PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22588708-2 2012 Effect of allantoin on imidazoline I1 receptor (I1R) relating to reduction of blood pressure and its merit in steatosis are still obscure. Allantoin 10-19 nischarin Mus musculus 20-51 23606885-5 2013 The chronic administration of allantoin to HFD-fed mice for 8 weeks significantly decreased their body weight, and this effect was reversed by efaroxan at a dose sufficient to block I1R. Allantoin 30-39 nischarin Mus musculus 182-185 23606885-6 2013 The epididymal white adipose tissue (eWAT) cell size and weight in HFD-fed mice were also decreased by allantoin via the activation of I1R. Allantoin 103-112 nischarin Mus musculus 135-138 23606885-9 2013 Moreover, allantoin lowered HFD-induced hyperleptinemia, and this activity was abolished by I1R blockade with efaroxan. Allantoin 10-19 nischarin Mus musculus 92-95 23606885-10 2013 Taken together, these data suggest that allantoin can ameliorate energy intake and eWAT accumulation by activating I1R to improve HFD-induced obesity. Allantoin 40-49 nischarin Mus musculus 115-118