PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22366465-5 2012 Moreover, conjugated bilirubin and total bile acid in the serum were significantly reduced in patients with high MRP expression compared to patients with low expression. Bilirubin 21-30 ATP binding cassette subfamily C member 1 Homo sapiens 113-116 24138949-9 2013 We found increased cellular expression of multidrug resistance-associated protein 1 and P-glycoprotein in the hippocampus, known as defensive mechanisms against bilirubin-induced cytotoxicity. Bilirubin 161-170 ATP binding cassette subfamily C member 1 Homo sapiens 42-83 23811769-7 2013 Recently, we found that hyperbilirubinemia, which occurs in some disease states, increased intestinal accumulation and toxicity of methotrexate, an MRP substrate, because of the suppression of MRP function by high plasma concentrations of conjugated bilirubin. Bilirubin 29-38 ATP binding cassette subfamily C member 1 Homo sapiens 148-151 23811769-7 2013 Recently, we found that hyperbilirubinemia, which occurs in some disease states, increased intestinal accumulation and toxicity of methotrexate, an MRP substrate, because of the suppression of MRP function by high plasma concentrations of conjugated bilirubin. Bilirubin 29-38 ATP binding cassette subfamily C member 1 Homo sapiens 193-196 9355767-0 1997 ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Bilirubin 27-36 ATP binding cassette subfamily C member 1 Homo sapiens 86-90 19566819-6 2010 Unlike MRP1, MRP2 functions in the extrusion of endogenous organic anions, such as bilirubin glucuronide and certain anticancer agents. Bilirubin 83-92 ATP binding cassette subfamily C member 1 Homo sapiens 7-11 18713069-0 2009 The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1. Bilirubin 37-46 ATP binding cassette subfamily C member 1 Homo sapiens 124-128 18713069-9 2009 These data support the concept that limitation of cellular UCB accumulation, due to UCB export mediated by MRP1, but not MDR1, plays an important role in preventing bilirubin encephalopathy in the newborn. Bilirubin 165-174 ATP binding cassette subfamily C member 1 Homo sapiens 107-111 9355767-2 1997 We demonstrate for the first time that ATP-dependent transport of both bilirubin glucuronides is mediated by the multidrug resistance protein (MRP1) as well as by the distinct canalicular (apical) isoform MRP2, also termed cMRP or cMOAT (canalicular multispecific organic anion transporter). Bilirubin 71-80 ATP binding cassette subfamily C member 1 Homo sapiens 143-147