PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31313387-0	2019	JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy.	Methotrexate	18-30	hopscotch	Drosophila melanogaster	0-3	
31313387-4	2019	MTX has also been shown to exert JAK inhibition of JAK2 and JAK1 when tested in Drosophila melanogaster as a model of kinase activity and in human cell lines (nodular sclerosis Hodgkin"s lymphoma and acute myeloid leukemia cell lines).	Methotrexate	0-3	hopscotch	Drosophila melanogaster	33-36	
26131691-0	2015	Methotrexate Is a JAK/STAT Pathway Inhibitor.	Methotrexate	0-12	hopscotch	Drosophila melanogaster	18-21	
26131691-8	2015	We show that methotrexate suppresses human JAK/STAT signalling without affecting other phosphorylation-dependent pathways.	Methotrexate	13-25	hopscotch	Drosophila melanogaster	43-46	
26131691-16	2015	Given that multiple pro-inflammatory cytokines signal through the pathway, we suggest that suppression of the JAK/STAT pathway is likely to be the principal anti-inflammatory and immunosuppressive mechanism-of-action of low-dose methotrexate.	Methotrexate	229-241	hopscotch	Drosophila melanogaster	110-113	
26131691-17	2015	In addition, we suggest that patients with JAK/STAT-associated haematological malignancies may benefit from low-dose methotrexate treatments.	Methotrexate	117-129	hopscotch	Drosophila melanogaster	43-46	
26312921-0	2015	Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms.	Methotrexate	10-22	hopscotch	Drosophila melanogaster	26-29	
26312921-7	2015	FINDINGS: Methotrexate and the chemically similar drug aminopterin were independently identified as strong inhibitors of the Drosophila JAK/STAT pathway, an effect conserved to human cells.	Methotrexate	10-22	hopscotch	Drosophila melanogaster	136-139	
26312921-9	2015	Methotrexate caused significant suppression of JAK/STAT activation in HEL cells at a concentration equivalent to that seen in patients taking low-dose oral methotrexate (p<=0 001).	Methotrexate	0-12	hopscotch	Drosophila melanogaster	47-50	
26312921-14	2015	Methotrexate might bring the benefits of JAK/STAT pathway inhibition at a lower cost.	Methotrexate	0-12	hopscotch	Drosophila melanogaster	41-44