PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12054664-3 2002 Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface. Poly I 41-48 interferon beta 1 Homo sapiens 66-74 9920723-0 1999 Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-beta from polarized epithelial cell lines. Poly I 53-59 interferon beta 1 Homo sapiens 75-90 22358527-5 1997 The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA). Poly I 77-85 interferon beta 1 Homo sapiens 18-33 22358527-5 1997 The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA). Poly I 77-85 interferon beta 1 Homo sapiens 35-43 1660913-2 1991 We show that Poly I:C-induced antiviral activity is completely abrogated by antibodies to interferon-beta (IFN-beta) whereas antibodies to other interferons or to other cytokines have no effect. Poly I 13-19 interferon beta 1 Homo sapiens 90-105 10319138-5 1994 Taken together, these data indicate that interferon-beta produced in response to poly I:C acts in an autocrine manner to activate the 2"-5" oligoadenylate synthetase and to induce resistance to HSV-1. Poly I 81-87 interferon beta 1 Homo sapiens 41-56 1602741-9 1992 Vascular SMC treated with poly(I):poly(C) or tumor necrosis factor-alpha expressed IFN-beta mRNA. Poly I 26-33 interferon beta 1 Homo sapiens 83-91 1602741-10 1992 SMC treated with poly(I):poly(C) or Newcastle Disease virus elaborated biologically active IFN-beta as well. Poly I 17-24 interferon beta 1 Homo sapiens 91-99 1660913-2 1991 We show that Poly I:C-induced antiviral activity is completely abrogated by antibodies to interferon-beta (IFN-beta) whereas antibodies to other interferons or to other cytokines have no effect. Poly I 13-19 interferon beta 1 Homo sapiens 107-115 34695651-5 2021 PU.1 expression also primes the cells to develop a strong immune response against the dsRNA virus mimic polyinosinic:polycytidylic acid (poly I:C) by significantly up-regulating Interferon-beta (14.9 fold change with p-value <0.0001). Poly I 137-143 interferon beta 1 Homo sapiens 178-193 1690591-4 1990 The levels of these two induced activities after VIP treatment are comparable to those induced by the poly (I).poly (C), an inducer of IFN beta/alpha in mammalian cells. Poly I 102-110 interferon beta 1 Homo sapiens 135-143 34591979-0 2021 MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression. Poly I 26-32 interferon beta 1 Homo sapiens 105-120 2647497-0 1989 Production of interferon-beta upon induction with polyinosinic acid:polycytidylic acid during the cell cycle of human fibroblasts. Poly I 50-67 interferon beta 1 Homo sapiens 14-29 2647497-1 1989 The production of interferon-beta was examined at various stages of the cell cycle in synchronized and unsynchronized cell populations induced by poly(I):poly(C). Poly I 146-153 interferon beta 1 Homo sapiens 18-33 2459591-2 1988 Poly(I).poly(C), poly(A).poly(U) and rln.r(C13,U)n at 5 to 100 micrograms/ml produced 20 to 60% growth inhibition, whereas poly(ICLC) produced 40 to 80% growth inhibition at 0.05 to 25 micrograms/ml.Poly(I).poly(C) did not cause the secretion of interferon (IFN) into the medium, and addition of polyclonal antibodies to IFN-alpha and IFN-beta did not block the growth inhibition produced by poly(I).poly(C). Poly I 0-7 interferon beta 1 Homo sapiens 335-343 3182859-1 1988 The asparagine-linked sugar chains of natural interferon-beta 1 secreted from human foreskin fibroblasts by poly I:poly C induction and of three recombinant human interferon-beta 1 produced by Chinese hamster ovary cells, mouse epithelial cells (C127), and human lung adenocarcinoma cells (PC8) were released quantitatively as oligosaccharides by hydrazinolysis followed by N-acetylation. Poly I 108-114 interferon beta 1 Homo sapiens 46-63 2459591-2 1988 Poly(I).poly(C), poly(A).poly(U) and rln.r(C13,U)n at 5 to 100 micrograms/ml produced 20 to 60% growth inhibition, whereas poly(ICLC) produced 40 to 80% growth inhibition at 0.05 to 25 micrograms/ml.Poly(I).poly(C) did not cause the secretion of interferon (IFN) into the medium, and addition of polyclonal antibodies to IFN-alpha and IFN-beta did not block the growth inhibition produced by poly(I).poly(C). Poly I 0-6 interferon beta 1 Homo sapiens 335-343 3262700-7 1988 The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells. Poly I 32-39 interferon beta 1 Homo sapiens 56-64 3262700-10 1988 Simultaneous addition of TNF and poly(I).poly(C) to FS-4 cells enhanced IFN-beta synthesis. Poly I 33-40 interferon beta 1 Homo sapiens 72-80 2449288-4 1987 Fibroblast cells grown on microcarriers in the presence of glucocorticoid hormones maintained their ability to produce interferon (IFN)-beta in a superinduction method with poly I: poly C and antimetabolites. Poly I 173-179 interferon beta 1 Homo sapiens 119-140 3805129-4 1987 Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action. Poly I 45-52 interferon beta 1 Homo sapiens 13-34 3805129-2 1987 Poly(I).poly(C) is a potent inducer of interferon (IFN)-beta in human fibroblasts. Poly I 0-7 interferon beta 1 Homo sapiens 39-60 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly I 49-56 interferon beta 1 Homo sapiens 122-137 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly I 49-56 interferon beta 1 Homo sapiens 139-147 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly I 49-56 interferon beta 1 Homo sapiens 248-256 30387134-0 2019 Toll-like receptor 3 agonist poly I:C reinforces the potency of cytotoxic chemotherapy via the TLR3-UNC93B1-IFN-beta signaling axis in paclitaxel-resistant colon cancer. Poly I 29-35 interferon beta 1 Homo sapiens 108-116 6856471-1 1983 Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe. Poly I 98-105 interferon beta 1 Homo sapiens 134-142 6856471-1 1983 Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe. Poly I 98-105 interferon beta 1 Homo sapiens 256-264 22698190-1 2012 BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types. Poly I 55-72 interferon beta 1 Homo sapiens 164-185 27468646-4 2016 CAM treatment led to a significant reduction in poly I:C- and RSV-mediated IL-8, CCL5, IFN-beta and -lambda production. Poly I 48-54 interferon beta 1 Homo sapiens 87-95 23636788-5 2013 IFN-beta produced by poly I:C-activated human cancer cells increased the capacity of monocyte-derived DCs to stimulate IFN-gamma production in an allogeneic stimulatory culture in vitro. Poly I 21-27 interferon beta 1 Homo sapiens 0-8 18252870-7 2008 poly(I:C), on the other hand, induced a strong and long-lasting (>12 h) IFN-beta mRNA and protein response, particularly when transfected, whereas only a protracted TNF response was observed when poly(I:C) was transfected. Poly I 0-7 interferon beta 1 Homo sapiens 75-83 21964048-5 2011 The treatment of EPCs with TLR3 agonist Poly I:C up-regulated the expression of cytokines IL-1beta, IL-6, IL-8, TNF-alpha, IFN-alpha, and IFN-beta, indicating that EPCs expressed functional TLR3. Poly I 40-46 interferon beta 1 Homo sapiens 138-146 16399790-9 2006 Pretreatment with wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase, was able to abate the effect of DE(as) on poly(I:C)-induced IFN-beta expression. Poly I 127-133 interferon beta 1 Homo sapiens 145-153