PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23350153-7 2012 Regression analysis showed that the CYP1B1 Leu/Leu genotype can increase the experience of bloated stomach and facial hair increase in all the sampled women, while the Leu/Leu genotype may increase experience of palpitations and involuntary urination in the premenopausal women. Leucine 43-46 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 36-42 23821647-7 2013 In fact, mutation of this valine in human CYP1B1 to the leucine present in the rat enzyme produces a human enzyme that has the 2-hydroxylation specificity of the rat enzyme. Leucine 56-63 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 42-48 22011756-10 2012 Four atherogenic indices showed a decreasing trend in relationship to the CYP1B1 genotypes in women during their reproductive period (in the following order of magnitude: Leu/Leu + Leu/Val vs Val/Val) and an increasing trend among postmenopausal women in the same order. Leucine 171-174 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 74-80 22011756-10 2012 Four atherogenic indices showed a decreasing trend in relationship to the CYP1B1 genotypes in women during their reproductive period (in the following order of magnitude: Leu/Leu + Leu/Val vs Val/Val) and an increasing trend among postmenopausal women in the same order. Leucine 175-178 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 74-80 22011756-10 2012 Four atherogenic indices showed a decreasing trend in relationship to the CYP1B1 genotypes in women during their reproductive period (in the following order of magnitude: Leu/Leu + Leu/Val vs Val/Val) and an increasing trend among postmenopausal women in the same order. Leucine 175-178 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 74-80 23350153-7 2012 Regression analysis showed that the CYP1B1 Leu/Leu genotype can increase the experience of bloated stomach and facial hair increase in all the sampled women, while the Leu/Leu genotype may increase experience of palpitations and involuntary urination in the premenopausal women. Leucine 47-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 36-42 20678202-6 2010 Women carrying the variant CYP1B1 genotype (Leu/Val and Val/Val) showed significantly lower overall estrogen metabolite, estrogen, and 16-hydroxylation pathway levels in breast tissue in comparison to women carrying the wild type genotype. Leucine 44-47 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 21438753-15 2011 CYP1B1 susceptible genotypes (Val/Leu or Leu/Leu) also contribute to increased breast cancer risk, regardless of menopausal status, but high soy isoflavone intake may reduce this risk. Leucine 34-37 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 21438753-15 2011 CYP1B1 susceptible genotypes (Val/Leu or Leu/Leu) also contribute to increased breast cancer risk, regardless of menopausal status, but high soy isoflavone intake may reduce this risk. Leucine 41-44 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 21438753-15 2011 CYP1B1 susceptible genotypes (Val/Leu or Leu/Leu) also contribute to increased breast cancer risk, regardless of menopausal status, but high soy isoflavone intake may reduce this risk. Leucine 41-44 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 19274671-9 2009 Noteworthy, a saturation effect was observed for 4-ABP-Hb adduct formation at high smoking doses limited to carriers of the CYP1B1 (432)Leu allele. Leucine 136-139 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 124-130 19274671-7 2009 Indeed higher levels of 4-ABP-Hb adducts were observed in homo- and heterozygous carriers of the CYP1B1 (432)Leu as compared to the double CYP1B1 (432)Val genotype. Leucine 109-112 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 18977467-9 2009 In conclusion, women with the Leu allele for the CYP1B1 Val432polymorphism have increased estrogen catabolism, as indicated by higher urinary estrogen metabolites, compared to those with Val/Val genotype. Leucine 30-33 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 49-55 19536304-10 2009 Leucine, phenylalanine, and glycine are conserved at the 24th, 190th, and 329th position in the CYP1B1 protein in different species, suggestive of important functions at these loci. Leucine 0-7 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 96-102 18227148-8 2008 The Leu(437) variant also had a substantial amount of CYP1B1 protein in the microsomes, but there was a lack of detectable P450 peak and activity. Leucine 4-7 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 54-60 20037207-3 2009 The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. Leucine 20-27 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 99-105 20037207-3 2009 The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. Leucine 29-32 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 99-105 15734954-5 2005 The common alleles of the CYP1B1 gene were Arg (79.97%) in codon 48, Ala (80.53%) in codon 119, and Leu (86.57%) in codon 432. Leucine 100-103 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 26-32 17372243-10 2007 Among women homozygous for COMT Met(158), carriers of CYP1B1 Leu(432) had a 2.6-fold increase in risk relative to CYP1B1 Val(432) homozygotes (95% confidence interval, 1.1-5.9). Leucine 61-64 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 54-60 17063266-4 2007 However, a significant increase in the breast cancer risk was seen for women who had smoked 1-9 cigarettes/day and carried the CYP1B1 432Val allele; the OR was 2.6 (95% CI 1.07-6.46) for women carrying the Leu/Val genotype and 5.1 (95% CI 1.30-19.89, P for trend 0.005) for women with the Val/Val genotype compared to similarly smoking women homozygous for the 432Leu allele. Leucine 206-209 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 127-133 16569655-10 2006 The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer. Leucine 150-153 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 138-144 16569655-10 2006 The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer. Leucine 154-157 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 138-144 16569655-10 2006 The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer. Leucine 154-157 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 138-144 10698474-5 2000 Genomic DNA from cases and controls was analyzed for genetic polymorphism in codon 432 (Val-->Leu) of the CYP1B1 gene using a PCR-RFLP-based assay. Leucine 97-100 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 109-115 15075793-2 2004 The polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with change in catalytic function. Leucine 59-62 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 24-30 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Leucine 133-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Leucine 133-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 149-155 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Leucine 137-140 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Leucine 137-140 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 149-155 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Leucine 137-140 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 12398325-6 2002 It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Leucine 137-140 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 149-155