PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22056254-2 2012 Here we determine the effect of the tumor suppressor protein, p53, on trafficking (64)Cu to tumor cell nuclei from DOTA vs. CB-TE2A-conjugated agonist Y3-TATE and the antagonist (64)Cu-CB-TE2A-sst2-ANT in cell lines that are positive or negative for p53. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 115-119 tumor protein p53 Homo sapiens 62-65 17938576-7 2008 However, nuclear localization of (64)Cu-DOTA-cetuximab showed increased uptake in the nuclei of HCT 116 +/+ cells as early as 4 h. These data demonstrate that (64)Cu is delivered to tumor cell nuclei in a p53 positive cell line in significantly greater amounts than in p53 negative cells by both non-specific and receptor-mediated uptake mechanisms. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 37-44 tumor protein p53 Homo sapiens 205-208 17938576-7 2008 However, nuclear localization of (64)Cu-DOTA-cetuximab showed increased uptake in the nuclei of HCT 116 +/+ cells as early as 4 h. These data demonstrate that (64)Cu is delivered to tumor cell nuclei in a p53 positive cell line in significantly greater amounts than in p53 negative cells by both non-specific and receptor-mediated uptake mechanisms. 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 37-44 tumor protein p53 Homo sapiens 269-272