PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19549389-2 2009 Lentiviral system was utilized to introduce the mdr1 gene into MSCs which were isolated from human bone marrow and cultured in vitro; RT-PCR and GFP marker were used to determine the expression of mdr1; MTT and trypan blue staining were used to detect the proliferative capacity of the MSCs. monooxyethylene trimethylolpropane tristearate 203-206 ATP binding cassette subfamily B member 1 Homo sapiens 48-52 16728344-9 2006 The MTT results demonstrated that the increased chemoresistance was correlated with the increased production of gp-170 protein in either MIF or GSTpi transfectants. monooxyethylene trimethylolpropane tristearate 4-7 ATP binding cassette subfamily B member 1 Homo sapiens 112-118 19442043-5 2009 These compounds were found to be highly active in the growth inhibition MTT assay, including for paclitaxel resistant, p-glycoprotein overexpressed, MES-SA/DX5 tumor cells. monooxyethylene trimethylolpropane tristearate 72-75 ATP binding cassette subfamily B member 1 Homo sapiens 119-133 18673531-8 2008 MTT assay showed that Pgp inhibitors such as cyclosporine A, verapamil and PSC833 sensitized Colo320HSR (colon, highest MDR1 expression) but not SNU-668 (gastric, highest) and SNU-C5 (gastric, no expression) to paclitaxel. monooxyethylene trimethylolpropane tristearate 0-3 ATP binding cassette subfamily B member 1 Homo sapiens 22-25 17441962-3 2007 Using quantitative real-time polymerase chain reaction and Western blot, we found that overexpression of CD147 in MCF7 cells up-regulated MDR1, MMP2, and MMP9 on both transcription and expression levels, which promoted tumor cells metastasis and conferred them multidrug resistance to P-gp substrate drugs, as determined by in vitro invasion assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. monooxyethylene trimethylolpropane tristearate 414-417 ATP binding cassette subfamily B member 1 Homo sapiens 138-142 16836929-5 2006 The cytotoxicity and therapeutic effects of MDR1 anti-sense RNA combined with oxaliplatin and 5-FU were evaluated by colony-forming rate and MTT assay. monooxyethylene trimethylolpropane tristearate 141-144 ATP binding cassette subfamily B member 1 Homo sapiens 44-48 32711421-7 2020 The impacts of crocin on the expression and function of MDR1 were assessed by Real-time RT-PCR and MTT assay, respectively. monooxyethylene trimethylolpropane tristearate 99-102 ATP binding cassette subfamily B member 1 Homo sapiens 56-60 14706143-1 2003 To explore the possibility of leukemia cell line of both bcr-abl and mdr-1 positive were cross-resistant to tyrosine kinase inhibitor STI571 and its reversal way, the inhibitory effect of STI571 on K562-n/VCR cells was detected with MTT method and reverse effects of CsA, TAM, IFN-alpha and CsA cominated with IFN-alpha were observed. monooxyethylene trimethylolpropane tristearate 233-236 ATP binding cassette subfamily B member 1 Homo sapiens 69-74 11780384-6 2001 Drug resistance in the SKOV3/mdr1 cell line was observed by MTT assay and cell colony culture. monooxyethylene trimethylolpropane tristearate 60-63 ATP binding cassette subfamily B member 1 Homo sapiens 29-33 11877073-9 2001 The MTT analysis showed a 3.5 to 6.8-fold increase of resistance of transducted cells to cyclophosphamide and P-glycoprotein effluxes drug as compared with the nontransduced cells. monooxyethylene trimethylolpropane tristearate 4-7 ATP binding cassette subfamily B member 1 Homo sapiens 110-124 1687990-2 1991 The P-gp expression was evaluated by immunohistochemical method using JSB-1 monoclonal antibody and the results were visualized by peroxidase-antiperoxidase goat antimouse antibody and the in vitro chemosensitivity was measured by the semiautomated MTT colourimetric assay method. monooxyethylene trimethylolpropane tristearate 249-252 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 33364937-12 2020 P-gp inhibition potential of the derivatives 20-23 was evaluated in human non-small cell lung carcinoma NCI-H460 and its MDR counterpart NCI-H460/R with the P-gp overexpression, through MTT assay. monooxyethylene trimethylolpropane tristearate 186-189 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 33364937-12 2020 P-gp inhibition potential of the derivatives 20-23 was evaluated in human non-small cell lung carcinoma NCI-H460 and its MDR counterpart NCI-H460/R with the P-gp overexpression, through MTT assay. monooxyethylene trimethylolpropane tristearate 186-189 ATP binding cassette subfamily B member 1 Homo sapiens 157-161 11189514-2 1998 METHODS: The modulation effect of granulocyte-colony stimulating factor(G-CSF) on the mdr1 gene expression in AML cells was studied in vitro by using polymerase chain reaction(PCR), in vitro cell culture, immunocytochemical and MTT assays. monooxyethylene trimethylolpropane tristearate 228-231 ATP binding cassette subfamily B member 1 Homo sapiens 86-90 9009089-8 1997 PGP, but not MRP, overexpression significantly impaired paclitaxel accumulation and paclitaxel-induced apoptosis, as well as reduced its cytotoxic effects as determined by the MTT assay. monooxyethylene trimethylolpropane tristearate 176-179 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 1348973-2 1992 At 100 microM, both steroids inhibited the binding of a Vinca alkaloid photoaffinity analog to P-glycoprotein (P-gp) in MDR human neuroblastic SH-SY5Y/VCR cells [which show greater than 1500-fold resistance to vincristine (VCR) in the tetrazolium dye (MTT) assay]. monooxyethylene trimethylolpropane tristearate 252-255 ATP binding cassette subfamily B member 1 Homo sapiens 95-109 1348973-2 1992 At 100 microM, both steroids inhibited the binding of a Vinca alkaloid photoaffinity analog to P-glycoprotein (P-gp) in MDR human neuroblastic SH-SY5Y/VCR cells [which show greater than 1500-fold resistance to vincristine (VCR) in the tetrazolium dye (MTT) assay]. monooxyethylene trimethylolpropane tristearate 252-255 ATP binding cassette subfamily B member 1 Homo sapiens 111-115 26407111-3 2015 The activity of ABCB1 in Flp-In-293/ABCB1 cells were confirmed by typical substrates for ABCB1 (taxol and vinblastine) in MTT assay. monooxyethylene trimethylolpropane tristearate 122-125 ATP binding cassette subfamily B member 1 Homo sapiens 36-41 31199153-3 2019 The triple therapies produced a superior and synergistic effect on MDR-reversal and killing MCF-7/ADR in vitro, and the P-gp expression level was downregulated to 46%, as confirmed by means of MTT, Western blot, flow cytometry, and confocal laser scanning microscopy. monooxyethylene trimethylolpropane tristearate 193-196 ATP binding cassette subfamily B member 1 Homo sapiens 120-124 30466608-4 2018 STUDY DESIGN/METHODS: The interaction of epimagnolin A with ABCB1 was evaluated in calcein, ATPase, and MTT assays by using Flp-In-293/ABCB1 cells and purified ABCB1 and simulated in molecular docking studies. monooxyethylene trimethylolpropane tristearate 104-107 ATP binding cassette subfamily B member 1 Homo sapiens 60-65 28217977-14 2017 Lastly, we demonstrated low MDR1/P-gp expression in HCT116-OxR-miR-506 cells via inhibition of the Wnt/beta-catenin by WB, MTT and FCM analysis. monooxyethylene trimethylolpropane tristearate 123-126 ATP binding cassette subfamily B member 1 Homo sapiens 28-32 25586174-9 2015 The effect of glucose-induced stress on Pgp-mediated drug resistance was examined after incubating cells with the chemotherapeutic and Pgp substrate, doxorubicin (DOX), and performing MTT assays validated by viable cell counts. monooxyethylene trimethylolpropane tristearate 184-187 ATP binding cassette subfamily B member 1 Homo sapiens 40-43 26407111-3 2015 The activity of ABCB1 in Flp-In-293/ABCB1 cells were confirmed by typical substrates for ABCB1 (taxol and vinblastine) in MTT assay. monooxyethylene trimethylolpropane tristearate 122-125 ATP binding cassette subfamily B member 1 Homo sapiens 16-21 26407111-3 2015 The activity of ABCB1 in Flp-In-293/ABCB1 cells were confirmed by typical substrates for ABCB1 (taxol and vinblastine) in MTT assay. monooxyethylene trimethylolpropane tristearate 122-125 ATP binding cassette subfamily B member 1 Homo sapiens 36-41 25482933-3 2015 Our results showed that dasatinib significantly increased the sensitivity of P-gp-overexpressing MCF-7/Adr cells to doxorubicin in MTT assays; thus lead to an enhanced cytotoxicity of doxorubicin in MCF-7/Adr cells. monooxyethylene trimethylolpropane tristearate 131-134 ATP binding cassette subfamily B member 1 Homo sapiens 77-81 23466650-3 2013 Using the MTT assay, we found that DABB and DHBB could enhance the cytotoxicities of ABCB1 substrates doxorubicin, vincristine, and paclitaxel in ABCB1-overexpressing HepG2/ADM and MCF-7/ADR cells, whereas that of a non-ABCB1 substrate cisplatin was unaffected. monooxyethylene trimethylolpropane tristearate 10-13 ATP binding cassette subfamily B member 1 Homo sapiens 146-151 24284783-2 2014 The MTT assay was used to determine the effects of beta-elemene in combination with other anticancer drugs on ABCB1-overexpressing cancer cell lines. monooxyethylene trimethylolpropane tristearate 4-7 ATP binding cassette subfamily B member 1 Homo sapiens 110-115 23466650-3 2013 Using the MTT assay, we found that DABB and DHBB could enhance the cytotoxicities of ABCB1 substrates doxorubicin, vincristine, and paclitaxel in ABCB1-overexpressing HepG2/ADM and MCF-7/ADR cells, whereas that of a non-ABCB1 substrate cisplatin was unaffected. monooxyethylene trimethylolpropane tristearate 10-13 ATP binding cassette subfamily B member 1 Homo sapiens 85-90 23466650-3 2013 Using the MTT assay, we found that DABB and DHBB could enhance the cytotoxicities of ABCB1 substrates doxorubicin, vincristine, and paclitaxel in ABCB1-overexpressing HepG2/ADM and MCF-7/ADR cells, whereas that of a non-ABCB1 substrate cisplatin was unaffected. monooxyethylene trimethylolpropane tristearate 10-13 ATP binding cassette subfamily B member 1 Homo sapiens 146-151 23301649-8 2012 Patients with drug resistance in vitro by means of the MTT assay had higher Pgp and MRP expression. monooxyethylene trimethylolpropane tristearate 55-58 ATP binding cassette subfamily B member 1 Homo sapiens 76-79 21835258-3 2012 Using the MTT method, we investigated the influence of the COX-2 selective inhibitor Celecoxib on the proliferation of KB/VCR oral cancer cell lines and analyzed the effect of Celecoxib on the regulation of P-glycoprotein (P-gp) expression and function. monooxyethylene trimethylolpropane tristearate 10-13 ATP binding cassette subfamily B member 1 Homo sapiens 207-221 20642825-8 2010 The drug sensitivities of 4T1/HA117 and 4T1/MDR1 to chemotherapeutic agents were detected by Methyl-Thiazolyl-Tetrazolium (MTT) assay. monooxyethylene trimethylolpropane tristearate 123-126 ATP binding cassette subfamily B member 1 Homo sapiens 44-48