PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7628292-2 1995 A full-length cDNA-encoding human UGT1.4 (the so-called "minor" human bilirubin UGT) was inserted into the expression vector pREP9 and transfected into human embryonic kidney 293 cells, and stable transfectants were obtained after geneticin selection. Bilirubin 70-79 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 34-40 14744950-4 2004 The formation of glucuronide by human liver microsomes and UGT1A4 was inhibited by bilirubin, a known inhibitor of UGT1A4. Bilirubin 83-92 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 59-65 14744950-4 2004 The formation of glucuronide by human liver microsomes and UGT1A4 was inhibited by bilirubin, a known inhibitor of UGT1A4. Bilirubin 83-92 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 115-121 12433823-7 2002 Nicotine and cotinine N-glucuronidations in pooled human liver microsomes were competitively inhibited by bilirubin as a substrate for UGT1A1 (K(i) = 3.9 and 3.3 micro M), imipramine as a substrate for UGT1A4 (K(i) = 6.1 and 2.7 micro M), and propofol as a substrate for UGT1A9 (K(i) = 6.0 and 12.0 micro M). Bilirubin 106-115 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 202-208 17620344-3 2007 The coexpression of UGT1A4 and UGT1A6 decreased the S(50) and V(max) values of UGT1A1-catalyzed estradiol 3-O-glucuronide formation and increased the V(max) value of UGT1A1-catalyzed bilirubin O-glucuronide formation. Bilirubin 183-192 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 20-26 10427418-1 1999 The kinetic analysis of the enzyme UDP-glucuronosyltransferase (UDPGT) responsible for the conjugation of bilirubin, suggest that it is a multisubunit enzyme in which there is cooperative binding of substrate to the subunits. Bilirubin 106-115 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 35-62 10427418-1 1999 The kinetic analysis of the enzyme UDP-glucuronosyltransferase (UDPGT) responsible for the conjugation of bilirubin, suggest that it is a multisubunit enzyme in which there is cooperative binding of substrate to the subunits. Bilirubin 106-115 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 64-69 10427418-2 1999 The binding of bilirubin to UDP-glucuronosyltransferase shows positive cooperativity with an apparent dissociation constant of 7.824 x 10(-4) +/- 6.405 x 10(-4) mM. Bilirubin 15-24 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 28-55 10427418-3 1999 The apparent Hill coefficient for bilirubin to UDPGT is 2.9. Bilirubin 34-43 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 47-52 10220490-7 1999 From the known substrate specificities of UGT1A4 toward lamotrigine and bilirubin and our activity and inhibition data, we conclude that UGT1A4 is a major retigabine N-glucuronosyl transferase in vivo and significantly contributes to the enterohepatic cycling of the drug. Bilirubin 72-81 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 42-48 10220490-7 1999 From the known substrate specificities of UGT1A4 toward lamotrigine and bilirubin and our activity and inhibition data, we conclude that UGT1A4 is a major retigabine N-glucuronosyl transferase in vivo and significantly contributes to the enterohepatic cycling of the drug. Bilirubin 72-81 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 137-143 7936809-0 1994 A new type of defect in the gene for bilirubin uridine 5"-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I. Crigler-Najjar syndrome (CN) type I, which is characterized by the complete absence of bilirubin uridine 5"-diphosphate-glucuronosyltransferase (UGT) activity, is inherited as an autosomal recessive trait associated with unconjugated hyperbilirubinemia. Bilirubin 37-46 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 289-292 7936809-2 1994 Recently, cDNA for two human liver bilirubin UGT (UGT1A and UGT1D) were isolated, and their genetic organization was determined. Bilirubin 35-44 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 45-48 7936809-2 1994 Recently, cDNA for two human liver bilirubin UGT (UGT1A and UGT1D) were isolated, and their genetic organization was determined. Bilirubin 35-44 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 60-65 7936809-5 1994 We describe here a new type of defect in the gene for bilirubin UGT in a patient with CN type I, namely, an abnormality in the exon 1 that is characteristic of the UGT1A gene. Bilirubin 54-63 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 64-67 1749222-2 1991 Bilirubin UDPGT activity, assayed by a microassay with HPLC analysis, was not detectable in type I livers, and low levels (9-26% of controls) of monoglucuronide conjugates only were observed in type II livers. Bilirubin 0-9 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 10-15 8280139-2 1993 Two bilirubin UGT isozymes, UGT1A and UGT1D, have been identified. Bilirubin 4-13 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 38-43 1920916-1 1991 The human liver bilirubin UDP-glucuronosyl transferase (bilirubin UDPGT) [EC 2.4.1.17] is responsible for the enzyme deficiency in Crigler-Najjar syndrome and/or Gilbert"s syndrome. Bilirubin 16-25 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 66-71 1920916-2 1991 The UDPGT, former shows severe jaundice resulted from a complete absence of bilirubin while the latter has a mild manifestation due to a reduction of the enzyme activity. Bilirubin 76-85 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 4-9 1920916-3 1991 The gene locus of bilirubin UDPGT was mapped to chromosome 1 by spot-blot hybridization using a cell-sorter, and its regional locus was assigned to 1q21-q23 by high resolution in situ hybridization. Bilirubin 18-27 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 28-33 1673394-6 1991 In addition, purified human liver UDPGT did not catalyze the glucuronidation of cholate, deoxycholate, chenodeoxycholate, ursodeoxycholate, lithocholate, hyocholate, hyodeoxycholate, bilirubin, morphine, or 4-hydroxybiphenyl. Bilirubin 183-192 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 34-39