PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34423275-1 2021 Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1beta (IL-1beta). Leucine 26-33 interleukin 1 beta Mus musculus 170-187 34076707-3 2021 This study aims to investigate the effects of FSTL1 in ovalbumin (OVA)-induced mice and macrophages on nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3)/interleukin-1beta (IL-1beta) signaling pathway. Leucine 133-140 interleukin 1 beta Mus musculus 171-188 32295623-7 2020 Mechanistically, the newly identified nucleotide-binding leucine-rich repeat-containing receptor (NLR) family pyrin domain-containing 12 (NLRP12) collaborated with NLR family pyrin domain-containing 3 (NLRP3) and NLR family CARD domain-containing protein 4 (NLRC4) downstream of the CASP8-HIF-1alpha axis, to elicit pyroptotic processes and interleukin-1beta (IL-1beta) maturation through caspase-1 activation, facilitating pyroptosis and neuroinflammation in acute glaucoma. Leucine 57-64 interleukin 1 beta Mus musculus 341-358 27439540-6 2016 Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes. Leucine 27-30 interleukin 1 beta Mus musculus 118-126