PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3263644-0	1988	Role of disulfide bridges in determining the biological activity of interleukin 3.	Disulfides	8-17	interleukin 3	Mus musculus	68-81	
3263644-5	1988	This shows that in IL-3 a single disulfide bridge, between cysteines 17 and 80, is required for biological activity that approximates physiological levels.	Disulfides	33-42	interleukin 3	Mus musculus	19-23	
3263644-1	1988	Total chemical synthesis of analog proteins was used to examine the requirement for specific disulfide bridges for the biological activity of interleukin 3 (IL-3), a growth factor that stimulates multiple lineages of hemopoietic cells.	Disulfides	93-102	interleukin 3	Mus musculus	142-161	
6429132-6	1984	After reduction, labeled PSF had a slightly higher Mr of 32,000, although reduction resulted in loss of 98% of PSF activity, thus suggesting that the integrity of internal disulfide bond(s) was required for activity.	Disulfides	172-181	interleukin 3	Mus musculus	25-28	
20516062-5	2010	We therefore investigated whether distortion of the domain 1-domain 4 ligand-binding epitope in hbetac and the related mouse receptor, beta(IL-3), could account for the loss of receptor signaling when the domain 1 D-E loop disulfide is disrupted.	Disulfides	223-232	interleukin 3	Mus musculus	135-144	
20516062-8	2010	Our data are most consistent with a role for the domain 1 D-E loop disulfide of hbetac and beta(IL-3) in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling.	Disulfides	67-76	interleukin 3	Mus musculus	91-100	
19961363-2	2010	Although bacterial expression has been used for the preparation of recombinant mIL-3 for more than 20 years, the resultant cytokine is known to exhibit poor solubility, be prone to aggregation, and may contain mispaired disulfide bonds.	Disulfides	220-229	interleukin 3	Mus musculus	79-84	
9422786-3	1998	We found that substitution of Cys-86, Cys-91, and Cys-96 in betac but not of Cys-100 or Cys-234 abrogated disulfide-linked IL-3 receptor dimerization.	Disulfides	106-115	interleukin 3	Mus musculus	123-127	
20174897-6	2010	The mIL-3 construct used in the present study was engineered by eliminating residues 27-32 of the N-terminus (the first 26 residues of the primary sequence of mIL-3 are cleaved in vivo during secretion), the C-terminal 10 residues (157-166), and a disulfide bond between Cys105 and Cys166 that is poorly conserved in orthologue sequences.	Disulfides	248-257	interleukin 3	Mus musculus	4-9