PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34356659-9 2021 The renin-angiotensin (RA) system affects the inflammatory process by increasing the IL-6 level. Radium 23-25 interleukin 6 Homo sapiens 85-89 9734662-7 1998 Effects of RA + DEX were also least able to be overcome by exogenous IL-6. Radium 11-13 interleukin 6 Homo sapiens 69-73 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Radium 90-92 interleukin 6 Homo sapiens 40-44 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Radium 90-92 interleukin 6 Homo sapiens 116-120 9734662-9 1998 Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. Radium 90-92 interleukin 6 Homo sapiens 116-120 9734662-10 1998 Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA. Radium 42-44 interleukin 6 Homo sapiens 17-21 9734662-11 1998 In summary, combinations of RA + DEX were not only more effective in inhibiting myeloma cells growth by the dual mechanisms of decreasing proliferative fraction and increasing apoptotic fraction, but were also less able to be overcome by IL-6. Radium 28-30 interleukin 6 Homo sapiens 238-242 7720709-4 1995 RA, but not these "dissociating" retinoids, induced transcription of an interleukin-6 promoter-based reporter gene transiently transfected into HeLa cells together with RARs. Radium 0-2 interleukin 6 Homo sapiens 72-85 15989786-6 2005 CONCLUSION: RA can up-regulate the expression of C3 and Bf of A549 cells induced with TNF-alpha, IL-1beta, IL-6 and IFN-gamma, and regulate the immunological defence of local lung tissue, which provides a theoretical basis for prevention and treatment of pulmonary diseases by using RA and cytokines. Radium 12-14 interleukin 6 Homo sapiens 107-111 34047081-8 2021 It mainly acted on multiple targets, such as IL6, TNF, IL1 B and MAPK1, involving TNF signaling pathway and Toll-like receptor signaling pathway in RA treatment. Radium 148-150 interleukin 6 Homo sapiens 45-48 23650978-0 2013 Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases. Radium 114-116 interleukin 6 Homo sapiens 31-49 28171867-15 2017 CONCLUSION: The IL-6 (-174) GC genotype is associated with a smaller C/D ratio, larger RA, and thicker RNFL compared with IL-6 (-174) GG in NTG patients. Radium 87-89 interleukin 6 Homo sapiens 16-20 23650978-0 2013 Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases. Radium 114-116 interleukin 6 Homo sapiens 51-55 22489869-11 2012 The clinical significance of the higher postoperative mean serum IL-6 and IL-10 levels in the RA group remains to be clarified in a future study. Radium 94-96 interleukin 6 Homo sapiens 65-69 19715447-5 2009 RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Radium 138-140 interleukin 6 Homo sapiens 47-51 19715447-5 2009 RESULTS/CONCLUSIONS: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Radium 138-140 interleukin 6 Homo sapiens 63-67