PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32366561-11 2020 TB was positively correlated with Hb and Alb, but negatively correlated with ESR and CRP (p<0.05). Bilirubin 0-2 C-reactive protein Homo sapiens 85-88 33485635-10 2021 We found that blood pressure, cholesterol, C-reactive protein, alcohol and white blood cell count played important roles in the causal pathway from bilirubin to CVD. Bilirubin 148-157 C-reactive protein Homo sapiens 43-61 33571217-10 2021 In turn, multivariate regression analysis showed that bilirubin levels were negatively associated with high-sensitivity C-reactive protein levels and PDR, but positively correlated with urinary biopyrrin levels, oxidized metabolites of bilirubin. Bilirubin 54-63 C-reactive protein Homo sapiens 120-138 33398528-8 2021 Based on a generalized estimating equations analysis model with time interaction considered, the only significant factor associated with changes in phenylalanine was changes in C-reactive protein concentrations from baseline to 12 months [B (coefficient) = 0.81, P < 0.001] after adjusting for methionine sulfoxide and total bilirubin levels. Bilirubin 325-334 C-reactive protein Homo sapiens 177-195 32724271-6 2020 We found a significant negative association between total bilirubin and CRP, TNF-alpha, visfatin and resistin values, and a significant positive association between total bilirubin and adiponectin values in both normal-weight and overweight groups. Bilirubin 58-67 C-reactive protein Homo sapiens 72-75 32724271-7 2020 Importantly, after adjusting for body mass index, we also found a significant negative association between total serum bilirubin levels and both visfatin and CRP serum levels. Bilirubin 119-128 C-reactive protein Homo sapiens 158-161 32724271-8 2020 Moreover, visfatin, resistin and CRP were predictors of the total serum bilirubin levels. Bilirubin 72-81 C-reactive protein Homo sapiens 33-36 34276670-11 2021 TBIL was inversely proportional to CRP (rs=-0.328) and TNF(rs=-0.360), and positively proportional to C3 (rs=0.174) and C4 (rs=0.172). Bilirubin 0-4 C-reactive protein Homo sapiens 35-38 35327498-5 2022 Serum bilirubin levels are positively correlated with the levels of the antioxidative enzymes as superoxide dismutase, catalase, and glutathione peroxidase, while it is inversely correlated with C-reactive protein, TNF-alpha, interleukin (IL)-2, IL-6, and IL-10 release in diabetic kidney disease. Bilirubin 6-15 C-reactive protein Homo sapiens 195-213 27349017-0 2016 Low Serum Total Bilirubin Concentration was Associated with Increased High Sensitive C Reactive Protein Level in Patients with Impaired Glucose Tolerance and Type 2 Diabetes Mellitus Subjects. Bilirubin 16-25 C-reactive protein Homo sapiens 85-103 30467439-7 2018 Bilirubin and albumin levels were lower in the serum of active CD patients than inactive CD patients and controls and negatively correlated with the CD activity index (r = -0328, p = 0.036, r = -0.518, p = 0.002) and CRP (r = -0.433, p = 0.002). Bilirubin 0-9 C-reactive protein Homo sapiens 217-220 27061381-8 2016 Meanwhile, the serum CRP was negatively correlated with serum TB levels but positively correlated with peripheral WBC and the Psoriasis Area and Severity Index (PASI). Bilirubin 62-64 C-reactive protein Homo sapiens 21-24 30637206-11 2018 Direct Bb was negatively correlated with CRP (P = 0.002). Bilirubin 7-9 C-reactive protein Homo sapiens 41-44 29113390-4 2017 Studying the correlation of serum bilirubin levels with iron, zinc, copper and high-sensitivity C-reactive protein, we found positive correlations for iron and zinc, and negative correlations for high-sensitivity C-reactive protein and copper in whole participants. Bilirubin 34-43 C-reactive protein Homo sapiens 96-114 29113390-4 2017 Studying the correlation of serum bilirubin levels with iron, zinc, copper and high-sensitivity C-reactive protein, we found positive correlations for iron and zinc, and negative correlations for high-sensitivity C-reactive protein and copper in whole participants. Bilirubin 34-43 C-reactive protein Homo sapiens 213-231 28410854-4 2017 Serum bilirubin was found to be negatively correlated with C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) (r=-0.165, P=0.030; r=-192, P=0.012) in patients with RA. Bilirubin 6-15 C-reactive protein Homo sapiens 59-77 28410854-4 2017 Serum bilirubin was found to be negatively correlated with C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) (r=-0.165, P=0.030; r=-192, P=0.012) in patients with RA. Bilirubin 6-15 C-reactive protein Homo sapiens 79-82 26996761-0 2016 Serum Bilirubin and Their Association With C-Reactive Protein in Patients With Migraine. Bilirubin 6-15 C-reactive protein Homo sapiens 43-61 26996761-2 2016 An inverse relationship between serum bilirubin and CRP has been observed in various diseases. Bilirubin 38-47 C-reactive protein Homo sapiens 52-55 26005382-0 2015 Correlation Between C-reactive Protein and Non-enzymatic Antioxidants (Albumin, Ferritin, Uric Acid and Bilirubin) in Hemodialysis Patients. Bilirubin 104-113 C-reactive protein Homo sapiens 20-38 25770689-2 2015 Herein, we aimed to assess the relationship between serum total bilirubin level and severity of coronary artery disease (CAD) in association with the direct inflammatory marker such as C-reactive protein (CRP), the other indirect markers included in inflammation process such as neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) in patients with stable CAD. Bilirubin 64-73 C-reactive protein Homo sapiens 185-203 25770689-2 2015 Herein, we aimed to assess the relationship between serum total bilirubin level and severity of coronary artery disease (CAD) in association with the direct inflammatory marker such as C-reactive protein (CRP), the other indirect markers included in inflammation process such as neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) in patients with stable CAD. Bilirubin 64-73 C-reactive protein Homo sapiens 205-208 25770689-8 2015 Futhermore, there was a moderate and significant inverse correlation between serum total bilirubin level and the severity of CAD (r=-0.173, p<0.001), CRP (r=-0.112, p<0.001), NLR (r=-0.070, p=0.026) and RDW (r=-0.074, p=0.027). Bilirubin 89-98 C-reactive protein Homo sapiens 153-156 25770689-10 2015 In addition, total bilirubin level was inversely correlated with CRP, NLR and RDW. Bilirubin 19-28 C-reactive protein Homo sapiens 65-68 26005382-12 2015 Furthermore, the positive, linear correlation was determined between serum CRP and ferritin (r = 0.159, p = 0.114) and positive linear correlation between CRP and total serum bilirubin (r = 0.121, p = 0.230). Bilirubin 175-184 C-reactive protein Homo sapiens 155-158 24442509-7 2014 CONCLUSIONS/INTERPRETATION: The minor rs1183910 A allele prompts a potential adverse metabolic profile with increased levels of non-fasting glucose, total cholesterol, LDL-cholesterol, ApoB, and alkaline phosphatase, but simultaneously has potential beneficial effects through decreased levels of CRP, gamma-glutamyltransferase and bilirubin. Bilirubin 332-341 C-reactive protein Homo sapiens 297-300 24903748-11 2014 Unconjugated bilirubin correlated with haemoglobin, which was inversely correlated with CRP. Bilirubin 13-22 C-reactive protein Homo sapiens 88-91 24696418-0 2014 Bilirubin levels and their association with carotid intima media thickness and high-sensitivity C-reactive protein in patients with psoriasis vulgaris. Bilirubin 0-9 C-reactive protein Homo sapiens 96-114 23091796-9 2012 Elevated CRP levels were associated with the highest risk for complicated appendicitis (hazard ratio [HR], 2.53; 95% confidence interval [CI], 1.38 to 4.65) followed by WBC (HR, 2.42; 95% CI, 1.07 to 5.46) and bilirubin (HR, 2.04; 95% CI, 1.09 to 3.82). Bilirubin 210-219 C-reactive protein Homo sapiens 9-12 22653321-6 2013 Bilirubin is inversely related to baPWV (R (2) = 0.0032, P = 0.003) and C-reactive protein (CRP) (correlation coefficient = -0.13, P < 0.001). Bilirubin 0-9 C-reactive protein Homo sapiens 72-90 22653321-6 2013 Bilirubin is inversely related to baPWV (R (2) = 0.0032, P = 0.003) and C-reactive protein (CRP) (correlation coefficient = -0.13, P < 0.001). Bilirubin 0-9 C-reactive protein Homo sapiens 92-95 22653321-9 2013 Additionally, reduced CRP may be one of mediators on the mechanisms how bilirubin reduces baPWV. Bilirubin 72-81 C-reactive protein Homo sapiens 22-25 23669654-7 2013 The decreasing trend of CRP levels is encouraging and may be related to the increase in total bilirubin levels. Bilirubin 94-103 C-reactive protein Homo sapiens 24-27 24209691-0 2013 High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome. Bilirubin 85-94 C-reactive protein Homo sapiens 15-33 24209691-4 2013 We determined relationships of high sensitive C-reactive protein (hs-CRP) and SAA with bilirubin in subjects with and without metabolic syndrome (MetS). Bilirubin 87-96 C-reactive protein Homo sapiens 46-64 23414908-7 2013 RESULTS: Serum bilirubin levels were lower in overweight healthy individuals of both sexes, and were negatively associated with abdominal obesity, insulin resistance, fasting glucose, fasting insulin, fasting triglycerides, total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein levels but positively associated with aerobic body capabilities. Bilirubin 15-24 C-reactive protein Homo sapiens 284-302 21671781-11 2011 CONCLUSIONS: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR). Bilirubin 19-28 C-reactive protein Homo sapiens 252-255 22262261-9 2012 Bilirubin was inversely correlated with high-sensitivity C-reactive protein (hsCRP) (r = -0.117, P < 0.001). Bilirubin 0-9 C-reactive protein Homo sapiens 57-75 22907525-9 2012 CRP was highly correlated with direct bilirubin. Bilirubin 38-47 C-reactive protein Homo sapiens 0-3 22745870-0 2011 Association of Serum Total Bilirubin with Serum High Sensitivity C-reactive Protein in Middle-aged Men. Bilirubin 27-36 C-reactive protein Homo sapiens 65-83 21726166-0 2011 Relationship between bilirubin and C-reactive protein. Bilirubin 21-30 C-reactive protein Homo sapiens 35-53 21726166-2 2011 However, the number of studies which have focused on the relationship between bilirubin and C-reactive protein (CRP), which is a marker reflecting chronic vascular inflammation, are limited. Bilirubin 78-87 C-reactive protein Homo sapiens 92-110 21726166-2 2011 However, the number of studies which have focused on the relationship between bilirubin and C-reactive protein (CRP), which is a marker reflecting chronic vascular inflammation, are limited. Bilirubin 78-87 C-reactive protein Homo sapiens 112-115 21726166-4 2011 RESULT: CRP level showed a declining tendency as total bilirubin increased according to total bilirubin quartiles. Bilirubin 55-64 C-reactive protein Homo sapiens 8-11 21726166-4 2011 RESULT: CRP level showed a declining tendency as total bilirubin increased according to total bilirubin quartiles. Bilirubin 94-103 C-reactive protein Homo sapiens 8-11 21726166-5 2011 Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin. Bilirubin 53-62 C-reactive protein Homo sapiens 22-25 21726166-5 2011 Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin. Bilirubin 259-268 C-reactive protein Homo sapiens 22-25 21726166-5 2011 Negative relations of CRP with both total and direct bilirubin were found after adjustment of age, body mass index, hypertension, diabetes, hypercholesterolemia, cardiovascular disease, taking aspirin, smoking, alcohol drinking and regular exercise and total bilirubin or direct bilirubin. Bilirubin 259-268 C-reactive protein Homo sapiens 22-25 21726166-6 2011 CONCLUSIONS: This study found that elevation of the two types of bilirubin (total and direct) have a relationship with a low serum CRP level among apparently healthy Korean adults. Bilirubin 65-74 C-reactive protein Homo sapiens 131-134 21726166-7 2011 It is hypothesized that a low serum CRP level may be due to the antioxidant and anti-inflammatory effects of bilirubin metabolism. Bilirubin 109-118 C-reactive protein Homo sapiens 36-39 21852972-12 2011 Increased C-reactive protein and gamma-glutamyl transferase levels were associated with decreased protein expression of both enzymes, and increased bilirubin levels, cholestasis, and presurgical exposure to omeprazole or pantoprazole were related to decreased PON3 protein. Bilirubin 148-157 C-reactive protein Homo sapiens 10-28 20495302-8 2010 Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses. Bilirubin 6-15 C-reactive protein Homo sapiens 135-153 21167147-5 2011 Unconjugated bilirubin was negatively correlated with sd-LDL-C, ox-LDL and hs-CRP (r=-0.594, p<0.001; r=-0.249, p=0.016 and r=-0.373, p<0.001 respectively). Bilirubin 13-22 C-reactive protein Homo sapiens 78-81 20495302-8 2010 Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses. Bilirubin 6-15 C-reactive protein Homo sapiens 155-158 20083320-0 2010 Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women. Bilirubin 30-39 C-reactive protein Homo sapiens 62-80 20083320-1 2010 AIM: The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n=12,400). Bilirubin 67-76 C-reactive protein Homo sapiens 133-151 20379040-10 2010 Although the correlation index for this inverse association has been weak, both are independently associated with a higher prevalence of coronary artery disease, total bilirubin <or= 0.56 mg/dL (OR: 10.04; IC: 3.48-28.90; P < 0.001), and ultrasensitive C reactive protein > 3 mg/L (OR: 1.17; IC: 1.04-1.33; P = 0.009). Bilirubin 168-177 C-reactive protein Homo sapiens 259-277 9095612-6 1997 After the decrease in CRP, the decrease in total bilirubin concentration was delayed. Bilirubin 49-58 C-reactive protein Homo sapiens 22-25 20027140-2 2009 RESULTS: A term newborn delivered by caesarean section (birth weight 2550 g, birth length 47 cm, value of Apgar score 9/10) with good direct adaptation had on the first day of life increased levels of conjugated bilirubin (23 micromol/l), unconjugated bilirubin (55 micromol/l) and C-reactive protein 39.4 g/l. Bilirubin 212-221 C-reactive protein Homo sapiens 282-300 17006702-10 2007 A significant correlation was found between C-RP levels and total and unconjugated bilirubin levels in FMF patients with attack (r = 0.43, P = 0.01; r = 0.40, P = 0.02, respectively). Bilirubin 83-92 C-reactive protein Homo sapiens 44-48 33972830-7 2021 Comparison of HCC patients with high (>2.5 mg/ dL) compared low serum CRP levels showed significant differences for blood levels of NLR, LMR, Hb, total bilirubin and liver transaminases, as well as Maximum Tumor Diameter (MTD) and percent of patients with Portal Vein Thrombosis (PVT). Bilirubin 152-161 C-reactive protein Homo sapiens 70-73