PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15749910-0	2005	Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration.	Bilirubin	13-22	vascular cell adhesion molecule 1	Mus musculus	32-38	
15749910-2	2005	Because bilirubin is a potent antioxidant, we examined the hypothesis that this bile pigment inhibits VCAM-1-dependent cellular events.	Bilirubin	8-17	vascular cell adhesion molecule 1	Mus musculus	102-108	
15749910-3	2005	The migration of isolated murine splenic lymphocytes across monolayers of murine endothelial cell lines (which constitutively express VCAM-1) is significantly inhibited by physiological concentrations of bilirubin, in the absence of an effect on lymphocyte adhesion.	Bilirubin	204-213	vascular cell adhesion molecule 1	Mus musculus	134-140	
15749910-4	2005	Bilirubin administration also suppresses VCAM-1-stimulated ROS generation and reduces endothelial cell matrix metalloproteinase activity.	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	41-47	
15749910-8	2005	CONCLUSION: bilirubin blocks VCAM-1-dependent lymphocyte migration in vitro and ameliorates VCAM-1-mediated airway inflammation in vivo, apparently through the suppression of cellular ROS production.	Bilirubin	12-21	vascular cell adhesion molecule 1	Mus musculus	29-35	
15749910-8	2005	CONCLUSION: bilirubin blocks VCAM-1-dependent lymphocyte migration in vitro and ameliorates VCAM-1-mediated airway inflammation in vivo, apparently through the suppression of cellular ROS production.	Bilirubin	12-21	vascular cell adhesion molecule 1	Mus musculus	92-98	
28365565-0	2017	Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling.	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	129-135	
28365565-4	2017	A potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1).	Bilirubin	22-31	vascular cell adhesion molecule 1	Mus musculus	146-179	
28365565-4	2017	A potent antioxidant, bilirubin effectively blocks the generation of cellular reactive oxygen species induced by the cross-linking of endothelial vascular cell adhesion molecule 1 (VCAM-1) or intercellular adhesion molecule 1 (ICAM-1).	Bilirubin	22-31	vascular cell adhesion molecule 1	Mus musculus	181-187	
28365565-7	2017	Aortic roots from bilirubin-treated animals exhibit reduced lipid and collagen deposition, decreased infiltration of monocytes and lymphocytes, fewer smooth muscle cells, and diminished levels of chlorotyrosine and nitrotyrosine, without changes in VCAM-1 or ICAM-1 expression.	Bilirubin	18-27	vascular cell adhesion molecule 1	Mus musculus	249-255	
28365565-8	2017	CONCLUSIONS: Bilirubin suppresses atherosclerotic plaque formation in Ldlr-/- mice by disrupting endothelial VCAM-1- and ICAM-1-mediated leukocyte migration through the scavenging of reactive oxygen species signaling intermediaries.	Bilirubin	13-22	vascular cell adhesion molecule 1	Mus musculus	109-115	
26925435-2	2016	Previous work by our group suggests that bilirubin is able to suppress inflammatory responses by preventing the migration of leukocytes into target tissues through disruption of vascular cell adhesion molecule-1 (VCAM-1)-dependent cell signaling.	Bilirubin	41-50	vascular cell adhesion molecule 1	Mus musculus	178-211	
26925435-2	2016	Previous work by our group suggests that bilirubin is able to suppress inflammatory responses by preventing the migration of leukocytes into target tissues through disruption of vascular cell adhesion molecule-1 (VCAM-1)-dependent cell signaling.	Bilirubin	41-50	vascular cell adhesion molecule 1	Mus musculus	213-219	
26925435-7	2016	Taken together, our findings support that bilirubin ameliorates DSS-induced colitis and disrupts the physiological trafficking of leukocytes to the intestine by preventing transmigration across the vascular endothelium, potentially through the inhibition VCAM-1-mediated signaling.	Bilirubin	42-51	vascular cell adhesion molecule 1	Mus musculus	255-261	
26381705-1	2015	Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS).	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	70-103	
26381705-1	2015	Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS).	Bilirubin	0-9	vascular cell adhesion molecule 1	Mus musculus	105-111