PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31313387-0 2019 JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy. Methotrexate 18-30 hopscotch Drosophila melanogaster 0-3 31313387-4 2019 MTX has also been shown to exert JAK inhibition of JAK2 and JAK1 when tested in Drosophila melanogaster as a model of kinase activity and in human cell lines (nodular sclerosis Hodgkin"s lymphoma and acute myeloid leukemia cell lines). Methotrexate 0-3 hopscotch Drosophila melanogaster 33-36 26131691-0 2015 Methotrexate Is a JAK/STAT Pathway Inhibitor. Methotrexate 0-12 hopscotch Drosophila melanogaster 18-21 26131691-8 2015 We show that methotrexate suppresses human JAK/STAT signalling without affecting other phosphorylation-dependent pathways. Methotrexate 13-25 hopscotch Drosophila melanogaster 43-46 26131691-16 2015 Given that multiple pro-inflammatory cytokines signal through the pathway, we suggest that suppression of the JAK/STAT pathway is likely to be the principal anti-inflammatory and immunosuppressive mechanism-of-action of low-dose methotrexate. Methotrexate 229-241 hopscotch Drosophila melanogaster 110-113 26131691-17 2015 In addition, we suggest that patients with JAK/STAT-associated haematological malignancies may benefit from low-dose methotrexate treatments. Methotrexate 117-129 hopscotch Drosophila melanogaster 43-46 26312921-0 2015 Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms. Methotrexate 10-22 hopscotch Drosophila melanogaster 26-29 26312921-7 2015 FINDINGS: Methotrexate and the chemically similar drug aminopterin were independently identified as strong inhibitors of the Drosophila JAK/STAT pathway, an effect conserved to human cells. Methotrexate 10-22 hopscotch Drosophila melanogaster 136-139 26312921-9 2015 Methotrexate caused significant suppression of JAK/STAT activation in HEL cells at a concentration equivalent to that seen in patients taking low-dose oral methotrexate (p<=0 001). Methotrexate 0-12 hopscotch Drosophila melanogaster 47-50 26312921-14 2015 Methotrexate might bring the benefits of JAK/STAT pathway inhibition at a lower cost. Methotrexate 0-12 hopscotch Drosophila melanogaster 41-44