PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22085648-6	2012	Benzil and bis-p-nitrophenyl phosphate (BNPP), two carboxylesterase inhibitors, abrogated the effect of carboxylesterases and resensitized carboxylesterase-expressing cells to the potent cytotoxic effects of phospho-NSAIDs.	bis(4-nitrophenyl)phosphate	11-38	carboxylesterase 1	Homo sapiens	104-121	
26817948-7	2016	Moreover, sacubitril activation was significantly inhibited by the carboxylesterase 1 (CES1) inhibitor bis-(p-nitrophenyl) phosphate in human liver S9.	bis(4-nitrophenyl)phosphate	103-132	carboxylesterase 1	Homo sapiens	67-85	
26817948-7	2016	Moreover, sacubitril activation was significantly inhibited by the carboxylesterase 1 (CES1) inhibitor bis-(p-nitrophenyl) phosphate in human liver S9.	bis(4-nitrophenyl)phosphate	103-132	carboxylesterase 1	Homo sapiens	87-91	
24212377-5	2014	The impact of CES1-mediated BIBR 1087 formation during transcellular transport experiments was assessed by comparing several combinations of three experimental approaches: radioactivity detection using [(14)C]dabigatran etexilate as substrate, liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantification of dabigatran etexilate, and in the presence and absence of a CES inhibitor bis(p-nitrophenyl) phosphate (BNPP).	bis(4-nitrophenyl)phosphate	393-421	carboxylesterase 1	Homo sapiens	14-18	
24212377-5	2014	The impact of CES1-mediated BIBR 1087 formation during transcellular transport experiments was assessed by comparing several combinations of three experimental approaches: radioactivity detection using [(14)C]dabigatran etexilate as substrate, liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantification of dabigatran etexilate, and in the presence and absence of a CES inhibitor bis(p-nitrophenyl) phosphate (BNPP).	bis(4-nitrophenyl)phosphate	423-427	carboxylesterase 1	Homo sapiens	14-18	
23275066-5	2013	Coincubation of clopidogrel with the CES1 inhibitor bis(4-nitrophenyl) phosphate in human liver s9 fractions significantly increased the concentrations of clopidogrel, 2-oxo-clopidogrel, and clopidogrel active metabolite, while the concentrations of all formed carboxylate metabolites were significantly decreased.	bis(4-nitrophenyl)phosphate	52-80	carboxylesterase 1	Homo sapiens	37-41	
22085648-6	2012	Benzil and bis-p-nitrophenyl phosphate (BNPP), two carboxylesterase inhibitors, abrogated the effect of carboxylesterases and resensitized carboxylesterase-expressing cells to the potent cytotoxic effects of phospho-NSAIDs.	bis(4-nitrophenyl)phosphate	40-44	carboxylesterase 1	Homo sapiens	104-121	
34904522-2	2022	One of the major in vivo metabolic pathways of vixotrigine in humans is the hydrolysis of the carboxamide to form the carboxylic acid metabolite M14.The in vitro formation of M14 in human hepatocytes was inhibited by the carboxylesterase (CES) inhibitor Bis(4-nitrophenyl) phosphate in a concentration-dependent manner.	bis(4-nitrophenyl)phosphate	254-282	carboxylesterase 1	Homo sapiens	221-237	
34933885-7	2022	The findings were further supported by a TAF incubation study with the CatA inhibitor telaprevir and the CES1 inhibitor bis-(p-nitrophenyl) phosphate.	bis(4-nitrophenyl)phosphate	120-149	carboxylesterase 1	Homo sapiens	105-109