PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27577789-7 2016 ABA promotes the interaction of PP2CA with both E3 ligases, which mediate ubiquitination of PP2CA and are required for ABA-dependent PP2CA turnover. Abscisic Acid 119-122 protein phosphatase 2CA Arabidopsis thaliana 92-97 27566404-8 2016 Several other ABI2-like phosphatases also function in this pathway, and ABA-dependent FER activation required PYRABACTIN RESISTANCE (PYR)/PYR1-LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR)-A-type protein phosphatase type 2C (PP2CA) modules. Abscisic Acid 72-75 protein phosphatase 2CA Arabidopsis thaliana 236-241 27577789-0 2016 Ubiquitin Ligases RGLG1 and RGLG5 Regulate Abscisic Acid Signaling by Controlling the Turnover of Phosphatase PP2CA. Abscisic Acid 43-56 protein phosphatase 2CA Arabidopsis thaliana 110-115 27577789-6 2016 We report that RGLG5, together with RGLG1, releases the PP2C blockade of ABA signaling by mediating PP2CA protein degradation. Abscisic Acid 73-76 protein phosphatase 2CA Arabidopsis thaliana 100-105 27577789-7 2016 ABA promotes the interaction of PP2CA with both E3 ligases, which mediate ubiquitination of PP2CA and are required for ABA-dependent PP2CA turnover. Abscisic Acid 0-3 protein phosphatase 2CA Arabidopsis thaliana 32-37 27577789-7 2016 ABA promotes the interaction of PP2CA with both E3 ligases, which mediate ubiquitination of PP2CA and are required for ABA-dependent PP2CA turnover. Abscisic Acid 0-3 protein phosphatase 2CA Arabidopsis thaliana 92-97 27577789-7 2016 ABA promotes the interaction of PP2CA with both E3 ligases, which mediate ubiquitination of PP2CA and are required for ABA-dependent PP2CA turnover. Abscisic Acid 0-3 protein phosphatase 2CA Arabidopsis thaliana 92-97 27577789-7 2016 ABA promotes the interaction of PP2CA with both E3 ligases, which mediate ubiquitination of PP2CA and are required for ABA-dependent PP2CA turnover. Abscisic Acid 119-122 protein phosphatase 2CA Arabidopsis thaliana 32-37 27577789-7 2016 ABA promotes the interaction of PP2CA with both E3 ligases, which mediate ubiquitination of PP2CA and are required for ABA-dependent PP2CA turnover. Abscisic Acid 119-122 protein phosphatase 2CA Arabidopsis thaliana 92-97 27577789-9 2016 Moreover, the reduced response to ABA in germination assays is suppressed in the rglg1 amiR (artificial microRNA)-rglg5 pp2ca-1 triple mutant, supporting a functional link among these loci. Abscisic Acid 34-37 protein phosphatase 2CA Arabidopsis thaliana 120-125 25919792-6 2015 Furthermore, genes encoding negative regulators of ABA signaling, such as the transcription factor ATHB7 and its target genes HAB1, HAB2, HAI1 and AHG3, were up-regulated in seeds of the wild-type upon ABA treatment; this up-regulation was impaired in seeds of S2P mutants. Abscisic Acid 51-54 protein phosphatase 2CA Arabidopsis thaliana 147-151 26499068-8 2016 Our data suggest that SnRK2-dependent phosphorylation of BRM leads to its inhibition, and PP2CA-mediated dephosphorylation of BRM restores the ability of BRM to repress ABA response. Abscisic Acid 169-172 protein phosphatase 2CA Arabidopsis thaliana 90-95 25919792-6 2015 Furthermore, genes encoding negative regulators of ABA signaling, such as the transcription factor ATHB7 and its target genes HAB1, HAB2, HAI1 and AHG3, were up-regulated in seeds of the wild-type upon ABA treatment; this up-regulation was impaired in seeds of S2P mutants. Abscisic Acid 202-205 protein phosphatase 2CA Arabidopsis thaliana 147-151 22198272-2 2012 We provide genetic evidence that a previously uncharacterized member of this PP2C family in Arabidopsis (Arabidopsis thaliana), At5g59220, is a negative regulator of osmotic stress and ABA signaling and that this function was only apparent when double loss-of-function mutants with pp2ca-1/ahg3 were generated. Abscisic Acid 185-188 protein phosphatase 2CA Arabidopsis thaliana 282-287 24165892-0 2013 Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13. Abscisic Acid 38-41 protein phosphatase 2CA Arabidopsis thaliana 68-73 24165892-3 2013 Here, we show that PYL13 selectively inhibits the phosphatase activity of PP2CA independent of ABA. Abscisic Acid 95-98 protein phosphatase 2CA Arabidopsis thaliana 74-79 23864556-3 2013 We generated an allele library composed of 10,000 mutant clones of Arabidopsis (Arabidopsis thaliana) PYL4 and selected mutations that promoted ABA-independent interaction with PP2CA/ABA-HYPERSENSITIVE3. Abscisic Acid 144-147 protein phosphatase 2CA Arabidopsis thaliana 177-182 23864556-5 2013 This interaction did not lead to significant inhibition of PP2CA in the absence of ABA; however, it improved ABA-dependent inhibition of PP2CA. Abscisic Acid 109-112 protein phosphatase 2CA Arabidopsis thaliana 137-142 23660402-3 2013 Following NaCl treatment, the expressions of ABI1, ABI2 and AtPP2CA, which encode type 2C serine/threonine protein phosphatases (PP2Cs) that act as negative regulators in abscisic acid (ABA) signaling, were suppressed in AtMYB20-OX but induced in AtMYB20-SRDX. Abscisic Acid 171-184 protein phosphatase 2CA Arabidopsis thaliana 60-67 23660402-3 2013 Following NaCl treatment, the expressions of ABI1, ABI2 and AtPP2CA, which encode type 2C serine/threonine protein phosphatases (PP2Cs) that act as negative regulators in abscisic acid (ABA) signaling, were suppressed in AtMYB20-OX but induced in AtMYB20-SRDX. Abscisic Acid 186-189 protein phosphatase 2CA Arabidopsis thaliana 60-67 22198272-2 2012 We provide genetic evidence that a previously uncharacterized member of this PP2C family in Arabidopsis (Arabidopsis thaliana), At5g59220, is a negative regulator of osmotic stress and ABA signaling and that this function was only apparent when double loss-of-function mutants with pp2ca-1/ahg3 were generated. Abscisic Acid 185-188 protein phosphatase 2CA Arabidopsis thaliana 290-294 22198272-4 2012 At5g59220 was selectively inhibited by some PYR/PYL ABA receptors, and close relatives of this PP2C, such as PP2CA/ABA-HYPERSENSITIVE GERMINATION3 (AHG3) and AHG1, showed a contrasting sensitivity to PYR/PYL inhibition. Abscisic Acid 52-55 protein phosphatase 2CA Arabidopsis thaliana 148-152 21525137-8 2011 Expression levels of abscisic acid-related genes ABI1, ABI2, RAB18, PP2CA, and SOT12 were substantially reduced in salt-treated npc4 plants. Abscisic Acid 21-34 protein phosphatase 2CA Arabidopsis thaliana 68-73 17461784-6 2007 We previously showed that the ahg3-1 mutant has a point mutation in the AtPP2CA gene, which encodes another PP2C that has a major role in the ABA response in seeds (Yoshida et al., 2006b). Abscisic Acid 142-145 protein phosphatase 2CA Arabidopsis thaliana 30-34 17461784-6 2007 We previously showed that the ahg3-1 mutant has a point mutation in the AtPP2CA gene, which encodes another PP2C that has a major role in the ABA response in seeds (Yoshida et al., 2006b). Abscisic Acid 142-145 protein phosphatase 2CA Arabidopsis thaliana 72-79 17461784-8 2007 Transcriptome analysis revealed that, in ABA-treated germinating seeds, many seed-specific genes and ABA-inducible genes were highly expressed in ahg1-1 and ahg3-1 mutants compared with the wild-type. Abscisic Acid 41-44 protein phosphatase 2CA Arabidopsis thaliana 157-161 17461784-8 2007 Transcriptome analysis revealed that, in ABA-treated germinating seeds, many seed-specific genes and ABA-inducible genes were highly expressed in ahg1-1 and ahg3-1 mutants compared with the wild-type. Abscisic Acid 101-104 protein phosphatase 2CA Arabidopsis thaliana 157-161 16339800-0 2006 ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs. Abscisic Acid 99-112 protein phosphatase 2CA Arabidopsis thaliana 0-31 16361522-0 2006 The protein phosphatase AtPP2CA negatively regulates abscisic acid signal transduction in Arabidopsis, and effects of abh1 on AtPP2CA mRNA. Abscisic Acid 53-66 protein phosphatase 2CA Arabidopsis thaliana 24-31 16361522-8 2006 Thus our data demonstrate that the PP2CA protein phosphatase is a strong negative regulator of ABA signal transduction. Abscisic Acid 95-98 protein phosphatase 2CA Arabidopsis thaliana 35-40 16361522-9 2006 Furthermore, it has been previously shown that the AtPP2CA transcript is down-regulated in the ABA-hypersensitive nuclear mRNA cap-binding protein mutant abh1. Abscisic Acid 95-98 protein phosphatase 2CA Arabidopsis thaliana 51-58 16339800-0 2006 ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs. Abscisic Acid 99-112 protein phosphatase 2CA Arabidopsis thaliana 66-73 16339800-4 2006 Among them, ABA-hypersensitive germination3 (ahg3) showed the strongest ABA hypersensitivity. Abscisic Acid 12-15 protein phosphatase 2CA Arabidopsis thaliana 45-49 16339800-6 2006 Although AtPP2CA has been reported to be involved in the ABA response on the basis of results obtained by reverse-genetics approaches, its physiological relevance in the ABA response has not been clarified yet. Abscisic Acid 57-60 protein phosphatase 2CA Arabidopsis thaliana 9-16 16339800-7 2006 We demonstrate in vitro and in vivo that the ahg3-1 missense mutation causes the loss of PP2C activity, providing concrete confirmation that this PP2C functions as a negative regulator in ABA signaling. Abscisic Acid 188-191 protein phosphatase 2CA Arabidopsis thaliana 45-49 16339800-8 2006 Furthermore, we compared the effects of disruption mutations of eight structurally related PP2C genes of Arabidopsis, including ABI1, ABI2, HAB1, and HAB2, and found that the disruptant mutant of AHG3/AtPP2CA had the strongest ABA hypersensitivity during germination, but it did not display any significant phenotypes in adult plants. Abscisic Acid 227-230 protein phosphatase 2CA Arabidopsis thaliana 196-200 16339800-8 2006 Furthermore, we compared the effects of disruption mutations of eight structurally related PP2C genes of Arabidopsis, including ABI1, ABI2, HAB1, and HAB2, and found that the disruptant mutant of AHG3/AtPP2CA had the strongest ABA hypersensitivity during germination, but it did not display any significant phenotypes in adult plants. Abscisic Acid 227-230 protein phosphatase 2CA Arabidopsis thaliana 201-208 16339800-10 2006 These results suggest that AHG3/AtPP2CA plays a major role among PP2Cs in the ABA response in seeds and that the functions of those PP2Cs overlap, but their unique tissue- or development-specific expression confers distinct and indispensable physiological functions in the ABA response. Abscisic Acid 78-81 protein phosphatase 2CA Arabidopsis thaliana 27-31 16339800-10 2006 These results suggest that AHG3/AtPP2CA plays a major role among PP2Cs in the ABA response in seeds and that the functions of those PP2Cs overlap, but their unique tissue- or development-specific expression confers distinct and indispensable physiological functions in the ABA response. Abscisic Acid 78-81 protein phosphatase 2CA Arabidopsis thaliana 32-39 16339800-10 2006 These results suggest that AHG3/AtPP2CA plays a major role among PP2Cs in the ABA response in seeds and that the functions of those PP2Cs overlap, but their unique tissue- or development-specific expression confers distinct and indispensable physiological functions in the ABA response. Abscisic Acid 273-276 protein phosphatase 2CA Arabidopsis thaliana 27-31 16339800-10 2006 These results suggest that AHG3/AtPP2CA plays a major role among PP2Cs in the ABA response in seeds and that the functions of those PP2Cs overlap, but their unique tissue- or development-specific expression confers distinct and indispensable physiological functions in the ABA response. Abscisic Acid 273-276 protein phosphatase 2CA Arabidopsis thaliana 32-39 15564532-10 2004 These results suggest that ahg1, ahg2, ahg3 and ahg4 are novel ABA-hypersensitive mutants representing distinct components in the ABA response. Abscisic Acid 63-66 protein phosphatase 2CA Arabidopsis thaliana 39-43 15564532-10 2004 These results suggest that ahg1, ahg2, ahg3 and ahg4 are novel ABA-hypersensitive mutants representing distinct components in the ABA response. Abscisic Acid 130-133 protein phosphatase 2CA Arabidopsis thaliana 39-43 31231596-0 2019 Genome-wide characterization and expression analysis of PP2CA family members in response to ABA and osmotic stress in Gossypium. Abscisic Acid 92-95 protein phosphatase 2CA Arabidopsis thaliana 56-61 12034902-4 2002 By screening a two-hybrid cDNA library, we isolated a protein phosphatase 2C (AtPP2CA) involved in abscisic acid signaling as a putative partner of AKT2. Abscisic Acid 99-112 protein phosphatase 2CA Arabidopsis thaliana 78-85 12034902-6 2002 The expression of AtPP2CA (beta-glucuronidase reporter gene) displayed a pattern largely overlapping that of AKT2 and was upregulated by abscisic acid. Abscisic Acid 137-150 protein phosphatase 2CA Arabidopsis thaliana 18-25 31832048-7 2019 gork and pp2ca mutants showed opposite responses to ABA in seed germination and seedling growth. Abscisic Acid 52-55 protein phosphatase 2CA Arabidopsis thaliana 9-14 31832048-9 2019 Thus, our results indicate that GORK enhances the sensitivity to ABA and negatively regulates the mechanisms involved in high salinity and osmotic stresses via PP2CA-mediated signals. Abscisic Acid 65-68 protein phosphatase 2CA Arabidopsis thaliana 160-165 31336603-1 2019 As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. Abscisic Acid 26-39 protein phosphatase 2CA Arabidopsis thaliana 70-74 31336603-1 2019 As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. Abscisic Acid 26-39 protein phosphatase 2CA Arabidopsis thaliana 76-82 31336603-1 2019 As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. Abscisic Acid 41-44 protein phosphatase 2CA Arabidopsis thaliana 70-74 31336603-1 2019 As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. Abscisic Acid 41-44 protein phosphatase 2CA Arabidopsis thaliana 76-82 31336603-1 2019 As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. Abscisic Acid 100-103 protein phosphatase 2CA Arabidopsis thaliana 70-74 31336603-1 2019 As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. Abscisic Acid 100-103 protein phosphatase 2CA Arabidopsis thaliana 76-82 11053467-2 2000 The deduced protein sequence of 416 amino acids showed the highest degree of similarity to the PP2C of Arabidopsis thaliana (AtPP2CA) implicated in abscisic acid signalling. Abscisic Acid 148-161 protein phosphatase 2CA Arabidopsis thaliana 125-132 33048351-0 2021 COP1 Promotes ABA-Induced Stomatal Closure by Modulating the Abundance of ABI/HAB and AHG3 Phosphatases. Abscisic Acid 14-17 protein phosphatase 2CA Arabidopsis thaliana 86-90 33048351-9 2021 Mutations in ABI1 and AHG3 partly rescue the cop1 stomatal phenotype and the phosphorylation level of OST1, a crucial SnRK2-type kinase in ABA signaling. Abscisic Acid 139-142 protein phosphatase 2CA Arabidopsis thaliana 22-26 31436880-0 2019 The RING finger E3 ligases PIR1 and PIR2 mediate PP2CA degradation to enhance abscisic acid response in Arabidopsis. Abscisic Acid 78-91 protein phosphatase 2CA Arabidopsis thaliana 49-54 31436880-5 2019 The PIR1.2 exhibited E3 ligase activity and determined PP2CA stability in the presence of ABA. Abscisic Acid 90-93 protein phosphatase 2CA Arabidopsis thaliana 55-60 31436880-9 2019 Using a cell-free degradation assay, ABA promoted degradation of PP2CA, however, such degradation was delayed when incubated with protein extract prepared from the pir1-1/pir2 double mutant. Abscisic Acid 37-40 protein phosphatase 2CA Arabidopsis thaliana 65-70 31436880-10 2019 Our data suggest that PIR1 and PIR2 positively modulate ABA signaling by targeting PP2CA for degradation. Abscisic Acid 56-59 protein phosphatase 2CA Arabidopsis thaliana 83-88 30556127-6 2019 A hypermorphic wnk8-ct Arabidopsis mutant allele suppressed ABA and glucose hypersensitivities of pp2ca-1 mutants during young seedling development, and WNK8 expression in protoplasts suppressed ABA-induced reporter gene expression. Abscisic Acid 60-63 protein phosphatase 2CA Arabidopsis thaliana 98-103 30556127-6 2019 A hypermorphic wnk8-ct Arabidopsis mutant allele suppressed ABA and glucose hypersensitivities of pp2ca-1 mutants during young seedling development, and WNK8 expression in protoplasts suppressed ABA-induced reporter gene expression. Abscisic Acid 195-198 protein phosphatase 2CA Arabidopsis thaliana 98-103 29250818-8 2018 Moreover, ATX4 and ATX5 occupancies at AHG3 are dramatically increased under ABA treatment, and are also essential for RNA polymerase II (RNAPII) occupancies. Abscisic Acid 77-80 protein phosphatase 2CA Arabidopsis thaliana 39-43 29490615-10 2018 Importantly, NCED3, ABI2, PP2CA, and major ABA-responsive marker genes, such as RD20 and RD29B, were down-regulated at both the transcript and protein levels in conjunction with lower contents of ABA and changes in the expression of a subset of LEA proteins in sahy9/apum23 mutants under salt stress. Abscisic Acid 196-199 protein phosphatase 2CA Arabidopsis thaliana 26-31 29250818-6 2018 Intriguingly, ABA-HYPERSENSITIVE GERMINATION 3 (AHG3), an essential negative regulator of ABA signaling, acts genetically downstream of ATX4 and ATX5 in response to ABA. Abscisic Acid 14-17 protein phosphatase 2CA Arabidopsis thaliana 48-52 29250818-6 2018 Intriguingly, ABA-HYPERSENSITIVE GERMINATION 3 (AHG3), an essential negative regulator of ABA signaling, acts genetically downstream of ATX4 and ATX5 in response to ABA. Abscisic Acid 90-93 protein phosphatase 2CA Arabidopsis thaliana 14-46 29250818-6 2018 Intriguingly, ABA-HYPERSENSITIVE GERMINATION 3 (AHG3), an essential negative regulator of ABA signaling, acts genetically downstream of ATX4 and ATX5 in response to ABA. Abscisic Acid 90-93 protein phosphatase 2CA Arabidopsis thaliana 48-52 28706187-10 2017 provide evidence that DOG1 can interact with the type 2C protein phosphatases AHG1 and AHG3 and that this represents the convergence point of the DOG1-regulated dormancy pathway and signalling by the plant hormone abscisic acid. Abscisic Acid 214-227 protein phosphatase 2CA Arabidopsis thaliana 87-91