PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24535843-1	2014	The process of hepatocarcinogenesis in the diethylnitrosamine (DEN) initiation/phenobarbital (PB) promotion mouse model involves the selective clonal outgrowth of cells harboring oncogene mutations in Ctnnb1, while spontaneous or DEN-only-induced tumors are often Ha-ras- or B-raf-mutated.	Diethylnitrosamine	43-61	Harvey rat sarcoma virus oncogene	Mus musculus	264-270	
2675901-7	1989	Our results demonstrate that approximately 15% of the glucose-6-phosphatase-negative lesions that occurred 24-28 wk after a single injection of diethylnitrosamine contain either C----A transversions at the first base or A----G transitions and A----T transversions at the second base of codon 61 of the Ha-ras gene.	Diethylnitrosamine	144-162	Harvey rat sarcoma virus oncogene	Mus musculus	302-308	
2827904-5	1988	Activating mutations in the H-ras genes from the DEN-induced mouse liver tumors were characterized by selective oligonucleotide hybridization and the detection of a new XbaI restriction site by Southern blot analysis.	Diethylnitrosamine	49-52	Harvey rat sarcoma virus oncogene	Mus musculus	28-33	
2827904-6	1988	In activated H-ras genes from the DEN-induced mouse liver tumor DNA, seven of 14 had a CG----AT transversion at the first base of the 61st codon, three of 14 had an AT----GC transition and four of 14 had the AT----TA transversion at the second base of codon 61.	Diethylnitrosamine	34-37	Harvey rat sarcoma virus oncogene	Mus musculus	13-18	
2827904-8	1988	Taken together, the data suggest that the DEN-induced rat and mouse liver carcinogenesis may involve genetic targets other than or in addition to the H-ras gene.	Diethylnitrosamine	42-45	Harvey rat sarcoma virus oncogene	Mus musculus	150-155	
24535843-1	2014	The process of hepatocarcinogenesis in the diethylnitrosamine (DEN) initiation/phenobarbital (PB) promotion mouse model involves the selective clonal outgrowth of cells harboring oncogene mutations in Ctnnb1, while spontaneous or DEN-only-induced tumors are often Ha-ras- or B-raf-mutated.	Diethylnitrosamine	63-66	Harvey rat sarcoma virus oncogene	Mus musculus	264-270	
17928010-3	2008	In total, 73% (102/140) of tumors induced by a single application of N-nitrosodiethylamine or 7,12-dimethylbenz[a]anthracene contained either B-raf or Ha-ras mutations and only <3% (4/140) were mutated in both genes.	Diethylnitrosamine	69-90	Harvey rat sarcoma virus oncogene	Mus musculus	151-157	
11753661-6	2001	In tumors from mice treated with DEN alone, the prevalence of Ha-ras mutations was approximately 30% (6/20), while no beta-catenin mutations (0/13) were detectable in tumors of this treatment group.	Diethylnitrosamine	33-36	Harvey rat sarcoma virus oncogene	Mus musculus	62-68	
15592514-4	2005	We now screened 82 N-nitrosodiethylamine-induced liver tumors from C3H/He mice for mutations within the hotspot positions in the Ha-ras and B-raf genes.	Diethylnitrosamine	19-40	Harvey rat sarcoma virus oncogene	Mus musculus	129-135	
11753661-7	2001	By contrast, Ha-ras mutations were undetectable in tumors from mice treated with DEN/PB (0/32), while approximately 80% (37/46) of tumors from this group showed beta-catenin mutations.	Diethylnitrosamine	81-84	Harvey rat sarcoma virus oncogene	Mus musculus	13-19	
1638698-0	1992	Temporal changes in the mutant frequency and mutation spectra of the 61st codon of the H-ras oncogene following exposure of B6C3F1 mice to N-nitrosodiethylamine (DEN).	Diethylnitrosamine	139-160	Harvey rat sarcoma virus oncogene	Mus musculus	87-92	
8142011-1	1994	Distinct differences have been described in the development of C3H/He mouse liver tumors induced by the genotoxic carcinogen diethylnitrosamine (DEN) and by the nongenotoxic agent phenobarbitone (PB) in terms of pathology and the frequency of mutation at codon 61 of the Ha-ras oncogene.	Diethylnitrosamine	145-148	Harvey rat sarcoma virus oncogene	Mus musculus	271-277	
8353844-1	1993	In a previous study, the spectrum of H-ras mutations detected in B6C3F1 mouse liver tumors induced by 5, 50 or 150 mumol/kg body wt of N-nitrosodiethylamine (NDEA) was similar to that in spontaneous B6C3F1 mouse liver tumors, suggesting that activation of the H-ras gene in NDEA-induced mouse liver tumors may not be the direct result of the chemical interaction with the H-ras gene.	Diethylnitrosamine	135-156	Harvey rat sarcoma virus oncogene	Mus musculus	37-42	
8353844-3	1993	Twenty-one of 66 NDEA-induced B6C3F1 mouse liver tumors contained activated H-ras gene with 2 of 21 having a CG to AT transversion at the first base of codon 61, 17 of 21 having AT to GC transition and 2 of 21 having an AT to TA transversion at the second base of codon 61 in the H-ras gene.	Diethylnitrosamine	17-21	Harvey rat sarcoma virus oncogene	Mus musculus	76-81	
8353844-3	1993	Twenty-one of 66 NDEA-induced B6C3F1 mouse liver tumors contained activated H-ras gene with 2 of 21 having a CG to AT transversion at the first base of codon 61, 17 of 21 having AT to GC transition and 2 of 21 having an AT to TA transversion at the second base of codon 61 in the H-ras gene.	Diethylnitrosamine	17-21	Harvey rat sarcoma virus oncogene	Mus musculus	280-285	
1638698-0	1992	Temporal changes in the mutant frequency and mutation spectra of the 61st codon of the H-ras oncogene following exposure of B6C3F1 mice to N-nitrosodiethylamine (DEN).	Diethylnitrosamine	162-165	Harvey rat sarcoma virus oncogene	Mus musculus	87-92	
1638698-9	1992	These data indicate that DEN-induced mutations at the 61st codon of the mouse H-ras oncogene (i) are an infrequent event, (ii) have different frequencies at the 38 and 65 week timepoints and (iii) are different from the types of mutations seen in spontaneous lesions.	Diethylnitrosamine	25-28	Harvey rat sarcoma virus oncogene	Mus musculus	78-83	
1323970-0	1992	Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice.	Diethylnitrosamine	58-76	Harvey rat sarcoma virus oncogene	Mus musculus	37-45	
1747936-0	1991	Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.	Diethylnitrosamine	100-118	Harvey rat sarcoma virus oncogene	Mus musculus	16-22	
1747936-1	1991	In a study of the mechanisms involved in the induction of tumours by chemicals, the Ha-ras oncogene was analysed in liver tumours induced by the genotoxic carcinogen diethylnitrosamine (DEN), or the non-genotoxic agent phenobarbitone (PB) in C3H/He mice.	Diethylnitrosamine	166-184	Harvey rat sarcoma virus oncogene	Mus musculus	84-90	
1747936-1	1991	In a study of the mechanisms involved in the induction of tumours by chemicals, the Ha-ras oncogene was analysed in liver tumours induced by the genotoxic carcinogen diethylnitrosamine (DEN), or the non-genotoxic agent phenobarbitone (PB) in C3H/He mice.	Diethylnitrosamine	186-189	Harvey rat sarcoma virus oncogene	Mus musculus	84-90	
1747936-6	1991	Low and variable expression of the Ha-ras gene was detected in all liver tissues with moderately raised levels (175-200%) in spontaneous, DEN and PB-induced tumours as compared to normal liver tissue.	Diethylnitrosamine	138-141	Harvey rat sarcoma virus oncogene	Mus musculus	35-41	
1747936-8	1991	The frequency of the Ha-ras mutation at codon 61 in DEN-induced tumours is greater than in spontaneously arising tumours.	Diethylnitrosamine	52-55	Harvey rat sarcoma virus oncogene	Mus musculus	21-27	
2000226-1	1991	By selective oligonucleotide hybridization of polymerase chain reaction (PCR) amplified tumor DNAs we have analysed the incidence of mutations at codon 61 of the Ha-ras gene in 42 liver tumors spontaneously developed in Balb/c, C3Hf and B6C3 male mice, and in 79 liver tumors induced by the chemical carcinogens diethylnitrosamine (NDEA) and urethan in B6C3 and B6C male and female mice.	Diethylnitrosamine	312-330	Harvey rat sarcoma virus oncogene	Mus musculus	162-168	
2000226-1	1991	By selective oligonucleotide hybridization of polymerase chain reaction (PCR) amplified tumor DNAs we have analysed the incidence of mutations at codon 61 of the Ha-ras gene in 42 liver tumors spontaneously developed in Balb/c, C3Hf and B6C3 male mice, and in 79 liver tumors induced by the chemical carcinogens diethylnitrosamine (NDEA) and urethan in B6C3 and B6C male and female mice.	Diethylnitrosamine	332-336	Harvey rat sarcoma virus oncogene	Mus musculus	162-168	
2000226-4	1991	NDEA-induced tumors showed a low incidence of Ha-ras mutations in both the hybrid mice (3/18 and 1/13 in B6C3 and B6C male mice, respectively).	Diethylnitrosamine	0-4	Harvey rat sarcoma virus oncogene	Mus musculus	46-52	
2000226-6	1991	Our results indicate that liver tumors induced by NDEA or urethan or spontaneously arisen have a different pattern of Ha-ras mutations at codon 61 and that these mutations constitute a rare molecular alteration in the pathogenesis of liver tumors in genetically resistant mice.	Diethylnitrosamine	50-54	Harvey rat sarcoma virus oncogene	Mus musculus	118-124