PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18268322-9 2008 We speculate that the contrasting roles of p85 and RAS-GTP in helical and kinase domain mutations reflect two distinct states of mutated p110alpha. Radium 51-54 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 137-146