PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10903140-9 2000 When co-expressed with 4F2hc in Xenopus laevis oocytes, y(+)LAT2 mediated uptake of arginine, leucine and glutamine. Leucine 94-101 solute carrier family 3 member 2 Homo sapiens 23-28 29538402-5 2018 The resultant decrease in cell surface 4F2hc leads to lowered cytoplasmic glutamine (Gln) and leucine (Leu) content, which down-regulates amino acid signaling. Leucine 94-101 solute carrier family 3 member 2 Homo sapiens 39-44 29538402-5 2018 The resultant decrease in cell surface 4F2hc leads to lowered cytoplasmic glutamine (Gln) and leucine (Leu) content, which down-regulates amino acid signaling. Leucine 103-106 solute carrier family 3 member 2 Homo sapiens 39-44 29150487-2 2018 It is activated by growth factors and amino acids, including essential amino acids (EAAs), such as leucine; Leu enters cells via the Leu transporter LAT1-4F2hc (also known as SLC7A5-SLC3A2) and potentially via endocytosis. Leucine 99-106 solute carrier family 3 member 2 Homo sapiens 182-188 29150487-2 2018 It is activated by growth factors and amino acids, including essential amino acids (EAAs), such as leucine; Leu enters cells via the Leu transporter LAT1-4F2hc (also known as SLC7A5-SLC3A2) and potentially via endocytosis. Leucine 108-111 solute carrier family 3 member 2 Homo sapiens 182-188 28274951-6 2017 Further analyses indicated that TGFbeta1 treatment of human breast epithelial cells reduces the expression of SLC3A2, a subunit of the leucine transporter, which diminishes leucine uptake and inhibits cell proliferation. Leucine 135-142 solute carrier family 3 member 2 Homo sapiens 110-116 22898570-7 2013 The leucine/glutamine antiporter SLC7A5/SLC3A2 and the amino acid sensor MAP4K3 were identified as crucial determinants of signaling leucine availability to downstream targets. Leucine 4-11 solute carrier family 3 member 2 Homo sapiens 40-46 11564694-4 2001 Injection of human 4F2 heavy chain cRNA alone stimulated the uptake of leucine and arginine due to dimerization of human 4F2 heavy chain with an endogenous Xenopus light chain, but did not affect the uptake of other ligands. Leucine 71-78 solute carrier family 3 member 2 Homo sapiens 19-22 11564694-4 2001 Injection of human 4F2 heavy chain cRNA alone stimulated the uptake of leucine and arginine due to dimerization of human 4F2 heavy chain with an endogenous Xenopus light chain, but did not affect the uptake of other ligands. Leucine 71-78 solute carrier family 3 member 2 Homo sapiens 121-124 11564694-6 2001 Coinjection of cRNAs for human 4F2 heavy chain and human LAT1 light chain stimulated the uptake of phenylalanine > tyrosine > leucine > tryptophan (100 microM) and of 3,3"-diiodothyronine > rT(3) approximately T(3) > T(4) (10 nM), which in all cases was Na(+) independent. Leucine 132-139 solute carrier family 3 member 2 Homo sapiens 31-46 25998567-5 2015 We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation. Leucine 76-79 solute carrier family 3 member 2 Homo sapiens 35-40 25998567-5 2015 We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation. Leucine 164-167 solute carrier family 3 member 2 Homo sapiens 35-40 1376926-4 1992 This is based on the following results: (i) Injection of in vitro transcripts from 4F2hc cDNA (4F2hc cRNA) into oocytes stimulates up to 10-fold the sodium-independent uptake of L-arginine and up to 4.1-fold the sodium-dependent uptake of L-leucine. Leucine 239-248 solute carrier family 3 member 2 Homo sapiens 83-88 7920863-3 1994 Injection of human 4F2hc cRNA into oocytes also results in induction of Leu/Lys transport activity, but with differing cation requirements for the two amino acids (Na(+)-dependent for Leu, Na(+)-independent for Lys: system y+L). Leucine 72-75 solute carrier family 3 member 2 Homo sapiens 19-24 7920863-3 1994 Injection of human 4F2hc cRNA into oocytes also results in induction of Leu/Lys transport activity, but with differing cation requirements for the two amino acids (Na(+)-dependent for Leu, Na(+)-independent for Lys: system y+L). Leucine 184-187 solute carrier family 3 member 2 Homo sapiens 19-24 1376926-4 1992 This is based on the following results: (i) Injection of in vitro transcripts from 4F2hc cDNA (4F2hc cRNA) into oocytes stimulates up to 10-fold the sodium-independent uptake of L-arginine and up to 4.1-fold the sodium-dependent uptake of L-leucine. Leucine 239-248 solute carrier family 3 member 2 Homo sapiens 95-100 1376926-6 1992 (ii) Basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine is completely inhibited by L-leucine in the presence of sodium. Leucine 104-113 solute carrier family 3 member 2 Homo sapiens 15-20 1376926-7 1992 Similarly, the basal and 4F2hc cRNA-stimulated sodium-dependent uptake of L-leucine is entirely inhibited by L-arginine. Leucine 74-83 solute carrier family 3 member 2 Homo sapiens 25-30 1376926-8 1992 (iii) The stimulation of sodium-independent uptake of L-arginine and the stimulation of sodium-dependent uptake of L-leucine induced by injection of 4F2hc cRNA are both completely inhibited by dibasic L amino acids and to a lesser extent by D-ornithine. Leucine 115-124 solute carrier family 3 member 2 Homo sapiens 149-154 35501367-5 2022 SCRIB interacts with SLC3A2, a heteromeric component of leucine amino acid transporter SLC7A5. Leucine 56-63 solute carrier family 3 member 2 Homo sapiens 21-27 34427144-6 2022 Of 7 Leu AAT genes expressed by D3 only the activity of SLC7A5-SLC3A2/LAT1-4F2HC (LAT1), SLC43A2/LAT4 (LAT4) and sodium-dependent AATs, SLC6A15/B0AT2 (B0AT2), and SLC7A7/y+LAT1 (y+LAT1) were calculated to be required for Leu uptake. Leucine 221-224 solute carrier family 3 member 2 Homo sapiens 63-69 33758168-4 2021 Here, we synthesized three potent inhibitors of human LAT1, which inhibit transport of leucine with IC50 values between 100 and 250 nM, and solved the cryo-EM structures of the corresponding LAT1-4F2hc complexes with these inhibitors bound at resolution of up to 2.7 or 2.8 A. Leucine 87-94 solute carrier family 3 member 2 Homo sapiens 196-201 33953707-7 2021 In particular, the amino acid transporters SLC1A5 and SLC7A5 as well as the ancillary subunit SLC3A2, which are required for efficient uptake of glutamine and leucine respectively, could strengthen the metabolic capabilities and effector functions of tumor-directed CAR-NK and T cells. Leucine 159-166 solute carrier family 3 member 2 Homo sapiens 94-100