PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22140566-5	2011	Moreover, 5-OH-HxMF-induced both CRE transcription activity and neurite outgrowth were inhibited by adenylate cyclase and protein kinase A (PKA) inhibitor, but not MEK1/2, protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) or calcium/calmodulin-dependent protein kinase (CaMK) inhibitor.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	10-19	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	122-138	
22140566-5	2011	Moreover, 5-OH-HxMF-induced both CRE transcription activity and neurite outgrowth were inhibited by adenylate cyclase and protein kinase A (PKA) inhibitor, but not MEK1/2, protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) or calcium/calmodulin-dependent protein kinase (CaMK) inhibitor.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	10-19	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	140-143	
22140566-6	2011	Consistently, 5-OH-HxMF treatment increased the intracellular cAMP level and downstream component, PKA activity.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	14-23	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	99-102	
22140566-8	2011	These results reveal for the first time that 5-OH-HxMF is an effective neurotrophic agent and its effect is mainly through a cAMP/PKA-dependent, but TrKA-independent, signaling pathway coupling with CRE-mediated gene transcription.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	45-54	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	130-133