PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21722948-6 2011 These findings highlight a dual role for TDG in promoting proper epigenetic states during development and suggest a two-step mechanism for DNA demethylation in mammals, whereby 5-methylcytosine and 5-hydroxymethylcytosine are first deaminated by AID to thymine and 5-hydroxymethyluracil, respectively, followed by TDG-mediated thymine and 5-hydroxymethyluracil excision repair. 5-hydroxymethyluracil 265-286 thymine DNA glycosylase Homo sapiens 41-44 22962365-0 2012 Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. 5-hydroxymethyluracil 12-33 thymine DNA glycosylase Homo sapiens 64-87 22962365-2 2012 TDG excises the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). 5-hydroxymethyluracil 83-104 thymine DNA glycosylase Homo sapiens 0-3 22962365-2 2012 TDG excises the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). 5-hydroxymethyluracil 106-110 thymine DNA glycosylase Homo sapiens 0-3 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-hydroxymethyluracil 92-113 thymine DNA glycosylase Homo sapiens 14-37 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-hydroxymethyluracil 92-113 thymine DNA glycosylase Homo sapiens 39-42 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-hydroxymethyluracil 115-119 thymine DNA glycosylase Homo sapiens 14-37 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-hydroxymethyluracil 115-119 thymine DNA glycosylase Homo sapiens 39-42 21722948-6 2011 These findings highlight a dual role for TDG in promoting proper epigenetic states during development and suggest a two-step mechanism for DNA demethylation in mammals, whereby 5-methylcytosine and 5-hydroxymethylcytosine are first deaminated by AID to thymine and 5-hydroxymethyluracil, respectively, followed by TDG-mediated thymine and 5-hydroxymethyluracil excision repair. 5-hydroxymethyluracil 339-360 thymine DNA glycosylase Homo sapiens 41-44 27036066-8 2016 Experimental evidence suggests that SMUG1 and TDG are main enzymes involved in removal of 5-hydroxymethyluracil from DNA. 5-hydroxymethyluracil 90-111 thymine DNA glycosylase Homo sapiens 46-49 27493500-2 2014 Both MBD4 and TDG excise the mismatch base from G:X, where X is uracil, thymine, and 5-hydroxymethyluracil (5hmU). 5-hydroxymethyluracil 85-106 thymine DNA glycosylase Homo sapiens 14-17 27493500-2 2014 Both MBD4 and TDG excise the mismatch base from G:X, where X is uracil, thymine, and 5-hydroxymethyluracil (5hmU). 5-hydroxymethyluracil 108-112 thymine DNA glycosylase Homo sapiens 14-17 26358812-2 2015 Initiating base excision repair, TDG removes thymine from mutagenic G : T mispairs caused by 5-methylcytosine (mC) deamination and other lesions including uracil (U) and 5-hydroxymethyluracil (hmU). 5-hydroxymethyluracil 171-192 thymine DNA glycosylase Homo sapiens 33-36 26358812-2 2015 Initiating base excision repair, TDG removes thymine from mutagenic G : T mispairs caused by 5-methylcytosine (mC) deamination and other lesions including uracil (U) and 5-hydroxymethyluracil (hmU). 5-hydroxymethyluracil 194-197 thymine DNA glycosylase Homo sapiens 33-36