PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34389380-8 2021 Molecular modeling experiments revealed N501Y-specific stacking interactions in the RBD-ACE2 complex and provided insight into EGCG interference with the complex formation. epigallocatechin gallate 127-131 angiotensin converting enzyme 2 Homo sapiens 88-92 34815622-4 2022 Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals. epigallocatechin gallate 0-26 angiotensin converting enzyme 2 Homo sapiens 166-197 34461999-0 2021 Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. epigallocatechin gallate 0-24 angiotensin converting enzyme 2 Homo sapiens 131-135 34461999-8 2021 Mechanistic studies revealed that EGCG blocked infection at the entry step through interfering with the engagement of the receptor binding domain (RBD) of the viral spikes to angiotensin-converting enzyme 2 (ACE2) receptor of the host cells. epigallocatechin gallate 34-38 angiotensin converting enzyme 2 Homo sapiens 175-206 34461999-8 2021 Mechanistic studies revealed that EGCG blocked infection at the entry step through interfering with the engagement of the receptor binding domain (RBD) of the viral spikes to angiotensin-converting enzyme 2 (ACE2) receptor of the host cells. epigallocatechin gallate 34-38 angiotensin converting enzyme 2 Homo sapiens 208-212 33746069-7 2021 Nigellidine effectively binds in the Angiotensin- II binding-site/entry-pocket (-7.54 kcal/mol, -211.76, Atomic-Contact-Energy; ACE-value) of ACE2 (Ki 8.68 and 8.3 mumol) in comparison to known-binder EGCG (-4.53) and Theaflavin-di-gallate (-2.85). epigallocatechin gallate 201-205 angiotensin converting enzyme 2 Homo sapiens 142-146 34403732-7 2021 Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2. epigallocatechin gallate 15-19 angiotensin converting enzyme 2 Homo sapiens 42-46 34403732-7 2021 Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2. epigallocatechin gallate 15-19 angiotensin converting enzyme 2 Homo sapiens 107-111 34243689-8 2021 Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid. epigallocatechin gallate 125-129 angiotensin converting enzyme 2 Homo sapiens 69-73 34208050-5 2021 EGCG, TSA, and TFDG significantly inhibited interaction between recombinant ACE2 and RBD of S protein. epigallocatechin gallate 0-4 angiotensin converting enzyme 2 Homo sapiens 76-80 35382132-8 2022 Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2. epigallocatechin gallate 12-16 angiotensin converting enzyme 2 Homo sapiens 71-76 35475273-8 2022 Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2. epigallocatechin gallate 12-16 angiotensin converting enzyme 2 Homo sapiens 71-76 34054222-4 2021 Key findings and conclusions: EGCG, via activating Nrf2, can suppress ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2, which mediate cell entry of the virus. epigallocatechin gallate 30-34 angiotensin converting enzyme 2 Homo sapiens 70-74