PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11034387-5 2000 Target engagement also rapidly activated Ras, detected as active Ras-GTP bound to GST-Raf-RBD, a GST fusion protein linked to the Raf protein fragment containing the Ras-GTP binding domain. Radium 41-44 zinc fingers and homeoboxes 2 Homo sapiens 130-133 8550565-5 1996 Therefore, mutations that impair Ras activity by perturbing regions that distinguish Ras-GDP from Ras-GTP (switch I and II) may disrupt interactions with either Raf-1-binding domain. Radium 33-36 zinc fingers and homeoboxes 2 Homo sapiens 161-164 8307946-3 1994 The formation of a Ras-Raf complex is absolutely dependent on prior treatment of the cells with a stimulus that activates Ras: phorbol ester or anti-T cell receptor antibody in the case of human peripheral blood T lymphoblasts, or epidermal growth factor in the case of Rat-1 fibroblasts. Radium 19-22 zinc fingers and homeoboxes 2 Homo sapiens 23-26 34356620-4 2021 We propose a molecular model in which Ras binding is involved in the release of Raf autoinhibition while the Ras-Raf complex dimerizes to promote a platform for signal amplification, with Raf-CRD centrally located to impact regulation and function. Radium 38-41 zinc fingers and homeoboxes 2 Homo sapiens 80-83 34356620-4 2021 We propose a molecular model in which Ras binding is involved in the release of Raf autoinhibition while the Ras-Raf complex dimerizes to promote a platform for signal amplification, with Raf-CRD centrally located to impact regulation and function. Radium 38-41 zinc fingers and homeoboxes 2 Homo sapiens 188-191 12894505-10 2003 The addition of ET-18-OCH3 to the cytosolic fraction isolated from untreated cells also reduced the binding of Raf to activated GST-Ras-GTP-gamma-S. Radium 132-135 zinc fingers and homeoboxes 2 Homo sapiens 111-114 11034387-5 2000 Target engagement also rapidly activated Ras, detected as active Ras-GTP bound to GST-Raf-RBD, a GST fusion protein linked to the Raf protein fragment containing the Ras-GTP binding domain. Radium 41-44 zinc fingers and homeoboxes 2 Homo sapiens 86-89