PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12971424-8	2003	Genetic analysis confirmed that both patients are homozygous for a novel mutation c.1361C>T in the methionine synthase reductase gene leading to a replacement of serine by leucine (S454L) in a highly conserved FAD-binding domain.	Leucine	175-182	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	102-131