PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2715669-5 1989 Multiple phosphorylated species of a 72-kD protein were labeled in response to poly(I):poly(C) by extracts from IFN-treated cells but not by extracts from control cells. Poly C 87-94 interferon alpha 1 Homo sapiens 112-115 2502582-4 1989 Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression. Poly C 35-42 interferon alpha 1 Homo sapiens 107-110 2502585-2 1989 In MNC, poly(I):poly(C) and mismatched poly(I):poly(C) induced IFN-alpha in a dose-dependent manner, whereas poly(ICLC) was unable to do so in concentrations that ranged from 1 to 160 micrograms/ml. Poly C 16-22 interferon alpha 1 Homo sapiens 63-72 2502585-2 1989 In MNC, poly(I):poly(C) and mismatched poly(I):poly(C) induced IFN-alpha in a dose-dependent manner, whereas poly(ICLC) was unable to do so in concentrations that ranged from 1 to 160 micrograms/ml. Poly C 47-53 interferon alpha 1 Homo sapiens 63-72 2502585-4 1989 The capacity of poly(I):poly(C) to induce IFN-alpha was reestablished only in monocyte cultures when, prior to the stimulation, the cells were exposed for at least 2 h to supernatants from poly(I):poly(C)-stimulated lymphocyte cultures. Poly C 24-31 interferon alpha 1 Homo sapiens 42-51 2502585-4 1989 The capacity of poly(I):poly(C) to induce IFN-alpha was reestablished only in monocyte cultures when, prior to the stimulation, the cells were exposed for at least 2 h to supernatants from poly(I):poly(C)-stimulated lymphocyte cultures. Poly C 197-204 interferon alpha 1 Homo sapiens 42-51 3494192-5 1987 Exposure of cells to TNF enhanced IFN-beta 2 (but not IFN-beta 1) mRNA expression in response to poly(I).poly(C), an IFN inducer which is also known to stimulate FS-4 cell growth. Poly C 105-112 interferon alpha 1 Homo sapiens 34-37 2848929-4 1988 These results confirm earlier observations that IFN or polyinosinic.polycytidylic acid block the replication of HSV-1 in human, monkey and mouse cells no later than the immediate early phase of infection. Poly C 68-86 interferon alpha 1 Homo sapiens 48-51 2453506-1 1988 Human fibroblasts were induced to secrete interferon (IFN) by treatment with the double-stranded RNA poly(inosinic).poly(cytidylic) acid or by infection with Newcastle disease virus. Poly C 116-136 interferon alpha 1 Homo sapiens 54-57 3805129-4 1987 Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action. Poly C 53-60 interferon alpha 1 Homo sapiens 25-28 3805129-7 1987 This effect of dexamethasone correlated with its marked inhibitory action on poly(I).poly(C)-stimulated IFN production. Poly C 85-92 interferon alpha 1 Homo sapiens 104-107 6306284-2 1983 The optimal conditions for induction of human IFN and of its mRNA in these transformants resembled those needed for mouse IFN: high concentrations of DEAE-dextran and low concentrations of polyriboinosinic acid-polyribocytidylic acid. Poly C 211-233 interferon alpha 1 Homo sapiens 46-49 2578572-4 1985 IFN was implicated as mediating the effect of poly(I)-poly(C) because high systemic levels of IFN were evident after injection, and neither the magnitude of the inflammatory response nor the T-cell levels were affected when poly(I)-poly(C)-treated mice were also given anti-IFN antiserum. Poly C 54-61 interferon alpha 1 Homo sapiens 0-3 2578572-5 1985 However, the poly(I)-poly(C)-induced IFN did not seem to reduce the localized inflammatory response by affecting viral replication in brain tissue because the vaccinia virus titers present on days 6 through 8 of infection were similar to the titers in phosphate-buffered saline controls. Poly C 21-28 interferon alpha 1 Homo sapiens 37-40 2985717-3 1985 When nylon-column nonadherent cells (NNA cells) were induced by poly I:poly C which was prepared by heat-treatment, high levels of acid- and heat-labile interferon (IFN) were obtained. Poly C 71-77 interferon alpha 1 Homo sapiens 141-169 3745988-1 1986 The synthetic polyribonucleotide polyinosinate:polycytidylate [poly(I):poly(C)] was used to induce interferon (IFN) production in a rat leiomyosarcoma cell line. Poly C 71-78 interferon alpha 1 Homo sapiens 111-114 2428755-9 1986 The excellent IFN inducer, poly I:C, at the tested dose range (0.03-3.0 mg/kg), displayed only a relatively weak adjuvant activity. Poly C 27-35 interferon alpha 1 Homo sapiens 14-17 2428755-11 1986 This might be related to sufficient induction of IFN by low doses of poly I:C but not by DDA. Poly C 69-77 interferon alpha 1 Homo sapiens 49-52 6306284-2 1983 The optimal conditions for induction of human IFN and of its mRNA in these transformants resembled those needed for mouse IFN: high concentrations of DEAE-dextran and low concentrations of polyriboinosinic acid-polyribocytidylic acid. Poly C 211-233 interferon alpha 1 Homo sapiens 122-125 30224514-5 2018 In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression. Poly C 47-65 interferon alpha 1 Homo sapiens 124-127 6838554-0 1983 Induction of human leukocyte interferon by heat-treated poly I: poly C. Poly C 64-70 interferon alpha 1 Homo sapiens 29-39 6838554-1 1983 Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN). Poly C 39-45 interferon alpha 1 Homo sapiens 205-231 6838554-1 1983 Synthetic double stranded RNA (poly I: poly C) was prepared from polyinosinic acid (poly I) and polycytidylic acid (poly C) by heat-treated followed by gradual cooling, and was used for induction of human leukocyte interferon (IFN). Poly C 96-114 interferon alpha 1 Homo sapiens 205-231 6838554-2 1983 When poly I: poly C solution was heated at 37 - 65 degrees C for 30 minutes, high activity of human IFN (10,000 - 60,000 i. u./ml) was obtained. Poly C 13-19 interferon alpha 1 Homo sapiens 100-103 6838554-3 1983 In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum. Poly C 56-62 interferon alpha 1 Homo sapiens 73-76 6838554-3 1983 In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum. Poly C 56-62 interferon alpha 1 Homo sapiens 122-125 6838554-3 1983 In this system, the optimum molecular weight of poly I: poly C to induce IFN was 12.6 - 17.6 S. The properties of induced IFN were heat- and acid- stable, and it was neutralized with anti-IFN alpha serum. Poly C 56-62 interferon alpha 1 Homo sapiens 188-197 6187846-1 1983 Systemic inoculation of the interferon (IFN) inducer polyinosinic-polycytidylic polyribonucleotide (poly I:poly C) into CBA/J mice produces a significant decrease in the number of thoracic duct lymphocytes (TDL) collected 6 to 22 hr after injection. Poly C 107-113 interferon alpha 1 Homo sapiens 40-43 6187846-5 1983 2) Pretreatment of mice with sheep anti-murine IFN serum can block this effect of poly I:poly C. Poly C 89-95 interferon alpha 1 Homo sapiens 47-50 33086712-4 2020 We demonstrated that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of porTRIM26 promotes interferon (IFN)- production after poly (I:C) stimulation and virus infection (VSV or PRRSV). Poly C 34-52 interferon alpha 1 Homo sapiens 274-290 30224514-5 2018 In this study, we have shown that polyinosinic:polycytidylic acid (polyI:C) and influenza A virus (IAV) infection increased IFN-lambda expression at mRNA and protein levels in primary cultures of normal human bronchial epithelial cells, whereas IL-17A attenuated polyI:C- or IAV-induced IFN-lambda expression. Poly C 47-65 interferon alpha 1 Homo sapiens 287-290 27621733-8 2016 IFNalpha/beta increase HSC proliferation in models of sterile inflammation induced by polyinosinic:polycytidylic acid and lead to BM aplasia during viral infection. Poly C 99-117 interferon alpha 1 Homo sapiens 0-8 20181884-6 2010 CpG-B ODN inhibited induction of IFN-alphabeta by agonists of multiple receptors, including MyD88-dependent TLRs (CpG-A ODN signaling via TLR9, or R837 or Sendai virus signaling via TLR7) and MyD88-independent receptors (polyinosinic:polycytidylic acid signaling via TLR3 or ds break-DNA signaling via a cytosolic pathway). Poly C 234-252 interferon alpha 1 Homo sapiens 33-36 18845337-6 2009 Based on our previous findings that AML cells produce IFN-alpha upon electroporation with the synthetic double-stranded (ds)RNA polyriboinosinic polyribocytidylic acid (poly(I:C)), we hypothesized that dsRNA-loaded tumor cells provide both signals to elicit an NK cell-driven IFN-gamma production. Poly C 145-167 interferon alpha 1 Homo sapiens 54-63 19546225-8 2009 Reciprocally, depletion of PLK1 can increase IFN induction in response to RIG-I/SeV or RIG-I/poly(I)-poly(C) treatments. Poly C 101-108 interferon alpha 1 Homo sapiens 45-48 19686199-6 2009 Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds. Poly C 88-106 interferon alpha 1 Homo sapiens 165-168 19686199-6 2009 Administration of TLR ligands, lipopolysaccharide, and double-stranded RNA polyinosinic:polycytidylic acid, which mimics bacterial or viral infection, activates the IFN signaling pathways, upregulates the expression of IFN-inducible genes, and downregulates the expression of c-fos in taste buds. Poly C 88-106 interferon alpha 1 Homo sapiens 219-222 16308570-4 2005 In contrast, polyinosinic:polycytidylic acid strongly represses CpG"s as well as its own intrinsic ability to induce PDGF-B mRNA through type I IFN-mediated induction of Smad7, a negative regulator of Smad3/4. Poly C 26-44 interferon alpha 1 Homo sapiens 144-147 18505922-8 2008 Furthermore, polyinosinic:polycytidylic acid treatment of the IRF-overexpressing cells showed a more rapid induction of several IFN-regulated genes. Poly C 26-44 interferon alpha 1 Homo sapiens 128-131 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 interferon alpha 1 Homo sapiens 27-30 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 interferon alpha 1 Homo sapiens 265-268 16623926-5 2006 The synthetic dsRNA analogue polyinosinic acid : polycytidylic acid [Poly(I : C)] could only stimulate IFN-alpha production in enriched mDC but not in pDC. Poly C 49-67 interferon alpha 1 Homo sapiens 103-112 15507307-8 2004 When macrophages infected with isolates 3, 7, or 12 were treated with polycytidylic acid (polyI:C), IFN-alpha production was enhanced. Poly C 70-88 interferon alpha 1 Homo sapiens 100-109 15507307-8 2004 When macrophages infected with isolates 3, 7, or 12 were treated with polycytidylic acid (polyI:C), IFN-alpha production was enhanced. Poly C 90-97 interferon alpha 1 Homo sapiens 100-109 15507307-9 2004 Cells infected with isolate 3 and treated with polyI:C showed the most consistent and strongest enhancement of IFN-alpha production. Poly C 47-54 interferon alpha 1 Homo sapiens 111-120 15507307-10 2004 It was demonstrated that the relatively low concentrations of IFN-alpha produced by isolate 3 contributed to the enhanced IFN-alpha synthesis in response to polyI:C. Poly C 157-164 interferon alpha 1 Homo sapiens 62-71 15507307-10 2004 It was demonstrated that the relatively low concentrations of IFN-alpha produced by isolate 3 contributed to the enhanced IFN-alpha synthesis in response to polyI:C. Poly C 157-164 interferon alpha 1 Homo sapiens 122-131 15507307-11 2004 Isolates 7 and 12 significantly suppressed the enhanced IFN-alpha production by isolate 3 in polyI:C treated cells. Poly C 93-100 interferon alpha 1 Homo sapiens 56-65 15507307-15 2004 Furthermore, a PRRSV field isolate strongly enhance polyI:C-induced IFN-alpha production in PAM cultures and this priming effect was suppressed by other PRRSV isolates. Poly C 52-59 interferon alpha 1 Homo sapiens 68-71 14585200-6 2003 Poly(I)-poly(C) induced two IFN transcripts in head kidney of Atlantic salmon. Poly C 8-15 interferon alpha 1 Homo sapiens 28-31 12096926-7 2002 When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated. Poly C 89-107 interferon alpha 1 Homo sapiens 63-66 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 interferon alpha 1 Homo sapiens 147-156 12096926-7 2002 When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated. Poly C 89-107 interferon alpha 1 Homo sapiens 148-157 9629309-7 1998 Poly (i)-poly (c)-induced IFN-alpha production by monocytes was inhibited by glucocorticoids in the AIDS-C group and controls (approx. Poly C 9-17 interferon alpha 1 Homo sapiens 26-35 9920723-3 1999 When poly I:poly C was applied to the upper compartment, IFN was secreted predominantly from the apical membrane. Poly C 12-18 interferon alpha 1 Homo sapiens 57-60 9920723-4 1999 Inversely, poly I:poly C applied to the lower compartment caused preferential IFN secretion from the basolateral membrane. Poly C 18-24 interferon alpha 1 Homo sapiens 78-81 9756612-2 1998 However, the dose of poly I:poly C required for efficient IFN induction is so high as occasionally to be cytotoxic. Poly C 28-34 interferon alpha 1 Homo sapiens 58-61 9756612-3 1998 In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone. Poly C 57-63 interferon alpha 1 Homo sapiens 30-33 9756612-3 1998 In this work, we examined the IFN-inducibility of poly I:poly C complexed with several cationic reagents in mouse fibroblast L cells and found that Lipofectin and LipofectACE can induce the production of a substantial amount of type I IFNs (mostly beta-type) even at a two-order lower dose compared with poly I:poly C alone. Poly C 311-317 interferon alpha 1 Homo sapiens 30-33 9920723-1 1999 Mode of secretion of poly I:poly C-induced IFN was examined using epithelial cell lines in a bicameral culture system. Poly C 28-34 interferon alpha 1 Homo sapiens 43-46 9264143-7 1997 After poly(I):poly(C) stimulation, monocytes from AIDS-GR produce much more IFN alpha than other AIDS patients. Poly C 14-21 interferon alpha 1 Homo sapiens 76-85 7506512-4 1993 Non-viral inducers, such as poly(rl).poly(rC), induce exclusively IFN-beta whereas viruses such as Sendai and Newcastle Disease Virus (NDV) induce mixtures of IFN-alpha subtypes and IFN-beta. Poly C 37-45 interferon alpha 1 Homo sapiens 66-69 1379284-4 1992 Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression. Poly C 35-42 interferon alpha 1 Homo sapiens 107-110 2153928-3 1990 IFN-alpha mRNA remained undetectable in poly(I)-poly(C)-treated Daudi cells either before or after priming. Poly C 48-55 interferon alpha 1 Homo sapiens 0-9 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 interferon alpha 1 Homo sapiens 54-63 7589141-5 1995 Taken together, these data suggest that poly I:C is a Th1-inducing agent whose activity is mediated by its ability to stimulate the production of IFN-alpha and IL-12 by monocytes. Poly C 40-48 interferon alpha 1 Homo sapiens 146-155 7749068-5 1995 IFN-alpha and poly(I).poly(C) elicited small, transient gamma 2 responses in a few of the non-lymphoid cell lines, whereas none of the other six cytokines tested elicited a response. Poly C 22-29 interferon alpha 1 Homo sapiens 0-9 2211840-4 1990 The biological effect of Poly(I).Poly(C)-induced feedback interferon is inhibited by the addition of sarcolectins, which also abolishes cellular refractoriness to repeated IFN induction. Poly C 33-40 interferon alpha 1 Homo sapiens 58-68 2211840-4 1990 The biological effect of Poly(I).Poly(C)-induced feedback interferon is inhibited by the addition of sarcolectins, which also abolishes cellular refractoriness to repeated IFN induction. Poly C 33-40 interferon alpha 1 Homo sapiens 172-175 2211840-5 1990 Similarly, sequential association of, first, Poly(I).Poly(C); 4-5 h later, sarcolectin restores the full capacity of both to promote cell growth, unrestrained by IFN. Poly C 53-60 interferon alpha 1 Homo sapiens 162-165