PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18988736-6 2008 It is proposed that, in both cases, a protonated basic residue (Arg-37 in the case of human UroD; Lys-93 in the case of yeast ODCase) furnishes a counterion that helps the scissile carboxylate group of the substrate leave water and enter a relatively nonpolar environment, stabilizes the incipient carbanion generated by the departure of CO(2), and supplies the proton that takes its place. co(2) 338-343 uroporphyrinogen decarboxylase Homo sapiens 92-96