PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18474417-3 2008 In this work, we reported that RA treatment for 24 h decreases cell viability, induces apoptosis dependent on caspase-3 activation, and activates the transcription factor AP-1 in cultured Sertoli cells. Radium 31-33 caspase 3 Homo sapiens 110-119 10208436-3 1999 In addition, combined treatment of cells with RA plus 8-Cl-cAMP resulted in the release of cytochrome c, loss in mitochondrial membrane potential and activation of caspase-3 followed by cleavage of anti-poly(ADP-ribose)polymerase and DNA-dependent protein kinase (catalytic subunit). Radium 46-48 caspase 3 Homo sapiens 164-173 10208436-4 1999 Interestingly, inhibition of caspase-3 activation blocked RA plus 8-Cl-cAMP induced apoptosis. Radium 71-73 caspase 3 Homo sapiens 42-51 10208436-8 1999 These findings suggest that RA and 8-Cl-cAMP act in a synergistic fashion in inducing apoptosis via caspase-3 activation, and may have potential for combination biotherapy for the treatment of malignant disease such as ovarian cancer. Radium 28-30 caspase 3 Homo sapiens 100-109 29872770-9 2018 At the protein level, there was increased cleaved caspase-3 but decreased procaspase-3 expression in Met-, 9-cis RA- and Met+9-cis RA-treated C6 GSCs, as detected by western blotting. Radium 113-115 caspase 3 Homo sapiens 74-86 29872770-10 2018 The ratio of cleaved caspase-3/procaspase-3 was 1.6 times higher in Met+9-cis RA-treated groups compared to control. Radium 78-80 caspase 3 Homo sapiens 21-30 29872770-10 2018 The ratio of cleaved caspase-3/procaspase-3 was 1.6 times higher in Met+9-cis RA-treated groups compared to control. Radium 78-80 caspase 3 Homo sapiens 31-43 11054668-6 2000 Less cleavage of PARP and in vitro caspase-3 activity were observed in PCR3-B23 cells as compared with pCR3 cells treated with 10 microM RA for 3-4 days. Radium 137-139 caspase 3 Homo sapiens 35-44 34237409-10 2021 The Dox@mPH-RA increased the levels of apoptosis markers, caspase 3, 7, Ki-67, and caused the highest DNA fragmentation. Radium 12-14 caspase 3 Homo sapiens 58-67 18474417-7 2008 Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells. Radium 65-67 caspase 3 Homo sapiens 104-113 18474417-7 2008 Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells. Radium 65-67 caspase 3 Homo sapiens 129-138