PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32859884-7 2020 Plasma levels of leucine, isoleucine, valine, and overall BCAAs were correlated with the activation of mTOR (P < 0.001) and p70S6K (P < 0.001). Leucine 17-24 ribosomal protein S6 kinase B1 Rattus norvegicus 124-130 28536139-8 2017 Results showed that both leucine supplementation and resistance training elevated the activity of mTOR-p70S6K in diabetic rats (P < 0.05). Leucine 25-32 ribosomal protein S6 kinase B1 Rattus norvegicus 103-109 28536139-9 2017 Moreover, though leucine supplementation in combination with resistance training demonstrated synergistic effects on p70S6K (P < 0.05), both treatments were capable of recovering motor performance (P < 0.05). Leucine 17-24 ribosomal protein S6 kinase B1 Rattus norvegicus 117-123 25960953-3 2015 RESULTS: The expressions of PKB/Akt, mTOR and p70S6K were increased in L5 (Leucine 50% administration group) compared with the control group (CON) and exercise group (Ex, exercise training group); EL1 (exercise + 10% leucine administration group) and EL5 (exercise + 50% Leucine administration) also exhibited increased expressions of PKB/Akt, mTOR, and p70S6K, while no difference between EL1 and EL5 were observed. Leucine 75-82 ribosomal protein S6 kinase B1 Rattus norvegicus 46-52 25960953-3 2015 RESULTS: The expressions of PKB/Akt, mTOR and p70S6K were increased in L5 (Leucine 50% administration group) compared with the control group (CON) and exercise group (Ex, exercise training group); EL1 (exercise + 10% leucine administration group) and EL5 (exercise + 50% Leucine administration) also exhibited increased expressions of PKB/Akt, mTOR, and p70S6K, while no difference between EL1 and EL5 were observed. Leucine 75-82 ribosomal protein S6 kinase B1 Rattus norvegicus 354-360 22067655-5 2011 These findings suggest that downregulation of AMPK precedes mTOR/p70S6K activation in mediating glucose and leucine-induced insulin resistance, although the mechanism by which it does so remains to be determined. Leucine 108-115 ribosomal protein S6 kinase B1 Rattus norvegicus 65-71 25358492-10 2014 In contrast, leucine-stimulated phosphorylation of S6K1, a regulator of translation initiation and protein synthesis, was attenuated to approximately 56% of the control value (p < 0.05). Leucine 13-20 ribosomal protein S6 kinase B1 Rattus norvegicus 51-55 23563533-1 2013 Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in proportion to the amount of leucine administered, ranging from 0.169 to 1.35 g/kg of body weight. Leucine 182-189 ribosomal protein S6 kinase B1 Rattus norvegicus 89-116 23563533-1 2013 Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in proportion to the amount of leucine administered, ranging from 0.169 to 1.35 g/kg of body weight. Leucine 182-189 ribosomal protein S6 kinase B1 Rattus norvegicus 118-122 20682696-5 2010 RESULTS: In the EDL, incubation with 100 or 200 mumol/l leucine versus no added leucine suppressed the activity of the alpha2 isoform of AMPK by 50 and 70%, respectively, and caused concentration-dependent increases in protein synthesis and mTOR and p70S6K phosphorylation. Leucine 56-63 ribosomal protein S6 kinase B1 Rattus norvegicus 250-256 19940100-5 2010 The stimulatory effects of leucine on 3-MG transport and AMPK phosphorylation were canceled by STO-609 blockade of Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) or rapamycin blockade of p70S6K. Leucine 27-34 ribosomal protein S6 kinase B1 Rattus norvegicus 198-204 19940100-4 2010 Leucine (2 mM, 30 min) significantly enhanced contraction-stimulated 3-MG transport and AMPK phosphorylation, accompanied by increased phosphorylation of p70 S6 kinase (p70S6K) Thr(389). Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 154-167 19940100-4 2010 Leucine (2 mM, 30 min) significantly enhanced contraction-stimulated 3-MG transport and AMPK phosphorylation, accompanied by increased phosphorylation of p70 S6 kinase (p70S6K) Thr(389). Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 169-175 19940100-7 2010 Leucine increased insulin-stimulated p70S6K Thr(389) phosphorylation and enhanced the inhibitory phosphorylation of the insulin receptor substrate 1 (IRS1) Ser(636/639). Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 37-43 15534870-0 2005 TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle. Leucine 57-64 ribosomal protein S6 kinase B1 Rattus norvegicus 90-94 18806097-6 2008 AICAR also prevented the hyperphosphorylation of eukaryotic initiation factor (eIF) 4E binding protein (4E-BP1), ribosomal protein S6 kinase (S6K1), S6, and eIF4G in response to leucine, suggesting a decrease in mTOR activity. Leucine 178-185 ribosomal protein S6 kinase B1 Rattus norvegicus 113-140 18716165-6 2008 In comparison, the branched-chain amino acid leucine (Leu) activated pp70(s6k), was a weaker stimulator of migration (23% coverage), and did not increase NO. Leucine 54-57 ribosomal protein S6 kinase B1 Rattus norvegicus 74-77 18234235-8 2008 Particularly, the decrease in S6K-1 expression might be an important factor affecting either glucose- or leucine-induced insulin secretion. Leucine 105-112 ribosomal protein S6 kinase B1 Rattus norvegicus 30-35 16616211-8 2006 Similarly, in rats administered with leucine, clofibrate treatment attenuated the predicted increase in plasma leucine concentration as well as the phosphorylation of mTOR, 4E-BP1, and S6K1. Leucine 37-44 ribosomal protein S6 kinase B1 Rattus norvegicus 185-189 16772439-7 2006 BCAA gavage stimulated the phosphorylation of the initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and the ribosomal protein S6 kinase (S6K), with leucine being the most effective. Leucine 154-161 ribosomal protein S6 kinase B1 Rattus norvegicus 114-141 16772439-7 2006 BCAA gavage stimulated the phosphorylation of the initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and the ribosomal protein S6 kinase (S6K), with leucine being the most effective. Leucine 154-161 ribosomal protein S6 kinase B1 Rattus norvegicus 143-146 15389631-8 2005 LPS also antagonized the Leu-induced increase in phosphorylation of S6K1, ribosomal protein S6 and mTOR. Leucine 25-28 ribosomal protein S6 kinase B1 Rattus norvegicus 68-72 15534870-9 2005 In control rats, leucine failed to alter eIF4E distribution but increased the phosphorylation of S6K1 and S6. Leucine 17-24 ribosomal protein S6 kinase B1 Rattus norvegicus 97-108 12026190-0 2002 Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats. Leucine 23-30 ribosomal protein S6 kinase B1 Rattus norvegicus 72-77 15377887-9 2004 In control rats, leucine failed to alter eIF4E distribution but did increase the phosphorylation of S6K1 and S6. Leucine 17-24 ribosomal protein S6 kinase B1 Rattus norvegicus 100-104 15226457-7 2004 Moreover, signaling through mTOR, as monitored by the phosphorylation status of eukaryotic initiation factor (eIF)4E binding protein-1 (4E-BP1) or the 70-kDa ribosomal protein S6 kinase (S6K1), was not further enhanced by 10X compared with 1X leucine. Leucine 243-250 ribosomal protein S6 kinase B1 Rattus norvegicus 187-191 12944322-0 2003 Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Leucine 16-23 ribosomal protein S6 kinase B1 Rattus norvegicus 60-64 12153571-6 2002 Leucine, which is poorly metabolized by the liver and does not modify cell volume, activated ACC and p70S6K, and exerted a synergistic effect on the glutamine-induced activation of ACC and p70S6K. Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 189-195 12153571-9 2002 Nevertheless, it enhanced the activation of ACC and p70S6K induced by leucine. Leucine 70-77 ribosomal protein S6 kinase B1 Rattus norvegicus 52-58 11934675-8 2002 Somatostatin attenuated the leucine-induced changes in 4E-BP1 and S6K1 phosphorylation and completely blocked the change in rp S6 phosphorylation but had no effect on eIF4G small middle dot eIF4E assembly. Leucine 28-35 ribosomal protein S6 kinase B1 Rattus norvegicus 66-70 11934675-9 2002 Overall, the results suggest that the leucine-induced enhancement of protein synthesis and the phosphorylation states of 4E-BP1 and S6K1 are facilitated by the transient increase in serum insulin. Leucine 38-45 ribosomal protein S6 kinase B1 Rattus norvegicus 132-136 11916909-5 2002 Furthermore, leucine increased the phosphorylation of the 70-kDa ribosomal protein S6 (rp S6) and the ribosomal protein S6 kinase (S6K1). Leucine 13-20 ribosomal protein S6 kinase B1 Rattus norvegicus 102-129 11916909-5 2002 Furthermore, leucine increased the phosphorylation of the 70-kDa ribosomal protein S6 (rp S6) and the ribosomal protein S6 kinase (S6K1). Leucine 13-20 ribosomal protein S6 kinase B1 Rattus norvegicus 131-135 11916909-9 2002 Phosphorylation of 4E-BP1 and S6K1 was increased in diabetic rats infused with insulin in a dose-dependent manner, and the response was enhanced by leucine. Leucine 148-155 ribosomal protein S6 kinase B1 Rattus norvegicus 30-34 12944322-11 2003 EtOH also prevented the Leu-induced increase in phosphorylation of eIF4G, the serine/threonine protein kinase S6K1, and the ribosomal protein S6. Leucine 24-27 ribosomal protein S6 kinase B1 Rattus norvegicus 110-114 12565877-1 2003 We have previously demonstrated that N-acetylleucine amide, a derivative of L-leucine, inhibits leucine-induced p70(S6k) activation in a rat hepatoma cell line. Leucine 76-85 ribosomal protein S6 kinase B1 Rattus norvegicus 116-119 12565877-1 2003 We have previously demonstrated that N-acetylleucine amide, a derivative of L-leucine, inhibits leucine-induced p70(S6k) activation in a rat hepatoma cell line. Leucine 45-52 ribosomal protein S6 kinase B1 Rattus norvegicus 116-119 12026190-1 2002 Leucine performs a signaling role to enhance protein synthesis by phosphorylating eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1), two key regulatory proteins involved in the initiation of mRNA translation. Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 158-185 12026190-1 2002 Leucine performs a signaling role to enhance protein synthesis by phosphorylating eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1), two key regulatory proteins involved in the initiation of mRNA translation. Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 187-191 12026190-2 2002 The purpose of the current study was to assess whether the phosphorylation of 4E-BP1 and S6K1 was increased in skeletal muscle and liver by an oral administration of leucine to diabetic rats and to determine the in vivo contribution of insulin to a leucine-dependent induction of 4E-BP1 and S6K1 phosphorylation. Leucine 166-173 ribosomal protein S6 kinase B1 Rattus norvegicus 89-93 12026190-2 2002 The purpose of the current study was to assess whether the phosphorylation of 4E-BP1 and S6K1 was increased in skeletal muscle and liver by an oral administration of leucine to diabetic rats and to determine the in vivo contribution of insulin to a leucine-dependent induction of 4E-BP1 and S6K1 phosphorylation. Leucine 249-256 ribosomal protein S6 kinase B1 Rattus norvegicus 89-93 12026190-4 2002 Leucine administration resulted in enhanced phosphorylation of 4E-BP1 and S6K1 in skeletal muscle and in liver of nondiabetic rats. Leucine 0-7 ribosomal protein S6 kinase B1 Rattus norvegicus 74-78 12026190-5 2002 The stimulatory action of leucine on the phosphorylation of 4E-BP1 and S6K1 in skeletal muscle was not abolished in rats with streptozotocin-induced diabetes. Leucine 26-33 ribosomal protein S6 kinase B1 Rattus norvegicus 71-75 12026190-8 2002 In contrast to skeletal muscle, insulin is essential in mediating the leucine-dependent induction of 4E-BP1 and S6K1 phosphorylation in liver. Leucine 70-77 ribosomal protein S6 kinase B1 Rattus norvegicus 112-116 11767213-5 2001 The oral administration of leucine resulted in an enhanced phosphorylation of 4E-BP1 and S6K1 in both the liver and skeletal muscle. Leucine 27-34 ribosomal protein S6 kinase B1 Rattus norvegicus 89-93 11767213-0 2001 Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats. Leucine 15-22 ribosomal protein S6 kinase B1 Rattus norvegicus 42-46 11767213-7 2001 Our results indicate that the primary mediator in 4E-BP1 phosphorylation and S6K1 phosphorylation by the oral administration of leucine is an increase in the plasma concentration of leucine. Leucine 128-135 ribosomal protein S6 kinase B1 Rattus norvegicus 77-81 11767213-7 2001 Our results indicate that the primary mediator in 4E-BP1 phosphorylation and S6K1 phosphorylation by the oral administration of leucine is an increase in the plasma concentration of leucine. Leucine 182-189 ribosomal protein S6 kinase B1 Rattus norvegicus 77-81 10214966-1 1999 The addition of leucine induced activation of p70S6k in amino acid-depleted H4IIE cells. Leucine 16-23 ribosomal protein S6 kinase B1 Rattus norvegicus 46-52 11015466-5 2000 Furthermore, leucine was most effective among the BCAA at enhancing phosphorylation of eukaryotic initiation factor (eIF), 4E binding protein 1 (4E-BP1) and the 70-kDa ribosomal protein S6 kinase (S6K1). Leucine 13-20 ribosomal protein S6 kinase B1 Rattus norvegicus 197-201 10214966-2 1999 Whereas the activation of p70S6k by leucine was transient, the complete amino acid stimulated p70S6k more persistently. Leucine 36-43 ribosomal protein S6 kinase B1 Rattus norvegicus 26-32 10214966-3 1999 The effect of leucine on p70S6k was sensitive to rapamycin, but less sensitive to wortmannin. Leucine 14-21 ribosomal protein S6 kinase B1 Rattus norvegicus 25-31 10214966-4 1999 Using various amino acids and derivatives of leucine, we found that the chirality, the structure of the four branched hydrocarbons, and the primary amine are required for the ability of leucine to stimulate p70S6k, indicating that the structural requirement of leucine to induce p70S6k activation is very strict and precise. Leucine 45-52 ribosomal protein S6 kinase B1 Rattus norvegicus 207-213 10214966-4 1999 Using various amino acids and derivatives of leucine, we found that the chirality, the structure of the four branched hydrocarbons, and the primary amine are required for the ability of leucine to stimulate p70S6k, indicating that the structural requirement of leucine to induce p70S6k activation is very strict and precise. Leucine 186-193 ribosomal protein S6 kinase B1 Rattus norvegicus 207-213 10214966-4 1999 Using various amino acids and derivatives of leucine, we found that the chirality, the structure of the four branched hydrocarbons, and the primary amine are required for the ability of leucine to stimulate p70S6k, indicating that the structural requirement of leucine to induce p70S6k activation is very strict and precise. Leucine 186-193 ribosomal protein S6 kinase B1 Rattus norvegicus 279-285 10214966-4 1999 Using various amino acids and derivatives of leucine, we found that the chirality, the structure of the four branched hydrocarbons, and the primary amine are required for the ability of leucine to stimulate p70S6k, indicating that the structural requirement of leucine to induce p70S6k activation is very strict and precise. Leucine 186-193 ribosomal protein S6 kinase B1 Rattus norvegicus 207-213 10214966-4 1999 Using various amino acids and derivatives of leucine, we found that the chirality, the structure of the four branched hydrocarbons, and the primary amine are required for the ability of leucine to stimulate p70S6k, indicating that the structural requirement of leucine to induce p70S6k activation is very strict and precise. Leucine 186-193 ribosomal protein S6 kinase B1 Rattus norvegicus 279-285 10214966-5 1999 In addition, some leucine derivatives exhibited the ability to stimulate p70S6k and the other derivatives acted as inhibitors against the leucine-induced activation of p70S6k. Leucine 18-25 ribosomal protein S6 kinase B1 Rattus norvegicus 73-79 10214966-5 1999 In addition, some leucine derivatives exhibited the ability to stimulate p70S6k and the other derivatives acted as inhibitors against the leucine-induced activation of p70S6k. Leucine 18-25 ribosomal protein S6 kinase B1 Rattus norvegicus 168-174 10214966-5 1999 In addition, some leucine derivatives exhibited the ability to stimulate p70S6k and the other derivatives acted as inhibitors against the leucine-induced activation of p70S6k. Leucine 138-145 ribosomal protein S6 kinase B1 Rattus norvegicus 168-174 35334826-8 2022 Mild endurance exercise during fasting did not increase prefrontal cortex BHB levels nor was BDNF activated, whereas increased leucine levels were associated with Akt-independent increased phosphorylation of the mTORC1 target P70S6K. Leucine 127-134 ribosomal protein S6 kinase B1 Rattus norvegicus 226-232