PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22358527-5 1997 The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA). Poly C 87-95 interferon beta 1 Homo sapiens 18-33 22358527-5 1997 The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA). Poly C 87-95 interferon beta 1 Homo sapiens 35-43 1602741-10 1992 SMC treated with poly(I):poly(C) or Newcastle Disease virus elaborated biologically active IFN-beta as well. Poly C 25-32 interferon beta 1 Homo sapiens 91-99 3262700-7 1988 The inhibitory action of IL1 on poly(I).poly(C)-induced IFN-beta synthesis was abolished in the presence of cycloheximide, suggesting that it is mediated indirectly by an IL1-induced product in the FS-4 cells. Poly C 40-47 interferon beta 1 Homo sapiens 56-64 2647497-0 1989 Production of interferon-beta upon induction with polyinosinic acid:polycytidylic acid during the cell cycle of human fibroblasts. Poly C 68-86 interferon beta 1 Homo sapiens 14-29 2647497-1 1989 The production of interferon-beta was examined at various stages of the cell cycle in synchronized and unsynchronized cell populations induced by poly(I):poly(C). Poly C 154-161 interferon beta 1 Homo sapiens 18-33 3182859-1 1988 The asparagine-linked sugar chains of natural interferon-beta 1 secreted from human foreskin fibroblasts by poly I:poly C induction and of three recombinant human interferon-beta 1 produced by Chinese hamster ovary cells, mouse epithelial cells (C127), and human lung adenocarcinoma cells (PC8) were released quantitatively as oligosaccharides by hydrazinolysis followed by N-acetylation. Poly C 115-121 interferon beta 1 Homo sapiens 46-63 3262700-4 1988 To elucidate the mechanism of this inhibition, we examined the effect of IL1 on the synthesis of interferon-beta (IFN-beta), stimulated with polyinosinate.polycytidylate [poly(I).poly(C)]. Poly C 179-185 interferon beta 1 Homo sapiens 114-122 3262700-5 1988 When added 2 h or more before poly(I).poly(C), both forms of IL1 had a strong inhibitory effect on IFN-beta synthesis, as determined by antiviral assay of the IFN-beta protein or by quantitation of IFN-beta mRNA levels in Northern blot analysis. Poly C 38-45 interferon beta 1 Homo sapiens 99-107 1690591-4 1990 The levels of these two induced activities after VIP treatment are comparable to those induced by the poly (I).poly (C), an inducer of IFN beta/alpha in mammalian cells. Poly C 111-118 interferon beta 1 Homo sapiens 135-143 34695651-5 2021 PU.1 expression also primes the cells to develop a strong immune response against the dsRNA virus mimic polyinosinic:polycytidylic acid (poly I:C) by significantly up-regulating Interferon-beta (14.9 fold change with p-value <0.0001). Poly C 117-135 interferon beta 1 Homo sapiens 178-193 2647497-2 1989 Human fibroblasts were synchronized with mitotic detachment and, at different stages of the cell cycle, poly(I):poly(C) was added for induction of interferon-beta. Poly C 112-119 interferon beta 1 Homo sapiens 147-162 3805129-2 1987 Poly(I).poly(C) is a potent inducer of interferon (IFN)-beta in human fibroblasts. Poly C 8-15 interferon beta 1 Homo sapiens 39-60 3279118-9 1988 PCT-GF activity in supernatants of human FS-4 fibroblasts stimulated with TNF, IL-1 or poly(I).poly(C) was neutralized by antibody to rBSF-2, but not by antibodies neutralizing the antiviral activity of IFN-beta. Poly C 95-102 interferon beta 1 Homo sapiens 203-211 2449288-4 1987 Fibroblast cells grown on microcarriers in the presence of glucocorticoid hormones maintained their ability to produce interferon (IFN)-beta in a superinduction method with poly I: poly C and antimetabolites. Poly C 181-187 interferon beta 1 Homo sapiens 119-140 3805129-4 1987 Antiserum to interferon (IFN)-beta, added to poly(I).poly(C)-stimulated cultures in order to neutralize endogenously generated IFN, markedly amplified the mitogenic action. Poly C 53-60 interferon beta 1 Homo sapiens 13-34 6700582-3 1984 These cells were found to express high levels of human IFN-beta after polyriboinosinic acid-polyribocytidylic acid superinduction or NDV infection; this was a result of coamplification of the IFN-beta gene. Poly C 92-114 interferon beta 1 Homo sapiens 55-63 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly C 59-66 interferon beta 1 Homo sapiens 122-137 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly C 59-66 interferon beta 1 Homo sapiens 139-147 3758081-1 1986 When human fibroblast cells were stimulated with poly(I) X poly(C) in the presence of cycloheximide for the production of interferon-beta (IFN-beta), a 26-kDa protein could be immunoprecipitated by antiserum raised against partially purified human IFN-beta [Content, J., De Wit, L., Pierard, D., Derynck, R., De Clercq, E. & Fiers, W. (1982) Proc. Poly C 59-66 interferon beta 1 Homo sapiens 248-256 26283481-0 2015 Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-beta in Airway Epithelial Cells with Minimal Costimulation of IL-8. Poly C 54-72 interferon beta 1 Homo sapiens 85-93 6180119-2 1982 poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. Poly C 0-8 interferon beta 1 Homo sapiens 238-246 30387134-7 2019 Moreover, cotreatment of poly I:C and PTX acted synergistically to induce cell apoptosis of HCT-8/PTX via upregulating the expression of TLR3 and its molecular chaperone UNC93B1, assisting in the secretion of IFN-beta. Poly C 25-33 interferon beta 1 Homo sapiens 209-217 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 44-52 interferon beta 1 Homo sapiens 159-167 6856471-1 1983 Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe. Poly C 106-112 interferon beta 1 Homo sapiens 134-142 6856471-1 1983 Northern blot analysis reveals that total RNA from human fibroblastoid cells (MG 63) induced with poly(I).poly(C) under conditions of IFN-beta production, contains predominantly a +/- 1,200 nucleotide long poly (A) mRNA (mRNA.M) which hybridizes with a Hu IFN-beta cDNA specific probe. Poly C 106-112 interferon beta 1 Homo sapiens 256-264 30387134-9 2019 In conclusion, our studies demonstrate that poly I:C reinforces the potency of cytotoxic chemotherapeutics in PTX-resistant cell line through the TLR3-UNC93B1-IFN-beta signaling pathway, which supplies a novel mechanism of poly I:C for the chemotherapy sensitizing effect in a PTX-resistant tumor. Poly C 223-231 interferon beta 1 Homo sapiens 159-167 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 interferon beta 1 Homo sapiens 339-347 26243192-3 2015 We showed that the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) apoptosis signal-regulating kinase 1 (ASK1) was activated in cells by the synthetic double-stranded RNA analog polyinosinic:polycytidylic acid [poly(I:C)] and by RNA viruses, and that ASK1 played an essential role in both the induction of the gene encoding IFN-beta (IFNB) and apoptotic cell death. Poly C 206-224 interferon beta 1 Homo sapiens 349-353 22698190-1 2012 BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-beta in many cell types. Poly C 74-92 interferon beta 1 Homo sapiens 164-185 23871888-10 2013 Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in PAR2ko than in wt fibroblasts and reduced virus replication in PAR2ko fibroblasts was abrogated by neutralizing IFNbeta antibody. Poly C 37-55 interferon beta 1 Homo sapiens 70-77 23871888-10 2013 Treatment with CVB3 and polyinosinic:polycytidylic acid led to higher IFNbeta expression in PAR2ko than in wt fibroblasts and reduced virus replication in PAR2ko fibroblasts was abrogated by neutralizing IFNbeta antibody. Poly C 37-55 interferon beta 1 Homo sapiens 204-211 22065573-7 2011 We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter. Poly C 53-75 interferon beta 1 Homo sapiens 173-181 16624932-2 2006 Here, we describe that the IFN-beta released upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C) is responsible for a rapid and sustained signal transducer and activator of transcription 1 and 2 activation and expression of IFN-stimulated genes, such as the transcription factor IFN regulatory factor 7 and the chemokine CXC chemokine ligand 10. Poly C 108-126 interferon beta 1 Homo sapiens 27-35 17177965-8 2007 In vitro studies evaluating the cell source of these cytokines revealed that polyriboinosinic polyribocytidylic acid (poly I:C) activated retinal vascular endothelial cells produce sE-selectin, sICAM-1 and IFN-beta. Poly C 118-126 interferon beta 1 Homo sapiens 206-214 12054664-3 2002 Here, we show the mAb to TLR3 suppressed poly(I):poly(C)-mediated IFN-beta production by human fibroblasts naturally expressing TLR3 on their surface. Poly C 49-56 interferon beta 1 Homo sapiens 66-74 12186889-6 2002 poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). Poly C 0-7 interferon beta 1 Homo sapiens 244-252 9920723-0 1999 Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-beta from polarized epithelial cell lines. Poly C 60-66 interferon beta 1 Homo sapiens 75-90 12096926-7 2002 When melanocytes and melanoma cells were treated with a potent IFN inducer, polyinosinic:polycytidylic acid (poly I:C), the mRNA expression of both IFN-alpha and IFN-beta was significantly upregulated. Poly C 89-107 interferon beta 1 Homo sapiens 162-170