PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33716752-7 2021 Tellimagrandin I, SaikosaponinB2, Hesperidin and (-)-Epigallocatechin Gallate were the most prominent ones that showed strong binding affinity toward RdRp. epigallocatechin gallate 49-77 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 150-154 33760271-11 2021 The molecular docking binding energies of the six index components of Liupao tea with SARS-CoV-2 3CLpro were all less than -5.0 kJ/mol, among them, the enzyme activity experiment shows that EGCG has a certain inhibitory effect on SARS-CoV-2 3CLpro , it can be used as a potential SARS-CoV-2 3CLpro inhibitor. epigallocatechin gallate 190-194 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 241-247 32720577-11 2021 Further, a 150-ns molecular dynamic simulation revealed that EGCG, TF2a, TF2b, TF3 result in highly stable bound conformations with RdRp. epigallocatechin gallate 61-65 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 132-136 32720577-14 2021 Overall, our results suggest that EGCG, TF2a, TF2b, TF3 can inhibit RdRp and represent an effective therapy for COVID-19. epigallocatechin gallate 34-38 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 68-72 33760271-8 2021 The results of in vitro activity showed that the IC50 of EGCG was 8.84 mumol/L, which could inhibit SARS-CoV-2 3Clpro to a certain extent. epigallocatechin gallate 57-61 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 111-117 33760271-9 2021 This study unleashed that EGCG has a certain inhibitory effect on SARS-CoV-2 3CLpro , and Liupao tea has a certain significance as a tea drink for the prevention of COVID-19. epigallocatechin gallate 26-30 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 77-83 33760271-11 2021 The molecular docking binding energies of the six index components of Liupao tea with SARS-CoV-2 3CLpro were all less than -5.0 kJ/mol, among them, the enzyme activity experiment shows that EGCG has a certain inhibitory effect on SARS-CoV-2 3CLpro , it can be used as a potential SARS-CoV-2 3CLpro inhibitor. epigallocatechin gallate 190-194 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 97-103 33760271-11 2021 The molecular docking binding energies of the six index components of Liupao tea with SARS-CoV-2 3CLpro were all less than -5.0 kJ/mol, among them, the enzyme activity experiment shows that EGCG has a certain inhibitory effect on SARS-CoV-2 3CLpro , it can be used as a potential SARS-CoV-2 3CLpro inhibitor. epigallocatechin gallate 190-194 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 241-247