PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34798156-2 2022 Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO2) nanosheets and glucose oxidase (GOx), multifunctional MPDA@MnO2-MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. manganese dioxide 79-96 hydroxyacid oxidase 1 Homo sapiens 136-139 33034314-5 2020 Once MONs-GOx@MnO2-Ce6 enter tumor cells, it catalyzes the oxidation of glucose using oxygen (O2) and generates hydrogen peroxide (H2O2) and gluconic acid, the former of which may accelerate the decomposition of MnO2 nanosheets. manganese dioxide 14-18 hydroxyacid oxidase 1 Homo sapiens 10-13 33034314-5 2020 Once MONs-GOx@MnO2-Ce6 enter tumor cells, it catalyzes the oxidation of glucose using oxygen (O2) and generates hydrogen peroxide (H2O2) and gluconic acid, the former of which may accelerate the decomposition of MnO2 nanosheets. manganese dioxide 212-216 hydroxyacid oxidase 1 Homo sapiens 10-13 34798156-2 2022 Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO2) nanosheets and glucose oxidase (GOx), multifunctional MPDA@MnO2-MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. manganese dioxide 79-96 hydroxyacid oxidase 1 Homo sapiens 119-134 34798156-2 2022 Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO2) nanosheets and glucose oxidase (GOx), multifunctional MPDA@MnO2-MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. manganese dioxide 79-96 hydroxyacid oxidase 1 Homo sapiens 171-174 34798156-2 2022 Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO2) nanosheets and glucose oxidase (GOx), multifunctional MPDA@MnO2-MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. manganese dioxide 98-102 hydroxyacid oxidase 1 Homo sapiens 119-134 34798156-2 2022 Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO2) nanosheets and glucose oxidase (GOx), multifunctional MPDA@MnO2-MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. manganese dioxide 98-102 hydroxyacid oxidase 1 Homo sapiens 136-139 34798156-2 2022 Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO2) nanosheets and glucose oxidase (GOx), multifunctional MPDA@MnO2-MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. manganese dioxide 98-102 hydroxyacid oxidase 1 Homo sapiens 171-174 34798156-3 2022 In tumor microenvironment (TME), MnO2 nanosheets on the surface of mesoporous polydopamine (MPDA) could react with endogenous hydrogen peroxide (H2O2) and generate oxygen (O2) to relieve tumor hypoxia, thus enhancing the efficacy of PDT and GOx catalysis. manganese dioxide 33-37 hydroxyacid oxidase 1 Homo sapiens 241-244 34798156-4 2022 Glucose consumption under the catalysis of GOx will enhance the acidity of TME and increase intracellular H2O2 concentration, which in turn promotes the production of O2 by MnO2 nanosheets, thus forming efficient cascade reaction and maximizing the efficacy of the functional agents. manganese dioxide 173-177 hydroxyacid oxidase 1 Homo sapiens 43-46 34553729-0 2021 A flowerlike FePt/MnO2/GOx-based cascade nanoreactor with sustainable O2 supply for synergistic starvation-chemodynamic anticancer therapy. manganese dioxide 18-22 hydroxyacid oxidase 1 Homo sapiens 23-26 34517657-2 2021 Herein, an interrelated catalytic enzyme system has been developed, termed as CataFlower, which is composed of nanoflower MoS2 (peroxidase) decorated with GOx (glucose oxidase) and MnO2 (oxygen generator), and exhibits synergistic oxidative capability for sensitively monitoring sweat glucose. manganese dioxide 181-185 hydroxyacid oxidase 1 Homo sapiens 160-175 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 123-127 hydroxyacid oxidase 1 Homo sapiens 119-122 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 123-127 hydroxyacid oxidase 1 Homo sapiens 157-172 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 123-127 hydroxyacid oxidase 1 Homo sapiens 174-177 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 180-197 hydroxyacid oxidase 1 Homo sapiens 119-122 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 180-197 hydroxyacid oxidase 1 Homo sapiens 157-172 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 180-197 hydroxyacid oxidase 1 Homo sapiens 174-177 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 199-203 hydroxyacid oxidase 1 Homo sapiens 119-122 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 199-203 hydroxyacid oxidase 1 Homo sapiens 157-172 34553729-2 2021 Herein, in this study, we rationally designed and prepared a novel flowerlike multifunctional cascade nanoreactor, BSA-GOx@MnO2@FePt (BGMFP), by integrating glucose oxidase (GOx), manganese dioxide (MnO2) and FePt for synergetic cancer treatment with satisfying therapeutic efficiency. manganese dioxide 199-203 hydroxyacid oxidase 1 Homo sapiens 174-177 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 125-142 hydroxyacid oxidase 1 Homo sapiens 89-104 34585187-3 2021 Fe3O4@ZIF-8/GOx@MnO2 multi-layer core shell nanostructure was constructed as a hybrid nanozyme. manganese dioxide 16-20 hydroxyacid oxidase 1 Homo sapiens 12-15 34020663-3 2021 RESULTS: Here, a targeting nano-reactor was facilely constructed to reverse the multiple resistances of PDT by incorporating glucose oxidase (GOx) and chlorin e6 (Ce6) into poly (D, L-lactic-co-glycolic acid) (PLGA)/ metal-organic framework (MOF) core-shell nanoassembly, with surface deposition of hyaluronic acid (HA) stabilized MnO2. manganese dioxide 331-335 hydroxyacid oxidase 1 Homo sapiens 125-140 34020663-3 2021 RESULTS: Here, a targeting nano-reactor was facilely constructed to reverse the multiple resistances of PDT by incorporating glucose oxidase (GOx) and chlorin e6 (Ce6) into poly (D, L-lactic-co-glycolic acid) (PLGA)/ metal-organic framework (MOF) core-shell nanoassembly, with surface deposition of hyaluronic acid (HA) stabilized MnO2. manganese dioxide 331-335 hydroxyacid oxidase 1 Homo sapiens 142-145 33964699-2 2021 Herein, an intelligent reactive oxygen species (ROS) nanogenerator Ce6/GOx@ZIF-8/PDA@MnO2 (denoted as CGZPM; Ce6, GOx, ZIF-8, PDA, MnO2 are chlorin e6, glucose oxidase, zeolitic imidazolate framework-8, polydopamine and manganese dioxide respectively) with O2-generating and GSH-/glucose-depleting abilities was constructed by a facile and green one-pot method. manganese dioxide 220-237 hydroxyacid oxidase 1 Homo sapiens 71-74 33720684-3 2021 This theranostic nanoplatform is constructed by using polyethyleneimine-modified black phosphorus nanosheets as a "fishnet" to attach l-Arginine (l-Arg) and glucose oxidase (GOx) and then depositing mini-sized MnO2 nanosheets (MNs) on the surface by a facile situ biomineralization method. manganese dioxide 210-214 hydroxyacid oxidase 1 Homo sapiens 174-177 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 125-142 hydroxyacid oxidase 1 Homo sapiens 106-109 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 125-142 hydroxyacid oxidase 1 Homo sapiens 220-223 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 144-148 hydroxyacid oxidase 1 Homo sapiens 89-104 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 144-148 hydroxyacid oxidase 1 Homo sapiens 106-109 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 144-148 hydroxyacid oxidase 1 Homo sapiens 220-223 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 211-215 hydroxyacid oxidase 1 Homo sapiens 89-104 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 211-215 hydroxyacid oxidase 1 Homo sapiens 106-109 31179709-3 2019 Here we report a biomimetic hybrid nanozyme (named rMGB) which integrates natural enzyme glucose oxidase (GOx) with nanozyme manganese dioxide (MnO2) by mutual promotion for maximizing the enzymatic activity of MnO2 and GOx. manganese dioxide 211-215 hydroxyacid oxidase 1 Homo sapiens 220-223 31179709-4 2019 Under hypoxia environment, we observed that MnO2 could react with endogenous H2O2 to produce O2 for enhancing the catalytic efficiency of GOx for starvation therapy. manganese dioxide 44-48 hydroxyacid oxidase 1 Homo sapiens 138-141 31179709-6 2019 The biochemical reaction cycle, consisting of MnO2, O2, GOx, and H+, was triggered by the tumor microenvironment and accelerated each other so as to achieve self-supplied H+ and accelerate O2 generation, enhancing the starvation therapy, alleviating tumor hypoxia and accelerating the reactive oxygen species generation in photodynamic therapy. manganese dioxide 46-50 hydroxyacid oxidase 1 Homo sapiens 56-59 29790497-2 2018 Here, we have designed an intelligent glucose detection system composed of glucose, glucose oxidase (GOx), MnO2 and 3,3",5,5"-tetramethylbenzidine (TMB), based on the enzymatic oxidation of glucose and dual roles of synthesized MnO2 nanosheets acting as both an oxidant and catalyst. manganese dioxide 228-232 hydroxyacid oxidase 1 Homo sapiens 84-99 29790497-2 2018 Here, we have designed an intelligent glucose detection system composed of glucose, glucose oxidase (GOx), MnO2 and 3,3",5,5"-tetramethylbenzidine (TMB), based on the enzymatic oxidation of glucose and dual roles of synthesized MnO2 nanosheets acting as both an oxidant and catalyst. manganese dioxide 228-232 hydroxyacid oxidase 1 Homo sapiens 101-104 29790497-3 2018 Upon the addition of glucose/GOx, the MnO2 nanosheets partially decompose due to H2O2in situ generated via glucose oxidation. manganese dioxide 38-42 hydroxyacid oxidase 1 Homo sapiens 29-32 32260974-3 2013 The hierarchical MnO2 showed mesoporous structure and good biocompatibility for the immobilization of glucose oxidase (GOx). manganese dioxide 17-21 hydroxyacid oxidase 1 Homo sapiens 102-117 32260974-3 2013 The hierarchical MnO2 showed mesoporous structure and good biocompatibility for the immobilization of glucose oxidase (GOx). manganese dioxide 17-21 hydroxyacid oxidase 1 Homo sapiens 119-122 32260974-4 2013 The bioconjugate of a GOx/MnO2-modified electrode was successfully employed for the mediatorless biosensing of glucose. manganese dioxide 26-30 hydroxyacid oxidase 1 Homo sapiens 22-25