 12960019-2 2003 To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR). Vitamin D 38-47 vitamin D receptor Rattus norvegicus 58-61 12960019-2 2003 To further define the residues in the vitamin D receptor (VDR) DNA binding domain (DBD) that mediate its interaction as a retinoid X receptor (RXR) heterodimer with the rat osteocalcin vitamin D-responsive element (VDRE), chimeric receptors were created in which the core DBD of VDR was replaced with that of the homodimerizing glucocorticoid receptor (GR). Vitamin D 38-47 vitamin D receptor Rattus norvegicus 215-218 14705237-1 2004 OBJECTIVE: The homologous upregulation produced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on vitamin D receptor (VDR) levels, and the effects produced by the heterologous agents hydrocortisone or deflazacort, alone or in conjunction with this vitamin D metabolite, were studied in rat osteoblastic UMR-106 osteosarcoma cells. Vitamin D 65-74 vitamin D receptor Rattus norvegicus 93-111 14705237-1 2004 OBJECTIVE: The homologous upregulation produced by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on vitamin D receptor (VDR) levels, and the effects produced by the heterologous agents hydrocortisone or deflazacort, alone or in conjunction with this vitamin D metabolite, were studied in rat osteoblastic UMR-106 osteosarcoma cells. Vitamin D 65-74 vitamin D receptor Rattus norvegicus 113-116 12198242-7 2002 This study provides evidence for the first time that ICER has a key regulatory role in the PKA enhancement of VDR transcription and therefore in the cross-talk between the PKA signaling pathway and the vitamin D endocrine system. Vitamin D 202-211 vitamin D receptor Rattus norvegicus 110-113 11834737-7 2002 The synthetic vitamin D analog KH1060 is a more potent stimulator of transcription and inducer of VDRE binding of VDR/RXR in the presence of nuclear factors isolated from ROS 17/2.8 osteoblast-like cells than the natural ligand 1,25-(OH)(2)D(3). Vitamin D 14-23 vitamin D receptor Rattus norvegicus 98-101 11967012-5 2002 In order to study the effect of calcitriol on EGFR gene transcription, a candidate vitamin D-responsive element (VDRE) was identified in the EGFR gene promoter and complimentary 30-mer oligonucleotides spanning this region were tested for binding to recombinant VDR using EMSA. Vitamin D 83-92 vitamin D receptor Rattus norvegicus 113-116 11834737-0 2002 A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands. Vitamin D 30-39 vitamin D receptor Rattus norvegicus 107-125 11818502-9 2002 Taken together, these findings suggest that increased interaction between VDR and coactivators such as DRIP205 may be a major mechanism that couples extracellular signals to vitamin D action. Vitamin D 174-183 vitamin D receptor Rattus norvegicus 74-77 11592788-9 2001 RESULTS: Vitamin D supplementation decreased VDR and Smad3 protein levels. Vitamin D 9-18 vitamin D receptor Rattus norvegicus 45-48