PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23814701-7 2012 RESULTS: Dietary ABA-supplementation prevented colitis, reduced disease severity, improved colonic histopathology, and upregulated epithelial lanthionine synthetase C-like protein 2 (LANCL2) expression in VC+ mice. Abscisic Acid 17-20 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 142-181 33182586-0 2020 Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2. Abscisic Acid 13-26 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 117-136 33182586-7 2020 Interestingly, these effects were not associated with activation of peroxisome proliferator-activated receptor gamma, well known as a molecular target of ABA, but related with modulation of the LanC-like protein 2 (LANCL2), known as a receptor of ABA. Abscisic Acid 247-250 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 194-213 33182586-7 2020 Interestingly, these effects were not associated with activation of peroxisome proliferator-activated receptor gamma, well known as a molecular target of ABA, but related with modulation of the LanC-like protein 2 (LANCL2), known as a receptor of ABA. Abscisic Acid 247-250 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 215-221 33182586-8 2020 Taken together, our results indicate that ABA reduced Abeta deposition, neuroinflammation, and memory impairment, which is the most characteristic pathology of AD, via the upregulation of LANCL2. Abscisic Acid 42-45 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 188-194 34098144-9 2021 LANCL2-/- mice have a reduced glucose tolerance compared with WT; they spontaneously overexpress LANCL1 in the SM and respond to chronic ABA treatment (1 mug/Kg body weight/day) with an improved glycemia response to glucose load and an increased SM transcription of GLUT4 and GLUT1 (20-fold), of the AMPK/PGC-1alpha/Sirt1 pathway and of sarcolipin, UCP3 and NAMPT (4-6-fold). Abscisic Acid 137-140 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 32591558-0 2020 Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Abscisic Acid 0-13 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 115-121 32591558-2 2020 In humans and mice, lanthionine synthetase C-like 2 (LANCL2) has been characterized as the natural receptor for ABA. Abscisic Acid 112-115 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 20-51 32591558-2 2020 In humans and mice, lanthionine synthetase C-like 2 (LANCL2) has been characterized as the natural receptor for ABA. Abscisic Acid 112-115 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 53-59 31996711-5 2020 LANCL2 silencing reduced all these ABA-induced effects. Abscisic Acid 35-38 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 27871880-4 2017 Silencing of LANCL2 abrogated both the ABA- and insulin-induced increase of glucose transporter-4 expression and of glucose uptake in differentiated 3T3-L1 murine adipocytes; conversely, overexpression of LANCL2 enhanced basal, ABA- and insulin-stimulated glucose uptake. Abscisic Acid 39-42 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 13-19 27871880-4 2017 Silencing of LANCL2 abrogated both the ABA- and insulin-induced increase of glucose transporter-4 expression and of glucose uptake in differentiated 3T3-L1 murine adipocytes; conversely, overexpression of LANCL2 enhanced basal, ABA- and insulin-stimulated glucose uptake. Abscisic Acid 39-42 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 205-211 27871880-4 2017 Silencing of LANCL2 abrogated both the ABA- and insulin-induced increase of glucose transporter-4 expression and of glucose uptake in differentiated 3T3-L1 murine adipocytes; conversely, overexpression of LANCL2 enhanced basal, ABA- and insulin-stimulated glucose uptake. Abscisic Acid 228-231 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 13-19 27871880-4 2017 Silencing of LANCL2 abrogated both the ABA- and insulin-induced increase of glucose transporter-4 expression and of glucose uptake in differentiated 3T3-L1 murine adipocytes; conversely, overexpression of LANCL2 enhanced basal, ABA- and insulin-stimulated glucose uptake. Abscisic Acid 228-231 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 205-211 24628287-2 2014 LANCL2 is the molecular target of abscisic acid (ABA), a compound with insulin-sensitizing and immune modulatory actions. Abscisic Acid 34-47 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 24628287-2 2014 LANCL2 is the molecular target of abscisic acid (ABA), a compound with insulin-sensitizing and immune modulatory actions. Abscisic Acid 49-52 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 24628287-3 2014 LANCL2 is required for membrane binding and signaling of ABA in immune cells. Abscisic Acid 57-60 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 24628287-4 2014 Direct binding of ABA to LANCL2 was predicted in silico using molecular modeling approaches and validated experimentally using ligand-binding assays and kinetic surface plasmon resonance studies. Abscisic Acid 18-21 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 25-31 23814701-7 2012 RESULTS: Dietary ABA-supplementation prevented colitis, reduced disease severity, improved colonic histopathology, and upregulated epithelial lanthionine synthetase C-like protein 2 (LANCL2) expression in VC+ mice. Abscisic Acid 17-20 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 183-189 23814701-10 2012 LANCL2 in IECs and T cell-derived IL-10 may be implicated in the mechanism underlying ABA"s immune modulatory activity in IBD. Abscisic Acid 86-89 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 22042223-4 2012 In RAW264.7 cells, autocrine ABA released after quartz stimulation sequentially activates the plasma membrane receptor LANCL2 and NADPH oxidase, generating a Ca(2+) influx resulting in NFkappa B nuclear translocation and PGE(2) and TNF-alpha release (3-, 2-, and 3.5-fold increase, respectively, compared to control, unstimulated cells). Abscisic Acid 29-32 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 119-125 22042223-5 2012 Quartz-stimulated RAW264.7 cells silenced for LANCL2 or preincubated with a monoclonal antibody against ABA show an almost complete inhibition of NFkappa B nuclear translocation and PGE(2) and TNF-alpha release compared to controls electroporated with a scramble oligonucleotide or preincubated with an unrelated antibody. Abscisic Acid 104-107 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 46-52 22509338-2 2012 Recently, LANCL2 is a target for the binding and signaling of abscisic acid (ABA), a plant hormone with anti-diabetic and anti-inflammatory effects. Abscisic Acid 62-75 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 10-16 22509338-2 2012 Recently, LANCL2 is a target for the binding and signaling of abscisic acid (ABA), a plant hormone with anti-diabetic and anti-inflammatory effects. Abscisic Acid 77-80 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 10-16 21088297-2 2011 This study investigates the role of peroxisome proliferator-activated receptor gamma (PPAR gamma) and lanthionine synthetase C-like 2 (LANCL2) as molecular targets for ABA. Abscisic Acid 168-171 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 102-133 21088297-2 2011 This study investigates the role of peroxisome proliferator-activated receptor gamma (PPAR gamma) and lanthionine synthetase C-like 2 (LANCL2) as molecular targets for ABA. Abscisic Acid 168-171 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 135-141 21088297-4 2011 LANCL2 knockdown studies provide evidence that ABA-mediated activation of macrophage PPAR gamma is dependent on lancl2 expression. Abscisic Acid 47-50 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 0-6 21088297-5 2011 Consistent with the association of LANCL2 with G proteins, we provide evidence that ABA increases cAMP accumulation in immune cells. Abscisic Acid 84-87 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 35-41 21088297-9 2011 In conclusion, ABA decreases LPS-mediated inflammation and regulates innate immune responses through a bifurcating pathway involving LANCL2 and an alternative, ligand-binding domain-independent mechanism of PPAR gamma activation. Abscisic Acid 15-18 LanC (bacterial lantibiotic synthetase component C)-like 2 Mus musculus 133-139