PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27896829-2 2017 The role of vitamin D in autoimmune diseases has increased significantly in the recent past from its functions in calcium and phosphate homoeostasis, and it is now involved in the regulations and proliferations of Th1 and Th17 lymphocyte. Vitamin D 12-21 negative elongation factor complex member C/D Homo sapiens 214-217 27896829-8 2017 Vitamin D supplementation assists in autoimmune disorders by making qualitative and quantitative changes in the immune system (downregulation of Th1 and upregulations of Th2 cells). Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 145-148 27273785-10 2016 CONCLUSIONS: Vitamin D deficiency was associated with pulmonary function deficits among obese children, but not among normal-weight children with asthma, an association that was independent of Th1 and Th2 serum inflammatory measures. Vitamin D 13-22 negative elongation factor complex member C/D Homo sapiens 193-196 29391997-1 2015 Objective: With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1alpha,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-gamma), which are important for immune response of patients with allergic rhinitis. Vitamin D 116-125 negative elongation factor complex member C/D Homo sapiens 71-74 27318428-8 2016 In infants with vitamin D level below the median the prevalence of CD4+ CXCR3+ (Th1) and CD8+ CXCR3+ cell subsets was higher, while the prevalence of CD4+ CCR4+ (Th2), CD8+ CCR4+ and plasmacytoid dendritic cell (pDC) subsets was lower than in those with vitamin D level above median. Vitamin D 16-25 negative elongation factor complex member C/D Homo sapiens 80-83 27318428-11 2016 CONCLUSIONS: Vitamin D levels may together with cortisol levels and gestational age have an effect on Th1/Th2 balance and the prevalence of plasmocytoid dendritic cells in the preterm newborn. Vitamin D 13-22 negative elongation factor complex member C/D Homo sapiens 102-105 27489574-3 2016 However, the various U-shaped associations for allergic reactions may be due to vitamin D modulation of the phenotype of the immune response, shifting the Th1-Th2 balance toward Th2 formation. Vitamin D 80-89 negative elongation factor complex member C/D Homo sapiens 155-158 29391997-7 2015 Conclusion: In our study, 1alpha,25-dihydroxyvitamin D3 levels were associated with Th1/Th2 balance in allergic rhinitis, and a remarkable correlation was observed among vitamin D deficiency and allergy. Vitamin D 45-54 negative elongation factor complex member C/D Homo sapiens 84-87 26291576-7 2015 Vitamin D also increases T helper (Th) 2 cytokine production and the efficiency of Treg lymphocytes but suppresses the secretion of Th1 and Th17 cytokines. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 132-135 26257123-1 2015 Vitamin D has a pivotal role in regulating immune responses by promoting Th2 immune responses and suppressing Th1 responses. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 110-113 25740667-4 2015 The purpose of the study is to find out the Th1/Th2 status by estimating TNF-alpha (Th1 marker) and IL-4 (Th2 marker) in ovarian cancer cases and controls and to correlate these with serum vitamin D levels. Vitamin D 189-198 negative elongation factor complex member C/D Homo sapiens 44-47 25740667-11 2015 CONCLUSIONS: Low vitamin D levels promotes Th1 activity increasing TNF-alpha levels and inhibits Th2 activity decreasing IL-4 levels in ovarian cancer. Vitamin D 17-26 negative elongation factor complex member C/D Homo sapiens 43-46 25228524-3 2014 It is claimed that vitamin D inhibits immunological reactions with Th1 and Th17 lymphocytes. Vitamin D 19-28 negative elongation factor complex member C/D Homo sapiens 67-70 25801892-2 2015 Recent studies highlight that vitamin D may exert actions on T-cells, inhibiting Th1 and Th17 response and enhancing Th2 and T-regulatory (T-reg) function. Vitamin D 30-39 negative elongation factor complex member C/D Homo sapiens 81-84 25852682-5 2015 Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. Vitamin D 83-92 negative elongation factor complex member C/D Homo sapiens 149-152 25852682-5 2015 Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. Vitamin D 83-92 negative elongation factor complex member C/D Homo sapiens 157-160 25791938-10 2015 CONCLUSIONS: This study showed vitamin D supplementation to be an effective treatment in reducing AD severity in children through normalization of the Th1 and Th2 interleukin serum pattern. Vitamin D 31-40 negative elongation factor complex member C/D Homo sapiens 151-154 25228524-6 2014 It was observed that vitamin D had a beneficial influence on diseases connected with excessive activation of Th1 lymphocytes, such as multiple sclerosis, rheumatoid arthritis, non-specific enteritis, diabetes type 1 or psoriasis. Vitamin D 21-30 negative elongation factor complex member C/D Homo sapiens 109-112 24358684-6 2013 Vitamin D inhibits IL-6, IL-17 and IL-23 secretions which are crucial in Th1 and Th17 differentiation and also decreases proinflammatorical cytokine production. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 73-76 24803805-4 2014 The active form of vitamin D, 1,25(OH)D3, acts on T cells to promote T helper (Th)2/regulatory T responses over Th1/Th17 responses; suppresses dendritic cell inflammatory activity; induces antibacterial activity; and regulates cytokine production in favor of an anti-inflammatory response. Vitamin D 19-28 negative elongation factor complex member C/D Homo sapiens 112-115 24398649-0 2014 Effect of vitamin D supplementation on cathelicidin, IFN-gamma, IL-4 and Th1/Th2 transcription factors in young healthy females. Vitamin D 10-19 negative elongation factor complex member C/D Homo sapiens 73-76 23370372-6 2013 Vitamin D acts on a number of cells involved in both innate and acquired immunity biasing the adaptive immune system away from Th17 and Th1, towards Th2 and Tregs. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 127-130 23800151-13 2013 After treated with activated vitamin D, the level of Th1 cytokines decreased while the Th2 cytokine level increased in the sera (p < 0.05). Vitamin D 29-38 negative elongation factor complex member C/D Homo sapiens 53-56 22796435-9 2012 Together, these data provide evidence that interfering with RhoA-ROCK signaling in autoreactive Th1/Th17 cells can improve vitamin D(3) efficacy in clinical trials of MS and related neurodegenerative disorders. Vitamin D 123-132 negative elongation factor complex member C/D Homo sapiens 96-99 22358381-1 2012 We aimed to study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-gamma, which play an important role in the immune response of patients with allergic rhinitis and/or nasal polyps, and determine the correlation between Th1/Th2 cell balance and 1alpha,25-dihydroxyvitamin D(3), an active metabolite of vitamin D. Vitamin D 294-303 negative elongation factor complex member C/D Homo sapiens 18-21 22358381-9 2012 The study demonstrates that vitamin D is effective on Th1/Th2 balance in patients with allergic rhinitis and that there is a significant relation between vitamin D deficiency and allergy. Vitamin D 28-37 negative elongation factor complex member C/D Homo sapiens 54-57 23075451-2 2012 Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells. Vitamin D 71-80 negative elongation factor complex member C/D Homo sapiens 133-136 23075451-6 2012 Vitamin D was well tolerated and induced a preferential increase of naive CD4+ T cells, an increase of regulatory T cells and a decrease of effector Th1 and Th17 cells. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 149-152 20868777-1 2011 Vitamin D deficiency may contribute to pathological changes in the number and function of CD4+ T helper cell subsets (CD4+Th1, CD4+Th17, CD4+CD25(bright)Foxp3-natural regulatory T cells-nTreg) in patients with undifferentiated connective tissue disease (UCTD). Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 122-125 22339716-2 2012 The present study aimed to evaluate vitamin D status and its relation to Th1/Th2 balance in subjects with T1D, their siblings and unrelated healthy controls during autumn and winter 2008-2009. Vitamin D 36-45 negative elongation factor complex member C/D Homo sapiens 73-76 21286859-8 2012 The low vitamin D concentration in H. pylori gastritis patients might act as predisposing factor for a more severe Th1-type aggression to the stomach epithelium. Vitamin D 8-17 negative elongation factor complex member C/D Homo sapiens 115-118 19269107-2 2009 A low vitamin D status has now been linked to several Th1-mediated autoimmune diseases, including multiple sclerosis, type 1 diabetes and rheumatoid arthritis, with the strongest evidence for the vitamin"s protective role in multiple sclerosis. Vitamin D 6-15 negative elongation factor complex member C/D Homo sapiens 54-57 21747838-1 2011 The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Vitamin D 44-53 negative elongation factor complex member C/D Homo sapiens 130-133 21747838-1 2011 The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. Vitamin D 44-53 negative elongation factor complex member C/D Homo sapiens 178-181 20868571-15 2010 Our results showed that low levels of vitamin D were associated with a decrease in Treg cells and a skewing of the Th1/Th2 balance towards Th1. Vitamin D 38-47 negative elongation factor complex member C/D Homo sapiens 115-118 20868571-15 2010 Our results showed that low levels of vitamin D were associated with a decrease in Treg cells and a skewing of the Th1/Th2 balance towards Th1. Vitamin D 38-47 negative elongation factor complex member C/D Homo sapiens 139-142 19269107-3 2009 Sunlight and vitamin D may be potent immunomodulatory agents by down-regulating Th1-driven immune responses and inducing the synthesis of antimicrobial peptides considered as natural antibiotics of the immune system. Vitamin D 13-22 negative elongation factor complex member C/D Homo sapiens 80-83 31914352-8 2021 Deficient vitamin D state was associated with higher serum Th1 and Th2 cytokines compared to insufficient state, but the highest cytokine levels were observed in normal vitamin D state. Vitamin D 10-19 negative elongation factor complex member C/D Homo sapiens 59-62 17268418-1 2007 Vitamin D has been suggested to affect the balance between T helper (Th1) and (Th2) type cytokines by favouring Th2 domination. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 69-72 15860047-8 2005 CONCLUSIONS: ZK156979 is a member of novel vitamin D analogues revealing prominent immunomodulatory and suppressive characteristics with distinctive inhibition of Th1-cytokines whereas the Th2 compartment is augmented, thus providing a considerable therapeutic potential in T-cell -mediated diseases. Vitamin D 43-52 negative elongation factor complex member C/D Homo sapiens 163-166 15564440-5 2004 The vitamin D hormone (1,25-dihydroxy vitamin D(3)) regulates T helper cell (Th1) and dendritic cell function while inducing regulatory T-cell function. Vitamin D 4-13 negative elongation factor complex member C/D Homo sapiens 77-80 19309553-2 2009 In addition to its classic role in calcium homeostasis, calcitriol, the hormonal active form of vitamin D, exerts immunoregulatory effects such as modulation of Th1/Th2 cytokines. Vitamin D 96-105 negative elongation factor complex member C/D Homo sapiens 161-164 19309553-10 2009 These results suggest an important modulatory role of vitamin D in the Th1/Th2 immune response. Vitamin D 54-63 negative elongation factor complex member C/D Homo sapiens 71-74 18561994-1 2008 Low vitamin D status is associated with an increased risk of Th1 mediated autoimmune diseases like inflammatory bowel disease. Vitamin D 4-13 negative elongation factor complex member C/D Homo sapiens 61-64 18561994-6 2008 The seemingly paradoxical effects of 1,25(OH)(2)D(3) and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. Vitamin D 57-66 negative elongation factor complex member C/D Homo sapiens 70-73 18561994-6 2008 The seemingly paradoxical effects of 1,25(OH)(2)D(3) and vitamin D on Th1 mediated autoimmunity versus infectious immunity point to a broad array of vitamin D targets in the immune system. Vitamin D 149-158 negative elongation factor complex member C/D Homo sapiens 70-73 17557889-3 2007 Moreover, recent evidence strongly suggests that vitamin D supplementation may be therapeutically beneficial, particularly for Th1-mediated autoimmune disorders. Vitamin D 49-58 negative elongation factor complex member C/D Homo sapiens 127-130 34764490-0 2022 Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Vitamin D 10-19 negative elongation factor complex member C/D Homo sapiens 72-75 31914352-9 2021 There was significant positive correlation between serum vitamin D and Th1 cytokines IL-2 and IL-8 as well as Th2 cytokines (ILs-3, 4, 5 and 9), but negative correlation with IL-13Conclusions: Serum Vitamin D and cytokines were lower in a sample of Nigerian children with asthma than controls. Vitamin D 57-66 negative elongation factor complex member C/D Homo sapiens 71-74 31274211-9 2019 Vitamin D seems to inhibit Th1 immune responses and have no effect on Th2 responses. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 27-30 31582399-9 2019 CONCLUSION: Vitamin D enhances IFN-beta induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-beta alone. Vitamin D 12-21 negative elongation factor complex member C/D Homo sapiens 93-96 31582399-6 2019 The combination of vitamin D plus IFN-beta reduced Th1 and Th17 cytokines, and increased Th2 responses, reversing the effect of IFN-beta alone. Vitamin D 19-28 negative elongation factor complex member C/D Homo sapiens 51-54 28801380-4 2017 Briefly, vitamin D immunomodulation includes attenuation and stimulation of Th1 and Th2 cell proliferation, respectively. Vitamin D 9-18 negative elongation factor complex member C/D Homo sapiens 76-79 30356853-7 2018 The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17. Vitamin D 4-13 negative elongation factor complex member C/D Homo sapiens 225-228 30356853-7 2018 The vitamin D status was assessed according to the level of 25(OH)D. Results: Patients with combined endocrine disorders (DM and AIT) with a decreased vitamin D status had significantly increased background concentrations of Th1-type cytokines and reduced concentrations of Th2-type cytokines (IL-4 and IL-5), IL-10, and IL-17. Vitamin D 151-160 negative elongation factor complex member C/D Homo sapiens 225-228 27925404-8 2018 Vitamin D inhibits the production of several proinflammatory cytokines and leads to suppression Th1 and Th17 responses which may be involved in the pathogenesis of COPD. Vitamin D 0-9 negative elongation factor complex member C/D Homo sapiens 96-99 30143987-6 2018 In contrast, vitamin D suppresses differentiation and maturation of antigen-presenting dendritic cells and B lymphocytes, and it inhibits proliferation of Th1 and Th17 cells. Vitamin D 13-22 negative elongation factor complex member C/D Homo sapiens 155-158 30588177-6 2018 Immune modulation by vitamin D includes enhancing innate immune response, attenuating and stimulating Th1 and Th2 cell proliferation, respectively, and promoting self-tolerance. Vitamin D 21-30 negative elongation factor complex member C/D Homo sapiens 102-105 28332200-4 2017 The binding of vitamin D to dendritic cells (DCs) through vitamin D receptors inhibits the action of IL-12 on DCs, resulting in the downregulation of Th1 and Th17. Vitamin D 15-24 negative elongation factor complex member C/D Homo sapiens 150-153 28376103-7 2017 We hypothesized that correction of vitamin D insufficiency or deficiency in CHC patients might restore immune dysregulation through a pathway linked to the TH1/Th2 cytokines, IP-10 or DPP IV. Vitamin D 35-44 negative elongation factor complex member C/D Homo sapiens 156-159