PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22761128-0 2012 In vivo bioluminescent imaging of alpha-fetoprotein-producing hepatocellular carcinoma in the diethylnitrosamine-treated mouse using recombinant adenoviral vector. Diethylnitrosamine 94-112 alpha fetoprotein Mus musculus 34-51 22500097-6 2012 Furthermore, the serum levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and alpha-fetal protein (AFP) in serum significantly increased in the DEN/PB model group in comparison with the control group. Diethylnitrosamine 163-166 alpha fetoprotein Mus musculus 97-116 21939363-0 2012 Preventive effect of phytoglycoprotein (38 kDa) on expression of alpha-fetoprotein and matrix metalloproteinase-9 in diethylnitrosamine-treated ICR mice. Diethylnitrosamine 117-135 alpha fetoprotein Mus musculus 65-82 22500097-6 2012 Furthermore, the serum levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and alpha-fetal protein (AFP) in serum significantly increased in the DEN/PB model group in comparison with the control group. Diethylnitrosamine 163-166 alpha fetoprotein Mus musculus 118-121 33173221-5 2020 Indeed, single-cell RNA sequencing reveals two subpopulations of Prom1+ Afp- DRPs and Prom1+ Afp+ TICs in the DEN-WAD model. Diethylnitrosamine 110-113 alpha fetoprotein Mus musculus 93-96 22768027-6 2012 Carcinogen diethylnitrosamine (DEN) was then administrated to induce HCC in these knock-in mice such that microPET imaging could be used to track the activity of Afp promoter during tumor development and progression by imaging tk expression first with [(18)F]-FHBG. Diethylnitrosamine 11-29 alpha fetoprotein Mus musculus 162-165 22768027-6 2012 Carcinogen diethylnitrosamine (DEN) was then administrated to induce HCC in these knock-in mice such that microPET imaging could be used to track the activity of Afp promoter during tumor development and progression by imaging tk expression first with [(18)F]-FHBG. Diethylnitrosamine 31-34 alpha fetoprotein Mus musculus 162-165 20961645-2 2011 METHODS: Diethylnitrosamine (DEN) injected into infant mice results in the development of multi-nodular HCC in which alpha-fetoprotein (AFP) is re-expressed. Diethylnitrosamine 9-27 alpha fetoprotein Mus musculus 117-134 20961645-2 2011 METHODS: Diethylnitrosamine (DEN) injected into infant mice results in the development of multi-nodular HCC in which alpha-fetoprotein (AFP) is re-expressed. Diethylnitrosamine 9-27 alpha fetoprotein Mus musculus 136-139 20961645-2 2011 METHODS: Diethylnitrosamine (DEN) injected into infant mice results in the development of multi-nodular HCC in which alpha-fetoprotein (AFP) is re-expressed. Diethylnitrosamine 29-32 alpha fetoprotein Mus musculus 117-134 20961645-2 2011 METHODS: Diethylnitrosamine (DEN) injected into infant mice results in the development of multi-nodular HCC in which alpha-fetoprotein (AFP) is re-expressed. Diethylnitrosamine 29-32 alpha fetoprotein Mus musculus 136-139 20961645-3 2011 DEN-injected animals received an antigen-specific immunization with a synthetic vector consisting of a low dose of AFP-encoding plasmid formulated with the amphiphilic block copolymer 704 (DNAmAFP/704). Diethylnitrosamine 0-3 alpha fetoprotein Mus musculus 115-118 34966449-15 2022 Reverse transcription-quantitative PCR showed increases in alpha-fetoprotein level in DEN-treated livers, and increases in MT-2 and tumor necrosis factor alpha (TNFalpha) levels in Cd-treated livers. Diethylnitrosamine 86-89 alpha fetoprotein Mus musculus 59-76 18788625-1 2008 OBJECTIVE: To construct a dendritic cell vaccine transduced by murine alpha-fetoprotein (mAFP) gene, and evaluate its immunoprotective effect on C57BL/6J mice during the induction of hepatocellular carcinoma by diethylnitrosamines, carbon tetrachloride and ethanol. Diethylnitrosamine 211-230 alpha fetoprotein Mus musculus 89-93 18788625-12 2008 CONCLUSION: mAFP transgenic DC tumor vaccine inoculation may induce strong immunoprotection against liver carcinogenesis and tumor development and reduce PLC incidence induced by DEN/CCl4/ethanol. Diethylnitrosamine 179-182 alpha fetoprotein Mus musculus 12-16 15766596-0 2005 AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated. Diethylnitrosamine 32-50 alpha fetoprotein Mus musculus 0-3 15766596-5 2005 Analysis of the expression of AFP derived transgenes not subject to Afr2 regulation and genetic analyses showed that the difference in timing of peak AFP gene expression after DEN intoxication was independent of Afr2 regulation. Diethylnitrosamine 176-179 alpha fetoprotein Mus musculus 150-153 34730871-7 2022 The acute response to DEN was reduced in OpnDeltaHep , which also showed more cancer stem/progenitor cells (CSCs, CD44+ AFP+ ) at 5 months. Diethylnitrosamine 22-25 alpha fetoprotein Mus musculus 120-123 35523338-6 2022 Developmental arsenic exposure aggravated tumor multiplicity and burden, and expression of PCNA and AFP in hepatic tumors induced by DEN. Diethylnitrosamine 133-136 alpha fetoprotein Mus musculus 100-103 6184154-1 1983 Single injections of diethylnitrosamine (5 and 50 micrograms/g body weight) in male C57BL/6J X C3HeB/FeJ F1 mice when they were 15 days old resulted in the induction of RNA-rich hepatocellular foci and nodules that contained alpha-fetoprotein (AFP)-positive hepatocytes after 20 and 28 weeks. Diethylnitrosamine 21-39 alpha fetoprotein Mus musculus 225-242 6184154-1 1983 Single injections of diethylnitrosamine (5 and 50 micrograms/g body weight) in male C57BL/6J X C3HeB/FeJ F1 mice when they were 15 days old resulted in the induction of RNA-rich hepatocellular foci and nodules that contained alpha-fetoprotein (AFP)-positive hepatocytes after 20 and 28 weeks. Diethylnitrosamine 21-39 alpha fetoprotein Mus musculus 244-247 6184154-3 1983 AFP-positive hepatocytes were found in almost one-fourth (14 of 60) of the foci and nodules in a serially sectioned block of liver from a mouse given one injection of 50 micrograms/g body weight diethylnitrosamine and killed at 28 weeks. Diethylnitrosamine 195-213 alpha fetoprotein Mus musculus 0-3 33009373-4 2020 In this study, we demostrated that depleting AFP significantly suppressed diethylnitrosamine (DEN)-induced liver tumor progression in an AFP gene-deficient mouse model. Diethylnitrosamine 74-92 alpha fetoprotein Mus musculus 45-48 33009373-4 2020 In this study, we demostrated that depleting AFP significantly suppressed diethylnitrosamine (DEN)-induced liver tumor progression in an AFP gene-deficient mouse model. Diethylnitrosamine 74-92 alpha fetoprotein Mus musculus 137-140 33009373-4 2020 In this study, we demostrated that depleting AFP significantly suppressed diethylnitrosamine (DEN)-induced liver tumor progression in an AFP gene-deficient mouse model. Diethylnitrosamine 94-97 alpha fetoprotein Mus musculus 45-48 33009373-4 2020 In this study, we demostrated that depleting AFP significantly suppressed diethylnitrosamine (DEN)-induced liver tumor progression in an AFP gene-deficient mouse model. Diethylnitrosamine 94-97 alpha fetoprotein Mus musculus 137-140 31017181-7 2019 RESULTS: The model of DEN injected hepatocellular carcinomic (HCC) mice elicited significant decline in levels of albumin with concomitant significant elevations in tumor markers aspartate aminotransferase, alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alpha feto protein (AFP), gamma glutamyl transferase (Y-GT), 5 nucleotidase (5NT), glucose-6-phosphate dehydrogenase (G6PDH) and bilirubin. Diethylnitrosamine 22-25 alpha fetoprotein Mus musculus 288-291 33488874-4 2021 Results: DEN administration significantly increased liver enzymes, vascular endothelial growth factor, tumor necrosis factor-alpha, alpha-fetoprotein, malondialdehyde, and nucelar factor-kappaB. Diethylnitrosamine 9-12 alpha fetoprotein Mus musculus 132-149 28337100-7 2016 The mRNA expression of Afp and Epcam was increased at all time points following DEN whereas CK19, Prom1 and Notch3 were increased after 17 weeks of DEN, without difference between PHD2+/- and WT mice. Diethylnitrosamine 80-83 alpha fetoprotein Mus musculus 23-26 27122661-15 2016 This correlated with increased serum alpha-fetoprotein, a marker of HCC, in alcohol-DEN mice. Diethylnitrosamine 84-87 alpha fetoprotein Mus musculus 37-54 27853646-9 2016 Liver fibrosis and serum AFP were significantly increased in DEN + HF-HC-HSD mice compared to controls. Diethylnitrosamine 61-64 alpha fetoprotein Mus musculus 25-28 26888602-5 2016 MRI and liver histology of alcohol+DEN mice shows hepatobiliary cysts, early hepatic neoplasia and increase in serum alpha-fetoprotein. Diethylnitrosamine 35-38 alpha fetoprotein Mus musculus 117-134