PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8868464-1 1996 Cells often acquire resistance to the antiproliferative agents methotrexate (MTX) or N-phosphonacetyl-L-aspartate (PALA) through amplification of genes encoding the target enzymes dihydrofolate reductase or carbamylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), respectively. Methotrexate 63-75 CAD protein Mesocricetus auratus 207-283 8868464-1 1996 Cells often acquire resistance to the antiproliferative agents methotrexate (MTX) or N-phosphonacetyl-L-aspartate (PALA) through amplification of genes encoding the target enzymes dihydrofolate reductase or carbamylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), respectively. Methotrexate 77-80 CAD protein Mesocricetus auratus 207-283