PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24531877-7	2014	Moreover, decreased expression of RASAL1 in MKN-28 cells resulted in increased expression of RAS-GTP and p-ERK1/2.	Radium	34-37	mitogen-activated protein kinase 3	Homo sapiens	107-113	
31358819-2	2019	In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras binding to the Ras binding domain (RBD) of Raf.	Radium	131-134	mitogen-activated protein kinase 3	Homo sapiens	96-102	
25663768-10	2015	In addition, pre-miR-21-LV or siRASA1 (down-regulation of RASA1) cells showed higher cell proliferation, reduced apoptosis, increased expression of RAS-GTP, p-AKT, Raf-1, KRAS, and p-ERK1/2, and higher invasion and tumor formation ability, compared with control, anti-miR-21-LV or pcDNA3.1-RASA1 (up-regulation of RASA1) cells (P < 0.05).	Radium	32-35	mitogen-activated protein kinase 3	Homo sapiens	183-189	
24531877-9	2014	The increased expression of RASAL1 in BGC-823 cells caused declined expression of RAS-GTP and p-ERK1/2, as well as promoted apoptosis and restrained cell proliferation, invasion and migration.	Radium	28-31	mitogen-activated protein kinase 3	Homo sapiens	96-102	
18474417-4	2008	Moreover, RA induced a rapid and non-classical stimulation of ERK1/2.	Radium	10-12	mitogen-activated protein kinase 3	Homo sapiens	62-68	
18474417-7	2008	Overall, our data suggest that a rapid and non-genomic effect of RA upon MEK1/2-ERK1/2 pathway leads to caspase-3 activation and caspase-3-dependent apoptosis in cultured Sertoli cells.	Radium	65-67	mitogen-activated protein kinase 3	Homo sapiens	80-86	
34893097-6	2021	In addition, RA could upregulate the phosphorylation levels of p38 and ERK1/2 in K562/ADM cells, but it has no effect on the expression of p-JNK.	Radium	13-15	mitogen-activated protein kinase 3	Homo sapiens	71-77	
34893097-7	2021	CONCLUSION: RA may participate in the regulation of MAPK signaling pathway by upregulating the expression levels of p-p38 and p-ERK1/2 in K562/ADM cells, and thus inhibit the transcription and translation levels of MDR1, and finally reverse the multidrug resistance of leukemia cells.	Radium	12-14	mitogen-activated protein kinase 3	Homo sapiens	52-56	
34893097-7	2021	CONCLUSION: RA may participate in the regulation of MAPK signaling pathway by upregulating the expression levels of p-p38 and p-ERK1/2 in K562/ADM cells, and thus inhibit the transcription and translation levels of MDR1, and finally reverse the multidrug resistance of leukemia cells.	Radium	12-14	mitogen-activated protein kinase 3	Homo sapiens	128-134