PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21864674-2	2012	SHIP1 mediates its regulatory function after relocalization from the cytoplasm to the plasma membrane where it converts its substrate PI(3,4,5)P(3) to PI(3,4)P(2) thereby terminating PI3-kinase mediated signaling.	pi(3,4,5)p	134-144	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-5	
22876243-4	2012	One such target is the SH2 domain-containing inositol-5-phosphatase-1 (SHIP-1) which de-phosphorylates PI(3,4,5)P(3) at the D5 position of the inositol ring to create PI(3,4)P(2).	pi(3,4,5)p	103-113	inositol polyphosphate-5-phosphatase D	Homo sapiens	23-69	
22876243-4	2012	One such target is the SH2 domain-containing inositol-5-phosphatase-1 (SHIP-1) which de-phosphorylates PI(3,4,5)P(3) at the D5 position of the inositol ring to create PI(3,4)P(2).	pi(3,4,5)p	103-113	inositol polyphosphate-5-phosphatase D	Homo sapiens	71-77	
11706019-1	2002	Phosphoinositide-specific inositol polyphosphate 5- phosphatase IV has the affinity for PI(3,4,5)P(3) (K(m) = 0.65 microM) that is approximately 10-fold greater than the other inositol polyphosphate 5-phosphatases, which use this substrate including SHIP, OCRL, and 5ptase II, suggesting that it may be important in controlling intracellular levels of this metabolite.	pi(3,4,5)p	88-98	inositol polyphosphate-5-phosphatase D	Homo sapiens	250-254	
12421919-11	2002	This study provides the first evidence that SHIP-1 can influence the constitutive levels of PI(3,4,5)P(3) and the activity of downstream phosphoinositide 3-kinase effectors in T lymphocytes.	pi(3,4,5)p	92-102	inositol polyphosphate-5-phosphatase D	Homo sapiens	44-50	
21155837-3	2011	This review also proposes that SHIP can have either inhibitory or activating roles in cell signaling that are determined by whether signaling pathways distal to PI3K are promoted by SHIP"s substrate (PI(3,4,5)P(3) ) or its product (PI(3,4)P(2) ).	pi(3,4,5)p	200-210	inositol polyphosphate-5-phosphatase D	Homo sapiens	31-35	
21155837-3	2011	This review also proposes that SHIP can have either inhibitory or activating roles in cell signaling that are determined by whether signaling pathways distal to PI3K are promoted by SHIP"s substrate (PI(3,4,5)P(3) ) or its product (PI(3,4)P(2) ).	pi(3,4,5)p	200-210	inositol polyphosphate-5-phosphatase D	Homo sapiens	182-186