PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31608620-12	2019	In contrast, EGCG"s inhibition of htt fibril formation persisted in the presence of lipids.	epigallocatechin gallate	13-17	huntingtin	Homo sapiens	34-37	
34594185-7	2021	There is evidence for EGCG"s ability to inhibit the aggregation of alpha-synuclein, amyloid-beta, and huntingtin proteins, respectively associated with PD, AD, and HD.	epigallocatechin gallate	22-26	huntingtin	Homo sapiens	102-112	
16893904-0	2006	Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington"s disease models.	epigallocatechin gallate	10-38	huntingtin	Homo sapiens	65-75	
16893904-3	2006	Here, we demonstrate that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) potently inhibits the aggregation of mutant htt exon 1 protein in a dose-dependent manner.	epigallocatechin gallate	51-81	huntingtin	Homo sapiens	133-136	
16893904-3	2006	Here, we demonstrate that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) potently inhibits the aggregation of mutant htt exon 1 protein in a dose-dependent manner.	epigallocatechin gallate	83-87	huntingtin	Homo sapiens	133-136	
16893904-4	2006	Dot-blot assays and atomic force microscopy studies revealed that EGCG modulates misfolding and oligomerization of mutant htt exon 1 protein in vitro, indicating that it interferes with very early events in the aggregation process.	epigallocatechin gallate	66-70	huntingtin	Homo sapiens	122-125	
16893904-5	2006	Also, EGCG significantly reduced polyQ-mediated htt protein aggregation and cytotoxicity in an yeast model of HD.	epigallocatechin gallate	6-10	huntingtin	Homo sapiens	48-51	
16893904-6	2006	When EGCG was fed to transgenic HD flies overexpressing a pathogenic htt exon 1 protein, photoreceptor degeneration and motor function improved.	epigallocatechin gallate	5-9	huntingtin	Homo sapiens	69-72	
16893904-7	2006	These results indicate that modulators of htt exon 1 misfolding and oligomerization like EGCG are likely to reduce polyQ-mediated toxicity in vivo.	epigallocatechin gallate	89-93	huntingtin	Homo sapiens	42-45	
27427935-4	2016	The most attractive advantage of nano-EGCG is that it efficiently protects neuronal cells from the toxic effect of extracellular amyloid beta or intracellular mutant huntingtin protein aggregates by preventing their aggregation.	epigallocatechin gallate	38-42	huntingtin	Homo sapiens	166-176	
19616561-1	2009	The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer"s, Parkinson"s and Huntington"s diseases, respectively.	epigallocatechin gallate	15-45	huntingtin	Homo sapiens	229-239	
19616561-1	2009	The polyphenol (-)-epigallocatechin-3-gallate (EGCG) has recently attracted much research interest in the field of protein-misfolding diseases because of its potent anti-amyloid activity against amyloid-beta, alpha-synuclein and huntingtin, the amyloid-fibril-forming proteins involved in Alzheimer"s, Parkinson"s and Huntington"s diseases, respectively.	epigallocatechin gallate	47-51	huntingtin	Homo sapiens	229-239