PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34427144-6	2022	Of 7 Leu AAT genes expressed by D3 only the activity of SLC7A5-SLC3A2/LAT1-4F2HC (LAT1), SLC43A2/LAT4 (LAT4) and sodium-dependent AATs, SLC6A15/B0AT2 (B0AT2), and SLC7A7/y+LAT1 (y+LAT1) were calculated to be required for Leu uptake.	Leucine	221-224	solute carrier family 3 member 2	Homo sapiens	63-69	
35501367-5	2022	SCRIB interacts with SLC3A2, a heteromeric component of leucine amino acid transporter SLC7A5.	Leucine	56-63	solute carrier family 3 member 2	Homo sapiens	21-27	
33953707-7	2021	In particular, the amino acid transporters SLC1A5 and SLC7A5 as well as the ancillary subunit SLC3A2, which are required for efficient uptake of glutamine and leucine respectively, could strengthen the metabolic capabilities and effector functions of tumor-directed CAR-NK and T cells.	Leucine	159-166	solute carrier family 3 member 2	Homo sapiens	94-100	
29538402-5	2018	The resultant decrease in cell surface 4F2hc leads to lowered cytoplasmic glutamine (Gln) and leucine (Leu) content, which down-regulates amino acid signaling.	Leucine	94-101	solute carrier family 3 member 2	Homo sapiens	39-44	
33758168-4	2021	Here, we synthesized three potent inhibitors of human LAT1, which inhibit transport of leucine with IC50 values between 100 and 250 nM, and solved the cryo-EM structures of the corresponding LAT1-4F2hc complexes with these inhibitors bound at resolution of up to 2.7 or 2.8 A.	Leucine	87-94	solute carrier family 3 member 2	Homo sapiens	196-201	
29538402-5	2018	The resultant decrease in cell surface 4F2hc leads to lowered cytoplasmic glutamine (Gln) and leucine (Leu) content, which down-regulates amino acid signaling.	Leucine	103-106	solute carrier family 3 member 2	Homo sapiens	39-44	
29150487-2	2018	It is activated by growth factors and amino acids, including essential amino acids (EAAs), such as leucine; Leu enters cells via the Leu transporter LAT1-4F2hc (also known as SLC7A5-SLC3A2) and potentially via endocytosis.	Leucine	99-106	solute carrier family 3 member 2	Homo sapiens	182-188	
29150487-2	2018	It is activated by growth factors and amino acids, including essential amino acids (EAAs), such as leucine; Leu enters cells via the Leu transporter LAT1-4F2hc (also known as SLC7A5-SLC3A2) and potentially via endocytosis.	Leucine	108-111	solute carrier family 3 member 2	Homo sapiens	182-188	
28274951-6	2017	Further analyses indicated that TGFbeta1 treatment of human breast epithelial cells reduces the expression of SLC3A2, a subunit of the leucine transporter, which diminishes leucine uptake and inhibits cell proliferation.	Leucine	135-142	solute carrier family 3 member 2	Homo sapiens	110-116	
22898570-7	2013	The leucine/glutamine antiporter SLC7A5/SLC3A2 and the amino acid sensor MAP4K3 were identified as crucial determinants of signaling leucine availability to downstream targets.	Leucine	4-11	solute carrier family 3 member 2	Homo sapiens	40-46	
25998567-5	2015	We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation.	Leucine	76-79	solute carrier family 3 member 2	Homo sapiens	35-40	
25998567-5	2015	We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation.	Leucine	164-167	solute carrier family 3 member 2	Homo sapiens	35-40	
7920863-3	1994	Injection of human 4F2hc cRNA into oocytes also results in induction of Leu/Lys transport activity, but with differing cation requirements for the two amino acids (Na(+)-dependent for Leu, Na(+)-independent for Lys: system y+L).	Leucine	72-75	solute carrier family 3 member 2	Homo sapiens	19-24	
11564694-4	2001	Injection of human 4F2 heavy chain cRNA alone stimulated the uptake of leucine and arginine due to dimerization of human 4F2 heavy chain with an endogenous Xenopus light chain, but did not affect the uptake of other ligands.	Leucine	71-78	solute carrier family 3 member 2	Homo sapiens	19-22	
11564694-4	2001	Injection of human 4F2 heavy chain cRNA alone stimulated the uptake of leucine and arginine due to dimerization of human 4F2 heavy chain with an endogenous Xenopus light chain, but did not affect the uptake of other ligands.	Leucine	71-78	solute carrier family 3 member 2	Homo sapiens	121-124	
11564694-6	2001	Coinjection of cRNAs for human 4F2 heavy chain and human LAT1 light chain stimulated the uptake of phenylalanine > tyrosine > leucine > tryptophan (100 microM) and of 3,3"-diiodothyronine > rT(3) approximately T(3) > T(4) (10 nM), which in all cases was Na(+) independent.	Leucine	132-139	solute carrier family 3 member 2	Homo sapiens	31-46	
10903140-9	2000	When co-expressed with 4F2hc in Xenopus laevis oocytes, y(+)LAT2 mediated uptake of arginine, leucine and glutamine.	Leucine	94-101	solute carrier family 3 member 2	Homo sapiens	23-28	
7920863-3	1994	Injection of human 4F2hc cRNA into oocytes also results in induction of Leu/Lys transport activity, but with differing cation requirements for the two amino acids (Na(+)-dependent for Leu, Na(+)-independent for Lys: system y+L).	Leucine	184-187	solute carrier family 3 member 2	Homo sapiens	19-24	
1376926-4	1992	This is based on the following results: (i) Injection of in vitro transcripts from 4F2hc cDNA (4F2hc cRNA) into oocytes stimulates up to 10-fold the sodium-independent uptake of L-arginine and up to 4.1-fold the sodium-dependent uptake of L-leucine.	Leucine	239-248	solute carrier family 3 member 2	Homo sapiens	83-88	
1376926-4	1992	This is based on the following results: (i) Injection of in vitro transcripts from 4F2hc cDNA (4F2hc cRNA) into oocytes stimulates up to 10-fold the sodium-independent uptake of L-arginine and up to 4.1-fold the sodium-dependent uptake of L-leucine.	Leucine	239-248	solute carrier family 3 member 2	Homo sapiens	95-100	
1376926-6	1992	(ii) Basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine is completely inhibited by L-leucine in the presence of sodium.	Leucine	104-113	solute carrier family 3 member 2	Homo sapiens	15-20	
1376926-7	1992	Similarly, the basal and 4F2hc cRNA-stimulated sodium-dependent uptake of L-leucine is entirely inhibited by L-arginine.	Leucine	74-83	solute carrier family 3 member 2	Homo sapiens	25-30	
1376926-8	1992	(iii) The stimulation of sodium-independent uptake of L-arginine and the stimulation of sodium-dependent uptake of L-leucine induced by injection of 4F2hc cRNA are both completely inhibited by dibasic L amino acids and to a lesser extent by D-ornithine.	Leucine	115-124	solute carrier family 3 member 2	Homo sapiens	149-154