PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16259621-10	2006	Interestingly, degradation of an intrinsically unstable mutant form of TS, containing a Pro-->Leu substitution at residue 303, is directed by C-terminal, rather than N-terminal, sequences.	Leucine	97-100	thymidylate synthetase	Homo sapiens	71-73	
9813027-2	1998	Human thymidylate synthase (TS) contains three highly conserved residues Ile-108, Leu-221, and Phe-225 that have been suggested to be important for cofactor and antifolate binding.	Leucine	82-85	thymidylate synthetase	Homo sapiens	6-26	
10471740-7	1999	The 5-FdUR resistant TS were found to share several structural features including hydrophobic substitutions at residue 197, retention of the wild-type leucine 198, the alteration C199L (present in 64% of the drug-resistant library), and polar alterations of valine 204.	Leucine	151-158	thymidylate synthetase	Homo sapiens	21-23	
9813027-2	1998	Human thymidylate synthase (TS) contains three highly conserved residues Ile-108, Leu-221, and Phe-225 that have been suggested to be important for cofactor and antifolate binding.	Leucine	82-85	thymidylate synthetase	Homo sapiens	28-30