PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29316635-6 2018 Furthermore, we confirmed the antioxidant activity of EGCG and also showed a preventive effect against radical-evoked apoptosis by downregulation of caspase-8 and -3 in HaCaT cells. epigallocatechin gallate 54-58 caspase 8 Homo sapiens 149-165 28040581-5 2017 Western blot confirmed that EGCG induced apoptosis in SW780 cells by activation of caspases-8, -9 and -3, Bax, Bcl-2 and PARP. epigallocatechin gallate 28-32 caspase 8 Homo sapiens 83-104 25647297-0 2015 (-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation. epigallocatechin gallate 0-27 caspase 8 Homo sapiens 70-77 19414399-8 2009 EGCG promoted caspase-8, -9 and -3 activities in a time-dependent manner. epigallocatechin gallate 0-4 caspase 8 Homo sapiens 14-34 25759589-4 2015 Treatment with EGCG activates the expression of the BAD, BAK, FAS, IGF1R, WNT11, and ZEB1 genes and inhibits CASP8, MYC, and TP53. epigallocatechin gallate 15-19 caspase 8 Homo sapiens 109-114 19894226-11 2010 (-)-Epigallocatechin and EGCG also induced caspase-8 activity. epigallocatechin gallate 25-29 caspase 8 Homo sapiens 43-52 22313388-5 2012 In concert with the caspase-8 activation by EGCG, an enhanced expression in functional Fas/CD95 was identified. epigallocatechin gallate 44-48 caspase 8 Homo sapiens 20-29 21687829-13 2010 In conclusion, these data demonstrated GrTP and EGCG induced apoptosis in intestinal epithelia mediated by caspase-8 through a FADD dependent pathway. epigallocatechin gallate 48-52 caspase 8 Homo sapiens 107-116 20037825-13 2009 The activity of caspase-3 rather than caspase-8 was substantially enhanced in the EGCG group. epigallocatechin gallate 82-86 caspase 8 Homo sapiens 38-47 15802789-6 2005 To study the molecular mechanisms behind the induction of apoptosis by EGCG, the activity of caspases in MKN-45 cells treated with EGCG was examined. epigallocatechin gallate 71-75 caspase 8 Homo sapiens 93-101 19212680-8 2009 Treatment of SH-SY5Y cells with EGCG activated caspase-8, indicating induction of the receptor-mediated pathway of apoptosis. epigallocatechin gallate 32-36 caspase 8 Homo sapiens 47-56 19082499-3 2009 In this report, using MIA PaCa-2 cells as in vitro model, we demonstrate EGCG-induced cell death involves activation of caspase-8 and disappearance of intact 21 kDa Bid protein. epigallocatechin gallate 73-77 caspase 8 Homo sapiens 120-129 19082499-4 2009 Furthermore, exogenous expression of dominant negative caspase-8 or dominant negative FADD significantly abrogates apoptosis inducing ability of EGCG in MIA PaCa-2 cells. epigallocatechin gallate 145-149 caspase 8 Homo sapiens 55-64 16988947-8 2006 Activation of caspase-8 cleaved Bid to truncated Bid (tBid) in cells treated with EGC and EGCG. epigallocatechin gallate 90-94 caspase 8 Homo sapiens 14-23 16988947-9 2006 EGC and EGCG induced apoptosis with caspase-8 activation and mitochondria-mediated pathway, whereas APG and GST caused apoptosis via an increase in intracellular free [Ca(2+)] with calpain activation and mitochondria-mediated pathway. epigallocatechin gallate 8-12 caspase 8 Homo sapiens 36-45 17585882-6 2007 Colorimetric assays of cells treated for 36 h with EGCG demonstrated a reduction in activities of caspases 3 (50%) and 9 (70%) but not caspase 8, indicating initiation of apoptosis. epigallocatechin gallate 51-55 caspase 8 Homo sapiens 135-144 15802789-6 2005 To study the molecular mechanisms behind the induction of apoptosis by EGCG, the activity of caspases in MKN-45 cells treated with EGCG was examined. epigallocatechin gallate 131-135 caspase 8 Homo sapiens 93-101 15802789-7 2005 Activity levels of caspases-3, -8 and -9 were elevated in EGCG-treated cells, suggesting that these caspases are involved in the apoptosis induced by EGCG. epigallocatechin gallate 58-62 caspase 8 Homo sapiens 19-27 15802789-7 2005 Activity levels of caspases-3, -8 and -9 were elevated in EGCG-treated cells, suggesting that these caspases are involved in the apoptosis induced by EGCG. epigallocatechin gallate 150-154 caspase 8 Homo sapiens 19-27 14676829-0 2004 Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. epigallocatechin gallate 30-56 caspase 8 Homo sapiens 18-26 14676829-4 2004 Here we show the essential role of caspases in EGCG-mediated inhibition of NF-kappa B and its subsequent apoptosis. epigallocatechin gallate 47-51 caspase 8 Homo sapiens 35-43 14676829-6 2004 EGCG treatment of cells also resulted in significant activation of caspases, as shown by the dose- and time-dependent increase in DEVDase activity, and protein expression of caspase-3, -8 and -9. epigallocatechin gallate 0-4 caspase 8 Homo sapiens 67-75 14676829-7 2004 EGCG-mediated caspase activation induces proteolytic cleavage of NF-kappa B/p65 subunit, leading to the loss of transactivation domains, and driving the cells towards apoptosis. epigallocatechin gallate 0-4 caspase 8 Homo sapiens 14-21 14676829-8 2004 EGCG-mediated induction of apoptosis was significantly blocked by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (Z-VAD-FMK), and moderately blocked by the specific caspase-3 inhibitor Z-DEVD-FMK. epigallocatechin gallate 0-4 caspase 8 Homo sapiens 70-77 14676829-10 2004 Taken together, these studies for the first time demonstrate that EGCG-mediated activation of caspases is critical, at least in part, for inhibition of NF-kappa B and subsequent apoptosis. epigallocatechin gallate 66-70 caspase 8 Homo sapiens 94-102 11478767-4 2001 The EGCG treatment of human monocytic leukemia U937 cells resulted in elevation of caspase 8 activity and fragmentation of caspase 8. epigallocatechin gallate 4-8 caspase 8 Homo sapiens 83-92 11478767-4 2001 The EGCG treatment of human monocytic leukemia U937 cells resulted in elevation of caspase 8 activity and fragmentation of caspase 8. epigallocatechin gallate 4-8 caspase 8 Homo sapiens 123-132 11478767-5 2001 The DNA ladder formation caused by the EGCG treatment was inhibited by the caspase 8 inhibitor. epigallocatechin gallate 39-43 caspase 8 Homo sapiens 75-84