PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27689826-4 2016 AREAS COVERED: In 2015, the FDA (Food and Drug Administration) approved rhPTH (1-84), named Natpara , a bioengineered recombinant human PTH, for the management of hypoparathyroidism of any etiology, except Autosomal Dominant Hypocalcemia, not well controlled with calcium and active vitamin D. Vitamin D 283-292 parathyroid hormone Homo sapiens 74-77 27116295-12 2016 The negative association with serum PTH levels suggests that vitamin D supplementation partly improves secondary hyperparathyroidism, yet other mechanisms may contribute to low bone mass after bariatric surgery. Vitamin D 61-70 parathyroid hormone Homo sapiens 36-39 27327576-7 2016 Binary logistic regression analysis showed a strong association between the presence of vitamin D deficiency and benign prostatic hyperplasia (BPH) after adjusting for age, International Prostate Symptom Score, urination time, urinary volume, abdominal obesity, aldosterone, glucose, insulin, parathyroid hormone, and C-reactive protein (odds ratio 5.22, 95% confidence interval 1.96-12.76, P = .001). Vitamin D 88-97 parathyroid hormone Homo sapiens 293-312 27561346-5 2016 However, even with concomitant administration of massive active vitamin D, the increase of intact PTH levels greater than 1000 pg/mL by this agent is not rare. Vitamin D 64-73 parathyroid hormone Homo sapiens 98-101 26696653-2 2016 The purpose of this study was to evaluate the associations between vitamin D with bone health and parathyroid hormone (PTH) concentrations in female runners who trained at 30.4 degrees north. Vitamin D 67-76 parathyroid hormone Homo sapiens 98-117 26696653-2 2016 The purpose of this study was to evaluate the associations between vitamin D with bone health and parathyroid hormone (PTH) concentrations in female runners who trained at 30.4 degrees north. Vitamin D 67-76 parathyroid hormone Homo sapiens 119-122 26454858-10 2016 CONCLUSION: Vitamin D reposition with oral calcifediol, in a biweekly or monthly regimen, is safe and effective in improving 25(OH)D blood levels and in decreasing PTH in kidney transplant recipients. Vitamin D 12-21 parathyroid hormone Homo sapiens 164-167 27683096-5 2016 After withdrawal of the vitamin D analogue and initiation of daily hemodialysis, there was rapid dissolution of her tumoral calcium deposits with the abrupt onset of parathyroid hormone (PTH)-independent transient hypercalcemia that resolved once the soft tissue deposits disappeared. Vitamin D 24-33 parathyroid hormone Homo sapiens 166-185 27026421-16 2016 Supplementation of vitamin D, B12 and calcium resulted in higher serum levels of vitamins, lower PTH levels and diminished severe vitamin D deficiency and is thus recommended as standard care. Vitamin D 19-28 parathyroid hormone Homo sapiens 97-100 26853879-0 2016 Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years. Vitamin D 0-9 parathyroid hormone Homo sapiens 38-41 26260151-0 2016 Association between vitamin D status and serum parathyroid hormone concentration and calcaneal stiffness in Japanese adolescents: sex differences in susceptibility to vitamin D deficiency. Vitamin D 20-29 parathyroid hormone Homo sapiens 47-66 26224363-0 2016 The association between vitamin D and parathyroid hormone and bone mineral density: the Dong-gu Study. Vitamin D 24-33 parathyroid hormone Homo sapiens 38-57 27514770-5 2016 Parathyroid hormone was inversely correlated with vitamin D level in both seasons (r = -0.044, P < .001). Vitamin D 50-59 parathyroid hormone Homo sapiens 0-19 26853879-5 2016 Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Vitamin D 10-19 parathyroid hormone Homo sapiens 44-47 26279316-13 2016 Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D levels (p<0.0001), and was accompanied by a reduction in parathyroid hormone concentrations (p=0.032). Vitamin D 0-9 parathyroid hormone Homo sapiens 136-155 27277007-14 2016 In addition, we express caution in using daily supplementation with a high vitamin D dose to improve vitamin D status and decrease parathyroid hormone. Vitamin D 75-84 parathyroid hormone Homo sapiens 131-150 26725707-12 2016 PTH levels differed marginally (P = 0 0759) due to tendency to lowering immediately after vitamin D boluses. Vitamin D 90-99 parathyroid hormone Homo sapiens 0-3 27843822-9 2016 Deficiency of Vitamin D is commonly described as a cause for the bone loss in epileptic patients while others being decreased absorption of calcium, increased PTH levels, and inhibition of calcitonin secretion, etc. Vitamin D 14-23 parathyroid hormone Homo sapiens 159-162 26938200-9 2016 The recent availability of recombinant human PTH (1-84) has given hope that management of hypoparathyroidism with the missing hormone in this disorder will provide better control and reduced needs for calcium and vitamin D. Vitamin D 213-222 parathyroid hormone Homo sapiens 45-48 27312912-1 2016 Management of secondary hyperparathyroidism (SHPT) in dialysis population includes the use of active vitamin D forms, among which paricalcitol was shown to be more effective at reducing parathyroid hormone (PTH) concentrations. Vitamin D 101-110 parathyroid hormone Homo sapiens 186-205 27023469-4 2016 Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three factors have been implicated in prostate cancer. Vitamin D 0-9 parathyroid hormone Homo sapiens 60-79 26733373-1 2016 UNLABELLED: A normal reference value of parathyroid hormone (PTH) was established for the first time in a large sample of healthy Chinese subjects by completely excluding interference of vitamin D deficiency. Vitamin D 187-196 parathyroid hormone Homo sapiens 40-59 26733373-1 2016 UNLABELLED: A normal reference value of parathyroid hormone (PTH) was established for the first time in a large sample of healthy Chinese subjects by completely excluding interference of vitamin D deficiency. Vitamin D 187-196 parathyroid hormone Homo sapiens 61-64 26843386-1 2016 Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD). Vitamin D 6-15 parathyroid hormone Homo sapiens 66-85 26843386-1 2016 Serum vitamin D (25-hydroxyvitamin D (25OHD)) may influence serum parathyroid hormone (PTH) levels and bone mineral density (BMD). Vitamin D 6-15 parathyroid hormone Homo sapiens 87-90 26745256-1 2016 CONTEXT: Patients with 25-hydroxyvitamin D deficiency (25OHD <20 ng/ml) and primary hyperparathyroidism (PHPT) have more severe disease reflected by higher serum PTH levels compared to those with vitamin D levels in the insufficient (20-29 ng/ml) or replete range (>= 30 ng/ml). Vitamin D 33-42 parathyroid hormone Homo sapiens 165-168 26724218-11 2016 Knowledge of the signaling pathways involved in the lipolytic action of PTH is important for our understanding of how metabolic derangements develop in states of hyperparathyroidism, including vitamin D deficiency. Vitamin D 193-202 parathyroid hormone Homo sapiens 72-75 27065162-3 2016 PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. Vitamin D 8-17 parathyroid hormone Homo sapiens 60-63 27065162-3 2016 PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. Vitamin D 8-17 parathyroid hormone Homo sapiens 60-63 27065162-3 2016 PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. Vitamin D 92-101 parathyroid hormone Homo sapiens 0-3 27065162-3 2016 PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. Vitamin D 92-101 parathyroid hormone Homo sapiens 60-63 27065162-3 2016 PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. Vitamin D 92-101 parathyroid hormone Homo sapiens 60-63 27065162-3 2016 PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. Vitamin D 132-141 parathyroid hormone Homo sapiens 0-3 26315471-0 2016 Vitamin D and its relation with ionic calcium, parathyroid hormone, maternal and neonatal characteristics in pregnancy after roux-en-Y gastric bypass. Vitamin D 0-9 parathyroid hormone Homo sapiens 47-66 26315471-1 2016 PURPOSE: The objective of this study was to evaluate vitamin D nutritional status and its relation with ionic calcium, parathyroid hormone (PTH), maternal anthropometry and perinatal outcomes in pregnant women who previously underwent Roux-en-Y gastric bypass (RYGB) surgery. Vitamin D 53-62 parathyroid hormone Homo sapiens 119-138 27666692-4 2016 Meta-analyses have shown that aberrant PTH-vitamin D axis may affect bone metabolism in smokers. Vitamin D 43-52 parathyroid hormone Homo sapiens 39-42 27229347-5 2016 Fibroblast growth factor-23-parathyroid hormone (PTH)-vitamin D axis, immunosuppressive therapy and previous bone status have been associated with PTBD. Vitamin D 54-63 parathyroid hormone Homo sapiens 49-52 27229347-6 2016 Although several studies reported reduced PTH levels in KTRs receiving nutritional vitamin D, its effects on bone mineral density (BMD) remain controversial. Vitamin D 83-92 parathyroid hormone Homo sapiens 42-45 27229347-7 2016 Active vitamin D reduced PTH levels and increased BMD after transplantation, but paricalcitol treatment was not accompanied by benefits on osteopenia. Vitamin D 7-16 parathyroid hormone Homo sapiens 25-28 26424141-3 2015 Activated vitamin D has been proven to decrease parathyroid hormone (PTH) levels in dialysis patients and is currently used for this indication. Vitamin D 10-19 parathyroid hormone Homo sapiens 48-67 26758099-0 2016 Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research. Vitamin D 69-78 parathyroid hormone Homo sapiens 0-19 26844688-2 2016 Our aim is to find out the effect of replacement of low dose oral vitamin-D (800 International unit) with calcium (500mg) as a once daily regimen along with antiretroviral (ARV) on serum vitamin-D and parathyroid hormone (PTH) level and bone mineral density (BMD) changes on patients with HIV infection who have vitamin- D deficiency. Vitamin D 66-75 parathyroid hormone Homo sapiens 201-220 26337807-0 2015 Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials. Vitamin D 48-57 parathyroid hormone Homo sapiens 16-35 26337807-1 2015 This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation. Vitamin D 107-116 parathyroid hormone Homo sapiens 63-82 26337807-1 2015 This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation. Vitamin D 107-116 parathyroid hormone Homo sapiens 84-87 26337807-9 2015 Vitamin D supplementation significantly reduced PTH level with PMD of -8 0 pg/ml, with significant heterogeneity ((test for heterogeneity: P<0 001) and the I 2 value was 97 3%). Vitamin D 0-9 parathyroid hormone Homo sapiens 48-51 26337807-11 2015 Despite the present meta-analysis being hindered by some limitations, it provided some interesting evidence, suggesting that suppression of PTH level needs higher vitamin D intake (75 mug/d) than the current recommendations and longer durations (12 months), which should be taken into account for nutritional recommendations. Vitamin D 163-172 parathyroid hormone Homo sapiens 140-143 26561037-18 2015 One study reported vitamin D preparations significantly reduced PTH levels (-55.00 pmol/L, 95% CI -83.03 to -26.97). Vitamin D 19-28 parathyroid hormone Homo sapiens 64-67 26561037-28 2015 AUTHORS" CONCLUSIONS: Bone disease, assessed by changes in PTH levels, is improved by all vitamin D preparations. Vitamin D 90-99 parathyroid hormone Homo sapiens 59-62 27396549-11 2016 A significant positive correlation between FS and PTH at 12 months was found, which persisted after adjusting for vitamin D levels. Vitamin D 114-123 parathyroid hormone Homo sapiens 50-53 27396549-12 2016 CONCLUSION: FS is positively correlated with secondary hyperparathyroidism using vitamin D-adjusted PTH levels as a biochemical marker. Vitamin D 81-90 parathyroid hormone Homo sapiens 100-103 26540562-4 2015 The cutoff value for vitamin D deficiency was based on the changes in parathyroid hormone (PTH) level according to serum 25(OH)D value. Vitamin D 21-30 parathyroid hormone Homo sapiens 70-89 26186566-10 2015 Parathyroid hormone levels decreased over the study period with patients achieving vitamin D sufficiency at day 7 having significantly lower parathyroid hormone levels (p<0.01). Vitamin D 83-92 parathyroid hormone Homo sapiens 0-19 26186566-10 2015 Parathyroid hormone levels decreased over the study period with patients achieving vitamin D sufficiency at day 7 having significantly lower parathyroid hormone levels (p<0.01). Vitamin D 83-92 parathyroid hormone Homo sapiens 141-160 26398210-3 2015 The association between values of vitamin D and parathyroid hormone (PTH), and COPD severity including lung function and quality of life, were analyzed. Vitamin D 34-43 parathyroid hormone Homo sapiens 69-72 26048596-0 2015 Parathyroid hormone response to two levels of vitamin D deficiency is associated with high risk of medical problems during hospitalization in patients with hip fracture. Vitamin D 46-55 parathyroid hormone Homo sapiens 0-19 26398210-4 2015 RESULTS: In COPD patients, lung function was inversely related to PTH values (P = 0.02 for FVC [% predicted]; P < 0.001 for FEV1 [% predicted]); however, the association of lung function with vitamin D levels was not statistically significant in a multivariable analysis. Vitamin D 195-204 parathyroid hormone Homo sapiens 66-69 26079779-10 2015 CONCLUSION: Vitamin D deficiency is associated with more severe PHPT as reflected by PTH levels, but effects on BMD are limited to the cortical 1/3 radius and are quite modest. Vitamin D 12-21 parathyroid hormone Homo sapiens 85-88 25980743-6 2015 PTH values were higher and BMD at both femoral sites were lower in patients with vitamin D<20 ng/ml. Vitamin D 81-90 parathyroid hormone Homo sapiens 0-3 26179930-7 2015 Vitamin D administered to patients with macroprolactinemia increased 25-hydroxyvitamin, reduced total prolactin and macroprolactin, as well tended to reduce PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 157-160 26154099-4 2015 The case of an 82-years old woman with PTH-independent hypercalcemia, lymphocytosis, normal serum 1,25 (OH)vitamin D levels, and low serum PTHrp levels, is described. Vitamin D 107-116 parathyroid hormone Homo sapiens 39-42 26300676-2 2015 Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status. Vitamin D 72-81 parathyroid hormone Homo sapiens 6-25 26339419-0 2015 Association between promoter region genetic variants of PTH SNPs and serum 25(OH)-vitamin D level. Vitamin D 82-91 parathyroid hormone Homo sapiens 56-59 26339419-1 2015 Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level. Vitamin D 107-116 parathyroid hormone Homo sapiens 0-19 26339419-1 2015 Parathyroid hormone (PTH) plays a crucial role in calcium metabolism and skeletal development via altering vitamin D level. Vitamin D 107-116 parathyroid hormone Homo sapiens 21-24 26339419-8 2015 In conclusion, our study indicated significant association between specific PTH gene promoter region variants and altered levels of 25(OH)D and vitamin D deficiency among specific nationals. Vitamin D 144-153 parathyroid hormone Homo sapiens 76-79 26151689-0 2015 Association between serum vitamin D and parathyroid hormone levels in Turkish patients with colonic polyps. Vitamin D 26-35 parathyroid hormone Homo sapiens 40-59 26300934-8 2015 In an unadjusted logistic model, PTH was the only variable in vitamin D endocrine system which was significantly associated with NASH (odds ratio (OR): 1.04, 95%CI: 1.01 - 1.07). Vitamin D 62-71 parathyroid hormone Homo sapiens 33-36 25904755-1 2015 BACKGROUND AND OBJECTIVES: Direct comparison of cinacalcet and vitamin D analogs as monotherapies to lower parathyroid hormone (PTH) levels has not been undertaken. Vitamin D 63-72 parathyroid hormone Homo sapiens 107-126 25904755-10 2015 CONCLUSIONS: Participants had similar modest reductions in PTH with either cinacalcet or vitamin D analog monotherapy over 52 weeks of treatment, but effects varied by region. Vitamin D 89-98 parathyroid hormone Homo sapiens 59-62 25882890-2 2015 Detection of this biological presentation is frequent in routine practice all the more that PTH reference values established in vitamin D replete subjects with a normal renal function are used by the clinical laboratories. Vitamin D 128-137 parathyroid hormone Homo sapiens 92-95 26296372-2 2015 It is important to understand how FGF23 interacts with vitamin D and parathyroid hormone (PTH) in a FGF23-Vitamin D-PTH axis to regulate mineral homeostasis. Vitamin D 106-115 parathyroid hormone Homo sapiens 69-88 25636811-8 2015 Among RCTs, compared to placebo, vitamin D supplementation was associated with significant decrease in fasting glucose [SMD -1.13, (-2.11 to -0.11)] and PTH levels [SMD -1.50, (-2.95 to -0.04)] but no difference in fasting insulin levels [SMD 1.32, (-0.15 to 2.79)]. Vitamin D 33-42 parathyroid hormone Homo sapiens 153-156 25923487-0 2015 Fortification of Yogurts with Vitamin D and Calcium Enhances the Inhibition of Serum Parathyroid Hormone and Bone Resorption Markers: A Double Blind Randomized Controlled Trial in Women over 60 Living in a Community Dwelling Home. Vitamin D 30-39 parathyroid hormone Homo sapiens 85-104 25923487-1 2015 OBJECTIVE: To evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum parathyroid hormone (PTH) and bone resorption markers (BRM) as compared to iso-caloric and iso-protein dairy products in aged white women at risk of fragility fractures. Vitamin D 61-70 parathyroid hormone Homo sapiens 129-148 25582993-3 2015 Since vitamin D exerts important immune-regulatory roles, it has been claimed that derangement of the vitamin D/parathyroid hormone (PTH) system, a well-known determinant of bone health, may play a pathogenic role in autoimmunity; animal models and clinical data support this hypothesis. Vitamin D 6-15 parathyroid hormone Homo sapiens 110-131 26204641-7 2015 Vitamin D deficiency may mask hypercalcemia despite high serum PTH levels, and does not seem to diminish but on the contrary increases the risk of kidney lithiasis, as well as the deleterious effects of hyperparathyroidism on bone. Vitamin D 0-9 parathyroid hormone Homo sapiens 63-66 25636720-10 2015 Therefore, measurements of parathyroid hormone (PTH) and vitamin D metabolites 25(OH)D3, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3 are useful to investigate whether the underlying cause of vitamin D toxicity is iatrogenic versus genetic. Vitamin D 192-201 parathyroid hormone Homo sapiens 27-46 25886311-9 2015 Plasma PTH levels in the children with hypovitaminosis D were significantly higher than in the children with normal levels of vitamin D (4.34 +- 1.38 vs 3.78 +- 1.25 pmol/L; P-value = 0.04). Vitamin D 126-135 parathyroid hormone Homo sapiens 7-10 25636811-9 2015 Among NRIS, there was only a significant decrease in PTH levels [SMD -1.68, (-2.55 to -0.82)] between pre- and post-vitamin D treatment levels. Vitamin D 116-125 parathyroid hormone Homo sapiens 53-56 25294851-9 2015 CONCLUSION: In SHPT, correction of vitamin D and calcitriol deficiency induces parathyroid C/EBPbeta to efficaciously attenuate the severe ADAM17/TGFalpha synergy, which drives PTG enlargement and high PTH. Vitamin D 35-44 parathyroid hormone Homo sapiens 202-205 25634511-22 2015 We found a baseline level of vitamin D that was 10 nmol/l higher was associated with a small but statistically significant decrease in UACR by 0.92% (p = 0.02), but a non-significantly lower PTH. Vitamin D 29-38 parathyroid hormone Homo sapiens 191-194 25695075-1 2015 Single nucleotide polymorphisms (SNPs), R990G and A986S of the calcium sensing receptor (CaSR) gene, are shown to influence response of parathyroid hormone (PTH) in subjects with optimal vitamin D levels. Vitamin D 187-196 parathyroid hormone Homo sapiens 136-155 25271011-2 2015 This study investigated whether high-dose vitamin D3 given once to healthy adults before winter will (1) prevent the wintertime decline in vitamin D status, (2) promote vitamin D sufficiency 1 year following the dose and (3) prevent the rise of parathyroid hormone (PTH) concentrations. Vitamin D 42-51 parathyroid hormone Homo sapiens 245-264 26439891-1 2015 BACKGROUND: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). Vitamin D 102-111 parathyroid hormone Homo sapiens 148-167 26168767-2 2015 In 43.6 % of the sample, levels of vitamin D were below 20 ng/mL and showed an inverse relationship with parathyroid hormone (PTH; p < 0.01). Vitamin D 35-44 parathyroid hormone Homo sapiens 105-124 26168767-2 2015 In 43.6 % of the sample, levels of vitamin D were below 20 ng/mL and showed an inverse relationship with parathyroid hormone (PTH; p < 0.01). Vitamin D 35-44 parathyroid hormone Homo sapiens 126-129 25359317-6 2015 However in patients with vitamin D deficiency, a significant proportion had PTH, calcium, phosphate and alkaline phosphatase levels within the laboratory normal range. Vitamin D 25-34 parathyroid hormone Homo sapiens 76-79 26858840-0 2015 Reduction of Parathyroid Hormone with Vitamin D Supplementation in Blacks: A Randomized Controlled Trial. Vitamin D 38-47 parathyroid hormone Homo sapiens 13-32 26858840-1 2015 BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Vitamin D 53-62 parathyroid hormone Homo sapiens 24-43 26858840-1 2015 BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Vitamin D 133-142 parathyroid hormone Homo sapiens 24-43 25705243-6 2015 PTH (1-84) has been demonstrated to maintain serum calcium while reducing or eliminating requirements for calcium and active vitamin D supplementation. Vitamin D 125-134 parathyroid hormone Homo sapiens 0-3 25100378-3 2015 In this study, we examined the association between vitamin D and parathyroid hormone (PTH) levels and HF in and elderly population in China. Vitamin D 51-60 parathyroid hormone Homo sapiens 65-84 25100378-3 2015 In this study, we examined the association between vitamin D and parathyroid hormone (PTH) levels and HF in and elderly population in China. Vitamin D 51-60 parathyroid hormone Homo sapiens 86-89 26159447-5 2015 Vitamin D sterols reduce parathyroid hormone (PTH) secretion while normalizing calcium (Ca) and vitamin D levels. Vitamin D 0-9 parathyroid hormone Homo sapiens 25-44 24875346-5 2014 On multiple-adjusted linear regression analyses, vitamin D deficiency/insufficiency with PTH in the highest tertile at 3 months independently predicted poorer beta-cell function (P = 0.03) and insulin sensitivity (P = 0.01) and increased fasting (P = 0.03) and 2-h glucose (P = 0.002) at 12 months postpartum. Vitamin D 49-58 parathyroid hormone Homo sapiens 89-92 26780278-0 2015 A Vitamin D-Calcium-Fortified Yogurt Drink Decreased Serum PTH but did not Affect Osteocalcin in Subjects with Type 2 Diabetes. Vitamin D 2-11 parathyroid hormone Homo sapiens 59-62 26068724-3 2015 The aim of this study was to elucidate which factor, FGF-23 or PTH, plays a more important role in the regulation of vitamin D metabolites in subjects with estimated glomerular filtration (eGFR) >=60 ml/min/1.73 m(2). Vitamin D 117-126 parathyroid hormone Homo sapiens 63-66 25423925-4 2014 However, in CKD, PTH hypersecretion and hyperplasia are started by hyperphosphatemia, hypocalcemia, and activated-vitamin-D deficiency, and the secondary hyperparathyroidism develops. Vitamin D 114-123 parathyroid hormone Homo sapiens 17-20 25411034-3 2014 The metabolism of vitamin D is regulated by parathyroid hormone (PTH). Vitamin D 18-27 parathyroid hormone Homo sapiens 44-63 25118085-0 2014 Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: a randomized, double-blind, placebo controlled trial. Vitamin D 12-21 parathyroid hormone Homo sapiens 48-67 24875346-6 2014 In contrast, vitamin D deficiency/insufficiency with lower PTH did not predict these outcomes. Vitamin D 13-22 parathyroid hormone Homo sapiens 59-62 24875346-7 2014 In conclusion, only vitamin D deficiency/insufficiency with increased PTH is an independent predictor of beta-cell dysfunction, insulin resistance, and glycemia, highlighting the need for consideration of the PTH/25-OH-D axis when studying the impact of vitamin D status on glucose homeostasis. Vitamin D 20-29 parathyroid hormone Homo sapiens 70-73 24140234-2 2014 We examined whether vitamin D deficiency was positively associated with sarcopenia in a gender-specific manner in adults aged >=50 years, independent of other covariates and possible confounders, including body composition, blood tests, including serum parathyroid hormone (PTH) levels, dietary intake, and hormone replacement therapy in women. Vitamin D 20-29 parathyroid hormone Homo sapiens 277-280 25092061-9 2014 Vitamin level was negatively correlated with PTH and the correlation was more marked in subjects with vitamin D deficiency. Vitamin D 102-111 parathyroid hormone Homo sapiens 45-48 25498380-2 2014 However, in other situations, the initial increase in parathyroid hormone and bone remodeling may be slowed down excessively by a multitude of factors including age, ethnic origin, sex, and treatments such as vitamin D, calcium salts, calcimimetics, steroids, and so forth, leading to low bone turnover or adynamic bone disease. Vitamin D 209-218 parathyroid hormone Homo sapiens 54-73 24878040-2 2014 OBJECTIVE: The objective of the study was to determine the combined effects of vitamin D deficiency and CKD on BMD in the elderly population and their relationships with sarcopenia and PTH levels. Vitamin D 79-88 parathyroid hormone Homo sapiens 185-188 25161115-11 2014 Nonadjusted analyses showed higher i-PTH concentration in vitamin D deficient patients (p < 0.05). Vitamin D 58-67 parathyroid hormone Homo sapiens 37-40 25161115-14 2014 Vitamin D deficient patients also tended to have higher i-PTH levels. Vitamin D 0-9 parathyroid hormone Homo sapiens 58-61 24878040-8 2014 Multivariable logistic regression analyses demonstrated that CKD subjects with vitamin D deficiency showed a significantly increased risk of osteoporosis or osteopenia [odds ratios 1.49 and 2.06 (1.81 and 2.65) at the femur neck and total hip, respectively, in women (men)], which was mainly associated with elevated levels of PTH and sarcopenia in these groups. Vitamin D 79-88 parathyroid hormone Homo sapiens 327-330 25111832-0 2014 Vitamin D status among Thai school children and the association with 1,25-Dihydroxyvitamin D and parathyroid hormone levels. Vitamin D 0-9 parathyroid hormone Homo sapiens 97-116 25194407-0 2014 Relationship between vitamin D receptor gene FokI and ApaI polymorphisms and serum levels of fetuin-A, vitamin D, and parathyroid hormone in patients on hemodialysis. Vitamin D 21-30 parathyroid hormone Homo sapiens 118-137 24973411-4 2014 Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. Vitamin D 83-92 parathyroid hormone Homo sapiens 43-46 24973411-4 2014 Thus, the two major phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitamin D at the nexus of phosphate homeostasis. Vitamin D 113-122 parathyroid hormone Homo sapiens 43-46 24854576-2 2014 Publications on the health effects of vitamin D (25(OH) D) had almost triplicate in the last 10years, not only for its known "calcemic effects" (calcium, phosphor, PTH), but for the more recent findings on its "non-calcemic effects" (all-cause and cardiovascular mortality, and relation with certain types of cancer). Vitamin D 38-47 parathyroid hormone Homo sapiens 164-167 24429404-0 2014 The impact of vitamin D status on the relative increase in fibroblast growth factor 23 and parathyroid hormone in chronic kidney disease. Vitamin D 14-23 parathyroid hormone Homo sapiens 91-110 25505940-5 2014 METHOD: In a double blind randomized placebo controlled study we evaluated the effect of a monthly dose of 100,000IU of vitamin D3 for three months on the level of serum 25(OH)D, intact parathyroid hormone (PTH), urinary isoprostane, adipocyte cytokine expression and arterial stiffness among 130 overweight and obese (BMI > 25) African Americans with elevated blood pressure (130 - 150/85 - 100 mmHg) and low serum vitamin D level (10 - 25 ng/ml). Vitamin D 120-129 parathyroid hormone Homo sapiens 186-205 25077091-0 2014 Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels. Vitamin D 0-9 parathyroid hormone Homo sapiens 93-112 25077091-1 2014 PURPOSE: This study was performed to investigate the relationship between serum vitamin D and parathyroid hormone (PTH) levels as well as to describe the prevalence and the risk factors of vitamin D deficiency (VDD) in Korean children. Vitamin D 80-89 parathyroid hormone Homo sapiens 94-113 24382124-8 2014 CONCLUSION: Vitamin D replacement in subjects with PHPT and coexistent vitamin D deficiency increase 25 (OH) D and reduce serum PTH significantly without causing hypercalcaemia and hypercalciuria. Vitamin D 12-21 parathyroid hormone Homo sapiens 128-131 24382124-8 2014 CONCLUSION: Vitamin D replacement in subjects with PHPT and coexistent vitamin D deficiency increase 25 (OH) D and reduce serum PTH significantly without causing hypercalcaemia and hypercalciuria. Vitamin D 71-80 parathyroid hormone Homo sapiens 128-131 22708508-9 2014 Serum PTH levels were significantly higher in severely vit D deficient than sufficient infants. Vitamin D 55-60 parathyroid hormone Homo sapiens 6-9 24305924-13 2014 Furthermore it was seen that the mean PTH in vitamin D sufficient hypocalcemic patients (n = 15) was 7.12 +- 1.79 and that in vitamin D deficient hypocalcemic patients (n = 26) was 16 +- 9.77 (p = 0.001) CONCLUSIONS: Our findings suggest that the fall in PTH after TT in vitamin D deficient patients is unreliable in predicting hypocalcemia and should not be relied on to plan early postoperative discharge. Vitamin D 45-54 parathyroid hormone Homo sapiens 38-41 24517148-9 2014 The CaSRQ459R mutation leads to mild functional inactivation in vitro, which explains the FHH-like phenotype in homozygous family members and the grossly exaggerated PTH response to vitamin D deficiency in the index case. Vitamin D 182-191 parathyroid hormone Homo sapiens 166-169 24566583-3 2014 Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation INTRODUCTION: As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter. Vitamin D 4-13 parathyroid hormone Homo sapiens 51-70 24566583-3 2014 Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation INTRODUCTION: As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter. Vitamin D 4-13 parathyroid hormone Homo sapiens 72-75 24522558-7 2014 Low vitamin D concentrations in CKD stages 3-5 should be treated under consideration of serum calcium and parathyroid hormone (PTH) with calcidiol (25-cholecalciferol) and in dialysis patients (CKD 5D) with calcitriol (1,25 dihydroxycholecalciferol, activated vitamin D). Vitamin D 4-13 parathyroid hormone Homo sapiens 106-125 24747593-2 2014 In bone metabolism, vitamin D increases the plasma levels of calcium and phosphorus, regulates osteoblast and osteoclast the activity, and combats PTH hypersecretion, promoting bone formation and preventing/treating osteoporosis. Vitamin D 20-29 parathyroid hormone Homo sapiens 147-150 24690624-8 2014 On the basis of the available evidence, an association between vitamin D concentrations and birth weight, dental caries in children, maternal vitamin D concentrations at term, and parathyroid hormone concentrations in patients with chronic kidney disease requiring dialysis is probable, but further studies and better designed trials are needed to draw firmer conclusions. Vitamin D 63-72 parathyroid hormone Homo sapiens 180-199 24527713-8 2014 Among vitamin D-replete subjects (25OHD status of 20 ng/mL or greater), the 97.5th percentile of plasma PTH was higher in overweight/obese subjects (51.9 vs 43.5 ng/L among normal weight subjects). Vitamin D 6-15 parathyroid hormone Homo sapiens 104-107 24527713-9 2014 CONCLUSIONS: The reference value for plasma PTH defined in this vitamin D-replete population was far below the value currently provided by the manufacturer (65 ng/L) and varied according to overweight status. Vitamin D 64-73 parathyroid hormone Homo sapiens 44-47 24535147-0 2014 Parathyroid hormone as a functional indicator of vitamin D sufficiency in children. Vitamin D 49-58 parathyroid hormone Homo sapiens 0-19 24618074-6 2014 Vitamin D status was assessed by 25(OH)D3, PTH and electrolyte levels. Vitamin D 0-9 parathyroid hormone Homo sapiens 43-46 24423366-10 2014 Compared with placebo, vitamin D decreased PTH significantly by 17% before PTX (P = .01), increased lumbar spine bone mineral density by 2.5% (P = .01), and decreased C-terminal beta-CrossLaps by 22% (P < .005). Vitamin D 23-32 parathyroid hormone Homo sapiens 43-46 24423366-14 2014 CONCLUSIONS: Daily supplementation with a high vitamin D dose safely improves vitamin D status and decreases PTH in PHPT patients. Vitamin D 47-56 parathyroid hormone Homo sapiens 109-112 24305924-3 2014 The aim of the present study was to evaluate the accuracy of PTH as a predictor of post-TT hypocalcemia in patients with vitamin D deficiency. Vitamin D 121-130 parathyroid hormone Homo sapiens 61-64 23857798-0 2014 In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations. Vitamin D 42-51 parathyroid hormone Homo sapiens 74-77 23857798-9 2014 These findings provide evidence that in a largely vitamin D-sufficient cohort, the biological effect of vitamin D on PTH levels is mainly independent of DBP concentration. Vitamin D 104-113 parathyroid hormone Homo sapiens 117-120 24854296-0 2014 Novel, selective vitamin D analog suppresses parathyroid hormone in uremic animals and postmenopausal women. Vitamin D 17-26 parathyroid hormone Homo sapiens 45-64 24053724-5 2014 Obese patients showed a vitamin D status that was compatible with moderate depletion, thus correlating negatively with parathyroid hormone (PTH) and positively with CTX. Vitamin D 24-33 parathyroid hormone Homo sapiens 119-138 23701502-0 2014 The relationship between vitamin D and PTH levels and cardiovascular risk in the elderly hypertensives. Vitamin D 25-34 parathyroid hormone Homo sapiens 39-42 24715441-4 2014 PURPOSE: Optimal vitamin D status for bone health has been inferred from the determination of serum 25OHD levels below which there is an increase in serum parathyroid hormone (PTH). Vitamin D 17-26 parathyroid hormone Homo sapiens 155-174 24715441-4 2014 PURPOSE: Optimal vitamin D status for bone health has been inferred from the determination of serum 25OHD levels below which there is an increase in serum parathyroid hormone (PTH). Vitamin D 17-26 parathyroid hormone Homo sapiens 176-179 24858401-1 2014 UNLABELLED: Risks of low vitamin D status in Kuwaiti adolescent girls are high parathyroid hormone (PTH), high waist/hip ratio, veiling and not having a private room. Vitamin D 25-34 parathyroid hormone Homo sapiens 79-98 24858401-1 2014 UNLABELLED: Risks of low vitamin D status in Kuwaiti adolescent girls are high parathyroid hormone (PTH), high waist/hip ratio, veiling and not having a private room. Vitamin D 25-34 parathyroid hormone Homo sapiens 100-103 25242259-0 2014 Effect of high parathyroid hormone level on bone mineral density in a vitamin D-sufficient population: Korea National Health and Nutrition Examination Survey 2008-2010. Vitamin D 70-79 parathyroid hormone Homo sapiens 15-34 25242259-6 2014 High PTH level was found in 50% of vitamin D-deficient subjects and 35% of vitamin D-sufficient subjects. Vitamin D 35-44 parathyroid hormone Homo sapiens 5-8 25242259-6 2014 High PTH level was found in 50% of vitamin D-deficient subjects and 35% of vitamin D-sufficient subjects. Vitamin D 75-84 parathyroid hormone Homo sapiens 5-8 25242259-7 2014 In the vitamin D-deficient group, subjects with normal PTH level had higher total hip and spine BMD than those with high PTH after adjusting for multiple confounding factors, regardless of gender. Vitamin D 7-16 parathyroid hormone Homo sapiens 55-58 25242259-7 2014 In the vitamin D-deficient group, subjects with normal PTH level had higher total hip and spine BMD than those with high PTH after adjusting for multiple confounding factors, regardless of gender. Vitamin D 7-16 parathyroid hormone Homo sapiens 121-124 25242259-8 2014 In the vitamin D-sufficient group, only women with high PTH showed lower total hip and spine BMD than those with normal PTH. Vitamin D 7-16 parathyroid hormone Homo sapiens 56-59 25242259-8 2014 In the vitamin D-sufficient group, only women with high PTH showed lower total hip and spine BMD than those with normal PTH. Vitamin D 7-16 parathyroid hormone Homo sapiens 120-123 25242259-9 2014 Multivariable linear regression analysis found that PTH level was independently associated with total hip BMD in vitamin D-sufficient women as well as vitamin D-insufficient women, but no association was found in men. Vitamin D 113-122 parathyroid hormone Homo sapiens 52-55 25242259-9 2014 Multivariable linear regression analysis found that PTH level was independently associated with total hip BMD in vitamin D-sufficient women as well as vitamin D-insufficient women, but no association was found in men. Vitamin D 151-160 parathyroid hormone Homo sapiens 52-55 25242259-10 2014 In conclusion, high serum PTH level has an additive detrimental effect on BMD in postmenopausal women even though they had sufficient vitamin D levels. Vitamin D 134-143 parathyroid hormone Homo sapiens 26-29 23761326-2 2014 The main objective of this trial was to measure the effect of different doses of vitamin D3 on serum 25OHD and serum parathyroid hormone (PTH) in young women with vitamin D insufficiency (serum 25OHD <= 20 ng/mL (50 nmol/L). Vitamin D 81-90 parathyroid hormone Homo sapiens 117-136 23761326-2 2014 The main objective of this trial was to measure the effect of different doses of vitamin D3 on serum 25OHD and serum parathyroid hormone (PTH) in young women with vitamin D insufficiency (serum 25OHD <= 20 ng/mL (50 nmol/L). Vitamin D 81-90 parathyroid hormone Homo sapiens 138-141 24334134-0 2013 [Clinical value of two methods to measure parathyroid hormone in chronic renal insufficiency, considering vitamin D metabolism]. Vitamin D 106-115 parathyroid hormone Homo sapiens 42-61 24334134-2 2013 AIM: To compare parathyroid hormone levels measured by two assays in correlation with vitamin D supply. Vitamin D 86-95 parathyroid hormone Homo sapiens 16-35 24334134-9 2013 CONCLUSIONS: Biointact parathyroid hormone levels better reflect the vitamin D supply and bone metabolism than intact levels, especially in hemodialysed patients. Vitamin D 69-78 parathyroid hormone Homo sapiens 23-42 24012652-0 2013 Prevalence of vitamin D deficiency and consequences for PTH reference values. Vitamin D 14-23 parathyroid hormone Homo sapiens 56-59 24445125-7 2013 Studies in hypoparathyroid subjects demonstrate that PTH(1-34) and PTH(1-84) lower or abolish supplemental calcium and vitamin D requirements as well as increase markers of bone turnover. Vitamin D 119-128 parathyroid hormone Homo sapiens 53-56 24445125-7 2013 Studies in hypoparathyroid subjects demonstrate that PTH(1-34) and PTH(1-84) lower or abolish supplemental calcium and vitamin D requirements as well as increase markers of bone turnover. Vitamin D 119-128 parathyroid hormone Homo sapiens 67-70 24304609-1 2013 We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men. Vitamin D 39-48 parathyroid hormone Homo sapiens 118-137 24304609-1 2013 We aim to evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25-OH-Vitamin D3) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) in independent elderly men. Vitamin D 39-48 parathyroid hormone Homo sapiens 139-142 24112673-9 2013 A parathyroid hormone level outside of the reference range may indicate a need for more aggressive postoperative calcium supplementation and treatment with activated vitamin D. Vitamin D 166-175 parathyroid hormone Homo sapiens 2-21 24012652-1 2013 Reference values of PTH depend on vitamin D status of the reference population. Vitamin D 34-43 parathyroid hormone Homo sapiens 20-23 24012652-8 2013 The relation between vitamin D and PTH was independent of age, gender, BMI and kidney function. Vitamin D 21-30 parathyroid hormone Homo sapiens 35-38 24026893-9 2013 One year of vitamin D supplementation resulted in lower parathyroid hormone (PTH) (40 (34-52) vs 49 (38-66) ng/l) and higher 25-OH-D (76 (65-93) vs 49 (40-62) nmol/l; P<0.05). Vitamin D 12-21 parathyroid hormone Homo sapiens 56-75 24064695-2 2013 OBJECTIVE: Our objective was to evaluate the influence of calcium and vitamin D supplementation on PTH and bone turnover. Vitamin D 70-79 parathyroid hormone Homo sapiens 99-102 24064695-9 2013 There was a decline in PTH in the vitamin D groups in the fasting state compared with placebo. Vitamin D 34-43 parathyroid hormone Homo sapiens 23-26 24064695-10 2013 Suppression of PTH was greater after a calcium load in the vitamin D groups. Vitamin D 59-68 parathyroid hormone Homo sapiens 15-18 24064695-12 2013 CONCLUSIONS: Fasting PTH declines with vitamin D supplementation. Vitamin D 39-48 parathyroid hormone Homo sapiens 21-24 23962009-10 2013 The only factors found to be associated with vitamin D deficiency were season of sample, ethnicity, and PTH levels. Vitamin D 45-54 parathyroid hormone Homo sapiens 104-107 23962009-14 2013 Initial post-transplant period and high PTH are significantly associated with vitamin D deficiency. Vitamin D 78-87 parathyroid hormone Homo sapiens 40-43 23999068-0 2013 Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children. Vitamin D 37-46 parathyroid hormone Homo sapiens 51-70 23999068-9 2013 CONCLUSION: Vitamin D deficiency, based on PTH elevation, was best defined by a 25OHD level of < 34 nmol/l. Vitamin D 12-21 parathyroid hormone Homo sapiens 43-46 24026893-9 2013 One year of vitamin D supplementation resulted in lower parathyroid hormone (PTH) (40 (34-52) vs 49 (38-66) ng/l) and higher 25-OH-D (76 (65-93) vs 49 (40-62) nmol/l; P<0.05). Vitamin D 12-21 parathyroid hormone Homo sapiens 77-80 24109497-2 2013 Additionally, vitamin D deficiency causes an increase in parathyroid hormone, which increases insulin resistance and is associated with diabetes, hypertension, inflammation, and increased cardiovascular risk. Vitamin D 14-23 parathyroid hormone Homo sapiens 57-76 23790578-0 2013 [Relation between parathyroid hormone and cardiovascular risk in patients with vitamin D deficiency]. Vitamin D 79-88 parathyroid hormone Homo sapiens 18-37 24076648-5 2013 On the basis of these data, it is suggested that appropriate doses of active vitamin D and phosphate are to be selected according to the data of serum PTH, ALP and the amount of urinary excretion of calcium. Vitamin D 77-86 parathyroid hormone Homo sapiens 151-154 24170964-7 2013 Serum intact PTH and urine PEA evaluations were helpful for diagnosing vitamin D deficiency and hypophosphatasia carrier status, respectively. Vitamin D 71-80 parathyroid hormone Homo sapiens 13-16 23377775-4 2013 We investigated the association between vitamin D status and 5-year changes in urine albumin creatinine ratio (UACR) and parathyroid hormone (PTH). Vitamin D 40-49 parathyroid hormone Homo sapiens 121-140 24073266-0 2013 Changes in the calcium-parathyroid hormone-vitamin d axis and prognosis for critically ill patients: a prospective observational study. Vitamin D 43-52 parathyroid hormone Homo sapiens 15-42 23885046-1 2013 BACKGROUND: Secondary hyperparathyroidism, which is defined by a high concentration of intact parathyroid hormone when circulating 25-hydroxyvitamin D [25(OH)D] is low, is a functional indicator of vitamin D insufficiency and a sign of impaired calcium metabolism. Vitamin D 141-150 parathyroid hormone Homo sapiens 94-113 23809192-12 2013 In conclusion, we arrived at the following: 1) severe vitamin D deficiency is common in DM patients and it is associated with secondary hyperparathyroidism; 2) primary hyperparathyroidism, though rare, may occur; 3) increased adiposity in DM may be a risk factor for hypovitaminosis D; and 4) high serum PTH levels may indicate a muscle impairment, at least in DM1. Vitamin D 54-63 parathyroid hormone Homo sapiens 304-307 23927947-0 2013 Parathyroid hormone has an important role in blood pressure regulation in vitamin D-insufficient individuals. Vitamin D 74-83 parathyroid hormone Homo sapiens 0-19 23787544-2 2013 Active vitamin D can suppress parathyroid hormone (PTH), but may raise serum calcium and phosphate concentrations. Vitamin D 7-16 parathyroid hormone Homo sapiens 30-49 23945218-0 2013 Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH. Vitamin D 32-41 parathyroid hormone Homo sapiens 120-123 23945218-10 2013 Low vitamin D levels were associated with obesity, being born outside Sweden and high PTH levels. Vitamin D 4-13 parathyroid hormone Homo sapiens 86-89 23509103-2 2013 The threshold of 25OHD needed to maximally suppress intact PTH has been suggested as a marker of optimal vitamin D status. Vitamin D 105-114 parathyroid hormone Homo sapiens 59-62 23653431-2 2013 OBJECTIVE: The objective was to evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum PTH and bone resorption markers as compared with isocaloric and isoprotein dairy products in elderly women. Vitamin D 79-88 parathyroid hormone Homo sapiens 147-150 23748358-1 2013 BACKGROUND: There is growing evidence to support an important role for vitamin D and related hormones, parathyroid hormone and fibroblast growth factor 23 (FGF23), on cardiac remodeling in chronic kidney disease. Vitamin D 71-80 parathyroid hormone Homo sapiens 103-122 23184178-4 2013 During recent years, a number of studies have shown that PTH replacement therapy (PTH-RT) may maintain calcium levels within the normal range, while the need for calcium and vitamin D supplements is reduced. Vitamin D 174-183 parathyroid hormone Homo sapiens 57-60 23184178-4 2013 During recent years, a number of studies have shown that PTH replacement therapy (PTH-RT) may maintain calcium levels within the normal range, while the need for calcium and vitamin D supplements is reduced. Vitamin D 174-183 parathyroid hormone Homo sapiens 82-85 22968355-0 2013 Do low preoperative vitamin D levels reduce the accuracy of quick parathyroid hormone in predicting postthyroidectomy hypocalcemia? Vitamin D 20-29 parathyroid hormone Homo sapiens 66-85 23596520-1 2013 INTRODUCTION: Though inconsistent, a number of studies have shown an association between vitamin D (25(OH)D) status, parathyroid hormone (PTH) and the metabolic syndrome (Met S). Vitamin D 89-98 parathyroid hormone Homo sapiens 117-136 23596520-1 2013 INTRODUCTION: Though inconsistent, a number of studies have shown an association between vitamin D (25(OH)D) status, parathyroid hormone (PTH) and the metabolic syndrome (Met S). Vitamin D 89-98 parathyroid hormone Homo sapiens 138-141 26236422-0 2013 BMI but Not Race Contributes to Vitamin D-Parathyroid Hormone Axis in Peripubertal Girls. Vitamin D 32-41 parathyroid hormone Homo sapiens 42-61 23393179-9 2013 In multiple regression analyses after adjustment for age, gender, hemodialysis duration, calcium, phosphate, vitamin D use, and phosphate binder use, intact PTH was associated significantly with body weight (beta = .190; P < .0001), body mass index (beta = .177; P < .0001), fat mass (beta = .142; P < .0005), and lean mass (beta = .192; P < .01). Vitamin D 109-118 parathyroid hormone Homo sapiens 157-160 23386641-3 2013 OBJECTIVES: The objective of the study was to measure the effect of vitamin D3 on serum 25OHD and serum PTH in older African American women with vitamin D insufficiency and the serum 25OHD 20 ng/mL or less (<50 nmol/L). Vitamin D 68-77 parathyroid hormone Homo sapiens 104-107 23364486-9 2013 Among the participants with a normal eGFR, the LAPACQ score, vitamin D supplementation, season, log PTH value and eGFR were correlated with log 25-OH-vitamin D levels. Vitamin D 150-159 parathyroid hormone Homo sapiens 100-103 23064465-1 2013 PURPOSE: A prospective multicentre cohort study was conducted to determine the prevalence of hypovitaminosis D in adult critically ill patients, to characterize alterations in the parathyroid hormone (PTH)-vitamin D-calcium axis and to explore associations between hypovitaminosis D and adverse clinical outcomes. Vitamin D 206-215 parathyroid hormone Homo sapiens 180-199 23064465-1 2013 PURPOSE: A prospective multicentre cohort study was conducted to determine the prevalence of hypovitaminosis D in adult critically ill patients, to characterize alterations in the parathyroid hormone (PTH)-vitamin D-calcium axis and to explore associations between hypovitaminosis D and adverse clinical outcomes. Vitamin D 206-215 parathyroid hormone Homo sapiens 201-204 23064465-7 2013 Secondary hyperparathyroidism (PTH > 7 pmol/L) was observed in 37.5 % of hypocalcaemic and 32.5 % of vitamin D insufficient/deficient patients, and was associated with higher SAPS-II [43 (31.3-60) vs. 36 (30-43), p = 0.03]. Vitamin D 104-113 parathyroid hormone Homo sapiens 31-34 23130887-0 2013 The ratio of parathyroid hormone to vitamin D is a determinant of cardiovascular risk and insulin sensitivity in adolescent girls. Vitamin D 36-45 parathyroid hormone Homo sapiens 13-32 23465502-2 2013 Renal vitamin D metabolism requires filtration and tubular reabsorption of 25-hydroxyvitamin D and is regulated by parathyroid hormone, fibroblast growth factor-23, and 1,25-dihydroxyvitamin D. Vitamin D 6-15 parathyroid hormone Homo sapiens 115-134 23364486-12 2013 Log 25-OH-vitamin D values, serum phosphorus levels, vitamin D supplementation (p=0.07), season (p=0.10) and eGFR were correlated with log PTH values in the patients with CKD. Vitamin D 10-19 parathyroid hormone Homo sapiens 139-142 24080758-0 2013 Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children? Vitamin D 13-22 parathyroid hormone Homo sapiens 23-42 23635517-8 2013 CONCLUSIONS: Baseline vitamin D status and serum phosphorous are independent determinants of the longitudinal variation in PTH and FGF23, respectively. Vitamin D 22-31 parathyroid hormone Homo sapiens 123-126 23724632-9 2013 There was a significant relationship between serum levels of vitamin D with ionized Ca, PTH, ALP, type of clothing, and egg consumption, while no significant relationship was found between serum levels of vitamin D with age, residency, menstruation status, skin color, sun light exposure, body mass index, waist to hip ratio, exercise, physical activity, fish consumption, and polymorphisms in exon 9 of VDR gene. Vitamin D 61-70 parathyroid hormone Homo sapiens 88-91 22972177-6 2013 Thus, vitamin D deficient Saudi children and adults with normal levels of 1,25-(OH)2D also had normal circulating calcium and PTH. Vitamin D 6-15 parathyroid hormone Homo sapiens 126-129 22215183-3 2012 We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective. Vitamin D 49-58 parathyroid hormone Homo sapiens 137-156 24375245-0 2013 Vitamin D status and its seasonal variations and association with parathyroid hormone concentration in healthy women in Riga. Vitamin D 0-9 parathyroid hormone Homo sapiens 66-85 22784837-1 2012 OBJECTIVE: Hypocalcemia and hyperphosphatemia in the setting of elevated parathyroid hormone (PTH) and normal vitamin D metabolites, raises the possibility of PTH resistance. Vitamin D 110-119 parathyroid hormone Homo sapiens 159-162 22710945-10 2012 Disruption of the vitamin D-PTH axis may contribute to the bone loss seen in the chronic SCI population. Vitamin D 18-27 parathyroid hormone Homo sapiens 28-31 23144471-13 2013 CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season. Vitamin D 45-54 parathyroid hormone Homo sapiens 220-223 28197433-8 2013 The reason may be due to excessive intake of calcium and Vitamin D analogues, which may suppress parathyroid hormone secretion. Vitamin D 57-66 parathyroid hormone Homo sapiens 97-116 22218874-0 2012 The impact of vitamin D status and tumor size on the intraoperative parathyroid hormone dynamics in patients with symptomatic primary hyperparathyroidism. Vitamin D 14-23 parathyroid hormone Homo sapiens 68-87 22215183-3 2012 We hypothesised that monthly dosing of 50,000 IU vitamin D (~1,600 IU daily) will increase serum 25-hydroxyvitamin D (25(OH)D), suppress parathyroid hormone (PTH) and improve bone mineral density (BMD), 50,000 IU alternate months (~800 IU daily) will maintain these measures, while a single 50,000 IU dose pre-departure (~1,00 IU daily) will not be protective. Vitamin D 49-58 parathyroid hormone Homo sapiens 158-161 22736772-8 2012 RESULTS: Five PHP1B patients developed concomitantly elevated serum calcium and PTH levels (range, 235-864 ng/liter) requiring termination of calcium and vitamin D therapy (time after diagnosis, 21-42 yr; median, 34 yr), consistent with tertiary hyperparathyroidism. Vitamin D 154-163 parathyroid hormone Homo sapiens 80-83 23021134-7 2012 Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P < .0001), greater PTH levels (P < .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05). Vitamin D 173-182 parathyroid hormone Homo sapiens 84-87 23021134-7 2012 Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P < .0001), greater PTH levels (P < .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05). Vitamin D 173-182 parathyroid hormone Homo sapiens 84-87 23021134-7 2012 Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P < .0001), greater PTH levels (P < .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05). Vitamin D 227-236 parathyroid hormone Homo sapiens 84-87 23021134-7 2012 Compared with patients with normal postoperative PTH levels, patients with elevated PTH levels had greater BMI (P < .0001), greater PTH levels (P < .0001), and lesser vitamin D levels (P = .014) preoperatively and lesser vitamin D levels at 6 months (P = .05). Vitamin D 227-236 parathyroid hormone Homo sapiens 84-87 23021134-11 2012 The greater PTH levels and lesser vitamin D levels support postoperative vitamin D supplementation in these patients. Vitamin D 73-82 parathyroid hormone Homo sapiens 12-15 23185165-9 2012 Malignancy-associated hypercalcemia occurs via four principal mechanisms: (1) tumor production of PTHrP; (2) osteolytic bone involvement by primary tumor or metastasis; (3) ectopic activation of vitamin D to 1,25-(OH)(2) vitamin D, and (4) ectopic production of parathyroid hormone. Vitamin D 195-204 parathyroid hormone Homo sapiens 262-281 22473758-13 2012 Vitamin D unresponsive hypoparathyroidism maybe safely and effectively controlled at long term by s. c. multipulse pump treatment recombinant human PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 148-151 22854402-7 2012 PTH decreased from baseline only in the vitamin D group (baseline: 89.1 +- 49.3 to 70.1 +- 24.8 pg/mL; P = 0.01) at 12 wk, but values were not significantly different from baseline at 1 y (75.4 +- 29.5 pg/mL; P = 0.16; group-by-time interaction: P = 0.09). Vitamin D 40-49 parathyroid hormone Homo sapiens 0-3 22736772-12 2012 CONCLUSIONS: PHP1B patients are at risk of developing tertiary hyperparathyroidism and/or hyperparathyroid bone disease and should therefore be treated with sufficient doses of calcium and vitamin D to achieve serum calcium and PTH levels within or as close to the normal range as possible. Vitamin D 189-198 parathyroid hormone Homo sapiens 228-231 22766894-11 2012 Seasonal measurements of vitamin D status, PTH levels and bone turnover markers exhibit that PTH levels, osteocalcin and beta crosslaps increase in response to low vitamin D levels. Vitamin D 164-173 parathyroid hormone Homo sapiens 93-96 22969780-3 2012 Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH to nitric oxide metabolites (NOx) - nitrate and nitrite - and oxidative stress in African-Americans is unknown. Vitamin D 30-39 parathyroid hormone Homo sapiens 75-78 22863393-3 2012 PTH is a key calcium regulating hormone essential for calcium homeostasis, vitamin D-dependant calcium absorption, renal calcium reabsorption and renal phosphate clearance. Vitamin D 75-84 parathyroid hormone Homo sapiens 0-3 22339716-12 2012 Considering that the active form of vitamin D suppresses PTH production, it is hypothesised that vitamin D replenishment of just those who are genetically prone to the disease (i.e. siblings) may be regarded as a preventive measure against T1D. Vitamin D 36-45 parathyroid hormone Homo sapiens 57-60 22339716-12 2012 Considering that the active form of vitamin D suppresses PTH production, it is hypothesised that vitamin D replenishment of just those who are genetically prone to the disease (i.e. siblings) may be regarded as a preventive measure against T1D. Vitamin D 97-106 parathyroid hormone Homo sapiens 57-60 23781299-1 2012 INTRODUCTION/BACKGROUND: Vitamin D deficiency further increases circulating parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism (pHPT), with potential detrimental effects on bone mass. Vitamin D 25-34 parathyroid hormone Homo sapiens 76-95 22453735-1 2012 BACKGROUND: The role of vitamin D status in patients with renal insufficiency and its relation to dietary intake and parathyroid hormone (PTH) secretion is of utmost interest given the morbidity and mortality associated with the disordered mineral metabolism seen in chronic kidney disease (CKD). Vitamin D 24-33 parathyroid hormone Homo sapiens 117-136 22644348-2 2012 The purpose of the study was to evaluate the impact of a high-calcium vitamin D fortified milk (HCM) intervention on parathyroid hormone (PTH) levels, vitamin D status and markers of bone turnover in postmenopausal Chinese women. Vitamin D 70-79 parathyroid hormone Homo sapiens 117-136 22797100-8 2012 There was a significant correlation between vitamin D deficiency and high serum parathyroid hormone (P = .04) and serum creatinine levels (P = .001). Vitamin D 44-53 parathyroid hormone Homo sapiens 80-99 22754549-1 2012 CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). Vitamin D 94-103 parathyroid hormone Homo sapiens 170-189 23781299-1 2012 INTRODUCTION/BACKGROUND: Vitamin D deficiency further increases circulating parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism (pHPT), with potential detrimental effects on bone mass. Vitamin D 25-34 parathyroid hormone Homo sapiens 97-100 23781299-9 2012 CONCLUSIONS: Prolonged treatment with vitamin D in various commonly prescribed preparations appeared to be safe and significantly reduced PTH levels by 21%. Vitamin D 38-47 parathyroid hormone Homo sapiens 138-141 22495973-14 2012 Patients who needed a supplementation with calcium and vitamin D after PTX preoperatively had higher serum levels of PTH. Vitamin D 55-64 parathyroid hormone Homo sapiens 117-120 22431675-14 2012 Parathyroid hormone levels at 12 months decreased with an increasing dose of vitamin D(3) (P = 0.012). Vitamin D 77-86 parathyroid hormone Homo sapiens 0-19 21995281-11 2012 CONCLUSION: Our findings suggest that both eGFR and PTH are significantly associated with vitamin D metabolism in men without known CKD. Vitamin D 90-99 parathyroid hormone Homo sapiens 52-55 22349668-7 2012 After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-alpha compared with the placebo group; these differences were statistically significant (p < 0.001). Vitamin D 32-41 parathyroid hormone Homo sapiens 335-338 22507651-0 2012 Oral vitamin D effects on PTH levels. Vitamin D 5-14 parathyroid hormone Homo sapiens 26-29 22130786-2 2012 The persistent increase in circulating parathyroid hormone (PTH) caused by vitamin D insufficiency reduces bone density response to antiresorptive agents in these postmenopausal women. Vitamin D 75-84 parathyroid hormone Homo sapiens 39-58 22431675-2 2012 OBJECTIVE: To determine the effect of increasing oral doses of vitamin D(3) on serum 25-(OH)D and serum parathyroid hormone (PTH) levels in postmenopausal white women with vitamin D insufficiency (defined as a 25-[OH]D level <=50 nmol/L) in the presence of adequate calcium intake. Vitamin D 63-72 parathyroid hormone Homo sapiens 125-128 22495973-10 2012 Patients who needed postoperative supplementation with calcium and vitamin D had significantly higher PTH levels. Vitamin D 67-76 parathyroid hormone Homo sapiens 102-105 22407786-1 2012 Vitamin D is essential for facilitating calcium absorption and preventing increases in parathyroid hormone (PTH), which can augment bone resorption. Vitamin D 0-9 parathyroid hormone Homo sapiens 87-106 21847642-1 2012 Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium. Vitamin D 42-51 parathyroid hormone Homo sapiens 203-222 21639815-3 2012 Cross-sectional data have linked tenofovir with higher parathyroid hormone (PTH) concentrations in patients with vitamin D deficiency. Vitamin D 113-122 parathyroid hormone Homo sapiens 55-74 22013980-9 2012 In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. Vitamin D 37-46 parathyroid hormone Homo sapiens 141-144 22470867-11 2012 There was an inverse correlation between Vitamin D deficiency and serum PTH level. Vitamin D 41-50 parathyroid hormone Homo sapiens 72-75 21625888-0 2012 High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Vitamin D 19-28 parathyroid hormone Homo sapiens 111-130 21847642-1 2012 Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium. Vitamin D 42-51 parathyroid hormone Homo sapiens 224-227 21847642-1 2012 Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium. Vitamin D 176-185 parathyroid hormone Homo sapiens 203-222 21847642-1 2012 Laboratory studies have demonstrated that vitamin D has a number of chemopreventive properties, and that these properties may be mediated or modified by other molecules in the vitamin D pathway, such as parathyroid hormone (PTH) or calcium. Vitamin D 176-185 parathyroid hormone Homo sapiens 224-227 22536774-8 2012 Measurement of Vitamin D concentrations should also be part of any exploration of calcium/phosphorus metabolism which includes measurement of serum calcium, phosphate and PTH. Vitamin D 15-24 parathyroid hormone Homo sapiens 171-174 22652727-3 2012 Unfortunately, at least one third of patients on chronic dialysis have high serum P levels, with a consequent higher serum PTH levels, commonly associated with vitamin D deficiency, increased vascular calcification and the highest ratios of morbidity and mortality. Vitamin D 160-169 parathyroid hormone Homo sapiens 123-126 22523198-8 2012 Counteracting elevated PTH levels by adequate doses of vitamin D may improve the efficacy of this drug. Vitamin D 55-64 parathyroid hormone Homo sapiens 23-26 23144810-1 2012 There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. Vitamin D 42-51 parathyroid hormone Homo sapiens 83-102 22937036-1 2012 BACKGROUND: Conflicting reports support or refute an association between vitamin D deficiency with high levels of parathyroid hormone (PTH) and raised blood pressure or hypertension. Vitamin D 73-82 parathyroid hormone Homo sapiens 114-133 22536764-7 2012 Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively. Vitamin D 17-26 parathyroid hormone Homo sapiens 69-88 22536764-7 2012 Both calcium and vitamin D metabolites can decrease the secretion of parathyroid hormone (PTH) through the calcium sensing receptor and the VDR respectively. Vitamin D 17-26 parathyroid hormone Homo sapiens 90-93 21956833-0 2012 Vitamin D insufficiency is prevalent and vitamin D is inversely associated with parathyroid hormone and calcitriol in pregnant adolescents. Vitamin D 41-50 parathyroid hormone Homo sapiens 80-99 21606669-2 2012 AIM: We sought to define skeletal-related vitamin D sufficiency by estimating maximum PTH suppression in the U.S. population. Vitamin D 42-51 parathyroid hormone Homo sapiens 86-89 21606669-11 2012 CONCLUSIONS: Optimal vitamin D status, defined by estimated maximum PTH suppression, does not occur until at least 25OHD levels >=40 ng/ml. Vitamin D 21-30 parathyroid hormone Homo sapiens 68-71 23144810-0 2012 High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover. Vitamin D 19-28 parathyroid hormone Homo sapiens 85-104 23304521-8 2012 Among prostate cancer patients, vitamin D levels correlated positively with age (r = 0.12, P < 0.02), and were negatively associated with BMI (r = -0.13, P = 0.003), glucose (r = -0.12, P < 0.007), HbA1C (r = -0.16, P = 0.001), and PTH (r = -0.21; P < 0.0001). Vitamin D 32-41 parathyroid hormone Homo sapiens 238-241 22189665-1 2012 Elevation in serum parathyroid hormone (PTH) often accompanies vitamin D deficiency and renal impairment. Vitamin D 63-72 parathyroid hormone Homo sapiens 19-38 22189665-1 2012 Elevation in serum parathyroid hormone (PTH) often accompanies vitamin D deficiency and renal impairment. Vitamin D 63-72 parathyroid hormone Homo sapiens 40-43 22189665-9 2012 The relation between PTH and vitamin D is complex and may show significant threshold variations, especially when calcium intake, age, and race are considered. Vitamin D 29-38 parathyroid hormone Homo sapiens 21-24 21664247-3 2011 PTH enhances vitamin D hydroxylation on carbon 1 in kidney cells thereby allowing the systemic release of 1-25-dihydroxy-vitamin D, which represents the fully active hormone. Vitamin D 13-22 parathyroid hormone Homo sapiens 0-3 22019806-9 2011 CONCLUSIONS: Patients with ARD had, on average, an increased PTH concentration for any plasma VITD range, suggesting an impaired vitamin D metabolism. Vitamin D 129-138 parathyroid hormone Homo sapiens 61-64 22019806-10 2011 Therefore, vitamin D supplementation to ARD patients may be targeted to reach PTH suppression and not simply to obtain VITD concentrations considered optimal in other categories of patients. Vitamin D 11-20 parathyroid hormone Homo sapiens 78-81 22172835-10 2011 On univariate analysis, proteinuria and i-PTH levels were independent predictors of vitamin D insufficiency (P<.01 and P=.03, respectively). Vitamin D 84-93 parathyroid hormone Homo sapiens 42-45 21872805-1 2011 In chronic kidney disease (CKD), abnormalities in vitamin D metabolism contribute to the development of mineral and skeletal disorders, elevations in parathyroid hormone (PTH), hypertension, systemic inflammation, renal and cardiovascular damage. Vitamin D 50-59 parathyroid hormone Homo sapiens 150-169 22040818-7 2011 To suppress PTH secretion without these potential complications, several vitamin D analogs including paricalcitol, maxacalcitol and doxercalciferol are already in clinical use. Vitamin D 73-82 parathyroid hormone Homo sapiens 12-15 21773992-5 2011 Compared with placebo, patients on PTH(1-84) reduced their daily dose of calcium and active vitamin D significantly by 75% and 73%, respectively, without developing hypocalcemia. Vitamin D 92-101 parathyroid hormone Homo sapiens 35-38 21773992-9 2011 In conclusion, the need for calcium and active vitamin D is reduced significantly during PTH-RT, whereas plasma calcium and phosphate levels are maintained within the physiologic range. Vitamin D 47-56 parathyroid hormone Homo sapiens 89-92 22616336-10 2011 PTH levels started rising at vitamin D level < 30 ng/ml. Vitamin D 29-38 parathyroid hormone Homo sapiens 0-3 20848081-0 2011 Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey. Vitamin D 47-56 parathyroid hormone Homo sapiens 84-103 21985980-1 2011 Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. Vitamin D 0-9 parathyroid hormone Homo sapiens 82-85 21985980-3 2011 In different cohorts of patients with P-HPT, vitamin D deficiency has been recently associated with higher PTH levels, larger adenomas, and a more severe phenotype (including osteitis fibrosa cystica) as well as negative post-operative outcomes following parathyroidectomy. Vitamin D 45-54 parathyroid hormone Homo sapiens 107-110 20668935-13 2011 Twenty-one (84.0%) of PD patients with vitamin D deficiency, and 22 (78.6%) PD patients whose 25 (OH)D levels were more than 15 ng/mL have been receiving active vitamin D compounds for parathyroid hormone (PTH) control (P > 0.05). Vitamin D 161-170 parathyroid hormone Homo sapiens 185-204 21851405-0 2011 Should activated vitamin D be used in patients with end-stage renal disease and low levels of parathyroid hormone? Vitamin D 17-26 parathyroid hormone Homo sapiens 94-113 20848081-8 2011 The impact of vitamin D deficiency (25(OH)D <= 20 ng/ml) on PTH levels was modified by race/ethnicity (P for interaction, 0.001). Vitamin D 14-23 parathyroid hormone Homo sapiens 63-66 21595844-4 2011 Significant determinants of poor vitamin D status were female gender, diabetes, high PTH, and high urinary protein (2+ or greater). Vitamin D 33-42 parathyroid hormone Homo sapiens 85-88 21366811-3 2011 The present study investigated the vitamin D status of a cohort of kidney-transplanted children and adolescents, and the association between vitamin D status and plasma concentrations of PTH, ionized calcium, and phosphate. Vitamin D 141-150 parathyroid hormone Homo sapiens 187-190 20567864-0 2011 Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 load in Japanese subjects. Vitamin D 0-9 parathyroid hormone Homo sapiens 65-84 21524245-7 2011 Treatment with vitamin D in PHPT may decrease PTH levels and bone turnover and potentially increase bone mass in various compartments. Vitamin D 15-24 parathyroid hormone Homo sapiens 46-49 21524245-11 2011 Vitamin D treatment is recommended and may decrease PTH levels in PHPT. Vitamin D 0-9 parathyroid hormone Homo sapiens 52-55 20957441-0 2011 The value of postoperative parathyroid hormone levels in predicting the need for long-term vitamin D supplementation after total thyroidectomy. Vitamin D 91-100 parathyroid hormone Homo sapiens 27-46 21181400-10 2011 In conclusion, PTH levels in the upper part or above the upper level of the reference interval increase risk of fracture in the presence of low vitamin D levels. Vitamin D 144-153 parathyroid hormone Homo sapiens 15-18 21454240-2 2011 METHODS: A review of the literature was undertaken regarding the function and metabolism of vitamin D; the role of the vitamin D receptor and calcium-sensing receptor in the secretion of parathyroid hormone; and the contemporary research regarding the interaction of vitamin D and parathyroid hormone in patients with vitamin D deficiency, primary hyperparathyroidism, and secondary hyperparathyroidism. Vitamin D 119-128 parathyroid hormone Homo sapiens 187-206 21454240-2 2011 METHODS: A review of the literature was undertaken regarding the function and metabolism of vitamin D; the role of the vitamin D receptor and calcium-sensing receptor in the secretion of parathyroid hormone; and the contemporary research regarding the interaction of vitamin D and parathyroid hormone in patients with vitamin D deficiency, primary hyperparathyroidism, and secondary hyperparathyroidism. Vitamin D 119-128 parathyroid hormone Homo sapiens 187-206 21454240-3 2011 RESULTS: Over the last several years, great interest has been generated about the interaction of vitamin D and the parathyroid glands, gastrointestinal tract, kidney, and bone in relation to calcium and parathyroid hormone levels. Vitamin D 97-106 parathyroid hormone Homo sapiens 203-222 21454240-4 2011 Vitamin D has an important role in calcium and parathyroid hormone metabolism. Vitamin D 0-9 parathyroid hormone Homo sapiens 47-66 20683712-3 2011 Vitamin D supplementation was more effective than advised sunlight exposure in improving vitamin D status and lowering parathyroid hormone levels. Vitamin D 0-9 parathyroid hormone Homo sapiens 119-138 21500723-7 2011 The areas under the ROC curves showed the low accuracy of PTH (0.579), Alk-Ph (0.478), Ca (0.496), and P (0.406) in detecting subjects with a vitamin D concentration < 20 ng/mL. Vitamin D 142-151 parathyroid hormone Homo sapiens 58-61 21647319-4 2011 Therefore, vitamin D analogs have been developed, which suppress PTH secretion and synthesis with reduced calcemic and phosphatemic effects. Vitamin D 11-20 parathyroid hormone Homo sapiens 65-68 21287159-0 2011 Role of parathyroid hormone in bone fragility of postmenopausal women with vitamin D insufficiency. Vitamin D 75-84 parathyroid hormone Homo sapiens 8-27 21287159-1 2011 Vitamin D insufficiency is related to an increase in PTH, which might be critical for an increase in bone fragility. Vitamin D 0-9 parathyroid hormone Homo sapiens 53-56 21287159-9 2011 The proportion of subjects with prevalent fractures was significantly higher in the group with lower PTH and lower 25(OH)D than in the group with lower PTH and higher 25(OH)D or higher PTH and higher 25(OH)D. In conclusion, vitamin D insufficiency was found to be related to prevalent fracture risk independently of PTH. Vitamin D 224-233 parathyroid hormone Homo sapiens 101-104 21303875-8 2011 Urine calcium concentration was 26% lower and serum parathyroid hormone (PTH) was 27% higher in patients with vitamin D deficiency when compared with patients without vitamin D deficiency. Vitamin D 110-119 parathyroid hormone Homo sapiens 52-71 21164021-4 2011 Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene. Vitamin D 94-103 parathyroid hormone Homo sapiens 140-143 21164021-4 2011 Independent of changes in intestinal calcium absorption and serum calcium, 1alpha,25-dihydroxyvitamin D also represses the transcription of PTH by associating with the vitamin D receptor, which heterodimerizes with retinoic acid X receptors to bind vitamin D-response elements within the PTH gene. Vitamin D 94-103 parathyroid hormone Homo sapiens 288-291 21697621-0 2011 Vitamin D deficiency and seasonal and inter-day variation in circulating 25-hydroxyvitamin D and parathyroid hormone levels in indoor daytime workers: a longitudinal study. Vitamin D 0-9 parathyroid hormone Homo sapiens 97-116 21777017-0 2011 Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failure. Vitamin D 32-41 parathyroid hormone Homo sapiens 0-19 21489355-8 2011 RESULTS: Vitamin D supplementation for 12 months of osteoporosis and low bone mass therapy in children caused a statistically significant increase in concentrations of the hepatic metabolite of vitamin D and a significant reduction in serum PTH levels. Vitamin D 9-18 parathyroid hormone Homo sapiens 241-244 20556359-18 2011 CONCLUSION: Supplementation with higher vitamin D dosages (2,000-3,000 IU/day) is required to achieve a relevant increase of 25(OH)D and normalisation of PTH. Vitamin D 40-49 parathyroid hormone Homo sapiens 154-157 21777017-3 2011 This study was designed to examine determinants of the PTH response in the vitamin D insufficient CHF patients. Vitamin D 75-84 parathyroid hormone Homo sapiens 55-58 20688883-6 2010 RESULTS: Higher leptin levels were associated with higher PTH and lower vitamin D levels, and adjustment for vitamin D attenuated the association between leptin and PTH. Vitamin D 109-118 parathyroid hormone Homo sapiens 165-168 20688883-8 2010 Path analysis indicated that the association of leptin with PTH was mostly mediated through vitamin D, and that the association between leptin and bone turnover was independent of PTH and vitamin D. Vitamin D 92-101 parathyroid hormone Homo sapiens 60-63 20962148-9 2010 Daily supplementation with 25 mug vitamin D resulted in a mean increase in serum 25(OH)D of 13.3 nmol/L (P < 0.01) but a decrease in fractional Ca absorption of 8.3% (P < 0.05) and no significant change in fasting serum 1,25-dihydroxyvitamin D, parathyroid hormone, net Ca absorption, or Ca skeletal retention. Vitamin D 34-43 parathyroid hormone Homo sapiens 251-270 20850786-10 2010 One year following gastric bypass surgery, 20% of patients with elevated PTH levels had normal Vit D levels. Vitamin D 95-100 parathyroid hormone Homo sapiens 73-76 20094706-1 2010 UNLABELLED: Hypoparathyroidism, a disorder characterized by low parathyroid hormone (PTH), is generally treated with oral calcium and vitamin D supplementation. Vitamin D 134-143 parathyroid hormone Homo sapiens 85-88 20872152-10 2010 High-dose cholecalciferol is safe and effective in correcting vitamin D insufficiency and results in a significant reduction in PTH levels in vitamin D-insufficient children. Vitamin D 142-151 parathyroid hormone Homo sapiens 128-131 20736967-10 2010 A negative correlation between PTH and both dietary vitamin D (r=-0.46; P<0.01) and calcium intake (r =-0.41; P<0.001) was observed. Vitamin D 52-61 parathyroid hormone Homo sapiens 31-34 20736967-11 2010 CONCLUSIONS: The low calcium and vitamin D intake observed in short-stature children and adolescents was associated with biochemical results, and suggested that PTH and calcium excretion may be useful screening tests for evaluating dietary calcium and vitamin D. Vitamin D 33-42 parathyroid hormone Homo sapiens 161-164 20601288-1 2010 INTRODUCTION: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered. Vitamin D 44-53 parathyroid hormone Homo sapiens 125-144 20148911-1 2010 OBJECTIVE: To investigate the influence of vitamin D status on parathyroid hormone and bone mass after a 2-year supplementation of calcium alone. Vitamin D 43-52 parathyroid hormone Homo sapiens 63-82 20451678-10 2010 PTH response and phosphate status (above or below median level) correctly discriminated HF type in 73.8% of patients with vitamin D deficiency. Vitamin D 122-131 parathyroid hormone Homo sapiens 0-3 20631996-1 2010 While the effects of calcium, phosphorus intake, and vitamin D on parathyroid hormone (PTH) have been well studied, less is known about other factors that impact PTH. Vitamin D 53-62 parathyroid hormone Homo sapiens 66-85 20308769-0 2010 Impact of two regimens of vitamin D supplementation on calcium - vitamin D - PTH axis of schoolgirls of Delhi. Vitamin D 26-35 parathyroid hormone Homo sapiens 77-80 20308769-0 2010 Impact of two regimens of vitamin D supplementation on calcium - vitamin D - PTH axis of schoolgirls of Delhi. Vitamin D 65-74 parathyroid hormone Homo sapiens 77-80 20672993-0 2010 Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users. Vitamin D 32-41 parathyroid hormone Homo sapiens 54-73 20672993-2 2010 We aimed to examine the impact of vitamin D status and tenofovir (TDF) use on PTH levels among HIV-infected patients receiving combination antiretroviral therapy (cART). Vitamin D 34-43 parathyroid hormone Homo sapiens 78-81 20672993-6 2010 Among subjects with suboptimal vitamin D status, PTH values greater than or equal to the ULN (87 pg/ml) were more common among TDF users than nonusers: 41% versus 0% (p = 0.018); and median PTH was higher in TDF users: 80 pg/ml versus 55 pg/ml (p = 0.02). Vitamin D 31-40 parathyroid hormone Homo sapiens 49-52 20214677-7 2010 Patients in the vitamin D-deficient group had higher serum PTH levels than those in the vitamin D-sufficient group : 71 +/- 24 pg/mL vs. 52 +/- 18 pg/mL (P = 0.04). Vitamin D 16-25 parathyroid hormone Homo sapiens 59-62 20484452-0 2010 Predictors of vitamin D status and its association with parathyroid hormone in young New Zealand children. Vitamin D 14-23 parathyroid hormone Homo sapiens 56-75 20484452-2 2010 OBJECTIVES: We aimed to assess vitamin D status on the basis of 25(OH)D and its relation with parathyroid hormone (PTH) and to identify possible predictors of 25(OH)D status in young children living in a country with minimal vitamin D fortification. Vitamin D 31-40 parathyroid hormone Homo sapiens 94-113 20649764-8 2010 Early intervention with intravenous or pulse oral vitamin D therapy at serum iPTH <300 pg/mL can control serum phosphorus, calcium-phosphorus product, and PTH levels to the target ranges and slow the progression of secondary hyperparathyroidism. Vitamin D 50-59 parathyroid hormone Homo sapiens 78-81 20585188-4 2010 Some clinical studies clarified the improvement of reduction in PTH levels and achievement targets for serum calcium and phosphate levels by the combined therapy with cinacalcet and vitamin D sterols, such as OPTIMA or ACHIEVE study. Vitamin D 182-191 parathyroid hormone Homo sapiens 64-67 20214991-1 2010 Parathyroid hormone (PTH) is used as a marker of vitamin D (VD) status. Vitamin D 49-58 parathyroid hormone Homo sapiens 0-19 20214991-1 2010 Parathyroid hormone (PTH) is used as a marker of vitamin D (VD) status. Vitamin D 49-58 parathyroid hormone Homo sapiens 21-24 20102676-2 2010 The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. Vitamin D 75-84 parathyroid hormone Homo sapiens 175-194 20398761-4 2010 On the other hand, it is possible that, in some patients, a persistent vitamin D deficiency induces, in the long-term, an autonomous secretion of PTH (i.e. tertiary hyperparathyroidism). Vitamin D 71-80 parathyroid hormone Homo sapiens 146-149 20398761-6 2010 Finally, as many, otherwise normal, subjects with vitamin D insufficiency may have an increased serum PTH level we believe that those with vitamin D insufficiency should be excluded from a reference population for serum PTH levels. Vitamin D 50-59 parathyroid hormone Homo sapiens 102-105 20398761-6 2010 Finally, as many, otherwise normal, subjects with vitamin D insufficiency may have an increased serum PTH level we believe that those with vitamin D insufficiency should be excluded from a reference population for serum PTH levels. Vitamin D 139-148 parathyroid hormone Homo sapiens 102-105 20429698-14 2010 Higher levels of PTH in winter and the elderly may reflect an impaired vitamin D status that may affect calcium homeostasis and bone health. Vitamin D 71-80 parathyroid hormone Homo sapiens 17-20 20102676-2 2010 The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. Vitamin D 75-84 parathyroid hormone Homo sapiens 196-199 19934619-10 2010 The role of vitamin D deficiency, the most common cause of elevated PTH in the elderly, needs to be further investigated. Vitamin D 12-21 parathyroid hormone Homo sapiens 68-71 20054540-12 2010 CONCLUSIONS: Vitamin D(3) deficiency was associated with a higher preoperative PTH level and a greater risk of LOH after MIP. Vitamin D 13-22 parathyroid hormone Homo sapiens 79-82 20089790-1 2010 The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status. Vitamin D 44-53 parathyroid hormone Homo sapiens 106-125 20175051-0 2010 Vitamin D treatment in hemodialysis patients with low serum levels of parathyroid hormone: which is the best choice? Vitamin D 0-9 parathyroid hormone Homo sapiens 70-89 20056760-2 2010 DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a randomized, blinded, 3-month trial in vitamin D-deficient CKD stage 3 and 4 patients with parathyroid hormone (PTH) values above the Kidney Disease Outcomes Quality Initiative target, comparing cholecalciferol (4000 IU/d x 1 month, then 2000 IU/d; n = 22) to doxercalciferol (1 microg/d; n = 25). Vitamin D 104-113 parathyroid hormone Homo sapiens 156-175 20308705-1 2010 There is increasing evidence for health benefits accomplished by activated vitamin D through interaction with the vitamin D receptor (VDR) that go beyond calcium and bone homeostasis and regulation of parathyroid hormone (PTH) secretion. Vitamin D 75-84 parathyroid hormone Homo sapiens 201-220 19531669-9 2009 After the 12-month vitamin D(3) supplementation, there was a marked decrease in [Ca(2+)](i) [105 (103-112) nmol/l, P < 0.001 versus baseline], independently of the increase in 25(OH)D(3) or the decrease in PTH levels. Vitamin D 19-28 parathyroid hormone Homo sapiens 209-212 20508384-11 2010 Possibly, active vitamin D(3) attenuates the effect of elevated calcium on PTH N-terminal truncation in PHP Ib patients. Vitamin D 17-26 parathyroid hormone Homo sapiens 75-78 20639672-1 2010 Recent observational studies of patients with stage 3-5 chronic kidney disease (CKD) not undergoing dialysis have shown that even slight increases in parathyroid hormone (PTH) levels are associated with an increased cardiovascular risk, regardless of the serum levels of calcium and phosphorus and vitamin D therapy. Vitamin D 298-307 parathyroid hormone Homo sapiens 150-169 19666939-1 2009 BACKGROUND: Toddlers in Pune, India, accustomed to low dietary calcium intake but vitamin D replete have low serum ionised calcium and inappropriately raised serum inorganic phosphorus concentrations together with elevated serum parathyroid hormone (PTH) concentrations. Vitamin D 82-91 parathyroid hormone Homo sapiens 229-248 20505259-11 2010 The present study indicated that patients with vitamin D deficiency occasionally showed biochemical findings suggestive of PHP and that such patients could exhibit not only PHP type II pattern of response to exogenous PTH but also of type I pattern. Vitamin D 47-56 parathyroid hormone Homo sapiens 218-221 20505259-12 2010 Thus our clinical observation suggests the complexity of PTH resistance in vitamin D deficiency and underscores the importance of diet to prevent the disorder. Vitamin D 75-84 parathyroid hormone Homo sapiens 57-60 20508384-0 2010 The administration of an active vitamin D(3) analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type Ib patients. Vitamin D 32-41 parathyroid hormone Homo sapiens 109-128 20508384-2 2010 However, the effect of active vitamin D(3) on PTH truncations remains controversial. Vitamin D 30-39 parathyroid hormone Homo sapiens 46-49 19151911-3 2009 With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was observed. Vitamin D 14-23 parathyroid hormone Homo sapiens 64-67 19821446-1 2009 BACKGROUND: Vitamin D compounds are used to suppress elevated serum parathyroid hormone (PTH) in people with chronic kidney disease (CKD). Vitamin D 12-21 parathyroid hormone Homo sapiens 68-87 19821446-1 2009 BACKGROUND: Vitamin D compounds are used to suppress elevated serum parathyroid hormone (PTH) in people with chronic kidney disease (CKD). Vitamin D 12-21 parathyroid hormone Homo sapiens 89-92 19821446-11 2009 Vitamin D compounds significantly lowered serum PTH (4 studies, 153 patients: MD -49.34 pg/mL, 95% CI -85.70 to -12.97 (-5.6 pmol/L, 95% CI -9.77 to -1.48)) and were more likely to reduce serum PTH > 30% from baseline value (264 patients: RR 7.87, 95% CI 4.87 to 12.73). Vitamin D 0-9 parathyroid hormone Homo sapiens 48-51 19821446-11 2009 Vitamin D compounds significantly lowered serum PTH (4 studies, 153 patients: MD -49.34 pg/mL, 95% CI -85.70 to -12.97 (-5.6 pmol/L, 95% CI -9.77 to -1.48)) and were more likely to reduce serum PTH > 30% from baseline value (264 patients: RR 7.87, 95% CI 4.87 to 12.73). Vitamin D 0-9 parathyroid hormone Homo sapiens 194-197 19821446-15 2009 While vitamin D compounds reduce serum PTH (49.3 pg/mL (5.6 pmol/L)) compared with placebo, the relative clinical benefits of PTH lowering versus treatment-related increases in serum phosphorus and calcium remain to be understood. Vitamin D 6-15 parathyroid hormone Homo sapiens 39-42 19763373-0 2009 Elevated serum PTH is independently associated with poor outcomes in older patients with hip fracture and vitamin D inadequacy. Vitamin D 106-115 parathyroid hormone Homo sapiens 15-18 19340862-1 2009 BACKGROUND: The aim of this study was to investigate vitamin D deficiency as an etiology for patients with elevated parathormone (PTH) levels after parathyroidectomy. Vitamin D 53-62 parathyroid hormone Homo sapiens 130-133 19821349-1 2009 BACKGROUND: Clinical guidelines recommend vitamin D compounds to suppress serum parathyroid hormone (PTH) in chronic kidney disease (CKD), however treatment may be associated with increased serum phosphorus and calcium, which are associated with increased mortality in observational studies. Vitamin D 42-51 parathyroid hormone Homo sapiens 80-99 19151911-12 2009 RESULTS: Vitamin D insufficiency (<50 nmol/L) was observed in 85% of expeditioners by 6 months when serum calcium decreased and PTH increased (p < 0.01). Vitamin D 9-18 parathyroid hormone Homo sapiens 131-134 19883895-7 2009 PTH showed a positive correlation with weight (r = 0.362, p = 0.03), lean mass (r = 0.372, p = 0.039), and a negative association with plasma concentrations of calcium (r = -0.48, p = 0.003) and 25(OH) vitamin D (r = -0.44, p = 0.014). Vitamin D 202-211 parathyroid hormone Homo sapiens 0-3 19473453-0 2009 Low parathyroid hormone levels in bedridden geriatric patients with vitamin D deficiency. Vitamin D 68-77 parathyroid hormone Homo sapiens 4-23 19301038-2 2009 However, the effect of chronic calcium changes and different vitamin D doses on these PTH measurements remains to be defined. Vitamin D 61-70 parathyroid hormone Homo sapiens 86-89 19403634-6 2009 Vitamin D supplementation (without calcium) significantly lowered circulating PTH (WMD: -0.29 pmol/L; 95% CI: -0.56, -0.02; 11 RCTs; I2 = 29%), but this was not apparent in the presence of calcium supplementation. Vitamin D 0-9 parathyroid hormone Homo sapiens 78-81 19403634-10 2009 Further research is needed to clarify which population subgroups show responses of PTH, BMD, and/or calcium absorption in response to changes in vitamin D status. Vitamin D 145-154 parathyroid hormone Homo sapiens 83-86 19473635-1 2009 BACKGROUND: Falecalcitriol is a novel vitamin D analog, which has a greater potential to suppress parathyroid hormone (PTH) and a longer half-life. Vitamin D 38-47 parathyroid hormone Homo sapiens 98-117 19473635-1 2009 BACKGROUND: Falecalcitriol is a novel vitamin D analog, which has a greater potential to suppress parathyroid hormone (PTH) and a longer half-life. Vitamin D 38-47 parathyroid hormone Homo sapiens 119-122 19473453-9 2009 PTH remained within reference values even after 6 months in 76.2% of the patients with persistent vitamin D deficiency in the placebo group. Vitamin D 98-107 parathyroid hormone Homo sapiens 0-3 19473453-1 2009 OBJECTIVES: To identify the clinical conditions associated with low parathyroid hormone (PTH) in patients with vitamin D deficiency and to evaluate the stability of the blunted PTH response to vitamin D deficiency over 6 months. Vitamin D 111-120 parathyroid hormone Homo sapiens 68-87 19473453-1 2009 OBJECTIVES: To identify the clinical conditions associated with low parathyroid hormone (PTH) in patients with vitamin D deficiency and to evaluate the stability of the blunted PTH response to vitamin D deficiency over 6 months. Vitamin D 111-120 parathyroid hormone Homo sapiens 89-92 19473453-1 2009 OBJECTIVES: To identify the clinical conditions associated with low parathyroid hormone (PTH) in patients with vitamin D deficiency and to evaluate the stability of the blunted PTH response to vitamin D deficiency over 6 months. Vitamin D 193-202 parathyroid hormone Homo sapiens 177-180 19188028-1 2009 There is suggestive evidence that chronic elevations of parathyroid hormone (PTH), associated with poor vitamin D status or low calcium intake, can increase risk for insulin resistance, weight gain, hypertension, and left ventricular hypertrophy, while stimulating production of acute phase reactants. Vitamin D 104-113 parathyroid hormone Homo sapiens 56-75 19213756-0 2009 Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. Vitamin D 21-30 parathyroid hormone Homo sapiens 44-63 19213756-1 2009 AIM: The aim of this study was to test the hypothesis that vitamin D deficiency is associated with abnormal levels of calcium and parathyroid hormone (PTH). Vitamin D 59-68 parathyroid hormone Homo sapiens 130-149 19213756-1 2009 AIM: The aim of this study was to test the hypothesis that vitamin D deficiency is associated with abnormal levels of calcium and parathyroid hormone (PTH). Vitamin D 59-68 parathyroid hormone Homo sapiens 151-154 19241329-2 2009 We hypothesized whether the cyclic course of vitamin D levels can be modelled with sunshine duration and would affect parathyroid hormone concentrations, but not calcium in a large patient population. Vitamin D 45-54 parathyroid hormone Homo sapiens 118-137 19129794-5 2009 Both 1,25(OH)(2) vitamin D and fibroblast growth factor 23 inhibit PTH gene expression and secretion. Vitamin D 17-26 parathyroid hormone Homo sapiens 67-70 19188028-1 2009 There is suggestive evidence that chronic elevations of parathyroid hormone (PTH), associated with poor vitamin D status or low calcium intake, can increase risk for insulin resistance, weight gain, hypertension, and left ventricular hypertrophy, while stimulating production of acute phase reactants. Vitamin D 104-113 parathyroid hormone Homo sapiens 77-80 18243368-0 2009 Responses of parathyroid hormone to vitamin D supplementation: a systematic review of clinical trials. Vitamin D 36-45 parathyroid hormone Homo sapiens 13-32 19019181-0 2009 Factors associated with elevated or blunted PTH response in vitamin D insufficient adults. Vitamin D 60-69 parathyroid hormone Homo sapiens 44-47 19019181-1 2009 OBJECTIVES: The purpose of this study was to examine factors associated with high or low parathyroid hormone (PTH) levels in relationship to vitamin D insufficiency. Vitamin D 141-150 parathyroid hormone Homo sapiens 89-108 19019181-1 2009 OBJECTIVES: The purpose of this study was to examine factors associated with high or low parathyroid hormone (PTH) levels in relationship to vitamin D insufficiency. Vitamin D 141-150 parathyroid hormone Homo sapiens 110-113 18243368-2 2009 In this systematic review, we have analyzed the results of 52 clinical trials, including 72 intervention groups and 6290 patients, on vitamin D supplementation in order to evaluate the experimental evidence and the effects of age and chronic immobility on responses of parathyroid hormone (PTH). Vitamin D 134-143 parathyroid hormone Homo sapiens 269-288 18243368-7 2009 The vitamin D supplementation of the chronically immobile patients resulted in a smaller decrease in PTH levels (-8.4 vs. -17.4%, p<0.001) despite a larger increase in 25-OHD levels (187.2% vs. 109.8%, p<0.001). Vitamin D 4-13 parathyroid hormone Homo sapiens 101-104 18243368-9 2009 This meta-analysis shows that responses of PTH to vitamin D supplementation are not only determined by the baseline PTH levels and changes in vitamin D status, but also by age and mobility of the patients. Vitamin D 50-59 parathyroid hormone Homo sapiens 43-46 18243368-9 2009 This meta-analysis shows that responses of PTH to vitamin D supplementation are not only determined by the baseline PTH levels and changes in vitamin D status, but also by age and mobility of the patients. Vitamin D 50-59 parathyroid hormone Homo sapiens 116-119 18243368-9 2009 This meta-analysis shows that responses of PTH to vitamin D supplementation are not only determined by the baseline PTH levels and changes in vitamin D status, but also by age and mobility of the patients. Vitamin D 142-151 parathyroid hormone Homo sapiens 43-46 18243368-10 2009 Our results also suggest that PTH decreases quite linearly during vitamin D supplementation at any given 25-OHD level. Vitamin D 66-75 parathyroid hormone Homo sapiens 30-33 18243368-12 2009 In determining the sufficient doses of vitamin D supplementation and adequate 25-OHD levels, these confounding effects and the inter-individual variation in responses of PTH to vitamin D supplementation should be taken into account. Vitamin D 177-186 parathyroid hormone Homo sapiens 170-173 19492580-6 2009 The mother-infant pairs underwent concurrent clinical, biochemical and hormonal evaluation for calcium-vitamin D-PTH axis. Vitamin D 103-112 parathyroid hormone Homo sapiens 113-116 19371802-3 2009 Activated vitamin D, a hormone produced by the proximal convoluted tubule of the kidney, appears to have beneficial effects beyond suppressing parathyroid hormone (PTH). Vitamin D 10-19 parathyroid hormone Homo sapiens 143-162 19287183-3 2009 Vitamin D suppresses parathyroid hormone (PTH) secretion in part through its action on the vitamin D receptor. Vitamin D 0-9 parathyroid hormone Homo sapiens 21-40 19187564-12 2009 Randomized controlled clinical trials, including different therapeutic strategies to lower PTH, e.g. calcium/vitamin D supplementation and weight reduction, are necessary to explore any cause-and-effect relationship. Vitamin D 109-118 parathyroid hormone Homo sapiens 91-94 18957950-0 2009 Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift? Vitamin D 17-26 parathyroid hormone Homo sapiens 51-70 18463127-1 2008 AIMS: The purpose of this study was to assess the vitamin D status of children with renal disease attending the outpatient clinics of our tertiary nephrology centre, allowing us to determine the prevalence of vitamin D deficiency and study its relationship with glomerular filtration rate (GFR) and serum parathyroid hormone (PTH) concentration. Vitamin D 50-59 parathyroid hormone Homo sapiens 305-324 19668299-2 2009 Namely, the use of calcium- based binders in combination with vitamin D analogues, has been shown to lead to an over-suppression of parathyroid hormone (PTH) and development of low-bone turnover adynamic bone disease (ABD). Vitamin D 62-71 parathyroid hormone Homo sapiens 132-151 18518931-1 2008 AIM: Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency. Vitamin D 97-106 parathyroid hormone Homo sapiens 5-24 19040987-11 2008 Vit D status affects gland size and postoperative PTH elevation. Vitamin D 0-5 parathyroid hormone Homo sapiens 50-53 19235038-2 2009 The association between elevated parathyroid hormone (PTH) and low 25-hydroxyvitamin D (25-OH-VitD) in plasma is used to define vitamin D deficiency, yet their associated mechanistic pathways are unclear. Vitamin D 77-86 parathyroid hormone Homo sapiens 33-52 19098950-0 2008 Vitamin D insufficiency in New Zealanders during the winter is associated with higher parathyroid hormone concentrations: implications for bone health? Vitamin D 0-9 parathyroid hormone Homo sapiens 86-105 19098950-1 2008 BACKGROUND: Parathyroid hormone concentration (PTH) is elevated in vitamin D insufficiency and when prolonged, this condition leads to reduced bone mass and possibly osteoporosis. Vitamin D 67-76 parathyroid hormone Homo sapiens 12-31 19098950-1 2008 BACKGROUND: Parathyroid hormone concentration (PTH) is elevated in vitamin D insufficiency and when prolonged, this condition leads to reduced bone mass and possibly osteoporosis. Vitamin D 67-76 parathyroid hormone Homo sapiens 47-50 19098950-2 2008 The threshold of 25-hydroxyvitamin D above which PTH plateaus, is a criterion often used to define vitamin D adequacy. Vitamin D 27-36 parathyroid hormone Homo sapiens 49-52 19098950-3 2008 AIMS: To determine whether the higher rates of vitamin D inadequacy reported in the winter than summer months in New Zealand also result in higher PTH concentrations. Vitamin D 47-56 parathyroid hormone Homo sapiens 147-150 18928396-16 2008 Evaluation of 25(OH)D(3) and PTH levels, especially in NNRTI-treated and dark skinned HIV-1-infected patients, is necessary to detect and treat vitamin D deficiency early. Vitamin D 144-153 parathyroid hormone Homo sapiens 29-32 18852718-3 2008 Low serum vitamin D levels are common in the general population and cause a decline in calcium absorption, leading to low serum levels of ionized calcium, which in turn trigger the release of parathyroid hormone, promoting skeletal resorption and, eventually, bone loss or osteomalacia. Vitamin D 10-19 parathyroid hormone Homo sapiens 192-211 18616960-2 2008 Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than the native hormone are preferred therapies for secondary hyperparathyroidism. Vitamin D 0-9 parathyroid hormone Homo sapiens 54-57 25983966-4 2008 Recent studies showed that the combination of PEIT and intravenous vitamin D pulse therapy lead to reduce serum PTH level and calcium-phosphorus products in haemodialysis patients. Vitamin D 67-76 parathyroid hormone Homo sapiens 112-115 18689390-4 2008 The vitamin D biomarkers that have shown the most utility to date are the plasma concentration of 25-hydroxyvitamin D (supply), the plasma concentration of parathyroid hormone (function), and the presence or absence of rickets (outcome). Vitamin D 4-13 parathyroid hormone Homo sapiens 156-175 18463168-2 2008 Among nondialyzed patients with chronic kidney disease (CKD), oral activated vitamin D reduces parathyroid hormone levels, but the impact on clinical outcomes is unknown. Vitamin D 77-86 parathyroid hormone Homo sapiens 95-114 18239958-1 2008 UNLABELLED: As the serum calcium and glomerular filtration rate decreased, the proportion of active PTH(1-84) molecules in PTH immunoreactivity increased in serum from predialysis uremic patients, particularly those with vitamin D insufficiency. Vitamin D 221-230 parathyroid hormone Homo sapiens 100-103 18400938-4 2008 In a prospective cohort of non-Hispanic white (n = 5110), Hispanic white (n = 979), and black (n = 3214) incident hemodialysis patients, higher parathyroid hormone levels at baseline were the primary determinant of prescribing activated vitamin D therapy. Vitamin D 237-246 parathyroid hormone Homo sapiens 144-163 18400938-5 2008 Median parathyroid hormone was highest among black patients, who were most likely to receive activated vitamin D and at the highest dosage. Vitamin D 103-112 parathyroid hormone Homo sapiens 7-26 18289904-5 2008 PTH was moderately elevated and after 4 months of supplemental therapy with calcium and vitamin D, it decreased to the normal range. Vitamin D 88-97 parathyroid hormone Homo sapiens 0-3 18208576-2 2008 However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT). Vitamin D 50-59 parathyroid hormone Homo sapiens 30-33 18208576-3 2008 AIM: We compared indices of calcium homeostasis, bone metabolism and body composition in subjects with differential PTH responses to low vitamin D levels. Vitamin D 137-146 parathyroid hormone Homo sapiens 116-119 18208576-11 2008 CONCLUSIONS: Effects of vitamin D insufficiency on bone is associated with the PTH responses. Vitamin D 24-33 parathyroid hormone Homo sapiens 79-82 18310602-2 2008 The objective of the current study was to determine whether treatment with cinacalcet combined with low doses of vitamin D sterols improves control of both PTH and Ca x P among haemodialysis patients with secondary hyperparathyroidism (sHPT). Vitamin D 113-122 parathyroid hormone Homo sapiens 156-159 18519464-10 2008 The inverse relationship between 25-hydroxyvitamin D and parathyroid hormone levels suggests a physiologic impact of insufficient vitamin D levels that may contribute to low bone mass or worsen the primary bone disease. Vitamin D 43-52 parathyroid hormone Homo sapiens 57-76 18426835-14 2008 The long-term prognostic impact of vitamin D deficiency, the most common cause of elevated PTH levels in the elderly, remains to be investigated. Vitamin D 35-44 parathyroid hormone Homo sapiens 91-94 18239958-1 2008 UNLABELLED: As the serum calcium and glomerular filtration rate decreased, the proportion of active PTH(1-84) molecules in PTH immunoreactivity increased in serum from predialysis uremic patients, particularly those with vitamin D insufficiency. Vitamin D 221-230 parathyroid hormone Homo sapiens 123-126 18239958-8 2008 CONCLUSION: As GFR declined with suppression of serum Ca, the proportion of active PTH molecules increased in predialysis CRF patients, particularly those with vitamin D insufficiency. Vitamin D 160-169 parathyroid hormone Homo sapiens 83-86 18560026-6 2008 RESULTS: vitamin D inadequacy was found in 61.9% of patients and 34.6% of them or 23.8% of total patients were also having high PTH level. Vitamin D 9-18 parathyroid hormone Homo sapiens 128-131 18304585-0 2008 Predominant role of 25OHD in the negative regulation of PTH expression: clinical relevance for hypovitaminosis D. Although severe deficiency of bioactive vitamin D (1,25OH2D) causes rickets, mild insufficiency of the hormone, known as hypovitaminosis D, is responsible for the occurrence of secondary hyperparathyroidism and osteoporosis. Vitamin D 154-163 parathyroid hormone Homo sapiens 56-59 18393917-3 2008 Treatment with calcitriol (CT), the active form of vitamin D, reduces parathyroid hormone (PTH) levels, but may result in elevations in serum calcium (Ca) and phosphorus (P), increasing the risk of cardio-vascular calcification in the HD population. Vitamin D 51-60 parathyroid hormone Homo sapiens 70-89 18393917-3 2008 Treatment with calcitriol (CT), the active form of vitamin D, reduces parathyroid hormone (PTH) levels, but may result in elevations in serum calcium (Ca) and phosphorus (P), increasing the risk of cardio-vascular calcification in the HD population. Vitamin D 51-60 parathyroid hormone Homo sapiens 91-94 18506273-0 2008 [Prevalence of vitamin D deficiency and its correlation with PTH, biochemical bone turnover markers and bone mineral density, among patients from ambulatories]. Vitamin D 15-24 parathyroid hormone Homo sapiens 61-64 18377338-3 2008 OBJECTIVE: Treatment with calcitriol, the active form of vitamin D, reduces serum parathyroid hormone (PTH) levels but may result in both hypercalcemia and hyperphosphatemia, increasing the risk of vascular calcification in CKD. Vitamin D 57-66 parathyroid hormone Homo sapiens 82-101 18304585-6 2008 These results suggest that the negative feedback regulation of vitamin D on PTH gene transcription occurs not by the end-product 1,25OH2D but by its prohormone 25OHD via intracellular activation by 1alpha-hydroxylase within the parathyroid cells. Vitamin D 63-72 parathyroid hormone Homo sapiens 76-79 18187872-6 2008 However, when subjects with the highest serum PTH levels (PTH>1000 pg/ml) were excluded from the analysis, the correlation was significant between serum 25(OH)D levels and PTH, indicating that vitamin D status affects the severity of pHPT when severe cases were excluded. Vitamin D 196-205 parathyroid hormone Homo sapiens 46-49 18238737-14 2008 Early detection of elevated PTH levels with appropriate intervention using active vitamin D therapy, even in the absence of elevated serum phosphorus and reduced serum calcium, is critical. Vitamin D 82-91 parathyroid hormone Homo sapiens 28-31 18241717-1 2008 OBJECTIVES: A 1-hour post-thyroidectomy parathyroid hormone (PTH) level of < or =8 ng/L is predictive of patients who will develop hypocalcemia and guides early supplementation with calcium and vitamin D. Vitamin D 197-206 parathyroid hormone Homo sapiens 40-59 17342165-0 2008 Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur. Vitamin D 0-9 parathyroid hormone Homo sapiens 42-61 18024243-8 2008 In 39 elderly osteoporotic women on a low calcium intake and given vitamin D supplements (2000-3000 IU daily for >8 months) able to increase 25(OH)D levels above 110 nMol/l, PTH levels were maintained below 35 pg/mL. Vitamin D 67-76 parathyroid hormone Homo sapiens 177-180 18227004-1 2008 The working group PTH-Vitamin D of the SFBC recently underlined the great intertechnic variability of parathormone (PTH) assays. Vitamin D 22-31 parathyroid hormone Homo sapiens 18-21 18227004-1 2008 The working group PTH-Vitamin D of the SFBC recently underlined the great intertechnic variability of parathormone (PTH) assays. Vitamin D 22-31 parathyroid hormone Homo sapiens 116-119 25983951-4 2008 However, doses of vitamin D sterols required to suppress parathyroid hormone (PTH) secretion often promote hypercalcaemia and hyperphosphataemia. Vitamin D 18-27 parathyroid hormone Homo sapiens 57-76 18816209-1 2008 BACKGROUND: A previous study using cinacalcet, as compared to vitamin D alone, showed a better reduction response of PTH levels and a significant diminution of secondary effects. Vitamin D 62-71 parathyroid hormone Homo sapiens 117-120 18087055-8 2007 Compared with placebo, established vitamin D sterols were associated with an increased risk for hypercalcemia (relative risk, 2.37 [95% CI, 1.16 to 4.85]) and hyperphosphatemia (relative risk, 1.77 [CI, 1.15 to 2.74]) but did not show a consistent reduction in parathyroid hormone (PTH) levels. Vitamin D 35-44 parathyroid hormone Homo sapiens 261-280 18259100-8 2008 Only 50.8% of the patients had received vitamin D(3) metabolites prior to the start of the study and at baseline they had higher i-PTH levels (600.3 +/- 360.5 vs. 489.9 +/- 292.6, p = 0.02). Vitamin D 40-49 parathyroid hormone Homo sapiens 131-134 18278205-7 2008 In pts with vitamin D deficiency the sensitivity of a (99m)Tc-MIBI SPECT study was lower than in those with normal vitamin D status (72% vs. 91%) and dependent on the value for PTH. Vitamin D 12-21 parathyroid hormone Homo sapiens 177-180 18087055-8 2007 Compared with placebo, established vitamin D sterols were associated with an increased risk for hypercalcemia (relative risk, 2.37 [95% CI, 1.16 to 4.85]) and hyperphosphatemia (relative risk, 1.77 [CI, 1.15 to 2.74]) but did not show a consistent reduction in parathyroid hormone (PTH) levels. Vitamin D 35-44 parathyroid hormone Homo sapiens 282-285 18087055-10 2007 For suppression of PTH, intravenous administration was superior to oral vitamin D, but higher intravenous doses were used. Vitamin D 72-81 parathyroid hormone Homo sapiens 19-22 17914135-5 2007 RESULTS: Vitamin D stores were inversely related gain in bone area (p < 0.002), BMC (p < 0.002) BMD (p < 0.027), as well as to PTH levels (p < 0.0001). Vitamin D 9-18 parathyroid hormone Homo sapiens 136-139 17908281-3 2007 This study aimed to determine vitamin D status after renal transplantation and its effect on parathyroid hormone (PTH) and bone mineral density (BMD). Vitamin D 30-39 parathyroid hormone Homo sapiens 93-112 18063090-2 2007 Vitamin D is a known inhibitor of PTH secretion and is associated with secondary HPT following adenoma resection. Vitamin D 0-9 parathyroid hormone Homo sapiens 34-37 18063090-12 2007 Vitamin D deficiency is associated with postoperative elevation of PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 67-70 17942777-3 2007 In normal animals and humans, factors such as phosphorus and vitamin D modify the basal parathyroid hormone level and the maximal parathyroid hormone response to hypocalcemia. Vitamin D 61-70 parathyroid hormone Homo sapiens 88-107 17942777-3 2007 In normal animals and humans, factors such as phosphorus and vitamin D modify the basal parathyroid hormone level and the maximal parathyroid hormone response to hypocalcemia. Vitamin D 61-70 parathyroid hormone Homo sapiens 130-149 17942777-7 2007 In three causes of secondary hyperparathyroidism--chronic kidney disease, vitamin D deficiency, and aging--factors that affect the dynamics of parathyroid hormone secretion are evaluated in detail. Vitamin D 74-83 parathyroid hormone Homo sapiens 143-162 17942777-8 2007 During recovery from vitamin D deficiency, the maximal parathyroid hormone remains elevated while the basal parathyroid hormone value rapidly becomes normal because of a shift in the set point of calcium. Vitamin D 21-30 parathyroid hormone Homo sapiens 55-74 17942777-8 2007 During recovery from vitamin D deficiency, the maximal parathyroid hormone remains elevated while the basal parathyroid hormone value rapidly becomes normal because of a shift in the set point of calcium. Vitamin D 21-30 parathyroid hormone Homo sapiens 108-127 17473068-9 2007 Vitamin D supplementation of both the proband and the baby resulted in reduction of serum PTH levels to the normal range. Vitamin D 0-9 parathyroid hormone Homo sapiens 90-93 17699936-1 2007 Vitamin D as a part of the endocrine system is an important component in the interaction between the kidney, bone, parathyroid hormone, and the intestine, which maintains extracellular calcium level within normal limits, in order to keep the vital physiologic process and skeletal integrity. Vitamin D 0-9 parathyroid hormone Homo sapiens 115-134 17351276-1 2007 OBJECTIVE: Accumulating research suggests low-circulating vitamin D concentrations, i.e., 25-hydroxyvitamin-D [25(OH)D], may be associated with an increased prevalence of metabolic syndrome; however, previous studies have not accounted for parathyroid hormone (PTH) levels. Vitamin D 58-67 parathyroid hormone Homo sapiens 240-259 17595934-11 2007 Our data implies that enhancing vitamin-D nutrition resulting in lower serum PTH levels could potentially influence their peak bone mass. Vitamin D 32-41 parathyroid hormone Homo sapiens 77-80 17605511-11 2007 Medical management of the PTH/vitamin D/calcium and phosphorus imbalances in SHPT focus on regulating PTH levels via vitamin D therapy. Vitamin D 30-39 parathyroid hormone Homo sapiens 102-105 17605511-11 2007 Medical management of the PTH/vitamin D/calcium and phosphorus imbalances in SHPT focus on regulating PTH levels via vitamin D therapy. Vitamin D 117-126 parathyroid hormone Homo sapiens 26-29 17605511-11 2007 Medical management of the PTH/vitamin D/calcium and phosphorus imbalances in SHPT focus on regulating PTH levels via vitamin D therapy. Vitamin D 117-126 parathyroid hormone Homo sapiens 102-105 17547711-2 2007 Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels. Vitamin D 16-25 parathyroid hormone Homo sapiens 79-98 17547711-2 2007 Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels. Vitamin D 16-25 parathyroid hormone Homo sapiens 100-103 17471001-1 2007 It is well known that vitamin D deficiency and associated elevation of parathyroid hormone (PTH) are common in general population. Vitamin D 22-31 parathyroid hormone Homo sapiens 71-90 17277339-11 2007 CONCLUSIONS: In summary, the combination of cinacalcet and low doses of vitamin D improved significantly the control of PTH and Ca x P in patients with severe secondary hyperparathyroidism on chronic haemodialysis, without adverse effects and with lower doses of phosphate binders. Vitamin D 72-81 parathyroid hormone Homo sapiens 120-123 17122955-0 2007 Calcium-PTH-vitamin D axis in older patients with hip fracture. Vitamin D 12-21 parathyroid hormone Homo sapiens 8-11 17368185-9 2007 Combining these agents with higher doses of vitamin D compounds may achieve greater suppression of PTH and possibly enhance survival in patients with chronic kidney disease. Vitamin D 44-53 parathyroid hormone Homo sapiens 99-102 17302875-4 2007 PATIENTS AND METHODS: Effects of vitamin D analogues and ketoconazole on parathyroid hormone (PTH) secretion (radioimmunoassay) and PTH mRNA expression (reverse transcription-polymerase chain reaction) were studied in primary bovine parathyroid cells. Vitamin D 33-42 parathyroid hormone Homo sapiens 73-92 17368185-5 2007 Vitamin D analogs that inhibit PTH gene transcription and parathyroid hyperplasia, and that have less calcemic activity than 1alpha,25(OH)(2)D(3,) have provided a greater safety margin for the treatment of 2 degrees HPT, as well as enhancing the survival of CKD patients. Vitamin D 0-9 parathyroid hormone Homo sapiens 31-34 17339744-2 2007 In developing these guidelines, the K/DOQI apparently considered the recently established fact that control of Ca, P and PTH influences not only the development of bone lesions but also patient prognostic factors such as arteriosclerosis, ectopic calcification, and cardiovascular complications, as well as the development of various vitamin D products and analogues and new P adsorbents. Vitamin D 334-343 parathyroid hormone Homo sapiens 121-124 17443033-1 2007 BACKGROUND: In hemodialysis patients, adynamic bone disease has been reported to be closely associated with low levels of parathyroid hormone (PTH) due to exposure to high levels of serum calcium following the administration of calcium carbonate (CaCO3) or vitamin D agents. Vitamin D 257-266 parathyroid hormone Homo sapiens 122-141 17237840-5 2007 Vitamin D analogs that inhibit PTH gene transcription and parathyroid hyperplasia (and have reduced calcemic activity) are a safer treatment for secondary hyperparathyroidism than calcitriol; these agents enhance the survival of patients with CKD. Vitamin D 0-9 parathyroid hormone Homo sapiens 31-34 17237840-8 2007 The risk of hypercalcemia with vitamin D analog therapy is reduced by the introduction of non-calcium-based phosphate binders and cinacalcet; furthermore, recent trials indicate that early intervention with vitamin D analogs in stage 3 and 4 CKD can correct PTH levels, and could prevent renal bone disease and prolong patient survival. Vitamin D 31-40 parathyroid hormone Homo sapiens 258-261 17237840-8 2007 The risk of hypercalcemia with vitamin D analog therapy is reduced by the introduction of non-calcium-based phosphate binders and cinacalcet; furthermore, recent trials indicate that early intervention with vitamin D analogs in stage 3 and 4 CKD can correct PTH levels, and could prevent renal bone disease and prolong patient survival. Vitamin D 207-216 parathyroid hormone Homo sapiens 258-261 17215573-0 2007 Impact of ergocalciferol treatment of vitamin D deficiency on serum parathyroid hormone concentrations in chronic kidney disease. Vitamin D 38-47 parathyroid hormone Homo sapiens 68-87 17003089-1 2006 CONTEXT: The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system"s antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas. Vitamin D 13-22 parathyroid hormone Homo sapiens 256-259 17890873-2 2007 BACKGROUND: Disturbances in mineral and vitamin D metabolism, which affect parathyroid hormone (PTH) synthesis, are well recognized in patients receiving dialysis. Vitamin D 40-49 parathyroid hormone Homo sapiens 75-94 17899431-4 2007 A number of therapies aimed at reducing PTH concentration are associated with an increase of calcaemia and Ca x P product, e.g. calcium-containing phosphate binders or active vitamin D. Vitamin D 175-184 parathyroid hormone Homo sapiens 40-43 17199880-12 2006 When the concentration of serum intact parathyroid hormone (PTH) was more than 200 pg/mL, the frequency of use of an orally administered vitamin D preparation decreased; but that of intravenous vitamin D preparation increased. Vitamin D 137-146 parathyroid hormone Homo sapiens 39-58 17199880-12 2006 When the concentration of serum intact parathyroid hormone (PTH) was more than 200 pg/mL, the frequency of use of an orally administered vitamin D preparation decreased; but that of intravenous vitamin D preparation increased. Vitamin D 194-203 parathyroid hormone Homo sapiens 39-58 16960175-1 2006 BACKGROUND: Optimal vitamin D status for the prevention of osteoporosis has been inferred from examinations of the serum 25-hydroxyvitamin D [25(OH)D] concentration below which there is an increase in serum parathyroid hormone (PTH). Vitamin D 20-29 parathyroid hormone Homo sapiens 207-226 21432355-5 2006 In young adults, a high intact PTH concentration due to vitamin D insufficiency, which adversely affects their bone mass, is common, suggesting that vitamin D nutrition, as well as dietary calcium intake, should be improved. Vitamin D 56-65 parathyroid hormone Homo sapiens 31-34 21432355-5 2006 In young adults, a high intact PTH concentration due to vitamin D insufficiency, which adversely affects their bone mass, is common, suggesting that vitamin D nutrition, as well as dietary calcium intake, should be improved. Vitamin D 149-158 parathyroid hormone Homo sapiens 31-34 16713028-7 2006 We have proposed that PTH reference values should be established in healthy subjects with a normal vitamin D status. Vitamin D 99-108 parathyroid hormone Homo sapiens 22-25 16644777-1 2006 BACKGROUND: Recent guidelines suggest supplementation with ergocalciferol (vitamin D(2)) in chronic kidney disease stages 3 and 4 patients with elevated parathyroid hormone (PTH) levels and 25-hydroxyvitamin D (25OHD) levels <75 nmol/l. Vitamin D 75-84 parathyroid hormone Homo sapiens 153-172 16644777-1 2006 BACKGROUND: Recent guidelines suggest supplementation with ergocalciferol (vitamin D(2)) in chronic kidney disease stages 3 and 4 patients with elevated parathyroid hormone (PTH) levels and 25-hydroxyvitamin D (25OHD) levels <75 nmol/l. Vitamin D 75-84 parathyroid hormone Homo sapiens 174-177 16563471-13 2006 Vitamin D supplementation to vitamin D-deficient elderly suppresses serum PTH, increases bone mineral density and may decrease fracture incidence especially in nursing home residents. Vitamin D 0-9 parathyroid hormone Homo sapiens 74-77 16563471-13 2006 Vitamin D supplementation to vitamin D-deficient elderly suppresses serum PTH, increases bone mineral density and may decrease fracture incidence especially in nursing home residents. Vitamin D 29-38 parathyroid hormone Homo sapiens 74-77 16868136-13 2006 CONCLUSION: In this material, low levels of 25OHD were related to higher levels of P-PTH and higher PTH:AW ratios in patients with PHPT suggesting that vitamin D deficiency increase PTH secretion activity. Vitamin D 152-161 parathyroid hormone Homo sapiens 100-103 17117291-7 2006 Serum PTH and bone markers are considerable higher in severely affected patients, who also have a high rate of vitamin D deficiency, and the parathyroid lesion is easier located compared with asymptomatic patients. Vitamin D 111-120 parathyroid hormone Homo sapiens 6-9 17117292-1 2006 The principal function of the parathyroid hormone (PTH) is maintenance of calcium plasmatic levels, withdrawing the calcium from bone tissue, reabsorbing it from the glomerular filtrate, and indirectly increasing its intestinal absorption by stimulating active vitamin D (calcitriol) production. Vitamin D 261-270 parathyroid hormone Homo sapiens 30-49 17117292-1 2006 The principal function of the parathyroid hormone (PTH) is maintenance of calcium plasmatic levels, withdrawing the calcium from bone tissue, reabsorbing it from the glomerular filtrate, and indirectly increasing its intestinal absorption by stimulating active vitamin D (calcitriol) production. Vitamin D 261-270 parathyroid hormone Homo sapiens 51-54 16884395-11 2006 Assay type, patient characteristics (race, underlying renal disease) and treatment attributes (vitamin D, corticosteroids, phosphate binders) have an impact on the PTH ratio, and care should be used in interpreting assay results and making subsequent treatment decisions. Vitamin D 95-104 parathyroid hormone Homo sapiens 164-167 17142943-1 2006 OBJECTIVE: To assess the effect of smoking and smoking cessation on bone density, bone remodeling markers, sex hormones, and vitamin D-PTH axis in healthy young subjects. Vitamin D 125-134 parathyroid hormone Homo sapiens 135-138 16807549-1 2006 Active vitamin D compounds repress parathyroid hormone (PTH) gene transcription and block chief cell hyperplasia, making them integral tools in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. Vitamin D 7-16 parathyroid hormone Homo sapiens 56-59 16901796-6 2006 These abnormalities were likely due to vitamin D deficiency, evidenced by a 25-hydroxyvitamin D level of 14 ng/mL, which provoked an elevation of the serum parathyroid hormone (PTH) concentration, documented by an intact PTH of 213 pg/mL (normal, 15 to 65) and a whole PTH (1-84 PTH) of 70.6 pg/mL (normal, 7 to 36). Vitamin D 39-48 parathyroid hormone Homo sapiens 156-175 17142943-7 2006 CONCLUSIONS: Tobacco increases bone resorption and affects bone mass by some alterations in sex hormone metabolism, but also importantly by alterations on the vitamin D-PTH axis. Vitamin D 159-168 parathyroid hormone Homo sapiens 169-172 16724654-2 2006 The vitamin D analog 19-Nor-1,25(OH)2-vitamin D2 (paricalcitol) and the prohormone 1alpha-OH-vitamin D2 (doxercalciferol) have been proposed as alternatives which may cause less hypercalcemia and elevated Ca x P, while still suppressing PTH. Vitamin D 4-13 parathyroid hormone Homo sapiens 237-240 16751687-5 2006 PTH also acts on renal tubule to promote urinary excretion of phosphate as well as production active vitamin D (1,25 [OH] 2D) . Vitamin D 101-110 parathyroid hormone Homo sapiens 0-3 16464653-9 2006 TM and TI patients with low 25-OH-vitamin D levels (<17.8 ng/ml) presented higher serum ferritin levels (P < 0.01) and higher PTH (P < 0.05) compared to those with normal vitamin D. Vitamin D 34-43 parathyroid hormone Homo sapiens 132-135 16217589-13 2006 SCI also leads to impaired calcium and phosphate metabolism and the parathyroid hormone (PTH)-vitamin D axis. Vitamin D 94-103 parathyroid hormone Homo sapiens 68-87 16789631-1 2006 In patients with pseudohypoparathyroidism, hormonal resistance first affects parathyroid hormone (PTH), which leads to calcipenia, a decrease in renal vitamin D activation, and a tendency to bone receptor remodeling. Vitamin D 151-160 parathyroid hormone Homo sapiens 77-96 16571177-10 2006 CONCLUSION: A high proportion of Irish postmenopausal women had low vitamin D status (<50 nmol l(-1)) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers. Vitamin D 68-77 parathyroid hormone Homo sapiens 180-183 16509457-0 2006 The impact of over-the-counter vitamin D supplements on vitamin D and parathyroid hormone levels in chronic kidney disease. Vitamin D 31-40 parathyroid hormone Homo sapiens 70-89 16509457-2 2006 The impact of supplementation with low-dose, nonactive forms of vitamin D (calciferol) on parathyroid hormone (PTH) levels in this population is unknown, however. Vitamin D 64-73 parathyroid hormone Homo sapiens 90-109 16596260-1 2006 The parathormone (PTH) production is controlled by calcium and vitamin D, which interact with the calcium-sensing receptor (CaSR) and vitamin D receptor (VDR), respectively. Vitamin D 63-72 parathyroid hormone Homo sapiens 18-21 16680589-21 2006 Adequate supplementation with calcium and vitamin D, often necessary after subtotal PTX to suppress inadequate PTH and protect from recurrence, will prevent severe hypocalcemia and with the modern aluminium-diminishing dialysis regimen, development of adynamic bone disease appears less likely than feared. Vitamin D 42-51 parathyroid hormone Homo sapiens 111-114 16310759-10 2006 Finally, we have proposed that PTH reference values should be established in healthy subjects with a normal vitamin D status. Vitamin D 108-117 parathyroid hormone Homo sapiens 31-34 16646366-6 2006 The secondary hyperparathyroidism characterized by an increase of PTH associated to a low vitamin D and a normal calcium, is quite frequent. Vitamin D 90-99 parathyroid hormone Homo sapiens 66-69 17002490-1 2006 black triangle An oral formulation of paricalcitol has been developed for the prevention and treatment of secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease.black triangle Paricalcitol is a synthetic vitamin D analog that binds to the vitamin D receptor inducing suppression of parathyroid hormone (PTH) secretion.black triangle Oral paricalcitol was significantly more effective than placebo in treating secondary hyperparathyroidism in patients with stage 3 or 4 chronic kidney disease. Vitamin D 232-241 parathyroid hormone Homo sapiens 310-329 16439822-14 2006 CONCLUSION: This study not only confirms previous reports that despite vitamin D food supplementation a vitamin D deficiency is still a finding in elderly population in the Northern hemisphere, but also that a compensatory change in PTH levels concurrently occurs with a potential significance on bone strength and risk of fractures. Vitamin D 104-113 parathyroid hormone Homo sapiens 233-236 16868704-2 2006 Parathyroid hormone (PTH) levels are affected by calcium, vitamin D, and phosphorus. Vitamin D 58-67 parathyroid hormone Homo sapiens 0-19 16868704-2 2006 Parathyroid hormone (PTH) levels are affected by calcium, vitamin D, and phosphorus. Vitamin D 58-67 parathyroid hormone Homo sapiens 21-24 16538874-4 2006 It is important to remember to reduce or discontinue any medication, whether it is vitamin D, a calcium salt, or any other agent that significantly lowers PTH, especially when intact PTH levels decline rapidly (to < 150 pg/mL) and serum calcium levels are higher than 10 mg/dL. Vitamin D 83-92 parathyroid hormone Homo sapiens 155-158 16393446-18 2006 Mean vitamin D levels in the 47 patients with PTH levels above the reference range were significantly lower than vitamin D levels in the 238 patients within the reference range for PTH: mean 31.1 nmol/L, SD = 21.1 versus mean 46.5 nmol/L, SD = 24.8 (p = 0.000092). Vitamin D 5-14 parathyroid hormone Homo sapiens 46-49 16439822-0 2006 Seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec. Vitamin D 37-46 parathyroid hormone Homo sapiens 85-104 16439822-2 2006 OBJECTIVE: To identify the variability and correlation between serum levels of vitamin D and PTH in a sample of community-dwelling elderly patients in the Province of Quebec, Canada, where vitamin D and calcium are supplemented in the food. Vitamin D 79-88 parathyroid hormone Homo sapiens 93-96 16439822-13 2006 These low levels of vitamin D corresponded with an inverse pattern in the levels of PTH more importantly in early spring. Vitamin D 20-29 parathyroid hormone Homo sapiens 84-87 16278362-0 2005 Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. Vitamin D 55-64 parathyroid hormone Homo sapiens 27-46 15928802-10 2005 However, after the threshold vitamin D level of 120 nmol/l, all PTH values were below 65 ng/l. Vitamin D 29-38 parathyroid hormone Homo sapiens 64-67 16368037-13 2005 Mean vitamin D levels in the 30 patients with parathyroid hormone (PTH) levels above the reference range were significantly lower than levels in the 71 patients within the range: mean 19.9 nmol/L, SD = 16.2 versus mean 37.5 nmol/L, SD = 18.5 (p < 0.0001). Vitamin D 5-14 parathyroid hormone Homo sapiens 46-65 16076940-1 2005 BACKGROUND: Evidence suggests that vitamin D status in adults, as assessed by serum 25-hydroxyvitamin D (25-OHD), is positively associated with calcium absorption fraction and inversely associated with serum PTH. Vitamin D 35-44 parathyroid hormone Homo sapiens 208-211 16160737-13 2005 These studies emphasize that much remains to be learned regarding the normal regulation of vitamin D metabolism and bone formation in response to PTH and PTHrP in humans. Vitamin D 91-100 parathyroid hormone Homo sapiens 146-149 16076940-8 2005 CONCLUSIONS: These data suggest that in adolescents, especially in the presence of vitamin D insufficiency, PTH secretion increases to adapt to higher rates of bone formation associated with growth. Vitamin D 83-92 parathyroid hormone Homo sapiens 108-111 16037412-10 2005 CONCLUSIONS: The results of the present study are in agreement with previous data supporting an association of increased PTH and decreased vitamin D metabolite concentrations with obesity. Vitamin D 139-148 parathyroid hormone Homo sapiens 121-124 16370566-1 2005 Vitamin D deficiency rickets occasionally resembles pseudohypoparathyroidism type II (PHP type II) with respect to the response to exogenous PTH in the presence of hypocalcemia. Vitamin D 0-9 parathyroid hormone Homo sapiens 141-144 15964254-16 2005 Given the poor vitamin D status of young Finnish men, intervention studies of vitamin D supplementation to lower serum PTH levels and to possibly reduce the incidence of stress fractures are warranted. Vitamin D 78-87 parathyroid hormone Homo sapiens 119-122 16272626-6 2005 It was possible to subdue the rise of intact PTH with vitamin D. Vitamin D 54-63 parathyroid hormone Homo sapiens 45-48 16299679-2 2005 Parathyroid hormone (PTH) gene expression and hormone secretion is regulated mainly by serum calcium, with a post-transcriptional effect, and by vitamin D with a transcriptional effect. Vitamin D 145-154 parathyroid hormone Homo sapiens 0-19 16299679-2 2005 Parathyroid hormone (PTH) gene expression and hormone secretion is regulated mainly by serum calcium, with a post-transcriptional effect, and by vitamin D with a transcriptional effect. Vitamin D 145-154 parathyroid hormone Homo sapiens 21-24 16229345-11 2005 Finally, PTH was inversely correlated with vitamin D intake and the animal/total calcium intake ratio (r = -0.18 and r = -0.22, p < 0.01), while no significant results were achieved for the vegetable calcium. Vitamin D 43-52 parathyroid hormone Homo sapiens 9-12 15551058-0 2005 Vitamin D status as the major factor determining the circulating levels of parathyroid hormone: a study in normal subjects. Vitamin D 0-9 parathyroid hormone Homo sapiens 75-94 15551058-9 2005 In subjects with vitamin D insufficiency (n = 53) [25(OH)D < 30 nmol/l], mean serum levels of parathyroid hormone were significantly higher (P < 0.001) than those in subjects of similar age with normal vitamin status (n = 209) with all the assays employed. Vitamin D 17-26 parathyroid hormone Homo sapiens 97-116 16076355-1 2005 Activated vitamin D continues to be the major treatment for suppressing parathyroid hormone (PTH) levels in dialysis patients who have secondary hyperparathyroidism. Vitamin D 10-19 parathyroid hormone Homo sapiens 72-91 15983179-8 2005 Baseline vitamin D intake was negatively associated with serum parathyroid hormone (r = -0.29, p <.0001), and not associated with bone mineral density or bone resorption. Vitamin D 9-18 parathyroid hormone Homo sapiens 63-82 15891005-4 2005 Treatment with active vitamin D can increase vitamin D receptor expression, inhibit growth of parathyroid tumors, and reduce PTH levels in patients with hyperparathyroidism (HPT). Vitamin D 22-31 parathyroid hormone Homo sapiens 125-128 15960864-0 2005 Vitamin D status and its relationship with parathyroid hormone and bone mineral status in older adolescents. Vitamin D 0-9 parathyroid hormone Homo sapiens 43-62 15730407-4 2005 Instead vitamin D insufficiency is defined as the lowest threshold value for plasma 25OHD (around 50 nmol/l) that prevents secondary hyperparathyroidism, increased bone turnover, bone mineral loss, or seasonal variations in plasma PTH. Vitamin D 8-17 parathyroid hormone Homo sapiens 231-234 15792756-0 2005 Intraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementation. Vitamin D 125-134 parathyroid hormone Homo sapiens 15-34 15730054-5 2005 Studies point to a prominent role of calcium, phosphate and vitamin D as regulators of PTH and parathyroid cell proliferation. Vitamin D 60-69 parathyroid hormone Homo sapiens 87-90 15698460-8 2005 Vitamin D was potentially underused in up to 34% of patients with high PTH, and overused in up to 46% of patients with low PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 71-74 15698460-8 2005 Vitamin D was potentially underused in up to 34% of patients with high PTH, and overused in up to 46% of patients with low PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 123-126 15868563-1 2005 BACKGROUND/PURPOSE: The aim of this study was to develop a surgically implantable controlled release delivery system for parathyroid hormone (PTH) that will maintain calcium homeostasis without the adverse side effects of long-term calcium and vitamin D replacement and can be used for the treatment of hypoparathyroidism. Vitamin D 244-253 parathyroid hormone Homo sapiens 121-140 15689574-1 2005 PTH is a major systemic regulator of the concentrations of calcium, phosphate, and active vitamin D metabolites in blood and of cellular activity in bone. Vitamin D 90-99 parathyroid hormone Homo sapiens 0-3 15733015-1 2005 Paricalcitol (Zemplar) is a synthetic vitamin D(2) analogue that inhibits the secretion of parathyroid hormone (PTH) through binding to the vitamin D receptor. Vitamin D 38-47 parathyroid hormone Homo sapiens 91-110 15733015-1 2005 Paricalcitol (Zemplar) is a synthetic vitamin D(2) analogue that inhibits the secretion of parathyroid hormone (PTH) through binding to the vitamin D receptor. Vitamin D 38-47 parathyroid hormone Homo sapiens 112-115 15297458-0 2004 Suppression of the human parathyroid hormone promoter by vitamin D involves displacement of NF-Y binding to the vitamin D response element. Vitamin D 57-66 parathyroid hormone Homo sapiens 25-44 15780503-10 2005 PTH secretion should be down-regulated by good vitamin D status -- achieved through supplementation or regular uv exposure -- and by vegan diets moderately low in bioavailable phosphate. Vitamin D 47-56 parathyroid hormone Homo sapiens 0-3 16050413-2 2005 In this second article we will analyze the new vitamin D analogs, capable of decreasing parathyroid hormone (PTH) levels with a lower effect on intestinal calcium and phosphorus absorption. Vitamin D 47-56 parathyroid hormone Homo sapiens 88-107 15175848-13 2005 We found that the widely used cutoff for vitamin D deficiency is associated with increasing PTH levels and is below the inflection point for a change in the slope of the regression line. Vitamin D 41-50 parathyroid hormone Homo sapiens 92-95 15531500-8 2004 Serum PTH appears to be associated with increased mortality in the frail elderly independent of vitamin D status, renal function, bone mass, and measures of general health. Vitamin D 96-105 parathyroid hormone Homo sapiens 6-9 15297458-0 2004 Suppression of the human parathyroid hormone promoter by vitamin D involves displacement of NF-Y binding to the vitamin D response element. Vitamin D 112-121 parathyroid hormone Homo sapiens 25-44 15297458-1 2004 An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex. Vitamin D 50-59 parathyroid hormone Homo sapiens 97-116 15297458-1 2004 An earlier report in the literature indicated the vitamin D response element (VDRE) in the human parathyroid hormone (hPTH) promoter could be specifically bound by an unidentified transcription factor in addition to the vitamin D receptor (VDR) complex. Vitamin D 50-59 parathyroid hormone Homo sapiens 118-122 15297458-8 2004 Furthermore, findings suggest that the repressive effects of vitamin D on hPTH gene transcription may involve displacement of NF-Y binding to the proximal site by the VDR heterodimer, which subsequently attenuates synergistic transactivation. Vitamin D 61-70 parathyroid hormone Homo sapiens 74-78 15334367-0 2004 Elevated serum parathyroid hormone concentration in eucalcemic patients after parathyroidectomy for primary hyperparathyroidism and its relationship to vitamin D profile. Vitamin D 152-161 parathyroid hormone Homo sapiens 15-34 15577115-2 2004 Vitamin D therapy brings about suppression of PTH and ameliorates oseitis fibrosa. Vitamin D 0-9 parathyroid hormone Homo sapiens 46-49 15577116-3 2004 There is a need to monitor serum corrected (ionized) calcium concentration and parathyroid hormone (PTH) in order to administer vitamin D and its analogues safely. Vitamin D 128-137 parathyroid hormone Homo sapiens 79-98 14730505-2 2004 Impaired production of 1,25-dihydroxyvitamin D (calcitriol), the hormonal form of vitamin D, is a major contributor to the generation and maintenance of parathyroid hyperplasia and increased synthesis and secretion of PTH. Vitamin D 37-46 parathyroid hormone Homo sapiens 218-221 15761507-0 2004 [Disturbances of calcium-PTH-vitamin D axis in chronic liver diseases]. Vitamin D 29-38 parathyroid hormone Homo sapiens 25-28 15761507-1 2004 Disturbances in Calcium-PTH-Vitamin D axis are frequently associated with chronic liver diseases (CLD). Vitamin D 28-37 parathyroid hormone Homo sapiens 24-27 15761507-4 2004 Therefore, other factors (i.e. inadequate diet, reduced exposure to sun light) would be responsible for the disturbances in calcium-PTH-vitamin D axis. Vitamin D 136-145 parathyroid hormone Homo sapiens 132-135 15761507-7 2004 Thus, the clinical relevance of calcium-PTH-vitamin D disturbances in hepatic osteodystrophy is still under discussion. Vitamin D 44-53 parathyroid hormone Homo sapiens 40-43 15296470-11 2004 Age, low calcium and vitamin D intakes were explanatory variables for serum PTH. Vitamin D 21-30 parathyroid hormone Homo sapiens 76-79 15323258-9 2004 Treatment with vitamin D pharmaceuticals was often limited by hyperphosphataemia, low PTH or hypercalinemia. Vitamin D 15-24 parathyroid hormone Homo sapiens 86-89 16819011-10 2004 Vitamin D insufficiency was seen among 14.5% of those participating according to traditional definition, but 50% were below [25(OH)D] of 45 nmol/l where negative correlation between [25(OH)D] and PTH became statistically significant. Vitamin D 0-9 parathyroid hormone Homo sapiens 196-199 15461740-2 2004 Data from the literature show that the majority of dialysis patients treated with traditional calcium-containing phosphorus binders and vitamin D or vitamin D analogue preparations have serum parathyroid hormone (PTH), calcium, and phosphorus levels outside these strict K/DOQI target ranges. Vitamin D 136-145 parathyroid hormone Homo sapiens 192-211 15461740-2 2004 Data from the literature show that the majority of dialysis patients treated with traditional calcium-containing phosphorus binders and vitamin D or vitamin D analogue preparations have serum parathyroid hormone (PTH), calcium, and phosphorus levels outside these strict K/DOQI target ranges. Vitamin D 149-158 parathyroid hormone Homo sapiens 192-211 15260882-13 2004 CONCLUSION: The highest AI for vitamin D brought summertime 25(OH)D to >40 nmol/L, lowered PTH, and its use was associated with improved wellbeing. Vitamin D 31-40 parathyroid hormone Homo sapiens 94-97 15070914-9 2004 Serum PTH is a predictor of time to first fall in the frail elderly independent of vitamin D status and measures of general health. Vitamin D 83-92 parathyroid hormone Homo sapiens 6-9 15576951-4 2004 Hypercalcemia, uncontrollable hyperphosphatemia, low ALP, and low PTH might impair the vitamin D introduction. Vitamin D 87-96 parathyroid hormone Homo sapiens 66-69 15576961-1 2004 Adequate intakes of calcium and vitamin D are necessary to prevent vitamin D deficiency or increase of plasma parathyroid hormone (PTH) level caused by vitamin D insufficiency. Vitamin D 32-41 parathyroid hormone Homo sapiens 110-129 15528944-0 2004 Intravenous vitamin D therapy reduces PTH-(1-84)/large C fragments ratio in chronic hemodialysis patients. Vitamin D 12-21 parathyroid hormone Homo sapiens 38-41 15528944-10 2004 CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy. Vitamin D 306-315 parathyroid hormone Homo sapiens 16-19 15528944-10 2004 CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy. Vitamin D 306-315 parathyroid hormone Homo sapiens 35-38 15528944-10 2004 CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy. Vitamin D 306-315 parathyroid hormone Homo sapiens 35-38 15528944-10 2004 CONCLUSION: The PTH-(1-84)/large C-PTH fragments ratio reflects the change of PTH biosynthesis, processing and secretion from the parathyroid glands, and it may be a beneficial marker to evaluate the overall biological PTH action and predict bone turnover status in hemodialysis patients under intravenous vitamin D therapy. Vitamin D 306-315 parathyroid hormone Homo sapiens 35-38 14531785-2 2003 The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH). Vitamin D 80-89 parathyroid hormone Homo sapiens 166-185 14531785-2 2003 The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH). Vitamin D 17-26 parathyroid hormone Homo sapiens 166-185 14531785-2 2003 The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH). Vitamin D 17-26 parathyroid hormone Homo sapiens 187-190 14531785-2 2003 The condition of vitamin D insufficiency is defined as the level of serum 25(OH)vitamin D at which vitamin D2 or D3 supplementation leads to a reduction of levels of parathyroid hormone (PTH). Vitamin D 80-89 parathyroid hormone Homo sapiens 187-190 14531785-6 2003 The actions of active vitamin D sterols to augment intestinal absorption of both calcium and phosphorus, the effect to reduce levels of PTH, and to be a factor contributing to the rising incidence of low bone turnover (adynamic bone) are discussed. Vitamin D 22-31 parathyroid hormone Homo sapiens 136-139 15012693-5 2003 To prevent hypercalcemia, non-calcium containing phosphorus binder (sevelamer hydrochloride) and vitamin D analogues, which suppress PTH secretion with minimum calcemic action, have been developed. Vitamin D 97-106 parathyroid hormone Homo sapiens 133-136 14592784-0 2003 PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Vitamin D 119-128 parathyroid hormone Homo sapiens 0-3 14592785-3 2003 Increased synthesis or intake of vitamin D can be expected to down-regulate parathyroid hormone (PTH), and to increase autocrine synthesis of its active metabolite calcitriol in certain tissues; these effects, in turn, may impact cancer risk, vascular health, immune regulation, and bone density through a variety of mechanisms. Vitamin D 33-42 parathyroid hormone Homo sapiens 76-95 14592785-3 2003 Increased synthesis or intake of vitamin D can be expected to down-regulate parathyroid hormone (PTH), and to increase autocrine synthesis of its active metabolite calcitriol in certain tissues; these effects, in turn, may impact cancer risk, vascular health, immune regulation, and bone density through a variety of mechanisms. Vitamin D 33-42 parathyroid hormone Homo sapiens 97-100 14592785-8 2003 An overview suggests that a vegan diet supplemented with high-dose vitamin D should increase both systemic and autocrine calcitriol production while suppressing PTH secretion, and thus should represent a highly effective way to achieve the wide-ranging health protection conferred by optimal UV exposure. Vitamin D 67-76 parathyroid hormone Homo sapiens 161-164 12753256-1 2003 1,25-dihydroxyvitamin D [1,25(OH)2D3], the hormonal form of vitamin D, controls serum levels of parathyroid hormone (PTH) and parathyroid hyperplasia. Vitamin D 14-23 parathyroid hormone Homo sapiens 96-115 12850281-4 2003 The human PTHrP gene contains a sequence element homologous to the negative vitamin D response element within the parathyroid hormone gene. Vitamin D 76-85 parathyroid hormone Homo sapiens 114-133 14666505-20 2003 The vitamin D dose should be proportional to PTH levels, with a larger dose given as a bolus (23 ug twice or three times per week). Vitamin D 4-13 parathyroid hormone Homo sapiens 45-48 12753273-4 2003 METHODS: This has led to the development of vitamin D analogs that retain the suppressive action on PTH and parathyroid gland growth, but that have less calcemic and phosphatemic activity. Vitamin D 44-53 parathyroid hormone Homo sapiens 100-103 12753256-1 2003 1,25-dihydroxyvitamin D [1,25(OH)2D3], the hormonal form of vitamin D, controls serum levels of parathyroid hormone (PTH) and parathyroid hyperplasia. Vitamin D 14-23 parathyroid hormone Homo sapiens 117-120 12637645-0 2003 Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone. Vitamin D 43-52 parathyroid hormone Homo sapiens 74-93 12692048-1 2003 BACKGROUND AND AIMS: Vitamin D deficiency is common in patients with small intestinal resection and may lead to secondary hypersecretion of parathyroid hormone (PTH), which in turn may result in increased bone turnover rate and loss of bone mineral. Vitamin D 21-30 parathyroid hormone Homo sapiens 140-159 12692048-1 2003 BACKGROUND AND AIMS: Vitamin D deficiency is common in patients with small intestinal resection and may lead to secondary hypersecretion of parathyroid hormone (PTH), which in turn may result in increased bone turnover rate and loss of bone mineral. Vitamin D 21-30 parathyroid hormone Homo sapiens 161-164 12692048-2 2003 The aims of this study were to investigate the prevalence of vitamin D deficiency, as assessed by low serum concentrations of 25-hydroxyvitamin D (25(OH)D) in patients with small intestinal resection and to explore the relation of 25(OH)D to PTH, markers of bone turnover rate, and bone mineral density (BMD) in these patients. Vitamin D 61-70 parathyroid hormone Homo sapiens 242-245 12692048-8 2003 Vitamin D deficiency (25(OH)D concentration </=8 ng/ml) was found in 38.1% of patients and was accompanied by raised concentrations of PTH and significantly increased markers of bone resorption (p<0.05). Vitamin D 0-9 parathyroid hormone Homo sapiens 138-141 12631365-1 2003 BACKGROUND: Management of secondary hyperparathyroidism has included the use of active vitamin D or vitamin D analogs for the suppression of parathyroid hormone (PTH) secretion. Vitamin D 87-96 parathyroid hormone Homo sapiens 141-160 12631365-1 2003 BACKGROUND: Management of secondary hyperparathyroidism has included the use of active vitamin D or vitamin D analogs for the suppression of parathyroid hormone (PTH) secretion. Vitamin D 100-109 parathyroid hormone Homo sapiens 141-160 12771290-2 2003 Effective clinical management includes measures to control phosphorus retention and prevent hyperphosphataemia, to maintain serum calcium concentrations within the normal range and to prevent excess parathyroid hormone (PTH) secretion by the judicious use of vitamin D sterols. Vitamin D 259-268 parathyroid hormone Homo sapiens 199-218 12730764-0 2003 Abnormalities of the PTH-vitamin D axis and bone turnover markers in children, adolescents and adults with cystic fibrosis: comparison with healthy controls. Vitamin D 25-34 parathyroid hormone Homo sapiens 21-24 12730772-0 2003 In a population study, can parathyroid hormone aid the definition of adequate vitamin D status? Vitamin D 78-87 parathyroid hormone Homo sapiens 27-46 12612963-4 2003 To prevent hypercalcemia, non-calcium-containing phosphorus binders and vitamin D analogues, which suppress parathyroid hormone (PTH) secretion with minimum calcemic action, have been developed. Vitamin D 72-81 parathyroid hormone Homo sapiens 108-127 18209441-1 2003 While the effects of vitamin D, one-alphahydroxycholecalciferol (alphacalcidol) administered intravenously on the serum levels of parathormone (PTH) and calcium in dialysis patients have been well studied in the past few years, no detailed studies were conducted in patients from this part of the world. Vitamin D 21-30 parathyroid hormone Homo sapiens 144-147 12587107-1 2003 The vitamin D(3) trial was a repeated measures randomized clinical trial for secondary hyperparathyroidism in haemodialysis patients where the efficacy of the vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups over 12 weeks. Vitamin D 4-13 parathyroid hormone Homo sapiens 215-234 12587107-1 2003 The vitamin D(3) trial was a repeated measures randomized clinical trial for secondary hyperparathyroidism in haemodialysis patients where the efficacy of the vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups over 12 weeks. Vitamin D 159-168 parathyroid hormone Homo sapiens 215-234 12612964-2 2003 Vitamin D analogues have been used successfully to reduce PTH levels, but increases in serum calcium, phosphorus, and calcium x phosphorus ion product levels may occur. Vitamin D 0-9 parathyroid hormone Homo sapiens 58-61 12778858-1 2003 As the chronic kidney disease patient is being managed for PTH, calcium, phosphate, vitamin D, calcium x phosphate product and bone quality an accurate PTH measurement is essential. Vitamin D 84-93 parathyroid hormone Homo sapiens 152-155 15775101-2 2003 Active vitamin D and these analogues influence the bone turnover in hemodialysis patients and recently we often encounter the patients whose bone turnover is not high in spite of high PTH level. Vitamin D 7-16 parathyroid hormone Homo sapiens 184-187 12616439-1 2003 We have previously shown that patients with elevated levels of parathyroid hormone (PTH) after surgery for parathyroid adenoma have normal parathyroid and renal function but demonstrate signs of remineralization of cortical bone, decreased calcium absorption, and low levels of vitamin D. Vitamin D 278-287 parathyroid hormone Homo sapiens 63-82 14763068-2 2003 Various active metabolites of vitamin D are used as oral treatment; however, in some patients, parathyroid hormone (PTH) is not ideally suppressed. Vitamin D 30-39 parathyroid hormone Homo sapiens 95-114 12468132-8 2002 This may suggests that widespread supplementation with calcium and vitamin D may be required in postmenopausal women for PTH suppression and preservation of bone mass. Vitamin D 67-76 parathyroid hormone Homo sapiens 121-124 12203199-3 2002 In recent decades, our understanding of the complex interactions between calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) has increased, resulting in a rational approach to therapy in which vitamin D analogs have become an essential component. Vitamin D 203-212 parathyroid hormone Homo sapiens 109-128 15775262-7 2002 The maintenance of normacalcemia and normophosphatemia are important for the arrival into the target zone of PTH using active vitamin D. Vitamin D 126-135 parathyroid hormone Homo sapiens 109-112 12376803-2 2002 Several advances have been made in the understanding of the pathogenesis of secondary hyperparathyroidism, particularly the critical roles of calcium, phosphorus, and vitamin D in promoting excess parathyroid hormone (PTH) synthesis and secretion, and parathyroid gland hyperplasia in renal failure. Vitamin D 167-176 parathyroid hormone Homo sapiens 197-216 12227689-3 2002 Recently, selective vitamin D analogs specifically designed to suppress parathyroid hormone (PTH) without causing hypercalcemia or hyperphosphatemia have shown promise for the treatment of secondary hyperparathyroidism in uremia. Vitamin D 20-29 parathyroid hormone Homo sapiens 72-91 12477579-1 2002 It is known that nursing-home patients with vitamin D insufficiency have elevated serum parathyroid hormone (PTH) as well as raised serum alkaline phosphatase (ALP). Vitamin D 44-53 parathyroid hormone Homo sapiens 88-107 12477579-1 2002 It is known that nursing-home patients with vitamin D insufficiency have elevated serum parathyroid hormone (PTH) as well as raised serum alkaline phosphatase (ALP). Vitamin D 44-53 parathyroid hormone Homo sapiens 109-112 12444900-2 2002 Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vitamin D receptor (VDR) is involved in regulation of the calcium homeostasis together with PTH. Vitamin D 7-16 parathyroid hormone Homo sapiens 166-169 12357732-2 2002 Vitamin D supplementation is necessary when the plasma level of 25-hydroxy-vitamin D is below 30 nmol/l (12 pg/l) in order to avoid any increase of the plasma parathyroid hormone level. Vitamin D 0-9 parathyroid hormone Homo sapiens 159-178 12203199-3 2002 In recent decades, our understanding of the complex interactions between calcium, phosphorus, vitamin D, and parathyroid hormone (PTH) has increased, resulting in a rational approach to therapy in which vitamin D analogs have become an essential component. Vitamin D 203-212 parathyroid hormone Homo sapiens 130-133 12203199-6 2002 The occurrence of significant hypercalcemia and hyperphosphatemia limiting their use has led to the development of alternative vitamin D analogs that effectively reduce PTH secretion without causing these complications. Vitamin D 127-136 parathyroid hormone Homo sapiens 169-172 12203203-3 2002 Effective medical strategies to reduce PTH secretion and PTH-mediated bone turnover in sHPT (eg, controlling hyperphosphatemia, normalizing serum calcium, and administering vitamin D analogs) has decreased the need for parathyroidectomy in recent years. Vitamin D 173-182 parathyroid hormone Homo sapiens 57-60 12386263-2 2002 Vitamin D levels decline in the early phase of renal failure, however, through a compensatory mechanism parathyroid hormone (PTH) stimulates the production of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), calcitriol) to return it to normal circulating concentrations. Vitamin D 0-9 parathyroid hormone Homo sapiens 125-128 12132525-0 2002 Isolated adrenocorticotropin deficiency presenting with impaired renin-angiotensin-aldosterone system and suppressed parathyroid hormone-vitamin D axis. Vitamin D 137-146 parathyroid hormone Homo sapiens 117-136 12132525-2 2002 She presented impaired renin-angiotensin-aldosterone (R-A-A) system and suppressed parathyroid hormone (PTH)-vitamin D system. Vitamin D 109-118 parathyroid hormone Homo sapiens 83-102 12077733-2 2002 In patients with humoral hypercalcemia of malignancy (HHM), it has been reported that plasma parathyroid hormone-related protein (PTHrP) and cyclic adenosine monophosphate (cAMP) levels were elevated, while plasma PTH and active vitamin D(3) levels were suppressed. Vitamin D 229-238 parathyroid hormone Homo sapiens 130-133 12046038-9 2002 Time-dependent PTH levels were associated directly with duration of dialysis therapy and use of vitamin D and phosphate and albumin levels, but inversely with age and ionized calcium and magnesium levels (but not glucose or HbA1c levels). Vitamin D 96-105 parathyroid hormone Homo sapiens 15-18 15775355-2 2002 In addition to the classic stimuli of PTH secretion such as hypocalcemia and decreased production of active vitamin D, new mechanisms has been suggested. Vitamin D 108-117 parathyroid hormone Homo sapiens 38-41 11912261-1 2002 Treatment with vitamin D sterols can lower plasma parathyroid hormone (PTH) in many patients with secondary hyperparathyroidism due to end-stage renal disease, but hypercalcemia, hyperphosphatemia, or both often develop during treatment. Vitamin D 15-24 parathyroid hormone Homo sapiens 50-69 12027147-7 2002 RESULTS: A significant difference was observed between the calcium-vitamin D (CaD) and the calcium (Ca) only groups for changes occurring during the 90 days of the study in PTH (-14.5+/-40% and +2.5+/-46%) (p=0.009) and 25(OH)D (+67+/-77% and +18+/-55%) (p<0.001) circulating levels. Vitamin D 67-76 parathyroid hormone Homo sapiens 173-176 12112013-1 2002 Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. Vitamin D 240-249 parathyroid hormone Homo sapiens 51-70 12386263-12 2002 1,25-dihydroxy-22-oxavitamin D(3) (22-oxacalcitriol, OCT) is a vitamin D analogue that could control serum PTH concentrations without deleterious effects on bone. Vitamin D 21-30 parathyroid hormone Homo sapiens 107-110 11994336-13 2002 5), the seasonal changes in vitamin D metabolism in elderly women are closely associated with small changes in serum PTH, changes in bone resorption, and BMD. Vitamin D 28-37 parathyroid hormone Homo sapiens 117-120 11738120-3 2001 The Vitamin D(3) Trial was a repeated-measures, randomized clinical trial for secondary hyperparathyroidism in hemodialysis patients in which the efficacy of vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups during dialysis over 12 weeks. Vitamin D 4-13 parathyroid hormone Homo sapiens 214-233 11770806-14 2001 As well as nutritional support, the new and recent therapeutic options in our team were: firstly, to avoid high doses of activated vitamin D to control PTH, as high doses are able to induce both a risk of adynamic bone disease and a direct bone cartilage toxicity: secondly, to maintain normal hemoglobin level; and thirdly, to deliver a high dialysis dose (urea, creatinine clearance) based on an individually adapted prescription. Vitamin D 131-140 parathyroid hormone Homo sapiens 152-155 11738120-3 2001 The Vitamin D(3) Trial was a repeated-measures, randomized clinical trial for secondary hyperparathyroidism in hemodialysis patients in which the efficacy of vitamin D(3) infusions for suppressing the secretion of parathyroid hormone (PTH) was compared among four dose groups during dialysis over 12 weeks. Vitamin D 158-167 parathyroid hormone Homo sapiens 214-233 11595067-0 2001 Calcium-parathyroid hormone-vitamin D axis and metabolic bone disease in chronic viral liver disease. Vitamin D 28-37 parathyroid hormone Homo sapiens 0-27 11846329-0 2001 Relationship between disease activity and serum levels of vitamin D metabolites and parathyroid hormone in ankylosing spondylitis. Vitamin D 58-67 parathyroid hormone Homo sapiens 84-103 11853285-4 2001 The active form of vitamin D benefits bone health by enhancing osteocalcin formation, in addition vitamin D has moderate antiresorption and suppression of PTH secretion. Vitamin D 98-107 parathyroid hormone Homo sapiens 155-158 11520426-0 2001 Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Vitamin D 0-9 parathyroid hormone Homo sapiens 130-149 11795018-15 2001 Only one patient has developed an exaggerated PTH response that has been controlled with oral vitamin D. Vitamin D 94-103 parathyroid hormone Homo sapiens 46-49 11470722-0 2001 Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Vitamin D 0-9 parathyroid hormone Homo sapiens 31-50 11470722-4 2001 OBJECTIVE: We studied the effect of vitamin D status on serum intact parathyroid hormone (iPTH) concentrations and bone metabolism in adolescents. Vitamin D 36-45 parathyroid hormone Homo sapiens 69-88 11271790-1 2001 AIMS: To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones. Vitamin D 216-225 parathyroid hormone Homo sapiens 167-186 11238511-24 2001 Treatment with vitamin D(3) and calcium increased serum 25OHD and decreased serum PTH significantly; the effect was greater for lower baseline serum 25OHD. Vitamin D 15-24 parathyroid hormone Homo sapiens 82-85 11158863-6 2001 The nephrology community is still waiting for the advent of nonhypercalcemic and nonhyperphosphatemic vitamin D analogs with PTH suppressive activity equal to the parent compound calcitriol or its immediate precursor, alfacalcidol. Vitamin D 102-111 parathyroid hormone Homo sapiens 125-128 11297596-8 2001 Compared with calcium, supplementation with vitamin D(3) and calcium resulted in an increase in serum 25OHD(3) of 72% (P < 0.01), a decrease in serum PTH of 17% (P = 0.04), a decrease in systolic blood pressure (SBP) of 9.3% (P = 0.02), and a decrease in heart rate of 5.4% (P = 0.02). Vitamin D 44-53 parathyroid hormone Homo sapiens 153-156 11297596-11 2001 Pearson coefficients of correlation between the change in PTH and the change in SBP were 0.49 (P < 0.01) for the vitamin D(3) plus calcium group and 0.23 (P < 0.01) for the calcium group. Vitamin D 116-125 parathyroid hormone Homo sapiens 58-61 11707147-4 2001 Administration of PTH in combination with antiresorptive agents such as estrogen, calcitonin, vitamin D and bisphosphonates augments its effect. Vitamin D 94-103 parathyroid hormone Homo sapiens 18-21 11271790-1 2001 AIMS: To investigate whether increasing the daily baseline of gut calcium can cause a gradual downregulation of the active intestinal transport of calcium via reduced parathyroid hormone (PTH) mediated activation of vitamin D, and to discuss why such a mechanism might prevent calcium oxalate rich stones. Vitamin D 216-225 parathyroid hormone Homo sapiens 188-191 11208041-3 2001 Two of these hormones, parathyroid hormone (PTH) and calcitriol (the active form of vitamin D), interact in multiple tissues in the body to regulate the flux of calcium and phosphorus between extra- and intracellular compartments. Vitamin D 84-93 parathyroid hormone Homo sapiens 23-42 10914987-6 2000 Administration of vitamin D metabolites constitutes the most promising form of prophylaxis and should be performed with monitoring of the PTH level to avoid adynamic bone disease. Vitamin D 18-27 parathyroid hormone Homo sapiens 138-141 10837301-0 2000 Vitamin D status: effects on parathyroid hormone and 1, 25-dihydroxyvitamin D in postmenopausal women. Vitamin D 0-9 parathyroid hormone Homo sapiens 29-48 11073568-1 2000 Chronic renal failure causes decreased vitamin D production, which profoundly alters parathyroid hormone (PTH) metabolism, and calcium and phosphorus balance. Vitamin D 39-48 parathyroid hormone Homo sapiens 85-104 11061498-5 2000 Our results suggest that coexistent vitamin D insufficiency can obscure the diagnosis of primary hyperparathyroidism and, when treated effectively, can result in substantial short-terms gains in BMD despite persistence of the inappropriate production of PTH. Vitamin D 36-45 parathyroid hormone Homo sapiens 254-257 10783492-0 2000 Parathyroid hormone may be a cancer promoter - an explanation for the decrease in cancer risk associated with ultraviolet light, calcium, and vitamin D. Vitamin D 142-151 parathyroid hormone Homo sapiens 0-19 10872194-2 2000 Although successful control of the parathyroid hormone (PTH) levels was achieved by treatment with vitamin D pulse therapy, the lesion progressed, invaded the maxillary sinus, and caused severe eating and speech disabilities. Vitamin D 99-108 parathyroid hormone Homo sapiens 35-54 10872194-2 2000 Although successful control of the parathyroid hormone (PTH) levels was achieved by treatment with vitamin D pulse therapy, the lesion progressed, invaded the maxillary sinus, and caused severe eating and speech disabilities. Vitamin D 99-108 parathyroid hormone Homo sapiens 56-59 10720039-9 2000 Suboptimal vitamin D nutrition stimulates parathyroid adenoma growth by a mechanism unrelated to hypocalcemia or 1,25-dihydroxyvitamin D deficiency and reduces the calcemic response to PTH, so that a higher PTH level and more parathyroid cells are needed to raise the patient"s serum calcium to the level corresponding to the increased set-point that is characteristic of the disease. Vitamin D 11-20 parathyroid hormone Homo sapiens 185-188 10720039-9 2000 Suboptimal vitamin D nutrition stimulates parathyroid adenoma growth by a mechanism unrelated to hypocalcemia or 1,25-dihydroxyvitamin D deficiency and reduces the calcemic response to PTH, so that a higher PTH level and more parathyroid cells are needed to raise the patient"s serum calcium to the level corresponding to the increased set-point that is characteristic of the disease. Vitamin D 11-20 parathyroid hormone Homo sapiens 207-210 10783492-3 2000 UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers. Vitamin D 23-32 parathyroid hormone Homo sapiens 73-92 10783492-3 2000 UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers. Vitamin D 23-32 parathyroid hormone Homo sapiens 94-97 10783492-3 2000 UV light, calcium, and vitamin D have the common property of suppressing parathyroid hormone (PTH) production; these considerations raise the possibility that PTH may have promotional activity for certain cancers. Vitamin D 23-32 parathyroid hormone Homo sapiens 159-162 11256894-8 2000 In summary, in this fairly vitamin D replete population with high calcium intake, PTH was negatively associated with total body BMD. Vitamin D 27-36 parathyroid hormone Homo sapiens 82-85 10633464-1 1999 Calcitriol, the most active metabolite of vitamin D, controls parathyroid gland growth and suppresses the synthesis and secretion of parathyroid hormone (PTH). Vitamin D 42-51 parathyroid hormone Homo sapiens 133-152 10602348-17 1999 The depression of the vitamin D-PTH system seen among smokers may represent another potential mechanism for the deleterious effects of smoking on the skeleton, and may contribute to the reported risk of osteoporosis among smokers. Vitamin D 22-31 parathyroid hormone Homo sapiens 32-35 10566687-8 1999 Since low concentrations of PTH are frequently associated with adynamic bone disease, our findings may have significant implications for the treatment of renal osteodystrophy with calcium and/or biologically active vitamin D analogs. Vitamin D 215-224 parathyroid hormone Homo sapiens 28-31 10485973-11 1999 Basal vitamin D status appeared to be a determinant of the degree of the PTH response in black women, with the peak PTH level being inversely correlated with levels of 25OHD. Vitamin D 6-15 parathyroid hormone Homo sapiens 73-76 10681663-0 1999 Transcriptional and post-transcriptional regulation of PTH gene expression by vitamin D, calcium and phosphate. Vitamin D 78-87 parathyroid hormone Homo sapiens 55-58 10356581-11 1999 Normalization of serum calcium by calcium substitution and vitamin D administration will normalize PTH and improve mineralization of the skeleton. Vitamin D 59-68 parathyroid hormone Homo sapiens 99-102 10222046-1 1999 A putative transcription factor binds a site adjacent to the negative vitamin D responsive element (VDRE) in the promoter region of the human parathyroid hormone gene. Vitamin D 70-79 parathyroid hormone Homo sapiens 142-161 10323401-1 1999 Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 68-71 10436401-12 1999 In conclusion, our data indicate that substitution with vitamin D(3) metabolites and calcium can prevent deleterious bone effects of hypoparathyroidism in hemodialysis patients and in patients with normal kidney function and may compensate for the missing PTH action. Vitamin D 56-65 parathyroid hormone Homo sapiens 256-259 10321413-4 1999 Paricalcitol is a new vitamin D analogue that is safe and effective in suppressing elevated concentrations of PTH in patients with established hyperparathyroidism who are maintained on chronic hemodialysis. Vitamin D 22-31 parathyroid hormone Homo sapiens 110-113 9808143-0 1998 Suppression of parathyroid hormone secretion in hemodialysis patients by a novel vitamin D analogue: 19-nor-1,25-dihydroxyvitamin D2. Vitamin D 81-90 parathyroid hormone Homo sapiens 15-34 10077002-1 1999 1 ,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] negatively regulates expression of the avian PTH (aPTH) gene transcript, and a vitamin D response element (VDRE) near the promoter of the aPTH gene had previously been identified. Vitamin D 15-24 parathyroid hormone Homo sapiens 86-89 9808145-2 1998 The treatment of this disorder with vitamin D compounds, such as calcitriol, although effective at suppressing parathyroid hormone (PTH) secretion, may promote the development of hypercalcemia and hyperphosphatemia, thus increasing the risk for metastatic calcification. Vitamin D 36-45 parathyroid hormone Homo sapiens 111-130 9792587-2 1998 The objective of this study was to determine the prevalence of bone hyperresorption and parathyroid hormone (PTH)-vitamin D axis abnormalities in these patients. Vitamin D 114-123 parathyroid hormone Homo sapiens 88-107 9697664-15 1998 This second generation vitamin D analog may have a wider therapeutic window than current vitamin D preparations, and thus may allow reduction in PTH with less hypercalcemia. Vitamin D 23-32 parathyroid hormone Homo sapiens 145-148 9718191-1 1998 The objective of this study was to compare the effect of ultraviolet radiation (UV) and oral vitamin D3 on the vitamin D status and parathyroid hormone (PTH) concentration in elderly nursing home patients. Vitamin D 93-102 parathyroid hormone Homo sapiens 132-151 9556566-1 1998 We found that the human parathyroid hormone-related peptide (hPTHrP) gene contained a DNA element (nVDREhPTHrP) homologous to a negative vitamin D response element in the human parathyroid hormone gene. Vitamin D 137-146 parathyroid hormone Homo sapiens 24-43 11490527-8 1998 Plasma PTH concentrations were negatively correlated to dialysis duration, and to plasma concentrations of aluminum, calcium and 25 OH vitamin D but not to those of phosphate and bicarbonate. Vitamin D 135-144 parathyroid hormone Homo sapiens 7-10 9525348-11 1998 In summary, the increase in serum PTH in the elderly can be explained more by changes in vitamin D status than by declining renal function. Vitamin D 89-98 parathyroid hormone Homo sapiens 34-37 9501950-0 1998 Relationship between disease activity and serum levels of vitamin D metabolites and PTH in rheumatoid arthritis. Vitamin D 58-67 parathyroid hormone Homo sapiens 84-87 9459385-0 1998 Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites. Vitamin D 20-29 parathyroid hormone Homo sapiens 71-90 9459385-1 1998 In this study, the effect of dietary calcium and vitamin D on serum parathyroid hormone and vitamin D metabolites was measured in 376 free-living women aged 65-77 y. Vitamin D 49-58 parathyroid hormone Homo sapiens 68-87 9459385-8 1998 Serum parathyroid hormone was inversely correlated with serum calcidiol (r = -0.33, P < 0.001) and the regression predicted that mean serum parathyroid hormone would be reduced in the elderly to concentrations considered normal in the young when serum calcidiol is 122 nmol/L (49 ng/mL); this would require a much higher recommended dietary allowance for vitamin D than 5 microg/d (200 IU/d). Vitamin D 358-367 parathyroid hormone Homo sapiens 6-25 9459385-8 1998 Serum parathyroid hormone was inversely correlated with serum calcidiol (r = -0.33, P < 0.001) and the regression predicted that mean serum parathyroid hormone would be reduced in the elderly to concentrations considered normal in the young when serum calcidiol is 122 nmol/L (49 ng/mL); this would require a much higher recommended dietary allowance for vitamin D than 5 microg/d (200 IU/d). Vitamin D 358-367 parathyroid hormone Homo sapiens 143-162 9509459-19 1998 Moreover, patients with low 25 (OH) vitamin D levels (n = 63) had significantly higher PTH concentrations (between 40 and 80 pg/ml, P < 0.01) throughout the study period compared to patients (n = 66) with a sufficient 25(OH)D supply irrespective of graft function. Vitamin D 36-45 parathyroid hormone Homo sapiens 87-90 9509459-25 1998 PTH is constantly elevated for up to 2 years after kidney transplantation and is most probably related (a) to impaired graft function and (b) to suboptimal 25 OH vitamin D supply. Vitamin D 162-171 parathyroid hormone Homo sapiens 0-3 9285381-2 1997 We hypothesized that magnesium deficiency alters vitamin D metabolism by decreasing parathyroid hormone (PTH) response, resulting in decreased serum osteocalcin and decreased bone accretion. Vitamin D 49-58 parathyroid hormone Homo sapiens 84-103 9792954-14 1998 These results indicate that 1,25(OH)2D3 upregulated PTH/PTHrP receptor expression at both mRNA and protein levels in a manner consistent with VDR/RXR heterodimers transactivating the PTH/PTHrP receptor gene by binding a vitamin D response element in the PTH/PTHrP gene. Vitamin D 220-229 parathyroid hormone Homo sapiens 52-55 9503046-7 1998 CONCLUSION: The use of both forms of vitamin D supplementation appears to be useful for patients with hypovitaminosis D, elevated PTH levels and high telopeptide excretion. Vitamin D 37-46 parathyroid hormone Homo sapiens 130-133 9260973-7 1997 This discussion presents the hypothesis that reduced epidermal vitamin D3 photosynthesis associated with high skin melanin content and/or decreased UV light intensity at distances from the equator, alone or when coupled with decreased dietary calcium and vitamin D, may be associated with reduced vitamin D stores and increased parathyroid hormone secretion. Vitamin D 63-72 parathyroid hormone Homo sapiens 328-347 9229185-4 1997 The decrease in circulating parathyroid hormone in osteoporotic patients treated with vitamin D reflects the success of the vitamin D treatment. Vitamin D 86-95 parathyroid hormone Homo sapiens 28-47 9229185-4 1997 The decrease in circulating parathyroid hormone in osteoporotic patients treated with vitamin D reflects the success of the vitamin D treatment. Vitamin D 124-133 parathyroid hormone Homo sapiens 28-47 9062528-9 1997 In contrast, neonates with subclinical vitamin D deficiency had normalized serum PTH within 1 mo only when they were given 1000 IU ergocalciferol (25 micrograms)/d in addition to their formula. Vitamin D 39-48 parathyroid hormone Homo sapiens 81-84 9143355-1 1997 The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes. Vitamin D 89-98 parathyroid hormone Homo sapiens 299-318 9143355-1 1997 The electrophoretic mobility shift assay was used to determine in vitro formation of the vitamin D receptor-retinoid X receptor beta (VDR-RXR beta) heterodimer complex on vitamin D-response elements (VDREs) from rat osteocalcin, mouse osteopontin, rat 25-hydroxyvitamin D3 24-hydroxylase, and human parathyroid hormone (PTH) genes. Vitamin D 89-98 parathyroid hormone Homo sapiens 320-323 9088064-4 1997 Based on histopathological and pathophysiological investigations, nodular hyperplasia is monoclonal neoplasia with abnormal parathyroid hormone (PTH) response to extracellular calcium and vitamin D. Vitamin D 188-197 parathyroid hormone Homo sapiens 124-143 8988915-1 1997 Wintertime declines in vitamin D lead to increased concentrations of parathyroid hormone (PTH) and accelerated bone loss in postmenopausal women. Vitamin D 23-32 parathyroid hormone Homo sapiens 69-88 8995749-2 1997 The safety and efficacy of the vitamin D analog, 1 alpha (OH)-vitamin D2, (1 alpha D2), which has less toxicity in animals than 1 alpha (OH)-vitamin D3, was tested in a multicenter study of 24 hemodialysis patients with secondary hyperparathyroidism [serum intact (i) PTH > 400 pg/ml]. Vitamin D 31-40 parathyroid hormone Homo sapiens 268-271 9030491-3 1997 Vitamin D supplementation in this age group improves calcium absorption, suppresses PTH, and decreases bone loss. Vitamin D 0-9 parathyroid hormone Homo sapiens 84-87 8835303-0 1995 Vitamin D-dependent seasonal variation of PTH in growing male adolescents. Vitamin D 0-9 parathyroid hormone Homo sapiens 42-45 8768839-9 1996 These results suggest a selective modulation by vitamin D of the renal response to PTH; 1,25-(OH)2D3 facilitates PTH-induced calcium and sodium reabsorption, but does not influence PTH-induced cAMP excretion; phosphorus, potassium, and bicarbonate tubular transport, or 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Vitamin D 48-57 parathyroid hormone Homo sapiens 83-86 8768839-9 1996 These results suggest a selective modulation by vitamin D of the renal response to PTH; 1,25-(OH)2D3 facilitates PTH-induced calcium and sodium reabsorption, but does not influence PTH-induced cAMP excretion; phosphorus, potassium, and bicarbonate tubular transport, or 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Vitamin D 48-57 parathyroid hormone Homo sapiens 113-116 8765644-17 1996 Children with <50 % of normal creatinine clearance should have PTH measured and activated vitamin D therapy should be started if PTH is elevated more than two to three times normal. Vitamin D 93-102 parathyroid hormone Homo sapiens 132-135 8842637-2 1996 The aim of this study was to evaluate the relation between maternal serum calcium and parathyroid hormone with reduced fetal growth in vitamin D deficient pregnant women. Vitamin D 135-144 parathyroid hormone Homo sapiens 86-105 8911879-4 1996 After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change. Vitamin D 110-119 parathyroid hormone Homo sapiens 70-73 8840332-2 1996 There is a search for other vitamin D sterols that suppress PTH but cause less hypercalcaemia. Vitamin D 28-37 parathyroid hormone Homo sapiens 60-63 9425501-6 1997 When the 25(OH)D concentration became equal to or lower than 11.3 nmol/l (4.6 ng/ml), the PTH values reached the upper limit of normal values (55 pg/ml) found in vitamin D replete subjects. Vitamin D 162-171 parathyroid hormone Homo sapiens 90-93 8772587-14 1996 The maintenance of PTH within the normal range for healthy adults by vitamin D and calcium treatment might constitute an approach for the prevention of bone loss in the entire aged population. Vitamin D 69-78 parathyroid hormone Homo sapiens 19-22 8883116-1 1996 Although vitamin D supplementation in the frail elderly improves calcium absorption, suppresses parathyroid hormone, decreases bone loss and reduces the risk of fractures, such treatment may be ineffective in patients with vertebral osteoporosis, because of impaired vitamin D metabolism or resistance to the action of vitamin D metabolites on the bowel. Vitamin D 9-18 parathyroid hormone Homo sapiens 96-115 8835303-13 1995 Modulation of PTH secretion by vitamin D appears to be a physiological mechanism occurring during adolescence. Vitamin D 31-40 parathyroid hormone Homo sapiens 14-17 8560596-12 1995 Since all of these patients have received vitamin D therapy for long periods, we suggest that vitamin D may have prevented the deleterious effect of PTH on myocardial function. Vitamin D 94-103 parathyroid hormone Homo sapiens 149-152 8748356-10 1995 CONCLUSIONS: In selected patients with depressed PTH levels, long-term withdrawal of vitamin D during HPN increases LSBMC and levels of PTH and 1,25(OH)2D. Vitamin D 85-94 parathyroid hormone Homo sapiens 49-52 8748356-10 1995 CONCLUSIONS: In selected patients with depressed PTH levels, long-term withdrawal of vitamin D during HPN increases LSBMC and levels of PTH and 1,25(OH)2D. Vitamin D 85-94 parathyroid hormone Homo sapiens 136-139 7714065-4 1995 The measurements were repeated in 283 women after 1 yr and in 248 women after 2 yr. Vitamin D supplementation significantly increased serum 25-hydroxyvitamin D (250HD) (+35 nmol/L) and 1,25-dehydroxyvitamin D [1,25-(OH)2D] (+7.0 pmol/L) levels and urinary calcium/creatinine ratios (+0.5%) and significantly decreased PTH(1-84) secretion (-0.74 pmol/L) after 1 yr. No effect was found for the parameters of bone turnover. Vitamin D 84-93 parathyroid hormone Homo sapiens 318-321 7751997-8 1995 During vitamin D treatment, serum 1,25(OH)2D values increased to supranormal concentrations in association with the restoration of the physiologic relationship of PTH to serum calcium and phosphate concentrations and urinary cAMP/creatinine ratio. Vitamin D 7-16 parathyroid hormone Homo sapiens 163-166 7752465-1 1995 The synthesis of human parathyroid hormon (PTH) is controlled by extracellular Ca2+ concentration and 1,25 (OH)2D3, independently, nCaRE (negative calcium responsive element) and nVDRE (negative vitamin D responsive element) have been detected on 5" flanking region of human PTH gene. Vitamin D 195-204 parathyroid hormone Homo sapiens 43-46 8238086-5 1993 The administration of vitamin D 200,000 U/month or calcitriol 0.5 microgram daily and 1 g of Ca supplementation daily, resulted in the normalization of PTH during 81 months of follow-up. Vitamin D 22-31 parathyroid hormone Homo sapiens 152-155 7736316-0 1995 Serum intact parathyroid hormone in a random population sample of men and women: relationship to anthropometry, life-style factors, blood pressure, and vitamin D. Vitamin D 152-161 parathyroid hormone Homo sapiens 13-32 8546173-1 1995 Secondary hyperparathyroidism in patients with end-stage renal disease is characterised by elevated circulating levels of parathyroid hormone, due to inadequate synthesis of calcitriol, the active metabolite of vitamin D. Vitamin D 211-220 parathyroid hormone Homo sapiens 122-141 7565453-4 1995 Significant correlations were observed between the dietary vitamin D intake and the plasma 25-OH-D or HS-PTH levels. Vitamin D 59-68 parathyroid hormone Homo sapiens 105-108 7565453-6 1995 These results suggest that dietary intake of sufficient amounts of vitamin D is effective for improving the vitamin D nutritional status through normalizing PTH levels. Vitamin D 67-76 parathyroid hormone Homo sapiens 157-160 7478147-4 1995 In at least some studies high dose intermittent bolus administration of vitamin D can reduce parathyroid hormone (PTH) secretion by a mechanism separated in time from an increase in ionized calcium (iCa2+). Vitamin D 72-81 parathyroid hormone Homo sapiens 93-112 7478147-4 1995 In at least some studies high dose intermittent bolus administration of vitamin D can reduce parathyroid hormone (PTH) secretion by a mechanism separated in time from an increase in ionized calcium (iCa2+). Vitamin D 72-81 parathyroid hormone Homo sapiens 114-117 7857076-6 1994 Main factors which regulate PTH synthesis are the level of extra-cellular calcium, vitamin D, and to a lesser extent steroid hormones. Vitamin D 83-92 parathyroid hormone Homo sapiens 28-31 8081065-4 1994 Vitamin D insufficiency and a deficit in calcium intake are very common in the elderly living either in institutions or at home and the cumulative response to these deficits is a negative calcium balance which stimulates parathyroid hormone secretion. Vitamin D 0-9 parathyroid hormone Homo sapiens 221-240 8238086-8 1993 This observation suggests that serum PTH could be an early marker for the detection of recurrence in parathyroid cancer with normal serum Ca, and that suppression of PTH secretion by vitamin D or calcitriol could avert or delay the progression of recurrence. Vitamin D 183-192 parathyroid hormone Homo sapiens 166-169 8212205-5 1993 Aggressive oral calcium and vitamin D supplementation in certain normocalcemic renal transplant patients may decrease endogenous PTH levels, improve hypophosphatemia, and provide a physiologic increase in levels of 1-25(OH)2D3. Vitamin D 28-37 parathyroid hormone Homo sapiens 129-132 8164616-3 1993 Net PTH-elicited AC (dPTH-AC) activation hence reflected individual vitamin D status. Vitamin D 68-77 parathyroid hormone Homo sapiens 4-7 8268047-1 1993 Resistance to the renal actions of parathyroid hormone (PTH) in pseudohypoparathyroidism (PsH) may be improved after treatment with vitamin D or its metabolites, but reports conflict. Vitamin D 132-141 parathyroid hormone Homo sapiens 35-54 8483256-5 1993 Intermittent and pharmacologically high levels of plasma calcitriol are reported to suppress the PTH secretion effectively and recently 22-oxacalcitriol, a new active vitamin D analogue, is found to suppress PTH secretion without increasing plasma calcium. Vitamin D 167-176 parathyroid hormone Homo sapiens 208-211 1474331-4 1992 The level of "ectopic" transcription of the PTH gene in lymphoblastoid cells appeared to be resistant to the administration of both vitamin D and phorbol esters. Vitamin D 132-141 parathyroid hormone Homo sapiens 44-47 2229313-6 1990 A negative correlation existed between PTH and 25-hydroxy-cholecalciferol (r = -0.49; P less than 0.05), the main circulating metabolite of vitamin D. Vitamin D 140-149 parathyroid hormone Homo sapiens 39-42 1488999-8 1992 The present investigation demonstrated (1) that intravenous administration of the 1-hydroxylated vitamin D metabolite 1 alpha(OH)D3 induced a significant decrease in circulating levels of biologically active intact PTH, and (2) that it was possible to maintain the marked suppression of PTH secretion by intravenous treatment of 1 alpha (OH)D3 for up to 2 years. Vitamin D 97-106 parathyroid hormone Homo sapiens 215-218 1488999-8 1992 The present investigation demonstrated (1) that intravenous administration of the 1-hydroxylated vitamin D metabolite 1 alpha(OH)D3 induced a significant decrease in circulating levels of biologically active intact PTH, and (2) that it was possible to maintain the marked suppression of PTH secretion by intravenous treatment of 1 alpha (OH)D3 for up to 2 years. Vitamin D 97-106 parathyroid hormone Homo sapiens 287-290 2017266-0 1991 Acute effects of repetitive hemodialysis on circulating immunoreactive parathyroid hormone levels in uremic patients undergoing vitamin D (calcitriol) therapy. Vitamin D 128-137 parathyroid hormone Homo sapiens 71-90 1303956-6 1992 Six possible mechanisms may explain the cadmium-induced bone effects: (1) interference with parathyroid hormone (PTH) stimulation of vitamin D production in kidney cells; (2) reduced activity of kidney enzymes activating vitamin D; (3) increased excretion of calcium in urine; (4) reduced absorption of calcium from intestines; (5) direct interference with calcium incorporation into bone cells; and (6) direct interference with collagen production in bone cells. Vitamin D 133-142 parathyroid hormone Homo sapiens 92-111 1997523-2 1991 Since the PTH-vitamin D endocrine system is a major regulator of calcium metabolism and bone turnover, this cross-sectional study examined the relationship of radial and lumbar bone density to vitamin D metabolite and PTH concentrations and to calcium intake and excretion in 67 white and 70 black highly comparable, healthy, premenopausal women. Vitamin D 14-23 parathyroid hormone Homo sapiens 10-13 1993948-0 1991 Hypomagnesemia and the parathyroid hormone-vitamin D endocrine system in children with insulin-dependent diabetes mellitus: effects of magnesium administration. Vitamin D 43-52 parathyroid hormone Homo sapiens 23-42 1993948-1 1991 Because insulin-dependent diabetes mellitus is associated with altered electrolyte metabolism and a derangement of the parathyroid hormone (PTH)-vitamin D endocrine system, we studied 23 children with diabetes (age 9.4 +/- 2.5 years) and found lower serum values for total and ionized calcium, magnesium, intact PTH, calcitriol, and osteocalcin than in age- and sex-matched control subjects. Vitamin D 145-154 parathyroid hormone Homo sapiens 119-138 2082223-0 1990 Seasonal fluctuations in parathyroid hormone in relation to vitamin D intake of postmenopausal women. Vitamin D 60-69 parathyroid hormone Homo sapiens 25-44 2082223-1 1990 Vitamin D deficiency in elderly living at northern latitudes results in increased serum parathyroid hormone (PTH) levels after winter. Vitamin D 0-9 parathyroid hormone Homo sapiens 88-107 33774081-10 2021 Agents that suppress PTH (vitamin D analogues and calcimimetics) are used to treat hyperparathyroid bone disease. Vitamin D 26-35 parathyroid hormone Homo sapiens 21-24 2163713-10 1990 In vitamin D- and Pi-treated patients 1,25(OH)2D levels are further depressed, with a resultant increase in PTH values, and the development of tertiary hyperparathyroidism in a small number of patients. Vitamin D 3-12 parathyroid hormone Homo sapiens 108-111 2387281-4 1990 The vitamin D status of 8-year-old Turkish, Moroccan and Caucasian children was assessed by measuring plasma concentrations of 25-OHD and parathyroid hormone (PTH) and related to the cumulated global sun radiation (CGSR). Vitamin D 4-13 parathyroid hormone Homo sapiens 138-157 2222569-3 1990 The changes reported in calciotropic hormones, mainly vitamin D and parathyroid hormone, are observed due in part to a deficient intestinal absorption of vitamin D and an inadequate synthesis of its hepatic metabolite, although greater emphasis has been given to dietary deficiencies or lack of exposure to sun. Vitamin D 154-163 parathyroid hormone Homo sapiens 68-87 23662440-9 2012 Proper supplementation with vitamin D increase the concentration of substrate for local 1,25(OH)2D synthesis 25(OH)D, which directly suppress PTH, increase Klotho, and decrease FGF-23 by proanabolic action on bone. Vitamin D 28-37 parathyroid hormone Homo sapiens 142-145 33762946-0 2021 A Prospective Study of Vitamin D Supplement in Thyroidectomy Patients Based on Relative Decline of Parathyroid Hormone. Vitamin D 23-32 parathyroid hormone Homo sapiens 99-118 33762946-4 2021 Aim: We conducted a prospective study to evaluate the effect of vitamin D supplement (calcitriol) on high-risk hypocalcemia patients based on relative decline of parathyroid hormone (RDP). Vitamin D 64-73 parathyroid hormone Homo sapiens 162-181 33504033-0 2021 Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants. Vitamin D 34-43 parathyroid hormone Homo sapiens 0-19 34956363-0 2021 Vitamin D Insufficiency Predicts Susceptibility of Parathyroid Hormone Reduction after Total Thyroidectomy in Thyroid Cancer Patients. Vitamin D 0-9 parathyroid hormone Homo sapiens 51-70 34649031-5 2022 This review showed that vitamin d-fortified bread is a promising vehicle for fortification strategy effects, leading to increased serum concentrations of 25(OH)D and decreased parathyroid hormone. Vitamin D 24-33 parathyroid hormone Homo sapiens 176-195 34508903-3 2022 The aim of this study was to assess the relationship between aldosterone levels and PTH-vitamin D-calcium axis in a cohort of patients with PA, compared to patients with non-secreting adrenocortical tumors in conditions of vitamin D sufficiency. Vitamin D 88-97 parathyroid hormone Homo sapiens 84-87 34956363-1 2021 Objective: Given its role in the regulation of calcium and PTH levels, vitamin D was presumed as a potential predictor of postoperative hypoparathyroidism. Vitamin D 71-80 parathyroid hormone Homo sapiens 59-62 34956363-3 2021 This study aims to reveal the relationship between preoperative vitamin D and postoperative parathyroid hormone (PTH). Vitamin D 64-73 parathyroid hormone Homo sapiens 92-111 34956363-3 2021 This study aims to reveal the relationship between preoperative vitamin D and postoperative parathyroid hormone (PTH). Vitamin D 64-73 parathyroid hormone Homo sapiens 113-116 34956363-10 2021 By multivariate logistic regression analysis, vitamin D insufficiency was an independent predictor of postoperative PTH reduction ratio >= 50% (OR = 2.2, p=0.017). Vitamin D 46-55 parathyroid hormone Homo sapiens 116-119 34956363-12 2021 However, vitamin D insufficiency is an independent predictor of postoperative PTH reduction ratio. Vitamin D 9-18 parathyroid hormone Homo sapiens 78-81 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Vitamin D 314-323 parathyroid hormone Homo sapiens 126-145 34950730-12 2021 Prevalence of insulin resistance, though negatively correlated with vitamin D, could be better explained by BMI and PTH levels. Vitamin D 68-77 parathyroid hormone Homo sapiens 116-119 34966771-11 2021 According to the multivariable analysis, young age, female gender, low albumin level, high parathyroid hormone (PTH) level, and high sequential organ failure assessment (SOFA) score were significantly associated risk factors for vitamin D deficiency. Vitamin D 229-238 parathyroid hormone Homo sapiens 91-110 34966771-11 2021 According to the multivariable analysis, young age, female gender, low albumin level, high parathyroid hormone (PTH) level, and high sequential organ failure assessment (SOFA) score were significantly associated risk factors for vitamin D deficiency. Vitamin D 229-238 parathyroid hormone Homo sapiens 112-115 34966771-15 2021 Age, gender, albumin level, PTH level, and SOFA score were significantly associated with vitamin D deficiency in these patients. Vitamin D 89-98 parathyroid hormone Homo sapiens 28-31 34948669-0 2021 Threshold for Relationship between Vitamin D and Parathyroid Hormone in Chinese Women of Childbearing Age. Vitamin D 35-44 parathyroid hormone Homo sapiens 49-68 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Vitamin D 314-323 parathyroid hormone Homo sapiens 147-150 34948669-1 2021 Background: The aim of this study was to assess the relationship between serum 25-hydroxyvitamin D (25(OH)D) and serum intact parathyroid hormone (PTH) in Chinese childbearing women, and to estimate the optimum threshold of 25(OH)D that maximally inhibits the PTH, which is considered to be the optimal status for vitamin D sufficiency. Vitamin D 314-323 parathyroid hormone Homo sapiens 260-263 34849546-13 2022 CONCLUSIONS: Of characteristics most commonly associated with vitamin D metabolism, only baseline 25(OH)D <20 ng/mL modified the PTH response to vitamin D supplementation, providing support from a clinical trial to use this threshold to define insufficiency. Vitamin D 145-154 parathyroid hormone Homo sapiens 129-132 34918524-4 2021 In kidneys, PTH stimulates 1alpha-hydroxylase to synthesize active vitamin D. Vitamin D 67-76 parathyroid hormone Homo sapiens 12-15 34695445-9 2021 Individuals with vitamin D sufficiency (25-OH-D >50 nmol/L) exhibited a 5% lower level of PTH compared to the whole sample population (p<.001). Vitamin D 17-26 parathyroid hormone Homo sapiens 90-93 34849546-13 2022 CONCLUSIONS: Of characteristics most commonly associated with vitamin D metabolism, only baseline 25(OH)D <20 ng/mL modified the PTH response to vitamin D supplementation, providing support from a clinical trial to use this threshold to define insufficiency. Vitamin D 62-71 parathyroid hormone Homo sapiens 129-132 34792092-13 2021 The addition of milk to the diet may potentially increase the likelihood of preventing bone loss by restoring bone homeostasis through the modulation of calcium-vitamin D-PTH axis, bone remodeling rate, and growth hormone/IGF-1 axis. Vitamin D 161-170 parathyroid hormone Homo sapiens 171-174 34604382-8 2021 In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality (r = -0.341, p = 0.002) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level. Vitamin D 47-56 parathyroid hormone Homo sapiens 222-241 34647284-4 2022 Other therapies are being explored, and among them, the use of recombinant human parathyroid hormone (PTH) has proved to decrease the requirements of calcium and active vitamin D to reach adequate therapeutic goals. Vitamin D 169-178 parathyroid hormone Homo sapiens 81-100 34647284-4 2022 Other therapies are being explored, and among them, the use of recombinant human parathyroid hormone (PTH) has proved to decrease the requirements of calcium and active vitamin D to reach adequate therapeutic goals. Vitamin D 169-178 parathyroid hormone Homo sapiens 102-105 34604382-8 2021 In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality (r = -0.341, p = 0.002) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level. Vitamin D 47-56 parathyroid hormone Homo sapiens 243-246 34604382-10 2021 PSQI scores in the normal range of PTH (r = -0.377, p = 0.006) and in >600 pg/ml of PTH (r = -0.675, p = 0.011) had a correlation with vitamin D levels. Vitamin D 135-144 parathyroid hormone Homo sapiens 35-38 34604382-10 2021 PSQI scores in the normal range of PTH (r = -0.377, p = 0.006) and in >600 pg/ml of PTH (r = -0.675, p = 0.011) had a correlation with vitamin D levels. Vitamin D 135-144 parathyroid hormone Homo sapiens 84-87 34580590-10 2021 A blunted PTH response to vitamin D deficiency is mainly observed among women with lower BMI. Vitamin D 26-35 parathyroid hormone Homo sapiens 10-13 34578863-1 2021 Considering the role of bone metabolism in understanding the pathogenesis of osteoporosis, the aim of the present study was to examine the effects of vitamin D-enriched cheese on the serum concentrations of the parathyroid hormone (PTH) and certain bone remodeling biomarkers in postmenopausal women in Greece. Vitamin D 150-159 parathyroid hormone Homo sapiens 211-230 34580590-0 2021 Prevalence and Determinants of a Blunted Parathyroid Hormone Response in Young Saudi Women with Vitamin D Deficiency: A Cross-Sectional Study. Vitamin D 96-105 parathyroid hormone Homo sapiens 41-60 34580590-4 2021 This study determined the prevalence of a blunted PTH response to vitamin D deficiency among apparently healthy young Saudi women and assessed anthropometric and biochemical factors associated with this response by performing a secondary analysis of data obtained from a cross-sectional study conducted at the "Center of Excellence for Osteoporosis research." Vitamin D 66-75 parathyroid hormone Homo sapiens 50-53 34510873-9 2021 Logistic regression analysis showed that having PA and deficiency of Vitamin D were risk factors for PTH elevation (both P<0.05). Vitamin D 69-78 parathyroid hormone Homo sapiens 101-104 34510873-10 2021 The ROC curve showed that the best cut-off value of PTH for the diagnosis of PA in patients with vitamin D deficiency was 56.44 ng/L, with a sensitivity of 66.5% and a specificity of 83.0%, and that in patients with normal vitamin D was 48.81 ng/L, with a sensitivity of 70.5% and a specificity of 72.6%. Vitamin D 97-106 parathyroid hormone Homo sapiens 52-55 34578863-1 2021 Considering the role of bone metabolism in understanding the pathogenesis of osteoporosis, the aim of the present study was to examine the effects of vitamin D-enriched cheese on the serum concentrations of the parathyroid hormone (PTH) and certain bone remodeling biomarkers in postmenopausal women in Greece. Vitamin D 150-159 parathyroid hormone Homo sapiens 232-235 34578863-5 2021 In vitamin D-insufficient women that were less than 5 years at menopause, consumption of vitamin D-enriched cheese was also associated with lower serum PTH (Beta -0.63 +- 1.11; p < 0.001) and TRAP-5b (Beta -0.65 +- 0.23; p = 0.004) levels at follow-up, compared with the CG. Vitamin D 89-98 parathyroid hormone Homo sapiens 152-155 34578863-6 2021 The present study showed that daily intake of 5.7 mug of vitamin D through enriched cheese increased serum 25(OH)D concentrations, prevented PTH increase and reduced bone resorption in vitamin D-insufficient early postmenopausal women, thus reflecting a potential food-based solution for reducing the risk of bone loss occurring after menopause. Vitamin D 57-66 parathyroid hormone Homo sapiens 141-144 34194851-2 2021 Causes of hypocalcemia with PTH elevation include increased phosphate load, vitamin D deficiency (VDD) or defects in metabolism, renal dysfunction, hypomagnesemia, genetic mutations resulting in end-organ resistance to PTH, or critical illness. Vitamin D 76-85 parathyroid hormone Homo sapiens 28-31 34759510-2 2021 Introduction: Assessment of serum Vitamin D levels in healthy North Indian sportspersons and its correlation with serum parathyroid hormone (PTH) levels and bone mineral density (BMD). Vitamin D 34-43 parathyroid hormone Homo sapiens 120-139 34759510-2 2021 Introduction: Assessment of serum Vitamin D levels in healthy North Indian sportspersons and its correlation with serum parathyroid hormone (PTH) levels and bone mineral density (BMD). Vitamin D 34-43 parathyroid hormone Homo sapiens 141-144 34759510-5 2021 BMD and serum PTH levels were assessed in all athletes and correlation was seen with Vitamin D levels. Vitamin D 85-94 parathyroid hormone Homo sapiens 14-17 34759510-9 2021 Serum PTH levels were found to have inverse relations with both Vitamin D (r= -0.629) and BMD (r=-0.267). Vitamin D 64-73 parathyroid hormone Homo sapiens 6-9 34759510-10 2021 Conclusions: Vitamin D deficiency is highly prevalent among the North Indian athletes and the presence of low Vitamin D (<20 ng/ml) levels is associated with low BMD and high PTH levels. Vitamin D 13-22 parathyroid hormone Homo sapiens 175-178 34759510-10 2021 Conclusions: Vitamin D deficiency is highly prevalent among the North Indian athletes and the presence of low Vitamin D (<20 ng/ml) levels is associated with low BMD and high PTH levels. Vitamin D 110-119 parathyroid hormone Homo sapiens 175-178 34117551-9 2021 What is Known: Vitamin D deficiency is more prevalent in obese children than nonobese controls, despite the same bone turnover markers and bone mineral density The cutoff value of vitamin D level for the diagnosis of VDD is based on the PTH elevation What is New: In obese adolescents, total and free vitamin D cutoff value for the diagnosis of VDD was lower than nonobese peers Using the same cutoff value for vitamin D deficiency in both obese and nonobese adolescents may cause overtreatment. Vitamin D 184-193 parathyroid hormone Homo sapiens 241-244 34733035-3 2021 It has been reported that there is an impaired response of parathyroid hormone (PTH) to vitamin D deficiency in critically ill children and adults. Vitamin D 88-97 parathyroid hormone Homo sapiens 59-78 34733035-3 2021 It has been reported that there is an impaired response of parathyroid hormone (PTH) to vitamin D deficiency in critically ill children and adults. Vitamin D 88-97 parathyroid hormone Homo sapiens 80-83 34733035-4 2021 Hence, we also sought to analyze the PTH response to vitamin D among the subgroup of critically ill children with sepsis. Vitamin D 53-62 parathyroid hormone Homo sapiens 37-40 34408941-2 2021 Defect in the activation of vitamin D in the kidneys due to chronic kidney disease (CKD) leads to hypocalcemia and hyperphosphatemia, resulting in a compensatory increase in parathyroid gland cellularity and parathyroid hormone production and causing secondary hyperparathyroidism (SHP). Vitamin D 28-37 parathyroid hormone Homo sapiens 208-227 34107534-0 2021 Vitamin D concentration and its association with parathyroid hormone in children and adolescents. Vitamin D 0-9 parathyroid hormone Homo sapiens 49-68 34107534-1 2021 BACKGROUND: Vitamin D (VD) deficiency has been inversely associated with parathyroid hormone (PTH) levels in the adult population but not in children and adolescents. Vitamin D 12-21 parathyroid hormone Homo sapiens 73-92 34107534-1 2021 BACKGROUND: Vitamin D (VD) deficiency has been inversely associated with parathyroid hormone (PTH) levels in the adult population but not in children and adolescents. Vitamin D 12-21 parathyroid hormone Homo sapiens 94-97 34603696-1 2021 Background: Secondary hyperparathyroidism (SHPT) is a common and major complication in chronic kidney disease (CKD), reflecting the increase of parathyroid hormone (PTH) in response to reduced vitamin D signalling and hypocalcaemia. Vitamin D 193-202 parathyroid hormone Homo sapiens 144-163 34063310-0 2021 Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism. Vitamin D 66-75 parathyroid hormone Homo sapiens 0-19 35505326-9 2022 CONCLUSION: PTH concentration decreased and calcium/creatinine ratio increased in subjects who received vitamin D and Calcium together compared to those who received vitamin D alone. Vitamin D 104-113 parathyroid hormone Homo sapiens 12-15 35351538-0 2022 Vitamin D status and its association with parathyroid hormone in 23,134 outpatients. Vitamin D 0-9 parathyroid hormone Homo sapiens 42-61 35351538-3 2022 Moreover, age and sex as well as confounding factors like calcium and phosphate may likewise affect the relationship between vitamin D and PTH in humans. Vitamin D 125-134 parathyroid hormone Homo sapiens 139-142 35202418-13 2022 The study displayed the short-term effect of Vitamin D supplementation on vitamin D, PTH levels, LTL and vitamin D associated gene expressions. Vitamin D 45-54 parathyroid hormone Homo sapiens 85-88 35446722-6 2022 Long-term (>6 months) activated vitamin D analogue therapy was required in five patients (4.3%), four of whom had normal serum PTH and one with undetectable PTH at 6 weeks post surgery. Vitamin D 32-41 parathyroid hormone Homo sapiens 127-130 35446722-9 2022 We were able to identify all patients requiring activated vitamin D supplementation 6 months postoperatively from the day 1 postoperative serum calcium and PTH values, while excluding those that may only need temporary calcium supplementation. Vitamin D 58-67 parathyroid hormone Homo sapiens 156-159 35510205-13 2022 However, sex, age, socioeconomic level, phototype, solar exposure score, smoking and bone mass index, were not statistically associated with hypovitaminosis D. The study of relationship between vitamin D status and serum PTH levels showed a significative and negative correlation (P < 0.005). Vitamin D 194-203 parathyroid hormone Homo sapiens 221-224 35409134-1 2022 Parathyroid hormone (PTH) is a key regulator of calcium, phosphate and vitamin D metabolism. Vitamin D 71-80 parathyroid hormone Homo sapiens 21-24 35410821-3 2022 The serum 25(OH)D value at which parathyroid hormone level plateaus, called the "inflection point," is considered the most appropriate criterion for defining an adequate vitamin D status. Vitamin D 170-179 parathyroid hormone Homo sapiens 33-52 35505326-7 2022 Sub-group analysis revealed that parathyroid hormone (PTH) concentration decreased and Calcium/creatinine ratio increased significantly in the combined vitamin D and Calcium group compared to the vitamin D alone or Calcium alone in contrast to the increase seen in the placebo group (p < 0.05 for between group difference at 6 months). Vitamin D 152-161 parathyroid hormone Homo sapiens 33-52 35505326-7 2022 Sub-group analysis revealed that parathyroid hormone (PTH) concentration decreased and Calcium/creatinine ratio increased significantly in the combined vitamin D and Calcium group compared to the vitamin D alone or Calcium alone in contrast to the increase seen in the placebo group (p < 0.05 for between group difference at 6 months). Vitamin D 152-161 parathyroid hormone Homo sapiens 54-57 35485213-15 2022 In conclusion, the meta-analysis of data from the largest collection to date of hypoparathyroid patients shows that PTH therapy is safe, well-tolerated and effective in normalizing serum phosphate and urinary calcium excretion, as well as enabling a reduction in calcium and vitamin D use and improving quality of life. Vitamin D 275-284 parathyroid hormone Homo sapiens 116-119 35435056-2 2022 Aim: To determine the prevalence of vitamin D deficiency and investigate its association with body mass index (BMI), waist circumference, and serum concentrations of parathyroid hormone, calcium, and phosphorus in a sample of Moroccan adult women. Vitamin D 36-45 parathyroid hormone Homo sapiens 166-185 35437440-0 2022 Occult Renal Calcifications in Patients with Normocalcemic Primary Hyperparathyroidism and Their Association with the Parathyroid Hormone-Vitamin D Axis. Vitamin D 138-147 parathyroid hormone Homo sapiens 118-137 35122668-13 2022 Regardless of vitamin D supplementation, participants with severe vitamin D deficiency had significantly higher intact parathyroid hormone levels and lower bone mineral content. Vitamin D 66-75 parathyroid hormone Homo sapiens 119-138 35516667-7 2022 Therefore, for any patient presenting with persistent vomiting, altered sensorium, and hypercalcemia, with normal to low parathyroid hormone levels, a diagnosis of an overdose of vitamin D should be considered. Vitamin D 179-188 parathyroid hormone Homo sapiens 121-140 35202418-9 2022 After vitamin D supplementation 25(OH)D, 1,25(OH)2D, PTH and VDBP levels were changed significantly compared to the placebo group. Vitamin D 6-15 parathyroid hormone Homo sapiens 53-56 34508607-7 2022 RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH). Vitamin D 23-32 parathyroid hormone Homo sapiens 171-190 34991572-12 2022 CONCLUSION: Older subjects with vitamin D deficiency have increased BMI, inflammation and PTH compared with those with insufficiency or optimal concentrations. Vitamin D 32-41 parathyroid hormone Homo sapiens 90-93 34508607-7 2022 RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH). Vitamin D 23-32 parathyroid hormone Homo sapiens 192-195 34347093-7 2022 RESULTS: By Week 26, 91% of subjects treated with TransCon PTH achieved independence from standard of care (SoC, defined as active vitamin D = 0 mcg/day and calcium (Ca) <= 500 mg/day). Vitamin D 131-140 parathyroid hormone Homo sapiens 59-62 34508607-7 2022 RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH). Vitamin D 88-97 parathyroid hormone Homo sapiens 171-190 34508607-7 2022 RESULTS: Men receiving vitamin D supplementation improved their vitamin D status, while vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone (PTH). Vitamin D 88-97 parathyroid hormone Homo sapiens 192-195 2911322-5 1989 We conclude that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in response to parathyroid hormone, and that in osteoporosis the age-appropriate parathyroid hormone response to the same hypocalcemic signal is diminished. Vitamin D 107-116 parathyroid hormone Homo sapiens 47-66 2788385-0 1989 Is intact PTH a sensitive biochemical indicator of deranged calcium homeostasis in vitamin D deficiency? Vitamin D 83-92 parathyroid hormone Homo sapiens 10-13 2788385-2 1989 Changes in intact PTH were disproportionately greater than for other biochemical parameters, making it the most sensitive early indicator of deranged calcium homeostasis in vitamin D deficiency. Vitamin D 173-182 parathyroid hormone Homo sapiens 18-21 2594036-0 1989 Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. Vitamin D 10-19 parathyroid hormone Homo sapiens 53-72 2594036-3 1989 The overall inverse relation between serum parathyroid hormone and 25(OH)D levels was found to be dependent on vitamin D intake. Vitamin D 111-120 parathyroid hormone Homo sapiens 43-62 2594036-4 1989 In women whose estimated intake of vitamin D was less than or equal to 220 IU a day, the mean (+/- SD) serum parathyroid hormone values were lowest in those studied between August and October (30 +/- 11 ng per liter; n = 72) and highest in those studied between March and May (37 +/- 16 ng per liter; n = 54); the respective serum 25(OH)D levels were 93 +/- 32 and 63 +/- 21 nmol per liter. Vitamin D 35-44 parathyroid hormone Homo sapiens 109-128 2594036-9 1989 We conclude that the dietary intake of more than 220 IU of vitamin D a day by postmenopausal women in Massachusetts may be sufficient to maintain constant serum 25(OH)D and parathyroid hormone concentrations throughout the year. Vitamin D 59-68 parathyroid hormone Homo sapiens 173-192 2548645-9 1989 However, when the magnitude of phosphaturic response is expressed as net increase during 2 h after PTH, it tends to be enhanced after vitamin D therapy in patients with PsH compared to the response before therapy. Vitamin D 134-143 parathyroid hormone Homo sapiens 99-102 2644746-1 1989 The parathyroid gland possesses receptors for 1,25-dihydroxyvitamin D3, the active metabolite of the vitamin D system, and in vitro experiments have shown that 1,25-dihydroxyvitamin D3 can inhibit the secretion of PTH. Vitamin D 60-69 parathyroid hormone Homo sapiens 214-217 3060161-11 1988 Through the vitamin D-PTH axis the endocrine system regulates the phosphate balance by influencing the kidney, gut, and bone. Vitamin D 12-21 parathyroid hormone Homo sapiens 22-25 3063116-7 1988 The PTH-vitamin D axis as modulated by the serum ionized calcium level controls adaptation to alterations in dietary calcium and sodium intake and to changes in skeletal turnover based on the level of physical activity. Vitamin D 8-17 parathyroid hormone Homo sapiens 4-7 2615719-2 1989 In a recent survey of 306 patients with primary hyperparathyroidism (PHPT), we hypothesized that the far higher degree of parathyroid hormone (PTH) hypersecretion in PHPT with osteitis fibrosa cystica than in PHPT without overt bone disease might be due to the absence of suppression of hormonal hypersecretion by the low-to-normal circulating 1,25(OH)2D reflecting a relative vitamin D deficiency. Vitamin D 377-386 parathyroid hormone Homo sapiens 122-141 2848397-2 1988 We showed previously that obese white subjects have low serum vitamin D and 25-hydroxyvitamin D (25-OHD) with increased serum-immunoreactive parathyroid hormone (PTH) and 1,25-(OH)2D, low urinary calcium, and increased urinary cyclic adenosine 3",5"-monophosphate (cyclic AMP) compared with nonobese white individuals. Vitamin D 62-71 parathyroid hormone Homo sapiens 141-160 3592447-1 1987 Studies of the parathyroid hormone-vitamin D axis. Vitamin D 35-44 parathyroid hormone Homo sapiens 15-34 3494037-7 1987 These results indicate that PTH concentrations are frequently elevated in PBC patients despite adequate vitamin D supplementation and normal or even supranormal plasma calcium concentrations. Vitamin D 104-113 parathyroid hormone Homo sapiens 28-31 6335331-4 1984 Under the combination therapy with KA and vitamin D despite the reduction of the phosphate binders another significant decrease of the PTH and the anorganic phosphate was observed. Vitamin D 42-51 parathyroid hormone Homo sapiens 135-138 3003405-10 1986 These data suggest tumor induction of parathyroid hormone-like humoral modulation of calcium, phosphate and vitamin D metabolism in vivo associated with a parathyroid hormone-like prostate carcinoma product. Vitamin D 108-117 parathyroid hormone Homo sapiens 38-57 3485617-3 1986 Our data suggest that the higher serum levels of vitamin D metabolites during the summer suppress PTH secretion. Vitamin D 49-58 parathyroid hormone Homo sapiens 98-101 3485617-4 1986 During the winter, the reduction of serum levels of vitamin D metabolites due to decreased endogenous production was accompanied by an increase in serum PTH levels. Vitamin D 52-61 parathyroid hormone Homo sapiens 153-156 3503535-1 1986 As compared to nonobese white men and women, age-matched nonobese black subjects and obese white individuals show alterations in the vitamin D-endocrine system that are characterized by increases in mean serum immunoreactive parathyroid hormone (PTH), serum 1,25-dihydroxyvitamin D [1,25-(OH)2D], and urinary cyclic adenosine 3,5-monophosphate (cAMP) and by decreases in mean serum 25-hydroxyvitamin D (25 OHD) and in urinary calcium. Vitamin D 133-142 parathyroid hormone Homo sapiens 225-244 3503535-1 1986 As compared to nonobese white men and women, age-matched nonobese black subjects and obese white individuals show alterations in the vitamin D-endocrine system that are characterized by increases in mean serum immunoreactive parathyroid hormone (PTH), serum 1,25-dihydroxyvitamin D [1,25-(OH)2D], and urinary cyclic adenosine 3,5-monophosphate (cAMP) and by decreases in mean serum 25-hydroxyvitamin D (25 OHD) and in urinary calcium. Vitamin D 133-142 parathyroid hormone Homo sapiens 246-249 6311459-3 1983 A possible mechanism for the vitamin D resistant osteoporosis has been identified following the observation that, in those patients with severe cirrhosis, the circulating concentration of intact PTH was elevated. Vitamin D 29-38 parathyroid hormone Homo sapiens 195-198 6611345-2 1984 These elevated PTH concentrations, though not as high as those in osteomalacic patients with hypocalcemia, often persisted despite treatment with vitamin D, normalization of 25-hydroxyvitamin D, and an increase in calcium concentrations. Vitamin D 146-155 parathyroid hormone Homo sapiens 15-18 6611345-5 1984 Persistent elevation of PTH despite normalization of 25-hydroxyvitamin D also points to autonomous PTH hypersecretion, which may result in osteolysis in the long term, and raises the question of the need for vitamin D supplementation in vegetarians with low dietary intake of vitamin D. Vitamin D 63-72 parathyroid hormone Homo sapiens 99-102 6321190-7 1984 This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets. Vitamin D 29-38 parathyroid hormone Homo sapiens 106-109 6321190-7 1984 This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets. Vitamin D 29-38 parathyroid hormone Homo sapiens 152-155 6411203-3 1983 The raised serum parathyroid hormone concentrations in the sick elderly were not due to poor renal function and may have been a response to vitamin D deficiency. Vitamin D 140-149 parathyroid hormone Homo sapiens 17-36 6744632-7 1984 Restoration of normocalcaemia reduced the concentrations of bioactive PTH in both pseudohypoparathyroidism and vitamin D deficiency. Vitamin D 111-120 parathyroid hormone Homo sapiens 70-73 6744632-9 1984 Immunoreactive PTH was also raised in patients with untreated pseudo-hypoparathyroidism and vitamin D deficiency, but restoration of normocalcaemia did not always reduce immunoreactive PTH to normal in these patients. Vitamin D 92-101 parathyroid hormone Homo sapiens 15-18 6294581-0 1983 Effect of parathyroid hormone on cAMP and 1,25-dihydroxyvitamin D formation and renal handling of phosphate in vitamin D-dependent rickets. Vitamin D 56-65 parathyroid hormone Homo sapiens 10-29 6853678-2 1983 The serum PTH concentrations were maximal in winter, when the vitamin D metabolites were lowest, suggesting a secondary phenomenon. Vitamin D 62-71 parathyroid hormone Homo sapiens 10-13 6978888-0 1982 Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging. Vitamin D 40-49 parathyroid hormone Homo sapiens 17-36 6279352-0 1982 Reversible resistance to the renal action of parathyroid hormone in human vitamin D deficiency. Vitamin D 74-83 parathyroid hormone Homo sapiens 45-64 6279352-2 1982 The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously. Vitamin D 120-129 parathyroid hormone Homo sapiens 26-45 6791781-0 1981 Action of vitamin D metabolites on PTH secretion in man. Vitamin D 10-19 parathyroid hormone Homo sapiens 35-38 6973423-8 1981 It appears that the decrease of the plasma level of these metabolites of Vitamin D precedes (or is concomitant with) the changes in the serum values of calcium (Ca), phosphorus (P) and parathyroid hormone (PTH) and the diminution of the intestinal absorption of Ca. Vitamin D 73-82 parathyroid hormone Homo sapiens 185-204 7036737-5 1982 As vitamin D is required for expression of the action of PTH at bone and as PTH is a prime regulator of vitamin D metabolism, the absence of either component results in important disturbances in calcium balance. Vitamin D 3-12 parathyroid hormone Homo sapiens 57-60 7036737-5 1982 As vitamin D is required for expression of the action of PTH at bone and as PTH is a prime regulator of vitamin D metabolism, the absence of either component results in important disturbances in calcium balance. Vitamin D 104-113 parathyroid hormone Homo sapiens 76-79 6264377-0 1981 Effect of parathyroid hormone on vitamin D metabolism in osteopetrosis. Vitamin D 33-42 parathyroid hormone Homo sapiens 10-29 6791781-5 1981 These results could be interpreted as a direct effect of metabolites of vitamin D on PTH secretion. Vitamin D 72-81 parathyroid hormone Homo sapiens 85-88 6246136-1 1980 Serum immunoreactive parathyroid hormone (PTH) levels were increased in a 50-yr-old man with a unique variant of adult-onset vitamin D-resistant osteomalacia, presenting with high phosphate clearance, mild hypocalcemia, and blunted hypercalcemic and phosphaturic responses to exogenous parathyroid extract. Vitamin D 125-134 parathyroid hormone Homo sapiens 21-40 6246136-4 1980 The evidence presented suggests that the resistance of PTH in this patient was due to secondary hyperparathyroidism rather than to a defect of PTH-sensitive receptors of the kidney and bone or to inadequacy of vitamin D per se. Vitamin D 210-219 parathyroid hormone Homo sapiens 55-58 6246136-1 1980 Serum immunoreactive parathyroid hormone (PTH) levels were increased in a 50-yr-old man with a unique variant of adult-onset vitamin D-resistant osteomalacia, presenting with high phosphate clearance, mild hypocalcemia, and blunted hypercalcemic and phosphaturic responses to exogenous parathyroid extract. Vitamin D 125-134 parathyroid hormone Homo sapiens 42-45 7353372-0 1980 Do vitamin D or its metabolites directly affect the release of PTH? Vitamin D 3-12 parathyroid hormone Homo sapiens 63-66 7398339-2 1980 The conspicuous effect of 1 alpha-OH-D3 on pseudohypoparathyroidism is likely to be attributed to the fact that the unresponsiveness of bone tissue to parathyroid hormone is corrected by the action of active vitamin D. Vitamin D 208-217 parathyroid hormone Homo sapiens 151-170 6995015-0 1980 PTH-vitamin D interrelationships. Vitamin D 4-13 parathyroid hormone Homo sapiens 0-3 225161-3 1979 With the combined calcium-PTH infusion or PTH infusion after vitamin D therapy, renal response was improved in these patients. Vitamin D 61-70 parathyroid hormone Homo sapiens 42-45 953799-0 1976 The effects of vitamin D metabolites and their analogues on the secretion of parathyroid hormone. Vitamin D 15-24 parathyroid hormone Homo sapiens 77-96 217686-0 1979 Parathyroid hormone and calcitonin levels in vitamin D deficient rickets. Vitamin D 45-54 parathyroid hormone Homo sapiens 0-19 787723-18 1976 An increase in plasma calcium in response to PTH can occur either in the untreated state or after treatment with vitamin D because either the error-correcting or remodeling system remains responsive to PTH. Vitamin D 113-122 parathyroid hormone Homo sapiens 45-48 787723-18 1976 An increase in plasma calcium in response to PTH can occur either in the untreated state or after treatment with vitamin D because either the error-correcting or remodeling system remains responsive to PTH. Vitamin D 113-122 parathyroid hormone Homo sapiens 202-205 717102-8 1978 This may suggest that the stimulating effect of biologically active vitamin D on the tubular reabsorption of phosphate is mediated via the parallel suppression of PTH, but does not exclude that biologically active vitamin D exerts a direct effect on the human renal tubule. Vitamin D 68-77 parathyroid hormone Homo sapiens 163-166 172936-11 1975 Thus the relationship between parathyroid hormone and metabolites of vitamin D may not be mediated through changes in serum calcium alone, and it is postulated that metabolites of vitamin D may directly affect the secretion of parathyroid hormone. Vitamin D 69-78 parathyroid hormone Homo sapiens 30-49 180058-1 1976 To determine whether the phosphaturic response to circulating parathyroid hormone (PTH) is exaggerated in patients with familial x-linked hypophosphatemic vitamin D-resistant rickets (FHR), we examined the phosphaturic response to parathyroid extract (PTE) (administered intravenously in the posthypercalcemic state) in two unrelated adult hemizygotes with FHR. Vitamin D 155-164 parathyroid hormone Homo sapiens 62-81 172936-11 1975 Thus the relationship between parathyroid hormone and metabolites of vitamin D may not be mediated through changes in serum calcium alone, and it is postulated that metabolites of vitamin D may directly affect the secretion of parathyroid hormone. Vitamin D 180-189 parathyroid hormone Homo sapiens 227-246 4369169-0 1974 Serum parathyroid hormone concentrations in hypophosphataemic vitamin D resistant rickets. Vitamin D 62-71 parathyroid hormone Homo sapiens 6-25 169419-0 1975 Influence of dialysate calcium concentration and vitamin D on serum parathyroid hormone during repetitive dialysis. Vitamin D 49-58 parathyroid hormone Homo sapiens 68-87 171472-3 1975 Even during vitamin D treatment renal camp formation by giving PTH extract cannot be stimulated, while in this situation. Vitamin D 12-21 parathyroid hormone Homo sapiens 63-66 171472-5 1975 Whether this is due to a PTH potentiated vitamin D effect is discussed. Vitamin D 41-50 parathyroid hormone Homo sapiens 25-28 1166791-4 1975 Under these conditions there was a significant decrease in the filtered fraction of phosphate and amino acid excreted in the vitamin D resistant group suggesting a depression of parathyroid hormone secretion. Vitamin D 125-134 parathyroid hormone Homo sapiens 178-197 1166791-5 1975 It seems likely, as demonstrated in the vitamin D resistant group, that in this disorder the renal tubule is particularly sensitive to changes in parathyroid hormone secretion in respect to amino acid reabsorption. Vitamin D 40-49 parathyroid hormone Homo sapiens 146-165 1112253-1 1975 The effect of dietary vitamin D levels on the response to iv injected parathyroid hormone (PTH) was studies in chicks fed one of three diets: D-deficient, Control-D (1.4IU cholecalciferol/g diet), or High-D (70 IU cholecalciferol/g diet) during the first 4 weeks post-hatching. Vitamin D 22-31 parathyroid hormone Homo sapiens 70-89 4338789-0 1972 Parathyroid hormone as a trophic hormone for 1,25-dihydroxyvitamin D3, the metabolically active form of vitamin D. Vitamin D 59-68 parathyroid hormone Homo sapiens 0-19 4358425-0 1973 Serum parathyroid hormone concentrations in vitamin D deficiency rickets of infancy: effects of intravenous calcium and vitamin D. Vitamin D 44-53 parathyroid hormone Homo sapiens 6-25 4355232-0 1973 Parathyroid hormone secretion in familial vitamin-D-resistant rickets. Vitamin D 42-51 parathyroid hormone Homo sapiens 0-19 6036323-0 1967 Relationship between vitamin D deficiency, thyrocalcitonin, and parathyroid hormone. Vitamin D 21-30 parathyroid hormone Homo sapiens 64-83 4339535-0 1972 Serum parathyroid hormone in hypophosphatemic vitamin D-resistant rickets. Vitamin D 46-55 parathyroid hormone Homo sapiens 6-25 4349621-0 1972 Nature of defect responsible for familial vitamin D-resistant rickets (VDRR) based on radioimmunoassay for parathyroid hormone (PTH). Vitamin D 42-51 parathyroid hormone Homo sapiens 107-126 6050348-0 1967 The parathyroid hormone and aminoaciduria in vitamin-D deficiency rickets. Vitamin D 45-54 parathyroid hormone Homo sapiens 4-23 4538286-0 1972 A case of adult-onset vitamin-D resistant osteomalacia with elevated plasma parathyroid hormone level. Vitamin D 22-31 parathyroid hormone Homo sapiens 76-95 33994379-10 2021 On univariate analysis i-PTH was significantly associated with sex, eGFR, serum calcium, and 25(OH) vit-D level and no association was found with age and FGF-23 levels. Vitamin D 100-105 parathyroid hormone Homo sapiens 25-28 33792853-10 2021 Experimental studies have demonstrated that low vitamin D may be implicated in adipose tissue differentiation and growth leading to obesity either by regulation of gene expression or through modulation of parathyroid hormone, calcium, and leptin. Vitamin D 48-57 parathyroid hormone Homo sapiens 205-224 33894440-1 2021 As a response to low levels of vitamin D serum Parathyroid Hormone (iPTH) is increased in some, but not all, patients. Vitamin D 31-40 parathyroid hormone Homo sapiens 47-66 33150518-10 2021 Relation among vitamin D and PTH through a natural year in children with obesity is partially known. Vitamin D 15-24 parathyroid hormone Homo sapiens 29-32 33150500-14 2021 Higher serum vitamin D levels may have roles in development of lower levels of PTH and higher levels of serum and urine calcium, leading to stone formation. Vitamin D 13-22 parathyroid hormone Homo sapiens 79-82 33995282-0 2021 Combined Effects of Vitamin D Status, Renal Function and Age on Serum Parathyroid Hormone Levels. Vitamin D 20-29 parathyroid hormone Homo sapiens 70-89 33995282-1 2021 Background: Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels. Vitamin D 12-21 parathyroid hormone Homo sapiens 95-114 33995282-1 2021 Background: Vitamin D status and renal function are well-known independent predictors of serum parathyroid hormone (PTH) levels. Vitamin D 12-21 parathyroid hormone Homo sapiens 116-119 33995282-11 2021 Conclusions: We showed that declining vitamin D and renal function have additive effects on serum PTH in subjects without vitamin D deficiency. Vitamin D 38-47 parathyroid hormone Homo sapiens 98-101 33895867-5 2021 Vitamin D supplementation had an inconsistent effect on PTH concentrations and meta-analysis showed non- significant reduction (P = 0.08) whereas calcifediol, calcitriol and paricalcitol consistently reduced PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 56-59 33893820-4 2021 CASE PRESENTATION: The patient was a 59-year-old asymptomatic woman who consistently showed elevated PTH levels (385-482 pg/ml) using the Roche Elecsys (Cobas e-411) and ADVIA Centaur assays, with normal calcium, phosphorus, vitamin D, and renal function parameters. Vitamin D 225-234 parathyroid hormone Homo sapiens 101-104 33026500-9 2021 Although the correlation between vitamin D and PTH was not statistically significant according to the Pearson correlation analysis, it was lower in the laryngomalacia group compared to the control group (p = 0.381, p > 0.05). Vitamin D 33-42 parathyroid hormone Homo sapiens 47-50 33791128-2 2021 Vitamin D supplementation leads to reduced serum parathyroid hormone levels and improved cardiovascular markers. Vitamin D 0-9 parathyroid hormone Homo sapiens 49-68 33640873-8 2021 Vitamin D suppressed PTH, while FGF23 was positively associated with PTH. Vitamin D 0-9 parathyroid hormone Homo sapiens 21-24 33898032-1 2021 Background: Estimation of parathyroid hormone (PTH) after thyroid surgery helps to predict the development of hypocalcemia and allows early intervention and management with oral calcium and/or vitamin D supplementation in the postoperative period. Vitamin D 193-202 parathyroid hormone Homo sapiens 26-45 33898032-1 2021 Background: Estimation of parathyroid hormone (PTH) after thyroid surgery helps to predict the development of hypocalcemia and allows early intervention and management with oral calcium and/or vitamin D supplementation in the postoperative period. Vitamin D 193-202 parathyroid hormone Homo sapiens 47-50 33898032-8 2021 Conclusion: PTH measurements at 3 h after total thyroidectomy is an accurate predictor for the development of hypocalcemia and allows starting early calcium and/or vitamin D supplements for the asymptotic patients with PTH level of less than 10 pg/ml, which is considered a high-risk group. Vitamin D 164-173 parathyroid hormone Homo sapiens 12-15 32617917-10 2020 There was a negative correlation between vitamin D and parathyroid hormone (r = - 0.235 p = 0.030). Vitamin D 41-50 parathyroid hormone Homo sapiens 55-74 33280041-10 2021 PTH was negatively associated with all vitamin D variables, with correlation coefficients ranging between -0.22 and -0.25; while calcium, and bone turnover markers (carboxy-terminal collagen crosslinks and osteocalcin) did not. Vitamin D 39-48 parathyroid hormone Homo sapiens 0-3 33479299-9 2021 Only PTH correlates always inversely with all six vitamin D compounds. Vitamin D 50-59 parathyroid hormone Homo sapiens 5-8 33604214-1 2021 It is established that normal calcium and vitamin D concentrations are maintained in the body through parathyroid hormone (PTH), a signaling molecule secreted from parathyroid glands. Vitamin D 42-51 parathyroid hormone Homo sapiens 102-121 33604214-1 2021 It is established that normal calcium and vitamin D concentrations are maintained in the body through parathyroid hormone (PTH), a signaling molecule secreted from parathyroid glands. Vitamin D 42-51 parathyroid hormone Homo sapiens 123-126 33453021-14 2021 Subgroup analysis according to the intervention time showed that vitamin D intervention for more than 1 month significantly reduced PTH levels. Vitamin D 65-74 parathyroid hormone Homo sapiens 132-135 33453021-17 2021 CONCLUSION: Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria. Vitamin D 12-21 parathyroid hormone Homo sapiens 107-110 33453021-17 2021 CONCLUSION: Vitamin D supplementation in patients with PHPT and vitamin D deficiency significantly reduces PTH and ALP levels without causing hypercalcemia and hypercalciuria. Vitamin D 64-73 parathyroid hormone Homo sapiens 107-110 33435644-7 2021 Results from epidemiological, preclinical and some clinical studies demonstrated the link between thyroid, parathyroid hormone and vitamin D and cognitive status, between diabetes, and insulin resistance in particular, and dementia, between sexual and adrenal hormones, particularly estrogen variation at menopause, and cognitive decline. Vitamin D 131-140 parathyroid hormone Homo sapiens 107-126 33475596-0 2020 Frequency of Vitamin D deficiency and its association with serum PTH levels in end stage renal disease patients. Vitamin D 13-22 parathyroid hormone Homo sapiens 65-68 33475596-1 2020 OBJECTIVE: To assess the frequency of Vitamin D Deficiency and its association with serum Parathormone (PTH) levels in End stage renal disease patients in a tertiary setup. Vitamin D 38-47 parathyroid hormone Homo sapiens 90-102 33475596-1 2020 OBJECTIVE: To assess the frequency of Vitamin D Deficiency and its association with serum Parathormone (PTH) levels in End stage renal disease patients in a tertiary setup. Vitamin D 38-47 parathyroid hormone Homo sapiens 104-107 33475596-6 2020 To determine association between Vitamin D and serum Parathormone (PTH) levels chi-square test was applied. Vitamin D 33-42 parathyroid hormone Homo sapiens 53-65 33475596-6 2020 To determine association between Vitamin D and serum Parathormone (PTH) levels chi-square test was applied. Vitamin D 33-42 parathyroid hormone Homo sapiens 67-70 33475596-15 2020 Both low and normal vitamin D was associated with High PTH (P <0.001) Other significant associations noted were that of High Alkaline Phosphatase with High PTH levels and a normal Vitamin D level (P<0.001). Vitamin D 20-29 parathyroid hormone Homo sapiens 55-58 33475596-16 2020 CONCLUSIONS: Our study revealed more than half of our participants were Vitamin D deficient and an association was found between Normal Vitamin D levels and high serum PTH levels with associated high alkaline phosphatase levels. Vitamin D 136-145 parathyroid hormone Homo sapiens 168-171 33330592-2 2020 Vitamin D deficiency can activate the parathyroid to induce the release of parathyroid hormone, which was thought to increase serum uric acid level, and low vitamin D status may also be associated with risk of CVD. Vitamin D 0-9 parathyroid hormone Homo sapiens 75-94 32964520-1 2020 Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism. Vitamin D 114-123 parathyroid hormone Homo sapiens 40-59 33190990-0 2021 Blunted PTH response to vitamin D insufficiency/deficiency and colorectal neoplasia risk. Vitamin D 24-33 parathyroid hormone Homo sapiens 8-11 33190990-2 2021 However, in previous studies, individuals with blunted parathyroid hormone (PTH) response to vitamin D insufficiency/deficiency (BPRVID), were not differentiated from those with high PTH response to vitamin D insufficiency/deficiency (HPRVID). Vitamin D 93-102 parathyroid hormone Homo sapiens 76-79 32964520-1 2020 Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) are regulators of renal phosphate excretion and vitamin D metabolism. Vitamin D 114-123 parathyroid hormone Homo sapiens 61-64 32213215-0 2020 The role of PTH during pregnancy on the relationship between maternal vitamin D deficiency and foetal growth restriction: a prospective birth cohort study. Vitamin D 70-79 parathyroid hormone Homo sapiens 12-15 32785694-1 2020 BACKGROUND: Elevated serum levels of parathyroid hormone (PTH), one of the main regulators of calcium homeostasis and vitamin D metabolism, have been proposed as predictors of mortality. Vitamin D 118-127 parathyroid hormone Homo sapiens 37-56 32785694-1 2020 BACKGROUND: Elevated serum levels of parathyroid hormone (PTH), one of the main regulators of calcium homeostasis and vitamin D metabolism, have been proposed as predictors of mortality. Vitamin D 118-127 parathyroid hormone Homo sapiens 58-61 32785694-9 2020 The impact of PTH on mortality risk in patients with T2DM remained significant after adjustment for glycated hemoglobin A1c, diabetes duration, classical cardiovascular risk factors, serum levels of vitamin D, and kidney function (HR = 2.10 [1.10-4.10]; P = .030). Vitamin D 199-208 parathyroid hormone Homo sapiens 14-17 33341829-3 2020 The trend of vitamin D deficiency and frequency was assessed in relation to age, gender and serum levels of calcium, phosphorus, magnesium, alkaline phosphatase and parathyroid hormone. Vitamin D 13-22 parathyroid hormone Homo sapiens 165-184 33289915-2 2020 The parathyroid hormone levels were in the lower normal range with highly elevated Vitamin D levels. Vitamin D 83-92 parathyroid hormone Homo sapiens 4-23 32579313-9 2020 CONCLUSIONS: Taking into account the lower 25(OH)D, 1,25(OH)D and Ca concentrations in the majority of centenarians, as well as the negative correlation between the vitamin D active metabolites and PTH, vitamin D and calcium supplementation should be systematically administered to the oldest of the elderly. Vitamin D 165-174 parathyroid hormone Homo sapiens 198-201 33109180-2 2020 In human research, the parathyroid hormone concentration in relation to the 25-hydroxyvitamin D concentration is used to determine vitamin D deficiency. Vitamin D 86-95 parathyroid hormone Homo sapiens 23-42 33114615-13 2020 Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002). Vitamin D 34-43 parathyroid hormone Homo sapiens 134-153 31874050-6 2020 Serum levels of 25(OH) D3 increased significantly with a simultaneous decrease in serum concentration of PTH in vitamin D group. Vitamin D 112-121 parathyroid hormone Homo sapiens 105-108 32306297-0 2020 Relationships Between Vitamin D Status and PTH over 5 Years After Roux-en-Y Gastric Bypass: a Longitudinal Cohort Study. Vitamin D 22-31 parathyroid hormone Homo sapiens 43-46 33154683-8 2020 There was a positive relationship between 25-(OH) D levels with temperature and solar radiation; however, parathyroid hormone, female and AQI were negatively correlated with Vitamin D levels. Vitamin D 174-183 parathyroid hormone Homo sapiens 106-125 32122880-6 2020 All six patients had high serum parathyroid hormone levels (median 45 pmol/L, range 27-120 pmol/L), a sensitive marker of total body calcium deprivation secondary to vitamin D deficiency. Vitamin D 166-175 parathyroid hormone Homo sapiens 32-51 32737345-6 2020 In these 299 patients, vitamin D supplementation had significant favorable effects on Diastolic Blood Pressure (DBP) (- 2.96, p = 0.02) and Parathyroid hormone (PTH) (- 4.05, p < 0.001). Vitamin D 23-32 parathyroid hormone Homo sapiens 140-159 32821633-0 2020 Response of Parathyroid Hormone to Vitamin D Deficiency in Otherwise Healthy Individuals. Vitamin D 35-44 parathyroid hormone Homo sapiens 12-31 32821633-5 2020 The objective of this study is to assess deficiency of vitamin D in otherwise healthy individuals, and to determine the response of the PTH to vitamin D deficiency. Vitamin D 143-152 parathyroid hormone Homo sapiens 136-139 32469401-9 2020 Further studies are needed to determine whether differences in the vitamin D-PTH endocrine system contribute to racial disparities in cardiovascular health. Vitamin D 67-76 parathyroid hormone Homo sapiens 77-80 32737345-6 2020 In these 299 patients, vitamin D supplementation had significant favorable effects on Diastolic Blood Pressure (DBP) (- 2.96, p = 0.02) and Parathyroid hormone (PTH) (- 4.05, p < 0.001). Vitamin D 23-32 parathyroid hormone Homo sapiens 161-164 32582730-1 2020 Aims/Introduction: Chronic kidney disease (CKD)-mineral and bone disorders (CKD-MBD) are an adverse outcome derived from decreases in kidney function, where abnormality of serum concentrations of calcium (Ca), phosphorus, parathyroid hormone (PTH), and vitamin D can be seen simultaneously. Vitamin D 253-262 parathyroid hormone Homo sapiens 222-241 32567548-10 2020 Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20-30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 +- 24.7pg/mL vs 44.2 +- 64.5pg/mL; p<0.01). Vitamin D 71-80 parathyroid hormone Homo sapiens 131-134 32407867-7 2020 In patients with vitamin D deficiency (defined as serum 25-hydroxyvitamin D levels 15 ng/mL or lower), gland weight, PTH, AP, and adjusted calcium were each significantly higher than in patients with 25-hydroxyvitamin D levels of 16 ng/mL or higher, but serum 1,25-dihydroxyvitamin D levels were similar in both groups. Vitamin D 17-26 parathyroid hormone Homo sapiens 117-120 32567548-10 2020 Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20-30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 +- 24.7pg/mL vs 44.2 +- 64.5pg/mL; p<0.01). Vitamin D 24-33 parathyroid hormone Homo sapiens 131-134 32582730-7 2020 Conclusions: These results indicate that a reduction in eGFR is a significant risk factor for an increase in serum PTH concentration when it is <60 mL/min/1.73 m2 and vitamin D is deficient, in the general Japanese population. Vitamin D 167-176 parathyroid hormone Homo sapiens 115-118 32450764-6 2020 A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = -0.280, p < 0.05; r = -0.407, p = 0.038; r = -0.445, p = 0.005), respectively. Vitamin D 52-61 parathyroid hormone Homo sapiens 86-105 32458373-6 2020 At the same time, vitamin D deficiency (< 20 ng/ml) increases parathyroid hormone levels and thus promotes bone loss and the risk of fracture. Vitamin D 18-27 parathyroid hormone Homo sapiens 62-81 32515572-2 2020 Vitamin D is the key regulator of bone metabolism and its deficiency contributes to higher level of parathyroid hormone (PTH), leading to the activation of bone turnover. Vitamin D 0-9 parathyroid hormone Homo sapiens 100-119 32515572-2 2020 Vitamin D is the key regulator of bone metabolism and its deficiency contributes to higher level of parathyroid hormone (PTH), leading to the activation of bone turnover. Vitamin D 0-9 parathyroid hormone Homo sapiens 121-124 32515572-10 2020 In obesity the real vitamin D deficiency could be estimate by serum 1,25(OH)2D concentrations whose lower levels contribute to the higher PTH production and consequently to bone loss and to a greater fracture risk. Vitamin D 20-29 parathyroid hormone Homo sapiens 138-141 32412426-8 2020 Serum parathyroid hormone (PTH) and change in PTH after vitamin D supplementation were related to serum 25(OH)D levels in steps of 25 nmol/L (<24, 25-49, 50-74, 75-99, and >99 nmol/L). Vitamin D 56-65 parathyroid hormone Homo sapiens 46-49 32367244-0 2020 Seasonal periodicity of serum parathyroid hormone and its relation with vitamin D in Romania. Vitamin D 72-81 parathyroid hormone Homo sapiens 30-49 32367244-2 2020 PTH was dependent on serum vitamin D, particularly below 12.82 ng/mL. Vitamin D 27-36 parathyroid hormone Homo sapiens 0-3 32391251-9 2020 Having PTH >= 6 pmol/L was also associated with a higher likelihood of having vitamin D deficiency. Vitamin D 78-87 parathyroid hormone Homo sapiens 7-10 32441564-3 2022 In this study, we report PTH levels according to the vitamin D status and BALP levels in a large cohort of 1200 children. Vitamin D 53-62 parathyroid hormone Homo sapiens 25-28 32412426-10 2020 In pooled RCTs, there was a significant reduction in serum PTH by vitamin D supplementation regardless of baseline serum 25(OH)D level. Vitamin D 66-75 parathyroid hormone Homo sapiens 59-62 32007562-10 2020 Group differences in relationships between vitamin D metabolites and with PTH were investigated with multiple regression analyses. Vitamin D 43-52 parathyroid hormone Homo sapiens 74-77 32874076-13 2020 Age > 50 years, being housewife, use of antiepileptic medications (AEDs), and higher serum parathyroid hormone are associated with severe vitamin D deficiency. Vitamin D 138-147 parathyroid hormone Homo sapiens 91-110 32318358-10 2020 It was found that reduction in serum Vitamin D level to <10.25 ng/mL results in a surge of serum PTH. Vitamin D 37-46 parathyroid hormone Homo sapiens 97-100 32344842-7 2020 RESULTS: Between-groups statistical analysis showed that a dose (50,000 IU/month) vitamin D significantly increased the serum levels of 25-hydroxyvitamin D (25 (OH) D) (p < 0.001) and decreased serum levels of PTH (p = 0.003). Vitamin D 82-91 parathyroid hormone Homo sapiens 210-213 32268827-10 2021 Measurement of parathyroid hormone decline added diagnostic value for one patient with preoperative parathyroid-hormone-elevation associated with vitamin D deficiency. Vitamin D 146-155 parathyroid hormone Homo sapiens 15-34 32052217-8 2020 CONCLUSION: Our findings suggest that excess adiposity confers resistance to vitamin D efficacy in suppressing PTH levels, even when given at high doses. Vitamin D 77-86 parathyroid hormone Homo sapiens 111-114 31619748-7 2020 PTH levels were border-line higher in TDF patients: non-European ancestry, females, TDF, VD levels < 30 ng/mL and SLC28A2-124CT/TT and ABCC2-24CC were predictors. Vitamin D 89-91 parathyroid hormone Homo sapiens 0-3 31996592-5 2020 Vitamin D supplementation decreases parathyroid hormone (PTH) levels and high levels of 25-hydroxyvitamin D may be required for maximal suppression. Vitamin D 0-9 parathyroid hormone Homo sapiens 36-55 31996592-5 2020 Vitamin D supplementation decreases parathyroid hormone (PTH) levels and high levels of 25-hydroxyvitamin D may be required for maximal suppression. Vitamin D 0-9 parathyroid hormone Homo sapiens 57-60 31996592-7 2020 The primary reason to use vitamin D in kidney disease remains to lower PTH levels. Vitamin D 26-35 parathyroid hormone Homo sapiens 71-74 31823044-6 2020 In addition, the potentially adverse effects of PTH-lowering measures, such as active vitamin D and calcimimetics, must be taken into account. Vitamin D 86-95 parathyroid hormone Homo sapiens 48-51 32367810-10 2020 S-PTH was negatively correlated to vitamin D concentrations at ages 7, 15 and 17 but there was not a significant correlation at age 9. Vitamin D 35-44 parathyroid hormone Homo sapiens 2-5 32231092-1 2020 Optimal vitamin D status has commonly been defined as the level of 25-hydroxyvitamin D (25(OH)D) at which parathyroid hormone (PTH) concentrations would be maximally suppressed, represented by an observed minimum plateau. Vitamin D 8-17 parathyroid hormone Homo sapiens 106-125 32231092-1 2020 Optimal vitamin D status has commonly been defined as the level of 25-hydroxyvitamin D (25(OH)D) at which parathyroid hormone (PTH) concentrations would be maximally suppressed, represented by an observed minimum plateau. Vitamin D 8-17 parathyroid hormone Homo sapiens 127-130 32231092-6 2020 Mean PTH concentrations for Brazilian women with vitamin D deficiency (<25 nmol/L) were significantly higher compared to those with vitamin D insufficiency (25-49.9 nmol/L) (p < 0.01), vitamin D adequacy (50-74.9 nmol/L) (p < 0.01) and those with optimal vitamin D status (>75 nmol/L) (p < 0.001). Vitamin D 49-58 parathyroid hormone Homo sapiens 5-8 31107101-3 2020 OBJECTIVE: To compare the effect of oral vitamin D supplementation with sunlight exposure on serum vitamin D and parathyroid hormone (PTH). Vitamin D 41-50 parathyroid hormone Homo sapiens 113-132 31668375-11 2020 Rates of changes in PTH and phosphate levels increased modestly and without marked acceleration around the same time, with modest deceleration immediately before ESKD, when use of active vitamin D and phosphate binders increased. Vitamin D 187-196 parathyroid hormone Homo sapiens 20-23 32024097-5 2020 RESULTS: Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. Vitamin D 23-32 parathyroid hormone Homo sapiens 289-292 31914999-2 2020 Patients with vitamin D deficiency may also be asymptomatic, with normal calcium and elevated PTH concentrations. Vitamin D 14-23 parathyroid hormone Homo sapiens 94-97 31892609-3 2020 RESULTS: There was a dose-dependent effect of vitamin D supplementation on serum 25(OH)D, PTH and broad gene expression. Vitamin D 46-55 parathyroid hormone Homo sapiens 90-93 32148490-1 2020 Background: The purpose of the current study is to determine PTH reference values in vitamin-D-replete Lebanese adults using 2nd and 3rd generation PTH assays and to look at the factors that affect PTH variations. Vitamin D 85-94 parathyroid hormone Homo sapiens 61-64 31107101-3 2020 OBJECTIVE: To compare the effect of oral vitamin D supplementation with sunlight exposure on serum vitamin D and parathyroid hormone (PTH). Vitamin D 41-50 parathyroid hormone Homo sapiens 134-137 31107101-4 2020 METHODS: A computer-based literature search through PubMed, Scopus and Google scholar search engines was conducted until April 2019 to find clinical trials which compared the effect of oral vitamin D supplementation with sunlight exposure on serum vitamin D and PTH. Vitamin D 190-199 parathyroid hormone Homo sapiens 262-265 32071501-0 2020 Association of Vitamin D and Parathyroid Hormone Levels in Overweight and Obese Adolescents. Vitamin D 15-24 parathyroid hormone Homo sapiens 29-48 32444536-12 2020 Serum level of PTH was a significant risk factor for severe vitamin D deficiency while calcium D supplementation, MET and sunscreen were significant protective factors. Vitamin D 60-69 parathyroid hormone Homo sapiens 15-18 31704050-0 2020 Paradoxical Response of Parathyroid Hormone to Vitamin D-Calcium Supplementation in Indian Children. Vitamin D 47-56 parathyroid hormone Homo sapiens 24-43 31704050-7 2020 At follow-up, 1-year post-supplementation, in the vitamin D group, PTH concentrations continued to remain high (but not significantly different from levels at 6 months), with low normal serum calcium, high normal phosphate, and ALK-P in reference range. Vitamin D 50-59 parathyroid hormone Homo sapiens 67-70 31704050-8 2020 CONCLUSIONS: In children who are vitamin D sufficient but with habitually low dietary calcium intake, vitamin D-calcium supplementation paradoxically and significantly increased serum PTH concentrations with no apparent effect on other bone biochemistry. Vitamin D 102-111 parathyroid hormone Homo sapiens 184-187 31704050-1 2020 OBJECTIVES: To investigate the effect of oral vitamin D-calcium supplementation on serum intact parathyroid hormone (PTH), calcium, phosphorous, and alkaline phosphatase (ALK-P) concentrations in children with habitually low calcium intakes. Vitamin D 46-55 parathyroid hormone Homo sapiens 96-115 31215092-0 2019 Effect of vitamin D supplementation on total and free 25 hydroxyvitamin D and parathyroid hormone. Vitamin D 10-19 parathyroid hormone Homo sapiens 78-97 31949415-12 2019 The increase of serum hepcidin levels may be inhibited by effective treatment of anemia with iron supplementation and erythropoietin, and the treatment of secondary hyperparathyroidism with phosphate binders and the active form of vitamin D, which decrease serum parathyroid hormone and fibroblast growth factor-23 levels, and control inflammation to some extent. Vitamin D 231-240 parathyroid hormone Homo sapiens 263-282 31522253-0 2019 Effects of Elevated Parathyroid Hormone Levels on Muscle Health, Postural Stability and Quality of Life in Vitamin D-Insufficient Healthy Women: A Cross-Sectional Study. Vitamin D 107-116 parathyroid hormone Homo sapiens 20-39 31215092-9 2019 There was a progressive decrease in serum PTH with increasing vitamin D doses and the per cent change was similar for F25D and T25D. Vitamin D 62-71 parathyroid hormone Homo sapiens 42-45 31310310-8 2019 RESULTS: PTH therapy was associated with a progressive reduction in supplemental calcium (57%; p < 0.01) and active vitamin D (76%; p < 0.001) requirements over 8 years. Vitamin D 119-128 parathyroid hormone Homo sapiens 9-12 31520697-0 2019 Parathyroid hormone response to different vitamin D levels in population-based old and very-old Polish cohorts. Vitamin D 42-51 parathyroid hormone Homo sapiens 0-19 30180151-3 2019 AIM: The aim of this study is to determine the association between parathyroid hormone (PTH) and vitamin D deficiency with GERD symptoms, erosive esophagitis, and Barrett"s esophagus. Vitamin D 97-106 parathyroid hormone Homo sapiens 67-86 31777705-6 2019 Results: During the intervention, PTH (mean difference, -33.36; 95% CI: -49.15 to -17.57;P<0.001) and LDL-C (mean difference, -15.91; 95% CI: -21.76 to -10.07; P<0.001) decreased and 25(OH) D (mean difference, 36.44; 95% CI: 29.05 to 43.83; P<0.001) increased significantly in the vitamin D group. Vitamin D 290-299 parathyroid hormone Homo sapiens 34-37 31273631-0 2019 Parathyroid hormone reference ranges in healthy individuals classified by vitamin D status. Vitamin D 74-83 parathyroid hormone Homo sapiens 0-19 31273631-5 2019 RESULTS: In vitamin D sufficiency, median PTH was 31.9 pg/mL [range (2.5th-97.5th percentile) 17.9-58.6] compared with 35.5 pg/mL (17.0-60.4) for insufficiency, and 39.8 pg/mL (19.5-86.4) for deficiency. Vitamin D 12-21 parathyroid hormone Homo sapiens 42-45 31273631-8 2019 CONCLUSIONS: Upper reference limits (URL) for PTH in vitamin D sufficiency/insufficiency were similar and lower than current values. Vitamin D 53-62 parathyroid hormone Homo sapiens 46-49 31273631-9 2019 Clinically important PTH elevations were observed in vitamin D deficiency, where revised reference ranges with a higher URL may be appropriate. Vitamin D 53-62 parathyroid hormone Homo sapiens 21-24 31273631-10 2019 These data may help to distinguish vitamin D-related PTH elevations from other causes [e.g., primary (normocalcemic) or secondary hyperparathyroidism]. Vitamin D 35-44 parathyroid hormone Homo sapiens 53-56 31675537-0 2019 Low dietary magnesium intake alters vitamin D-parathyroid hormone relationship in adults who are overweight or obese. Vitamin D 36-45 parathyroid hormone Homo sapiens 46-65 31400903-13 2019 Vitamin D-fortified yogurt may be beneficial in improving serum 25OHD, lipid profile, glucose metabolism, and anthropometric parameters and decreasing parathyroid hormone level in pregnant women and adult and elderly subjects with or without diabetes, prediabetes, or metabolic syndrome. Vitamin D 0-9 parathyroid hormone Homo sapiens 151-170 31065919-10 2019 Type of surgery, vitamin D serum concentrations, and 2-year BMI were all independently associated with PTH levels. Vitamin D 17-26 parathyroid hormone Homo sapiens 103-106 30701437-8 2019 Meanwhile, patients with absence of PTH response to low vitamin D levels, were not repeated fallers and suffered mostly from subcapital fractures. Vitamin D 56-65 parathyroid hormone Homo sapiens 36-39 30701437-9 2019 DISCUSSION AND CONCLUSION: Elevated PTH levels predispose both to falls and trochanteric fractures, while vitamin D-deficient patients with normal PTH levels are mostly related to subcapital fractures. Vitamin D 106-115 parathyroid hormone Homo sapiens 147-150 31485996-4 2019 Particularly, we focus on the adequate control of serum phosphorus by restricting intake and the use of phosphate binders, correction of hypocalcemia while minimizing calcium burden, and reduction in PTH levels through the use of vitamin D sterols and calcimimetics. Vitamin D 230-239 parathyroid hormone Homo sapiens 200-203 31675537-1 2019 Vitamin D metabolism is dependent on magnesium (Mg) as a cofactor; therefore, poor Mg status may alter the relationship between vitamin D metabolite serum 25-hydroxyvitamin D (s25OHD) and serum parathyroid hormone (sPTH). Vitamin D 0-9 parathyroid hormone Homo sapiens 194-213 31675537-1 2019 Vitamin D metabolism is dependent on magnesium (Mg) as a cofactor; therefore, poor Mg status may alter the relationship between vitamin D metabolite serum 25-hydroxyvitamin D (s25OHD) and serum parathyroid hormone (sPTH). Vitamin D 128-137 parathyroid hormone Homo sapiens 194-213 30858148-1 2019 BACKGROUND: Vitamin D deficiency is common among dialysis patients and may impact blood concentrations of calcium, phosphorus, intact parathyroid hormone (iPTH), and alkaline phosphatase (ALP). Vitamin D 12-21 parathyroid hormone Homo sapiens 134-153 31223605-0 2019 Preventive Effects of Low Parathyroid Hormone Levels on Hip Fracture in Patients with Vitamin D Deficiency. Vitamin D 86-95 parathyroid hormone Homo sapiens 26-45 30959189-10 2019 In conclusion, supplementation with vitamin D appears to suppress bone turnover, possibly mediated by PTH reduction. Vitamin D 36-45 parathyroid hormone Homo sapiens 102-105 31741900-1 2019 Context: There is no consensus about the inflection point for 25 hydroxy vitamin D below which the intact PTH level increases. Vitamin D 62-82 parathyroid hormone Homo sapiens 106-109 31741900-6 2019 An inverse relationship between 25 hydroxy vitamin D (25(OH)D) and intact PTH exist, but strength of such relationship is weak (r = -0.16, P = 0.018). Vitamin D 32-52 parathyroid hormone Homo sapiens 74-77 31176378-8 2019 Skin fold thickness, fasting and post-glucose insulin, HOMA-IR, PTH, LDL, Serum cholesterol and hs-CRP showed statistically significant negative correlations with Vitamin D levels. Vitamin D 163-172 parathyroid hormone Homo sapiens 64-67 31061425-0 2019 The dynamic relationships between the active and catabolic vitamin D metabolites, their ratios, and associations with PTH. Vitamin D 59-68 parathyroid hormone Homo sapiens 118-121 31061425-6 2019 Our three-dimensional model provides mechanistic insight into the vitamin D-PTH endocrine system, and further substantiates the role of 24,25(OH)2D in human physiology. Vitamin D 66-75 parathyroid hormone Homo sapiens 76-79 31061425-7 2019 The model sets a new paradigm for vitamin D treatment strategy, and may help the establishment of vitamin D-adjusted PTH reference intervals. Vitamin D 34-43 parathyroid hormone Homo sapiens 117-120 31061425-7 2019 The model sets a new paradigm for vitamin D treatment strategy, and may help the establishment of vitamin D-adjusted PTH reference intervals. Vitamin D 98-107 parathyroid hormone Homo sapiens 117-120 30959477-0 2019 The effect of vitamin D supplementation on plasma non-oxidised PTH in a randomised clinical trial. Vitamin D 14-23 parathyroid hormone Homo sapiens 63-66 30959477-3 2019 While vitamin D supplementation decreases total PTH (tPTH) concentration, the effect on n-oxPTH concentration is unexplored. Vitamin D 6-15 parathyroid hormone Homo sapiens 48-51 30959477-10 2019 Our study suggests that vitamin D supplementation reduces the oxidation of PTH, as we observed a small but significant increase in the non-oxidised proportion of PTH upon treatment. Vitamin D 24-33 parathyroid hormone Homo sapiens 75-78 30959477-10 2019 Our study suggests that vitamin D supplementation reduces the oxidation of PTH, as we observed a small but significant increase in the non-oxidised proportion of PTH upon treatment. Vitamin D 24-33 parathyroid hormone Homo sapiens 162-165 30737643-11 2019 For calcium (Ca) and parathyroid hormone (PTH), there was a significant difference between the vitamin D group and the placebo group. Vitamin D 95-104 parathyroid hormone Homo sapiens 21-40 30737643-11 2019 For calcium (Ca) and parathyroid hormone (PTH), there was a significant difference between the vitamin D group and the placebo group. Vitamin D 95-104 parathyroid hormone Homo sapiens 42-45 31223605-1 2019 Background: The objective of the current study is to determine the role of serum parathyroid hormone (PTH) on hip fracture development by retrospectively analyzing the relationship between vitamin D and PTH levels and hip fracture prevalence. Vitamin D 189-198 parathyroid hormone Homo sapiens 81-100 31223605-1 2019 Background: The objective of the current study is to determine the role of serum parathyroid hormone (PTH) on hip fracture development by retrospectively analyzing the relationship between vitamin D and PTH levels and hip fracture prevalence. Vitamin D 189-198 parathyroid hormone Homo sapiens 102-105 31223605-8 2019 Conclusions: Patients with low serum 25(OH)D and PTH levels showed lower hip fracture prevalence, indicating the potential protective role of low PTH levels on bone health in patients with vitamin D deficiency. Vitamin D 189-198 parathyroid hormone Homo sapiens 49-52 31223605-8 2019 Conclusions: Patients with low serum 25(OH)D and PTH levels showed lower hip fracture prevalence, indicating the potential protective role of low PTH levels on bone health in patients with vitamin D deficiency. Vitamin D 189-198 parathyroid hormone Homo sapiens 146-149 31223605-9 2019 Therefore, clinicians should pay more attention to the possibility of fractures in patients with vitamin D deficiency who present with high PTH levels. Vitamin D 97-106 parathyroid hormone Homo sapiens 140-143 30653195-4 2019 This is the major circulating form of vitamin D and keeps an inverse correlation with serum parathyroid hormone (PTH) concentration. Vitamin D 38-47 parathyroid hormone Homo sapiens 92-111 31089432-1 2019 Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia. Vitamin D 79-88 parathyroid hormone Homo sapiens 126-129 31089432-1 2019 Introduction: Loss of function mutations of CYP24A1 gene, which is involved in vitamin D catabolism, cause vitamin D-mediated PTH-independent hypercalcemia. Vitamin D 107-116 parathyroid hormone Homo sapiens 126-129 30944814-0 2019 High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases. Vitamin D 97-106 parathyroid hormone Homo sapiens 77-96 30927339-3 2019 Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D. Vitamin D 166-175 parathyroid hormone Homo sapiens 0-19 30927339-3 2019 Parathyroid hormone (PTH) secretion is primarily regulated by the ionized calcium concentration as well as the phosphate concentration in the extracellular fluid and vitamin D. Vitamin D 166-175 parathyroid hormone Homo sapiens 21-24 30944814-9 2019 Conclusions: Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in CLD. Vitamin D 128-137 parathyroid hormone Homo sapiens 124-127 30044347-0 2019 Hepatic Hemosiderosis Contributes to Abnormal Vitamin D-PTH Axis in Thalassemia Major. Vitamin D 46-55 parathyroid hormone Homo sapiens 56-59 30350311-3 2019 Clinical trial results indicated that although once-daily PTH reduced calcium and vitamin D dose requirement while maintaining the normocalcemia, the regimen was not adequate to control hypercalciuria. Vitamin D 82-91 parathyroid hormone Homo sapiens 58-61 30540559-13 2019 Parathyroid hormone replacement is of value in lowering the doses of calcium and active vitamin D analogues required and may be of value in lowering long term complications of hypoparathyroidism. Vitamin D 88-97 parathyroid hormone Homo sapiens 0-19 30044347-1 2019 OBJECTIVE: The aim of this study was to evaluate the vitamin D-PTH axis in thalassemia major (TM) in relation to hepatic siderosis liver iron content. Vitamin D 53-62 parathyroid hormone Homo sapiens 63-66 30044347-2 2019 DESIGN AND PARTICIPANTS: In this case-controlled observational study, vitamin D-PTH axis was studied in 158 TM and 84 age and ethnicity-matched healthy nonthalassemic controls attending University College Hospital, London. Vitamin D 70-79 parathyroid hormone Homo sapiens 80-83 30778159-9 2019 Although 1,25(OH)2D and 24,25(OH)2D are decreased in CKD patient serum, our findings suggest that PTH and FGF23 retain their effects to regulate vitamin D metabolism even in the kidneys of these patients, while production of 1,25(OH)2D and 24,25(OH)2D from 25(OH)D is restricted due to either impairment of megalin-mediated reabsorption of the 25(OH)D-DBP complex or reduced renal mass. Vitamin D 145-154 parathyroid hormone Homo sapiens 98-101 30788611-0 2019 Vitamin D cutoff point in relation to parathyroid hormone: a population based study in Riyadh city, Saudi Arabia. Vitamin D 0-9 parathyroid hormone Homo sapiens 38-57 30289192-12 2019 DISCUSSION: This study is the first study which showed a correlation between TST negativity and increased PTH levels and receiving vitamin D treatment. Vitamin D 131-140 parathyroid hormone Homo sapiens 106-109 30820485-11 2019 Maternal laboratory findings indicated normocalcemia, but vitamin D deficiency with a high PTH level for the lactation period was observed. Vitamin D 58-67 parathyroid hormone Homo sapiens 91-94 31149066-2 2019 Objective: In this study, we investigated the relationship between NLR-PLR and parathyroid hormone (PTH) and vitamin D in patients with high PTH levels. Vitamin D 109-118 parathyroid hormone Homo sapiens 79-98 30679399-4 2019 Prescription of active vitamin D or its analogues is associated with lower rates of cardiovascular events in predialysis and dialysis patients, however indication biases often seen in observational studies cannot preclude the possibility that the benefit of these agents is limited to patients with high parathyroid hormone(PTH)levels. Vitamin D 23-32 parathyroid hormone Homo sapiens 324-327 30465456-9 2019 CONCLUSION: In patients with temporomandibular disorders, increased parathyroid hormone levels in response to vitamin D deficiency was significantly more prominent. Vitamin D 110-119 parathyroid hormone Homo sapiens 68-87 32036848-8 2019 PTH levels, however, proved erratic and showed an upward trend over the first year of therapy; however its levels partially decreased following increase of vitamin D levels by replacement therapy. Vitamin D 156-165 parathyroid hormone Homo sapiens 0-3 30246883-7 2019 RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group. Vitamin D 9-18 parathyroid hormone Homo sapiens 130-133 30246883-9 2019 Between the groups, there were significant decrease in weight, fat mass, serum MCP-1 and PTH concentrations and significant increase in serum 25OHD concentrations after intervention with vitamin D supplementation compared to placebo (P < 0.05). Vitamin D 187-196 parathyroid hormone Homo sapiens 89-92 30651833-8 2019 Paricalcitol, cinacalcet plus vitamin D analogue and cinacalcet were significantly more efficacious in controlling PTH levels compared with conventional therapy (which comprises calcium-based phosphate binders, non-calcium-based phosphate binders and vitamin D analogues) [odds ratio (OR)=3.99, 2.91 and 2.47, respectively] and placebo (OR=20.32, 14.89 and 12.56, respectively). Vitamin D 30-39 parathyroid hormone Homo sapiens 115-118 31586507-7 2019 Very low level of vitamin D that disrupted calcium absorption through the intestine, and decreased calcemia increased parathyroid hormone levels with resulting bone effect. Vitamin D 18-27 parathyroid hormone Homo sapiens 118-137 31930870-12 2019 CONCLUSION: A significant interaction of vitamin D deficiency and high PTH on postural stability is detected among healthy adult males. Vitamin D 41-50 parathyroid hormone Homo sapiens 71-74 32105004-8 2019 The only difference between the two groups was PTH level which was higher in the vitamin D deficiency group. Vitamin D 81-90 parathyroid hormone Homo sapiens 47-50 29900589-9 2018 This is also the case when treating low PTH levels by decreasing vitamin D or calcium load. Vitamin D 65-74 parathyroid hormone Homo sapiens 40-43 30390810-1 2018 Parathyroid hormone (PTH) is the major secretory product of the parathyroid glands, and in hypocalcemic conditions, can enhance renal calcium reabsorption, increase active vitamin D production to increase intestinal calcium absorption, and mobilize calcium from bone by increasing turnover, mainly but not exclusively in cortical bone. Vitamin D 172-181 parathyroid hormone Homo sapiens 0-19 30390810-1 2018 Parathyroid hormone (PTH) is the major secretory product of the parathyroid glands, and in hypocalcemic conditions, can enhance renal calcium reabsorption, increase active vitamin D production to increase intestinal calcium absorption, and mobilize calcium from bone by increasing turnover, mainly but not exclusively in cortical bone. Vitamin D 172-181 parathyroid hormone Homo sapiens 21-24 30390818-2 2018 Impaired QOL in patients treated with conventional therapy with calcium and active vitamin D has been documented in epidemiologic (registry) studies, case-controlled studies, and surveys, and at baseline in clinical trials of parathyroid hormone (PTH). Vitamin D 83-92 parathyroid hormone Homo sapiens 226-245 29955908-4 2018 INTRODUCTION: In vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone. Vitamin D 17-26 parathyroid hormone Homo sapiens 51-70 30305067-6 2018 A few cut- offs have correlated vitamin D deficiency to physiological markers such as parathyroid hormone (PTH), calcium and phosphate with varying results. Vitamin D 32-41 parathyroid hormone Homo sapiens 86-105 30305067-6 2018 A few cut- offs have correlated vitamin D deficiency to physiological markers such as parathyroid hormone (PTH), calcium and phosphate with varying results. Vitamin D 32-41 parathyroid hormone Homo sapiens 107-110 30305067-8 2018 Vitamin D (25(OH)D) levels were assayed and correlated with PTH, calcium and phosphate. Vitamin D 0-9 parathyroid hormone Homo sapiens 60-63 30305067-15 2018 Vitamin D levels below 30 ng/mL was associated with a significant rise in PTH levels, suggesting that this cut off could be appropriate for defining Vitamin D deficiency in the population served by our laboratory. Vitamin D 0-9 parathyroid hormone Homo sapiens 74-77 30305067-15 2018 Vitamin D levels below 30 ng/mL was associated with a significant rise in PTH levels, suggesting that this cut off could be appropriate for defining Vitamin D deficiency in the population served by our laboratory. Vitamin D 149-158 parathyroid hormone Homo sapiens 74-77 30169726-2 2018 Objectives: We aimed to explore functional vitamin D deficiency in pregnancy by investigating associations between vitamin D status, parathyroid hormone (PTH), and perinatal outcomes. Vitamin D 43-52 parathyroid hormone Homo sapiens 133-152 29955908-4 2018 INTRODUCTION: In vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone. Vitamin D 17-26 parathyroid hormone Homo sapiens 72-75 29955908-5 2018 We assessed effects of PTH responses to vitamin D insufficiency on bone metabolism, density, and geometry. Vitamin D 40-49 parathyroid hormone Homo sapiens 23-26 30050908-11 2018 Conclusion: These findings suggest that vitamin D supplementation may act to protect against CVD through improving risk factors, including high blood pressure, elevated PTH, dyslipidemia, and inflammation. Vitamin D 40-49 parathyroid hormone Homo sapiens 169-172 30294564-7 2018 A trend towards a greater decrease in serum parathyroid hormone (PTH) levels was observed in vitamin D group compared to placebo group (-3.8 vs. +1.9, P = 0.07). Vitamin D 93-102 parathyroid hormone Homo sapiens 44-63 29677006-6 2018 Although vitamin D sterols raise these risk markers when lowering parathyroid hormone (PTH), calcimimetics lower them. Vitamin D 9-18 parathyroid hormone Homo sapiens 66-85 29574006-2 2018 The enzyme deficiency leads to an impaired vitamin D catabolism pathway, resulting in a syndrome characterized by recurrent hypercalcemia, hypercalciuria and suppressed parathyroid hormone (PTH) levels. Vitamin D 43-52 parathyroid hormone Homo sapiens 169-188 30260797-0 2018 Tenofovir disoproxil fumarate appears to disrupt the relationship of vitamin D and parathyroid hormone. Vitamin D 69-78 parathyroid hormone Homo sapiens 83-102 29743660-6 2018 CONCLUSION: Preterm infant vitamin D status was significantly associated with PTH status and femur mineralization with suggestion that achieving a specific 25-hydroxyvitamin concentration is associated with optimal calcium homeostasis and femur bone mineralization. Vitamin D 27-36 parathyroid hormone Homo sapiens 78-81 28455680-8 2018 In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH. Vitamin D 51-60 parathyroid hormone Homo sapiens 105-108 29658832-1 2018 OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). Vitamin D 53-62 parathyroid hormone Homo sapiens 119-122 29658832-12 2018 PTH is an important risk factor responsible for the higher 10-year probability of osteoporotic fractures in diabetic patients, especially in those with lower vitamin D levels. Vitamin D 158-167 parathyroid hormone Homo sapiens 0-3 29498343-13 2018 In conclusion, ethnic origin influenced PTH, PTH response to low vitamin D levels and Ca levels in populations in Greenland. Vitamin D 65-74 parathyroid hormone Homo sapiens 45-48 29252600-2 2018 The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR. Vitamin D 4-13 parathyroid hormone Homo sapiens 31-50 29955369-2 2018 The goal of this study was to assess parathyroid hormone (PTH) in its relationship to vitamin D and inflammation, as well as to better understand the role of human cathelicidin (LL-37) in pSLE. Vitamin D 86-95 parathyroid hormone Homo sapiens 37-56 29955369-2 2018 The goal of this study was to assess parathyroid hormone (PTH) in its relationship to vitamin D and inflammation, as well as to better understand the role of human cathelicidin (LL-37) in pSLE. Vitamin D 86-95 parathyroid hormone Homo sapiens 58-61 30134801-0 2018 Dysequilibrium of the PTH-FGF23-vitamin D axis in relapsing remitting multiple sclerosis; a longitudinal study. Vitamin D 32-41 parathyroid hormone Homo sapiens 22-25 30134801-3 2018 We therefore sought evidence for dysregulation of the PTH-FGF23-vitamin D axis in RRMS. Vitamin D 64-73 parathyroid hormone Homo sapiens 54-57 30134801-12 2018 CONCLUSIONS: This study revealed a dysequilibrium of the PTH-FGF23-vitamin D axis in RRMS, with lower plasma PTH, higher plasma iFGF23 and a lower serum 1,25(OH)2D to 25OHD ratio in RRMS compared with HC subjects. Vitamin D 67-76 parathyroid hormone Homo sapiens 57-60 29470176-4 2018 The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth factors in pre-pubertal girls with VDD. Vitamin D 91-100 parathyroid hormone Homo sapiens 115-118 28921422-10 2018 Pre-operative PTH correlated with age, BMI, and vitamin D levels. Vitamin D 48-57 parathyroid hormone Homo sapiens 14-17 29597231-0 2018 Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis. Vitamin D 46-55 parathyroid hormone Homo sapiens 26-45 32476902-15 2018 However, some statistically significant changes in serum vitamin D and PTH levels were demonstrated that were consistent with some amelioration of sarcoidosis-induced vitamin D dysregulation. Vitamin D 167-176 parathyroid hormone Homo sapiens 71-74 29238429-4 2018 The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH). Vitamin D 59-68 parathyroid hormone Homo sapiens 225-244 29238429-4 2018 The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH). Vitamin D 59-68 parathyroid hormone Homo sapiens 246-249 29238429-15 2018 Conclusions: This study suggested that vitamin D and low-fat milk supplementation improves bone metabolism by sustaining the 25(OH)D concentration and decreasing the PTH concentration in female high-school endurance runners regardless of the state of menses. Vitamin D 39-48 parathyroid hormone Homo sapiens 166-169 30379301-9 2018 Vitamin D insufficiency was estimated by compensatory elevations of PTH above the normal range (> 65 pg/mL). Vitamin D 0-9 parathyroid hormone Homo sapiens 68-71 30379314-6 2018 RESULTS: Vitamin D supplementation led to significant improvements in blood levels of [25(OH) D] (P< 0.0001), and a significant decreased of HOMA, PTH and FBG concentrations (P< 0.0001) in the intervention group compared to placebo. Vitamin D 9-18 parathyroid hormone Homo sapiens 150-153 29255137-3 2017 The optimal vitamin D level was determined according to the suppression of parathyroid hormone (PTH) and the highest bone mineral density (BMD). Vitamin D 12-21 parathyroid hormone Homo sapiens 75-94 29088221-1 2017 BACKGROUND: Although previous studies reported an association between serum vitamin D and parathyroid hormone (PTH) with carotid atherosclerosis or arterial stiffness, these were inconsistent. Vitamin D 76-85 parathyroid hormone Homo sapiens 90-109 29176783-1 2017 BACKGROUND: Previous reports about the relationship between a high parathyroid hormone (PTH) and low vitamin D levels with blood pressure in different hypertension groups are conflicting. Vitamin D 101-110 parathyroid hormone Homo sapiens 67-86 29285447-0 2017 Role of Parathyroid Hormone in Determination of Fat Mass in Patients with Vitamin D Deficiency. Vitamin D 74-83 parathyroid hormone Homo sapiens 8-27 27282116-8 2017 The differential vitamin D responsiveness of the VitDbol study participants was determined via individual changes in their PTH levels or chromatin accessibility in relation to alterations in 25(OH)D3 concentrations. Vitamin D 17-26 parathyroid hormone Homo sapiens 123-126 29084522-1 2017 BACKGROUND: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility. Vitamin D 12-21 parathyroid hormone Homo sapiens 126-145 29084522-1 2017 BACKGROUND: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility. Vitamin D 12-21 parathyroid hormone Homo sapiens 147-150 29088221-1 2017 BACKGROUND: Although previous studies reported an association between serum vitamin D and parathyroid hormone (PTH) with carotid atherosclerosis or arterial stiffness, these were inconsistent. Vitamin D 76-85 parathyroid hormone Homo sapiens 111-114 29135297-2 2017 Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Vitamin D 13-22 parathyroid hormone Homo sapiens 78-97 28902630-4 2017 At 6 years an elevated PTH was detected with normal calcium and a low 25(OH) vitamin D level (25OHD). Vitamin D 77-86 parathyroid hormone Homo sapiens 23-26 28835974-11 2017 Some patients continue to exhibit clinical symptoms despite adequate calcium levels; in these cases s. c. parathyroid hormone 1-84 should be considered to stabilize calcium levels and to lower the dosage of calcium and vitamin D supplements. Vitamin D 219-228 parathyroid hormone Homo sapiens 106-127 29135297-2 2017 Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Vitamin D 158-167 parathyroid hormone Homo sapiens 78-97 28615947-4 2017 Another important player in regulating mineral metabolism is vitamin D receptor (VDR), which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization. Vitamin D 61-70 parathyroid hormone Homo sapiens 196-199 28906406-0 2017 Parathyroid hormone in relation to various vitamin D metabolites in adult females. Vitamin D 43-52 parathyroid hormone Homo sapiens 0-19 28475987-0 2017 Attenuated PTH responsiveness to vitamin D deficiency among patients with type 2 diabetes and chronic hyperglycemia. Vitamin D 33-42 parathyroid hormone Homo sapiens 11-14 28475987-1 2017 BACKGROUND: The short and long-term relationship between hyperglycemia and PTH level among patients suffering from both diabetes type 2 and vitamin D deficiency were evaluated. Vitamin D 140-149 parathyroid hormone Homo sapiens 75-78 28475987-10 2017 CONCLUSIONS: Chronic hyperglycemia, as assessed by A1C level, is associated with a significantly attenuated PTH responsiveness to vitamin D deficiency without a significant change in calcium level. Vitamin D 130-139 parathyroid hormone Homo sapiens 108-111 28251655-6 2017 After vitamin D supplementation, the change in 25(OH)D, 24,25(OH)2 D3 and VMR was associated with the change in calcium absorption, PTH and CTX. Vitamin D 6-15 parathyroid hormone Homo sapiens 132-135 28130180-8 2017 CONCLUSION: The threshold for 25OHD at the point of maximal suppression of PTH estimated in this study was lower than the suggested threshold of vitamin D deficiency in the literature, perhaps due to race or assay differences, and the relationship between vitamin D and PTH changed with sex and age. Vitamin D 256-265 parathyroid hormone Homo sapiens 75-78 28101619-7 2017 The currently established reference range for the definition of a vitamin D deficiency came from studies where vitamin D deficiency was correlated to an increase in parathyroid hormone. Vitamin D 66-75 parathyroid hormone Homo sapiens 165-184 28101619-7 2017 The currently established reference range for the definition of a vitamin D deficiency came from studies where vitamin D deficiency was correlated to an increase in parathyroid hormone. Vitamin D 111-120 parathyroid hormone Homo sapiens 165-184 27927781-10 2017 Thus, common genetic variants located near genes involved in vitamin D metabolism and calcium and renal phosphate transport associated with differences in circulating PTH concentrations. Vitamin D 61-70 parathyroid hormone Homo sapiens 167-170 28095046-12 2017 The vitamin D composite score was associated with serum PTH, but this association was similar to that observed with 25(OH) D alone. Vitamin D 4-13 parathyroid hormone Homo sapiens 56-59 28272298-2 2017 Vitamin D supplementation typically leads to the reductions in serum parathyroid hormone (PTH) levels, as shown in normal weight individuals. Vitamin D 0-9 parathyroid hormone Homo sapiens 69-88 28272298-0 2017 Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Vitamin D 39-48 parathyroid hormone Homo sapiens 6-25 28491910-6 2017 Even for patients with vitamin D deficiency, a significant proportion had PTH, normal calcium, phosphate, and alkaline phosphatase levels. Vitamin D 23-32 parathyroid hormone Homo sapiens 74-77 28491910-7 2017 For patients with vitamin D <25 nmol/L, 62.7% had a PTH within reference range, 83.1% had normal serum-adjusted calcium, 80.6% had normal phosphate, and 85.1% had a normal serum alkaline phosphatase. Vitamin D 18-27 parathyroid hormone Homo sapiens 55-58 28378123-2 2017 The accumulation of phosphate, the increased FGF23 levels, the reduction in active vitamin D production, and the tendency to hypocalcemia are persistent stimuli for the development and progression of parathyroid hyperplasia with increased secretion of PTH. Vitamin D 83-92 parathyroid hormone Homo sapiens 252-255 27553017-2 2017 Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid hormone, acting on its classical target tissues, namely, bone, kidney, intestine, and parathyroid glands. Vitamin D 0-9 parathyroid hormone Homo sapiens 164-183 28429558-2 2017 Supplementation may improve some biochemical parameters, such as reducing PTH levels in patients to CKD-stage 4 who have vitamin D deficiency; but it remains to be established whether the role of nutritional vitamin D in maintaining bone health in the general population can be extrapolated to the CKD population. Vitamin D 121-130 parathyroid hormone Homo sapiens 74-77 27033542-7 2017 There was a statistically significant inverse correlation between vitamin D status [defined by quartiles of measured values as well as commonly accepted cutoffs of serum 25(OH)D] and severity of the disease, as reflected by higher PTH and BSAP, but not by meeting the latest guidelines for parathyroidectomy. Vitamin D 66-75 parathyroid hormone Homo sapiens 231-234 28458477-14 2017 Low Vitamin D levels were associated with high mean parathyroid hormone (PTH) levels statistically significant with P = 0.034. Vitamin D 4-13 parathyroid hormone Homo sapiens 52-71 27927221-3 2016 METHODS: We conducted a randomized, controlled clinical trial from July 2014 over 1 year, aiming to assess the changes in 25 (OH) D and biochemical outcome on calcium and PTH(parathyroid hormone) using 3 different regimens of vitamin D replacement. Vitamin D 226-235 parathyroid hormone Homo sapiens 175-194 27339172-2 2016 We report very high prevalence of vitamin D deficiency in a large database of Brazilian subjects and show seasonal and reciprocal relationship between vitamin D and parathyroid hormone (PTH) over the years in this tropical area. Vitamin D 151-160 parathyroid hormone Homo sapiens 165-184 27339172-2 2016 We report very high prevalence of vitamin D deficiency in a large database of Brazilian subjects and show seasonal and reciprocal relationship between vitamin D and parathyroid hormone (PTH) over the years in this tropical area. Vitamin D 151-160 parathyroid hormone Homo sapiens 186-189 27339172-13 2016 CONCLUSIONS: A sinusoidal interrelationship has been detected between vitamin D and PTH in this tropical population. Vitamin D 70-79 parathyroid hormone Homo sapiens 84-87 27919752-6 2017 An increment of PTH level, along with reduced bioavailable 25(OH)D levels, was evident when the bioavailable 25(OH)D level was <5ng/mL, which may be the optimal cutpoint for sufficient vitamin D in Chinese elderly women. Vitamin D 188-197 parathyroid hormone Homo sapiens 16-19 27792863-12 2017 Serum vitamin D was inversely correlated with PTH (p < 0.045). Vitamin D 6-15 parathyroid hormone Homo sapiens 46-49 28620554-1 2017 We present the clinical phenotype of a toddler who presented with vitamin D-resistant rickets, with one of the highest initial levels of alkaline phosphatase and parathyroid hormone (PTH) levels reported in the literature. Vitamin D 66-75 parathyroid hormone Homo sapiens 162-181 28620554-1 2017 We present the clinical phenotype of a toddler who presented with vitamin D-resistant rickets, with one of the highest initial levels of alkaline phosphatase and parathyroid hormone (PTH) levels reported in the literature. Vitamin D 66-75 parathyroid hormone Homo sapiens 183-186 29074836-3 2017 Parathyroid hormone(PTH)increases extracellular calcium concentration partly through the activation of vitamin D, and active vitamin D corrects hypocalcemia mainly by increasing intestinal calcium abosorption. Vitamin D 103-112 parathyroid hormone Homo sapiens 20-23 29074836-4 2017 PTH coordinately increases blood calcium level with vitamin D in bone and kidney, however, renal tubular reabsorption of calcium is regulated by PTH-dependent mechanism. Vitamin D 52-61 parathyroid hormone Homo sapiens 0-3 27827962-2 2016 Nutritional vitamin D supplementation is used for additional local parathyroid (PTH) suppression, with lower incidence of hypercalcemia and hyperphosphatemia. Vitamin D 12-21 parathyroid hormone Homo sapiens 80-83