PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34966788-0	2021	Unraveling the Influence of K280 Acetylation on the Conformational Features of Tau Core Fragment: A Molecular Dynamics Simulation Study.	argatroban	28-32	microtubule associated protein tau	Homo sapiens	79-82	
34966788-3	2021	Mounting experiment evidence demonstrated the acetylation of a single-lysine residue K280 in the PHF6* was a critical event for the formation of pathological Tau amyloid deposits.	argatroban	85-89	microtubule associated protein tau	Homo sapiens	158-161	
34966788-4	2021	However, the underlying mechanisms by which K280 acetylation affects Tau aggregation at the atomic level remain elusive.	argatroban	44-48	microtubule associated protein tau	Homo sapiens	69-72	
29684271-7	2018	Our results show that site-specific acetylation at K280 significantly enhances the aggregation rate of Tau and impairs microtubule assembly.	argatroban	51-55	microtubule associated protein tau	Homo sapiens	103-106	
26940749-4	2016	However, whether lysine acetylation at position 280 (K280) modulates hTau-induced toxicity in vivo is unknown.	argatroban	53-57	microtubule associated protein tau	Homo sapiens	69-73	
26940749-7	2016	In addition, modulation of K280 influenced total hTau levels and phosphorylation without changing hTau solubility.	argatroban	27-31	microtubule associated protein tau	Homo sapiens	49-53	
26940749-8	2016	Altogether, our results indicate that pseudo-acetylation of the single K280 residue is sufficient to exacerbate hTau neurotoxicity in vivo, suggesting that acetylated K280-hTau species contribute to the pathological events leading to neurodegeneration in AD.	argatroban	71-75	microtubule associated protein tau	Homo sapiens	112-116	
26940749-8	2016	Altogether, our results indicate that pseudo-acetylation of the single K280 residue is sufficient to exacerbate hTau neurotoxicity in vivo, suggesting that acetylated K280-hTau species contribute to the pathological events leading to neurodegeneration in AD.	argatroban	167-171	microtubule associated protein tau	Homo sapiens	112-116