PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23585822-0	2013	Design and Synthesis of Hydroxyethylene-Based BACE-1 Inhibitors Incorporating Extended P1 Substituents.	hydroxyethylene	24-39	beta-secretase 1	Homo sapiens	46-52	
23585822-1	2013	Novel BACE-1 inhibitors with a hydroxyethylene central core have been developed.	hydroxyethylene	31-46	beta-secretase 1	Homo sapiens	6-12	
20122837-0	2010	Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1" alkoxy residues and an aminoethylene (AE) central core.	hydroxyethylene	55-70	beta-secretase 1	Homo sapiens	20-26	
20128595-1	2010	Highly potent BACE-1 protease inhibitors have been developed from an inhibitors containing a hydroxyethylene (HE) core displaying aryloxymethyl or benzyloxymethyl P1 side chain and a methoxy P1" side chain.	hydroxyethylene	93-108	beta-secretase 1	Homo sapiens	14-20	
20128595-1	2010	Highly potent BACE-1 protease inhibitors have been developed from an inhibitors containing a hydroxyethylene (HE) core displaying aryloxymethyl or benzyloxymethyl P1 side chain and a methoxy P1" side chain.	hydroxyethylene	110-112	beta-secretase 1	Homo sapiens	14-20	
20122837-0	2010	Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1" alkoxy residues and an aminoethylene (AE) central core.	hydroxyethylene	72-74	beta-secretase 1	Homo sapiens	20-26	
20122837-1	2010	In a preceding study we have described the development of a new hydroxyethylene (HE) core motif displaying P1 aryloxymethyl and P1" methoxy substituents delivering potent BACE-1 inhibitors.	hydroxyethylene	64-79	beta-secretase 1	Homo sapiens	171-177	
20122837-1	2010	In a preceding study we have described the development of a new hydroxyethylene (HE) core motif displaying P1 aryloxymethyl and P1" methoxy substituents delivering potent BACE-1 inhibitors.	hydroxyethylene	81-83	beta-secretase 1	Homo sapiens	171-177	
19169270-1	2009	AIM: The aim of this study was to design and synthesize a series of high activity compounds against aspartyl protease beta-secretase (BACE-1) bearing hydroxyethylene (HE) framework.	hydroxyethylene	150-165	beta-secretase 1	Homo sapiens	134-140	
19995674-1	2010	Highly potent BACE-1 protease inhibitors derived from a novel hydroxyethylene-like core structure were recently developed by our group using X-ray crystal structure data and molecular modelling.	hydroxyethylene	62-77	beta-secretase 1	Homo sapiens	14-20	
19169270-1	2009	AIM: The aim of this study was to design and synthesize a series of high activity compounds against aspartyl protease beta-secretase (BACE-1) bearing hydroxyethylene (HE) framework.	hydroxyethylene	167-169	beta-secretase 1	Homo sapiens	134-140	
16510290-1	2006	With the aim of developing small molecular non-peptide beta-secretase (BACE) inhibitors, Leu*Ala hydroxyethylene (HE) was investigated as a scaffold to design and synthesize a series of compounds.	hydroxyethylene	114-116	beta-secretase 1	Homo sapiens	55-69	
16510290-1	2006	With the aim of developing small molecular non-peptide beta-secretase (BACE) inhibitors, Leu*Ala hydroxyethylene (HE) was investigated as a scaffold to design and synthesize a series of compounds.	hydroxyethylene	114-116	beta-secretase 1	Homo sapiens	71-75	
14695829-0	2004	Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.	hydroxyethylene	24-39	beta-secretase 1	Homo sapiens	81-95	
15341936-1	2004	A new linear binding affinity model has been developed for hydroxyethylene based inhibitors of beta-secretase (BACE).	hydroxyethylene	59-74	beta-secretase 1	Homo sapiens	95-109	
15341936-1	2004	A new linear binding affinity model has been developed for hydroxyethylene based inhibitors of beta-secretase (BACE).	hydroxyethylene	59-74	beta-secretase 1	Homo sapiens	111-115	
14695829-1	2004	The hydroxyethylene (HE) transition state isostere was developed as a scaffold to provide potent, small molecule inhibitors of human beta-secretase (BACE).	hydroxyethylene	4-19	beta-secretase 1	Homo sapiens	133-147	
14695829-1	2004	The hydroxyethylene (HE) transition state isostere was developed as a scaffold to provide potent, small molecule inhibitors of human beta-secretase (BACE).	hydroxyethylene	4-19	beta-secretase 1	Homo sapiens	149-153	
14695829-1	2004	The hydroxyethylene (HE) transition state isostere was developed as a scaffold to provide potent, small molecule inhibitors of human beta-secretase (BACE).	hydroxyethylene	21-23	beta-secretase 1	Homo sapiens	133-147	
14695829-1	2004	The hydroxyethylene (HE) transition state isostere was developed as a scaffold to provide potent, small molecule inhibitors of human beta-secretase (BACE).	hydroxyethylene	21-23	beta-secretase 1	Homo sapiens	149-153	
12206667-1	2002	The structure of the catalytic domain of human memapsin 2 bound to an inhibitor OM00-3 (Glu-Leu-Asp-LeuAla-Val-Glu-Phe, K(i) = 0.3 nM, the asterisk denotes the hydroxyethylene transition-state isostere) has been determined at 2.1 A resolution.	hydroxyethylene	160-175	beta-secretase 1	Homo sapiens	47-57	
12458195-2	2003	The steady-state kinetic mechanism of beta-amyloid precursor protein-cleaving enzyme (BACE)-catalyzed proteolytic cleavage was evaluated using product and statine- (Stat(V)) or hydroxyethylene-containing (OM99-2) peptide inhibition data, solvent kinetic isotope effects, and proton NMR spectroscopy.	hydroxyethylene	177-192	beta-secretase 1	Homo sapiens	38-84	
12458195-2	2003	The steady-state kinetic mechanism of beta-amyloid precursor protein-cleaving enzyme (BACE)-catalyzed proteolytic cleavage was evaluated using product and statine- (Stat(V)) or hydroxyethylene-containing (OM99-2) peptide inhibition data, solvent kinetic isotope effects, and proton NMR spectroscopy.	hydroxyethylene	177-192	beta-secretase 1	Homo sapiens	86-90