PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23700640-10 2004 PS is also accessible for annexin V binding in apoptosis and necrosis because of disruption of the plasma membrane. Phosphatidylserines 0-2 annexin A5 Mus musculus 26-35 30803987-2 2019 Here, using genetic engineering, we coupled the disintegrin protein echistatin, which specifically binds to the platelet integrin alphaIIbbeta3 receptor, to annexin V, which binds platelet membrane-associated phosphatidylserine (PS), to create the bifunctional antithrombotic molecule recombinant echistatin-annexin V fusion protein (r-EchAV). Phosphatidylserines 209-227 annexin A5 Mus musculus 157-166 27260166-10 2016 Interestingly, both apocynin and annexin V (used as inhibitor of PS-induced phagocytosis) fully abolished the DA neurotoxicity induced by the injection of histamine in the SN of adult mice in vivo. Phosphatidylserines 65-67 annexin A5 Mus musculus 33-42 24984896-3 2014 We previously showed that fluorescently labeled Annexin A5 (AnxA5), which binds specifically to phosphatidylserine (PS) on dead/dying cells, can be used in experimental stroke for monitoring cell death with optical imaging. Phosphatidylserines 96-114 annexin A5 Mus musculus 48-58 24984896-3 2014 We previously showed that fluorescently labeled Annexin A5 (AnxA5), which binds specifically to phosphatidylserine (PS) on dead/dying cells, can be used in experimental stroke for monitoring cell death with optical imaging. Phosphatidylserines 96-114 annexin A5 Mus musculus 60-65 24984896-6 2014 They were injected intravenously with either PS-binding AnxA5 or the nonfunctional AnxA5 (negative control), labeled with 99mTc and Alexa Fluor 568, respectively. Phosphatidylserines 45-47 annexin A5 Mus musculus 56-61 23700640-11 2004 Annexin V binds to PS with high affinity (dissociation constant = 7 nM). Phosphatidylserines 19-21 annexin A5 Mus musculus 0-9 22812025-2 2004 PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane. Phosphatidylserines 0-2 annexin A5 Mus musculus 26-35 22812025-2 2004 PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane. Phosphatidylserines 0-2 annexin A5 Mus musculus 40-50 22812025-3 2004 Annexin V, a 36-kDa protein, binds to PS with high affinity (Kd = 7 nM). Phosphatidylserines 38-40 annexin A5 Mus musculus 0-9 20531278-5 2010 Membrane changes of the spermatozoa were investigated by staining with phycoerythrin (PE)-conjugated Annexin V, which detects exteriorization of phosphotidylserine from the inner to the outer leaflet of the sperm plasma membrane, and 7-aminoactinomycin D (7-AAD), which binds to the sperm nucleus when the plasma membrane is damaged. Phosphatidylserines 145-163 annexin A5 Mus musculus 101-110 22415004-1 2012 UNLABELLED: Annexin A5 (AnxA5) has a high affinity for phosphatidylserine. Phosphatidylserines 55-73 annexin A5 Mus musculus 12-22 22415004-1 2012 UNLABELLED: Annexin A5 (AnxA5) has a high affinity for phosphatidylserine. Phosphatidylserines 55-73 annexin A5 Mus musculus 24-29 20201728-6 2011 Also, the loss of phosphatidylserine (PS) asymmetry in the phospholipid bilayer of plasma membrane during early apoptosis was monitored by imaging annexin-V labeled with fluorescein isocyanate binding to the externalized PS at various concentrations of STS. Phosphatidylserines 38-40 annexin A5 Mus musculus 147-156 21542558-19 2004 PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane. Phosphatidylserines 0-2 annexin A5 Mus musculus 26-35 21542558-19 2004 PS is also accessible for annexin V (or annexin A5) binding in necrosis because of disruption of the plasma membrane. Phosphatidylserines 0-2 annexin A5 Mus musculus 40-50 21542558-20 2004 Annexin V, a 36-kDa protein, binds to PS with high affinity (Kd = 7 nM). Phosphatidylserines 38-40 annexin A5 Mus musculus 0-9 20201728-6 2011 Also, the loss of phosphatidylserine (PS) asymmetry in the phospholipid bilayer of plasma membrane during early apoptosis was monitored by imaging annexin-V labeled with fluorescein isocyanate binding to the externalized PS at various concentrations of STS. Phosphatidylserines 18-36 annexin A5 Mus musculus 147-156 21571801-3 2011 METHODS: To modulate the pharmacokinetics of annexin A5, a 36-kDa protein that binds specifically with phosphatidylserine, annexin A5 was conjugated to polyethylene glycol-coated, core-cross-linked polymeric micelles (CCPMs) dually labeled with near-infrared fluorescence fluorophores and a radioisotope ((111)In). Phosphatidylserines 103-121 annexin A5 Mus musculus 45-55 21571801-3 2011 METHODS: To modulate the pharmacokinetics of annexin A5, a 36-kDa protein that binds specifically with phosphatidylserine, annexin A5 was conjugated to polyethylene glycol-coated, core-cross-linked polymeric micelles (CCPMs) dually labeled with near-infrared fluorescence fluorophores and a radioisotope ((111)In). Phosphatidylserines 103-121 annexin A5 Mus musculus 123-133 20796191-5 2010 The apoptosis induction was assessed by exposure to phosphatidylserine (ANNEXIN V-FITC). Phosphatidylserines 52-70 annexin A5 Mus musculus 72-81 18485093-6 2008 RESULTS: The number of lactadherin-binding sites on synthetic membranes was proportional to PS content, whereas annexin V required a threshold of 2.5-8% PS. Phosphatidylserines 153-155 annexin A5 Mus musculus 112-121 19198650-4 2009 Macrophage uptake of PS-coated nanotubes was suppressed by the PS-binding protein, Annexin V, and endocytosis inhibitors, and changed the pattern of pro- and anti-inflammatory cytokine secretion. Phosphatidylserines 21-23 annexin A5 Mus musculus 83-92 20798520-7 2010 Phosphatidylserine-exposing erythrocytes were identified by analysing annexin V-binding in FACS analysis. Phosphatidylserines 0-18 annexin A5 Mus musculus 70-79 20122665-3 2010 Annexin-V (AnxV) has been shown to have high affinity to externalized phosphatidylserine. Phosphatidylserines 70-88 annexin A5 Mus musculus 0-9 20122665-3 2010 Annexin-V (AnxV) has been shown to have high affinity to externalized phosphatidylserine. Phosphatidylserines 70-88 annexin A5 Mus musculus 11-15 18829952-2 2008 During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied annexin V, a calcium-dependent PS-binding protein. Phosphatidylserines 56-58 annexin A5 Mus musculus 136-145 18464157-6 2008 Phosphatidylserine-exposing platelets were present in thrombi of both vessel types, as detected with fluorescently labeled annexin A5. Phosphatidylserines 0-18 annexin A5 Mus musculus 123-133 17583394-3 2007 The IFN-gamma production was increased in a manner dependent on the PS content of the liposomes and inhibited by the addition of annexin V, a PS binding protein. Phosphatidylserines 142-144 annexin A5 Mus musculus 129-138 20641674-18 2004 PS is also accessible for annexin V binding in necrosis because of disruption of the plasma membrane. Phosphatidylserines 0-2 annexin A5 Mus musculus 26-35 20641674-19 2004 Annexin V binds to PS with high affinity (Kd = 7 nM). Phosphatidylserines 19-21 annexin A5 Mus musculus 0-9 17924964-4 2008 Moreover, the interaction of exposed PS with exogenously added annexin V perturbed PS-mediated cell signaling and transiently up-regulated the declining c-myb expression. Phosphatidylserines 37-39 annexin A5 Mus musculus 63-72 17924964-4 2008 Moreover, the interaction of exposed PS with exogenously added annexin V perturbed PS-mediated cell signaling and transiently up-regulated the declining c-myb expression. Phosphatidylserines 83-85 annexin A5 Mus musculus 63-72 17021816-2 2007 Radiolabeled annexin-V (anxV) is an ideal probe for in vivo apoptosis detection owing to its strong affinity for phosphatidylserine (PS), the molecular flag on the surface of apoptotic cells. Phosphatidylserines 113-131 annexin A5 Mus musculus 13-22 17021816-2 2007 Radiolabeled annexin-V (anxV) is an ideal probe for in vivo apoptosis detection owing to its strong affinity for phosphatidylserine (PS), the molecular flag on the surface of apoptotic cells. Phosphatidylserines 133-135 annexin A5 Mus musculus 13-22 17294366-1 2007 Expression of phosphotidylserine by fetal oocytes in culture renders significant numbers of such cells able to bind AnnexinV-coated microbeads and allows their separation from Annexin V-negative oocytes on a Magnetic Cell Separation (MACS) column in a magnetic field. Phosphatidylserines 14-32 annexin A5 Mus musculus 176-185 11760098-4 2001 The cell death was confirmed to be apoptosis by Annexin V binding to phosphatidylserine in the cell membrane and excluding propidium iodide. Phosphatidylserines 69-87 annexin A5 Mus musculus 48-57 15240711-10 2004 Annexin V assays showed that ATP stimulation resulted in a rapid phosphatidylserine (PS) exposure on the cell surface of RAW264.7 macrophages, and that PS-exposed microvesicles contained icIL-1ra1. Phosphatidylserines 152-154 annexin A5 Mus musculus 0-9 12058279-8 2002 These results indicate that annexin V inhibited the phagocytic clearance of apoptotic spermatogenic cells and suggest that PS-mediated phagocytosis of those cells occurs in vivo. Phosphatidylserines 123-125 annexin A5 Mus musculus 28-37 11893753-2 2002 Upon induction of ABCA1 in RAW264.7 cells by cAMP analogues there was a moderate increase in cell surface PS as detected by annexin V binding, whereas apoAI binding was increased more robustly. Phosphatidylserines 106-108 annexin A5 Mus musculus 124-133 11994533-12 2002 The Bolton-Hunter-labeled annexin V bound to apoptotic cells and immobilized phosphatidylserine in vitro. Phosphatidylserines 77-95 annexin A5 Mus musculus 26-35 9436535-7 1997 Further scrutiny of this fraction indicates that a) it shows the greatest reactivity with annexin V, which is specific for the detection of phosphatidylserine (PS) exposed on the outer leaflet of the erythrocyte membrane, b) it is the most susceptible to erythrophagocytosis by resident murine peritoneal macrophages, and c) this erythrophagocytosis of PKH 26-labeled erythrocytes can be inhibited by annexin V and by liposomes containing PS. Phosphatidylserines 140-158 annexin A5 Mus musculus 90-99 11004148-8 2000 In control mice, including those injected with annexin-V at the binding site of PS, no annexin-V-positive cells were observed. Phosphatidylserines 80-82 annexin A5 Mus musculus 47-56 10452909-0 1999 Annexin V inhibits phosphatidylserine-induced intrauterine growth restriction in mice. Phosphatidylserines 19-37 annexin A5 Mus musculus 0-9 10200565-4 1999 Similarly, annexin V was able to inhibit phagocytosis of lipid-symmetric erythrocytes, another target cell upon which PS is exposed. Phosphatidylserines 118-120 annexin A5 Mus musculus 11-20 9436535-7 1997 Further scrutiny of this fraction indicates that a) it shows the greatest reactivity with annexin V, which is specific for the detection of phosphatidylserine (PS) exposed on the outer leaflet of the erythrocyte membrane, b) it is the most susceptible to erythrophagocytosis by resident murine peritoneal macrophages, and c) this erythrophagocytosis of PKH 26-labeled erythrocytes can be inhibited by annexin V and by liposomes containing PS. Phosphatidylserines 160-162 annexin A5 Mus musculus 90-99 9436535-7 1997 Further scrutiny of this fraction indicates that a) it shows the greatest reactivity with annexin V, which is specific for the detection of phosphatidylserine (PS) exposed on the outer leaflet of the erythrocyte membrane, b) it is the most susceptible to erythrophagocytosis by resident murine peritoneal macrophages, and c) this erythrophagocytosis of PKH 26-labeled erythrocytes can be inhibited by annexin V and by liposomes containing PS. Phosphatidylserines 439-441 annexin A5 Mus musculus 90-99 34405304-0 2021 Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications. Phosphatidylserines 55-73 annexin A5 Mus musculus 25-35 9168822-6 1997 The specific binding of FL-SA-Ro to the apoptotic cells was also confirmed using a flourescence-activated cell sorter and the time-dependent cell surface exposure of PE correlated well with the exposure of PS, as detected by the binding of annexin V. Phosphatidylserines 206-208 annexin A5 Mus musculus 240-249 34804041-3 2021 Annexin V (AnnV) is a protein known to bind PS with high affinity and has been effectively utilized to anchor antigen to the surface of CD8 T cells. Phosphatidylserines 44-46 annexin A5 Mus musculus 0-9 34073384-6 2021 EVs from HeLa cells incubated with RAW264.7 cells induced phosphatidylserine exposure on the cells, suggesting a mechanism by which anxA5-coated EVs can bind to phagocytes before uptake. Phosphatidylserines 58-76 annexin A5 Mus musculus 132-137 32657463-5 2020 In hippocampal neuron and microglia co-cultures, synapse elimination can be partially prevented by blocking accessibility of exposed PS using Annexin V or through microglial loss of TREM2. Phosphatidylserines 133-135 annexin A5 Mus musculus 142-151