PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18474417-3	2008	In this work, we reported that RA treatment for 24 h decreases cell viability, induces apoptosis dependent on caspase-3 activation, and activates the transcription factor AP-1 in cultured Sertoli cells.	Radium	31-33	caspase 3	Homo sapiens	110-119	
10208436-3	1999	In addition, combined treatment of cells with RA plus 8-Cl-cAMP resulted in the release of cytochrome c, loss in mitochondrial membrane potential and activation of caspase-3 followed by cleavage of anti-poly(ADP-ribose)polymerase and <protein-id="5591">DNA-dependent protein kinase (catalytic subunit).	Radium	46-48	caspase 3	Homo sapiens	164-173	
10208436-4	1999	Interestingly</protein-id>, inhibition of caspase-3 activation blocked RA plus 8-Cl-cAMP induced apoptosis.	Radium	71-73	caspase 3	Homo sapiens	42-51	
10208436-8	1999	These findings suggest that RA and 8-Cl-cAMP act in a synergistic fashion in inducing apoptosis via caspase-3 activation, and may have potential for combination biotherapy for the treatment of malignant disease such as ovarian cancer.	Radium	28-30	caspase 3	Homo sapiens	100-109	
29872770-9	2018	At the protein level, there was increased cleaved caspase-3 but decreased procaspase-3 expression in Met-, 9-cis RA- and Met+9-cis RA-treated C6 GSCs, as detected by western blotting.	Radium	113-115	caspase 3	Homo sapiens	74-86	
29872770-10	2018	The ratio of cleaved caspase-3/procaspase-3 was 1.6 times higher in Met+9-cis RA-treated groups compared to control.	Radium	78-80	caspase 3	Homo sapiens	21-30	
29872770-10	2018	The ratio of cleaved caspase-3/procaspase-3 was 1.6 times higher in Met+9-cis RA-treated groups compared to control.	Radium	78-80	caspase 3	Homo sapiens	31-43	
11054668-6	2000	Less cleavage of PARP and in vitro caspase-3 activity were observed in PCR3-B23 cells as compared with pCR3 cells treated with 10 microM RA for 3-4 days.	Radium	137-139	caspase 3	Homo sapiens	35-44	
34237409-10	2021	The Dox@mPH-RA increased the levels of apoptosis markers, caspase 3, 7, Ki-67, and caused the highest DNA fragmentation.	Radium	12-14	caspase 3	Homo sapiens	58-67	
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	caspase 3	Homo sapiens	104-113	
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	caspase 3	Homo sapiens	129-138