PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17962218-3	2007	We found that the topical application of 5-OH-HxMF can effectively inhibit the transcriptional activation of iNOS and COX-2 mRNA and protein in mouse skin stimulated by TPA.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	41-50	prostaglandin-endoperoxide synthase 2	Mus musculus	118-123	
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	71-80	prostaglandin-endoperoxide synthase 2	Mus musculus	192-208	
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	71-80	prostaglandin-endoperoxide synthase 2	Mus musculus	210-215	
17962218-9	2007	Therefore, all these results revealed for the first time that 5-OH-HxMF is an effective antitumor agent and its inhibitory effect is through the down-regulation of inflammatory iNOS and COX-2 gene expression in mouse skin, suggesting that 5-OH-HxMF is a novel functional agent capable of preventing inflammation-associated tumorigenesis.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	62-71	prostaglandin-endoperoxide synthase 2	Mus musculus	186-191	
17962218-9	2007	Therefore, all these results revealed for the first time that 5-OH-HxMF is an effective antitumor agent and its inhibitory effect is through the down-regulation of inflammatory iNOS and COX-2 gene expression in mouse skin, suggesting that 5-OH-HxMF is a novel functional agent capable of preventing inflammation-associated tumorigenesis.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	239-248	prostaglandin-endoperoxide synthase 2	Mus musculus	186-191