PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1967122-2 1990 The most direct evidence for the involvement of CD4+ T cells is provided by recent studies which demonstrate rapid improvement in the joint disease manifestations of RA following the infusion of anti-CD4 monoclonal antibodies (Herzog et al. Radium 166-168 CD4 molecule Homo sapiens 48-51 8474061-3 1993 Five patients with RA, after previous anti-CD4 therapy (B-F5) without antimouse immunization were included in our open pilot study. Radium 19-21 CD4 molecule Homo sapiens 43-46 1967122-2 1990 The most direct evidence for the involvement of CD4+ T cells is provided by recent studies which demonstrate rapid improvement in the joint disease manifestations of RA following the infusion of anti-CD4 monoclonal antibodies (Herzog et al. Radium 166-168 CD4 molecule Homo sapiens 200-203 15480382-4 2004 Naive CD4 (4+62+RA+ and 4+CCR7+RA+) and CD8 (8+CCR7+RA+) lymphocytes were lower in GH-deficient children ( P = .003; P = .007; and P = .02, respectively). Radium 16-18 CD4 molecule Homo sapiens 6-9 15480382-4 2004 Naive CD4 (4+62+RA+ and 4+CCR7+RA+) and CD8 (8+CCR7+RA+) lymphocytes were lower in GH-deficient children ( P = .003; P = .007; and P = .02, respectively). Radium 31-33 CD4 molecule Homo sapiens 6-9 15480382-4 2004 Naive CD4 (4+62+RA+ and 4+CCR7+RA+) and CD8 (8+CCR7+RA+) lymphocytes were lower in GH-deficient children ( P = .003; P = .007; and P = .02, respectively). Radium 31-33 CD4 molecule Homo sapiens 6-9 33853479-5 2021 Furthermore, higher proportion of Tfh cells defined by all definitions and a specified definition (CD4+CXCR5+PD-1high) was observed when S+RA compared to S-RA patients.Expert opinion:The results demonstrate that circulating Tfh are highly elevated in RA patients highlights its potential use as a biomarker and a target for RA therapy. Radium 139-141 CD4 molecule Homo sapiens 99-102