PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2055276-6 1991 These results show that insulin and IGF-1 stimulate conversion of MtT/S cell line GH cells to PRL cells. monooxyethylene trimethylolpropane tristearate 66-69 insulin-like growth factor 1 Rattus norvegicus 36-41 11051049-0 2000 Insulin-like growth factor-1 causes a switch-like reduction of endogenous growth hormone mRNA in rat MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 101-104 insulin-like growth factor 1 Rattus norvegicus 0-28 11051049-1 2000 Reduction of mRNA expression from the endogenous GH gene by insulin-like growth factor 1 (IGF-1) in somatotroph-like rat MtT/S cells was measured. monooxyethylene trimethylolpropane tristearate 121-124 insulin-like growth factor 1 Rattus norvegicus 60-88 11051049-1 2000 Reduction of mRNA expression from the endogenous GH gene by insulin-like growth factor 1 (IGF-1) in somatotroph-like rat MtT/S cells was measured. monooxyethylene trimethylolpropane tristearate 121-124 insulin-like growth factor 1 Rattus norvegicus 90-95 11051049-5 2000 MtT/S cells were shown to have both IGF-1 and insulin receptors as detected by Western blotting. monooxyethylene trimethylolpropane tristearate 0-3 insulin-like growth factor 1 Rattus norvegicus 36-41 11051049-7 2000 Analysis of the effects of IGF-1 and insulin on MtT/S cells showed that each reduced GH mRNA in a dose-dependent manner gave a calculated EC50 of 15.5 nM for IGF-1 and 0.6 nM for insulin, suggesting that the respective receptors for each hormone were activated. monooxyethylene trimethylolpropane tristearate 48-51 insulin-like growth factor 1 Rattus norvegicus 27-32 11051049-7 2000 Analysis of the effects of IGF-1 and insulin on MtT/S cells showed that each reduced GH mRNA in a dose-dependent manner gave a calculated EC50 of 15.5 nM for IGF-1 and 0.6 nM for insulin, suggesting that the respective receptors for each hormone were activated. monooxyethylene trimethylolpropane tristearate 48-51 insulin-like growth factor 1 Rattus norvegicus 158-163 9886844-0 1999 Molecular mechanisms of the negative effect of insulin-like growth factor-I on growth hormone gene expression in MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 113-116 insulin-like growth factor 1 Rattus norvegicus 47-75 10395227-2 1998 MtT/S cell is known to differentiate into PRL-producing cells in response to stimulation with insulin or insulin-like growth factor-1 (IGF-1). monooxyethylene trimethylolpropane tristearate 0-3 insulin-like growth factor 1 Rattus norvegicus 105-133 10395227-2 1998 MtT/S cell is known to differentiate into PRL-producing cells in response to stimulation with insulin or insulin-like growth factor-1 (IGF-1). monooxyethylene trimethylolpropane tristearate 0-3 insulin-like growth factor 1 Rattus norvegicus 135-140 7510564-9 1993 We have demonstrated that this MTT ESTA provides a useful method for the study of complex interactions between IGF-I and IGF-II and their related binding proteins and that IGF bioactivity in serum may also be investigated using this ESTA bioassay. monooxyethylene trimethylolpropane tristearate 31-34 insulin-like growth factor 1 Rattus norvegicus 111-116 1734040-1 1992 Insulin and type I insulin-like growth factor (IGF-I) suppressed growth hormone (GH) expression followed by the induction of prolactin (PRL) biosynthesis in MtT/S cells cultured with normal sera. monooxyethylene trimethylolpropane tristearate 157-160 insulin-like growth factor 1 Rattus norvegicus 47-52 2982573-8 1985 Cells isolated from rats bearing the GH-secreting tumor, MtT/W15, had IGF I and BP production rates approximately twice as high as normal. monooxyethylene trimethylolpropane tristearate 57-60 insulin-like growth factor 1 Rattus norvegicus 70-75 18058266-5 2007 In addition, GH and insulin-like growth factor I (IGF-I) stimulated the growth of MtT/E cells. monooxyethylene trimethylolpropane tristearate 82-85 insulin-like growth factor 1 Rattus norvegicus 20-48 6286280-1 1982 Male and female Wistar-Furth rats bearing the pituitary tumor MtT/W15 had serum GH and PRL levels several hundred-fold higher, and immunoreactive somatomedin levels 3-fold higher, than those of controls. monooxyethylene trimethylolpropane tristearate 62-65 insulin-like growth factor 1 Rattus norvegicus 146-157 18058266-5 2007 In addition, GH and insulin-like growth factor I (IGF-I) stimulated the growth of MtT/E cells. monooxyethylene trimethylolpropane tristearate 82-85 insulin-like growth factor 1 Rattus norvegicus 50-55 18058266-6 2007 The messenger RNAs (mRNAs) of receptors for IGF-I and GH were expressed in the MtT/E cells. monooxyethylene trimethylolpropane tristearate 79-82 insulin-like growth factor 1 Rattus norvegicus 44-49 18058266-8 2007 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate 43-46 insulin-like growth factor 1 Rattus norvegicus 105-110 18058266-8 2007 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate 43-46 insulin-like growth factor 1 Rattus norvegicus 125-130 18058266-8 2007 Therefore, we concluded that somatotropes (MtT/S) maintain their progenitor cells (MtT/E) through the GH-IGF-I signaling and IGF-I directly, which might be involved in the maintenance of progenitors of GH-producing cells and might contribute to pituitary tumor development. monooxyethylene trimethylolpropane tristearate 83-86 insulin-like growth factor 1 Rattus norvegicus 105-110 11518805-1 2001 IGF-I-dependent decreases in endogenous GH mRNA expression were studied in individual rat MtT/S somatotroph cells using in situ hybridization. monooxyethylene trimethylolpropane tristearate 90-93 insulin-like growth factor 1 Rattus norvegicus 0-5