PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34047081-8	2021	It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment.	Radium	148-150	interleukin 6	Homo sapiens	45-48	
15989786-6	2005	CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines.	Radium	12-14	interleukin 6	Homo sapiens	107-111	
9734662-7	1998	Effects of RA + DEX were also least able to be overcome by exogenous IL-6.	Radium	11-13	interleukin 6	Homo sapiens	69-73	
9734662-9	1998	Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels.	Radium	90-92	interleukin 6	Homo sapiens	40-44	
9734662-9	1998	Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels.	Radium	90-92	interleukin 6	Homo sapiens	116-120	
9734662-9	1998	Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels.	Radium	90-92	interleukin 6	Homo sapiens	116-120	
9734662-10	1998	Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA.	Radium	42-44	interleukin 6	Homo sapiens	17-21	
9734662-11	1998	In summary, combinations of RA + DEX were not only more effective in inhibiting myeloma cells growth by the dual mechanisms of decreasing proliferative fraction and increasing apoptotic fraction, but were also less able to be overcome by IL-6.	Radium	28-30	interleukin 6	Homo sapiens	238-242	
7720709-4	1995	RA, but not these "dissociating" retinoids, induced transcription of an interleukin-6 promoter-based reporter gene transiently transfected into HeLa cells together with RARs.	Radium	0-2	interleukin 6	Homo sapiens	72-85	
34356659-9	2021	The renin-angiotensin (RA) system affects the inflammatory process by increasing the IL-6 level.	Radium	23-25	interleukin 6	Homo sapiens	85-89	
28171867-15	2017	CONCLUSION: The IL-6 (-174) GC genotype is associated with a smaller C/D ratio, larger RA, and thicker RNFL compared with IL-6 (-174) GG in NTG patients.	Radium	87-89	interleukin 6	Homo sapiens	16-20	
23650978-0	2013	Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases.	Radium	114-116	interleukin 6	Homo sapiens	31-49	
19715447-5	2009	RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate.	Radium	138-140	interleukin 6	Homo sapiens	47-51	
22489869-11	2012	The clinical significance of the higher postoperative mean serum IL-6 and IL-10 levels in the RA group remains to be clarified in a future study.	Radium	94-96	interleukin 6	Homo sapiens	65-69	
23650978-0	2013	Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases.	Radium	114-116	interleukin 6	Homo sapiens	51-55	
19715447-5	2009	RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate.	Radium	138-140	interleukin 6	Homo sapiens	63-67